Skip to main content
Top
Published in: Medical Oncology 2/2013

01-06-2013 | Original Paper

Appropriateness of cardiovascular care in elderly adult cancer survivors

Authors: Winson Y. Cheung, Raisa Levin, Soko Setoguchi

Published in: Medical Oncology | Issue 2/2013

Login to get access

Abstract

Research suggests that the quality of non-cancer-related care among cancer survivors (CS) is suboptimal. Secondary disease prevention is an important component of survivorship care that has not been previously evaluated. Our aims were (1) to assess the utilization of and adherence to medications and treatments for the secondary prevention of myocardial infarction (MI) in CS versus non-cancer patients (NCP) and (2) to compare temporal trends in cardiovascular care between these two patient cohorts. Linking data from Medicare, pharmacy assistance programs, and cancer registries, we calculated the percentage of individuals receiving preventive medications (statins, β-blockers, angiotensin-converting enzyme inhibitors) and revascularization interventions (angioplasty, stent, bypass surgery) within 90 days after acute MI in CS and propensity score–matched NCP. We assessed trends over time and determined predictors of appropriate preventive care using modified Poisson regression. We identified 1,119 CS and 7,886 NCP. Compared to NCP, more survivors received statins (38 vs. 31 %) and β-blockers (67 vs. 59 %), but fewer underwent bypass surgery (1.5 vs. 2.8 %) after MI. From 1997 to 2004, both survivors and NCP were increasingly prescribed medications to prevent future coronary events. Over the same time period, receipt of bypass surgery was significantly lower among survivors. Co-morbidities, such as depression and lung disease, and demographic factors, such as advanced age and female, were associated with underuse of preventive care among survivors when compared to NCP. Use of preventive medications and procedures has generally improved, but uptake of bypass surgery among CS still lags behind NCP.
Literature
1.
2.
go back to reference Jemal A, Center MM, DeSantis C, et al. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 2010;19:1893–907.PubMedCrossRef Jemal A, Center MM, DeSantis C, et al. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 2010;19:1893–907.PubMedCrossRef
3.
4.
go back to reference Hewitt M, Greenfield S, Stovall E, editors. Cancer patient to cancer survivor: lost in transition. Washington: National Academies Press; 2006. Hewitt M, Greenfield S, Stovall E, editors. Cancer patient to cancer survivor: lost in transition. Washington: National Academies Press; 2006.
5.
go back to reference Earle CC, Neville BA. Under use of necessary care among cancer survivors. Cancer. 2004;101:1712–9.PubMedCrossRef Earle CC, Neville BA. Under use of necessary care among cancer survivors. Cancer. 2004;101:1712–9.PubMedCrossRef
6.
go back to reference Snyder CF, Earle CC, Herbert RJ, et al. Preventive care for colorectal cancer survivors: a 5-year longitudinal study. J Clin Oncol. 2008;26:1073–9.PubMedCrossRef Snyder CF, Earle CC, Herbert RJ, et al. Preventive care for colorectal cancer survivors: a 5-year longitudinal study. J Clin Oncol. 2008;26:1073–9.PubMedCrossRef
7.
go back to reference Snyder CF, Earle CC, Herbert RJ, et al. Trends in follow-up and preventive care for colorectal cancer survivors. J Gen Intern Med. 2008;23:254–9.PubMedCrossRef Snyder CF, Earle CC, Herbert RJ, et al. Trends in follow-up and preventive care for colorectal cancer survivors. J Gen Intern Med. 2008;23:254–9.PubMedCrossRef
8.
go back to reference Gemmell I, Heller RF, Payne K, et al. Potential population impact of the UK government strategy for reducing the burden of coronary heart disease in England: comparing primary and secondary prevention strategies. Qual Saf Healthcare. 2006;15:339–43.CrossRef Gemmell I, Heller RF, Payne K, et al. Potential population impact of the UK government strategy for reducing the burden of coronary heart disease in England: comparing primary and secondary prevention strategies. Qual Saf Healthcare. 2006;15:339–43.CrossRef
9.
go back to reference Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50:105–16.PubMedCrossRef Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50:105–16.PubMedCrossRef
10.
go back to reference Kiyota Y, Schneeweiss S, Glynn RJ, et al. Accuracy of Medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records. Am Heart J. 2004;148:99–104.PubMedCrossRef Kiyota Y, Schneeweiss S, Glynn RJ, et al. Accuracy of Medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records. Am Heart J. 2004;148:99–104.PubMedCrossRef
11.
go back to reference Reeve BB, Smith AW, Arora NK, et al. Reducing bias in cancer research: application of propensity score matching. Healthcare Financ Rev. 2008;29:69–80. Reeve BB, Smith AW, Arora NK, et al. Reducing bias in cancer research: application of propensity score matching. Healthcare Financ Rev. 2008;29:69–80.
12.
go back to reference Rasmussen JN, Chong A, Alter DA. Relationship between adherence to evidence-based pharmacotherapy and long-term mortality after acute myocardial infarction. JAMA. 2007;297:177–86.PubMedCrossRef Rasmussen JN, Chong A, Alter DA. Relationship between adherence to evidence-based pharmacotherapy and long-term mortality after acute myocardial infarction. JAMA. 2007;297:177–86.PubMedCrossRef
