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Medical Oncology
Published in: Medical Oncology 5/2015

01-05-2015 | Original Paper

Suppressed expression of LDHB promotes pancreatic cancer progression via inducing glycolytic phenotype

Authors: Jiujie Cui, Ming Quan, Weihua Jiang, Hai Hu, Feng Jiao, Ning Li, Ziliang Jin, Lei Wang, Yu Wang, Liwei Wang

Published in: Medical Oncology | Issue 5/2015

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Abstract

Lactate dehydrogenase B (LDHB) is widely expressed in adult somatic tissue and is one of the two subunits of lactate dehydrogenase, which is the key glycolytic enzyme and catalyzes the interconversion of pyruvate and lactate. However, the roles of LDHB in glycolysis and tumor progression were obscure in different types of cancer. Here, we determined the roles of LDHB in pancreatic cancer development and progression. We found suppressed expression of LDHB in pancreatic cancer which was due to promoter hypermethylation and deceased expression of LDHB led to glycolytic transition. Functional analysis revealed that suppressed expression of LDHB promoted pancreatic cancer cells proliferation, invasion, and migration in hypoxia. Thus, LDHB might function as a suppressor of glycolysis and suppressed pancreatic cancer progression.
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Metadata
Title
Suppressed expression of LDHB promotes pancreatic cancer progression via inducing glycolytic phenotype
Authors
Jiujie Cui
Ming Quan
Weihua Jiang
Hai Hu
Feng Jiao
Ning Li
Ziliang Jin
Lei Wang
Yu Wang
Liwei Wang
Publication date
01-05-2015
Publisher
Springer US
Published in
Medical Oncology / Issue 5/2015
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-015-0589-8

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