13.
go back to reference Hill R, Bagust A, Bakhai A, et al.: Coronary artery stents: a rapid systematic review and economic evaluation. Health Technol Assess. 2004;8:iii–iv, 1–242. Hill R, Bagust A, Bakhai A, et al.: Coronary artery stents: a rapid systematic review and economic evaluation. Health Technol Assess. 2004;8:iii–iv, 1–242.
14.
go back to reference Dhalla IA, Smith MA, Choudhry NK, et al. Costs and benefits of free medications after myocardial infarction. Healthc Policy. 2009;5:68–86.PubMed Dhalla IA, Smith MA, Choudhry NK, et al. Costs and benefits of free medications after myocardial infarction. Healthc Policy. 2009;5:68–86.PubMed
15.
go back to reference Wright RS, Anderson JL, Adams CD, et al. ACCF/AHA focused update of the guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline): a report of the American college of cardiology Foundation/American heart association task force on practice guidelines. Circulation. 2011;123:2022–60.PubMedCrossRef Wright RS, Anderson JL, Adams CD, et al. ACCF/AHA focused update of the guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline): a report of the American college of cardiology Foundation/American heart association task force on practice guidelines. Circulation. 2011;123:2022–60.PubMedCrossRef
16.
go back to reference Bach PB, Guadagnoli E, Schrag D, et al. Patient demographic and socioeconomic characteristics in the SEER-Medicare database applications and limitations. Med Care. 2002;40:IV-19–25.CrossRef Bach PB, Guadagnoli E, Schrag D, et al. Patient demographic and socioeconomic characteristics in the SEER-Medicare database applications and limitations. Med Care. 2002;40:IV-19–25.CrossRef
17.
go back to reference Warren JL, Klabunde CN, Schrag D, et al. Overview of the SEER-Medicare data: content, research applications, and generalizability to the United States elderly population. Med Care. 2002;40:IV-3–-18. Warren JL, Klabunde CN, Schrag D, et al. Overview of the SEER-Medicare data: content, research applications, and generalizability to the United States elderly population. Med Care. 2002;40:IV-3–-18.
18.
go back to reference Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic co-morbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.PubMedCrossRef Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic co-morbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.PubMedCrossRef
19.
go back to reference Zou G. A modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol. 2004;159:702–6.PubMedCrossRef Zou G. A modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol. 2004;159:702–6.PubMedCrossRef
20.
go back to reference Hershman DL, Kushi LH, Shao T, et al. Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients. J Clin Oncol. 2010;28:4120–8.PubMedCrossRef Hershman DL, Kushi LH, Shao T, et al. Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients. J Clin Oncol. 2010;28:4120–8.PubMedCrossRef
21.
go back to reference Neugut AI, Subar M, Wilde ET, et al. Association between prescription co-payment amount and compliance with adjuvant hormonal therapy in women with early-stage breast cancer. J Clin Oncol. 2011;29:2534–42.PubMedCrossRef Neugut AI, Subar M, Wilde ET, et al. Association between prescription co-payment amount and compliance with adjuvant hormonal therapy in women with early-stage breast cancer. J Clin Oncol. 2011;29:2534–42.PubMedCrossRef
22.
go back to reference Partridge AH, Avorn J, Wang PS, et al. Adherence to therapy with oral antineoplastic agents. J Natl Cancer Inst. 2002;94:652–61.PubMedCrossRef Partridge AH, Avorn J, Wang PS, et al. Adherence to therapy with oral antineoplastic agents. J Natl Cancer Inst. 2002;94:652–61.PubMedCrossRef
23.
go back to reference Fang J, Gillespie C, Keenan NL, et al. Awareness of heart attack symptoms among US adults in 2007, and changes in awareness from 2001 to 2007. Future Cardiol. 2011;7:311–20.PubMedCrossRef Fang J, Gillespie C, Keenan NL, et al. Awareness of heart attack symptoms among US adults in 2007, and changes in awareness from 2001 to 2007. Future Cardiol. 2011;7:311–20.PubMedCrossRef
24.
go back to reference Greenlund KJ, Keenan NL, Giles WH, et al. Public recognition of major signs and symptoms of heart attack: seventeen states and the US virgin islands, 2001. Am Heart J. 2004;147:1010–6.PubMedCrossRef Greenlund KJ, Keenan NL, Giles WH, et al. Public recognition of major signs and symptoms of heart attack: seventeen states and the US virgin islands, 2001. Am Heart J. 2004;147:1010–6.PubMedCrossRef
25.
go back to reference Kon RH, Russo MW, Ory B, et al. Misperception among physicians and patients regarding the risks and benefits of statin treatment: the potential role of direct-to-consumer advertising. J Clin Lipidol. 2008;2:51–7.PubMedCrossRef Kon RH, Russo MW, Ory B, et al. Misperception among physicians and patients regarding the risks and benefits of statin treatment: the potential role of direct-to-consumer advertising. J Clin Lipidol. 2008;2:51–7.PubMedCrossRef
26.
go back to reference Rogers AM, Ramanath VS, Grzybowski M, et al. The association between guideline-based treatment instructions at the point of discharge and lower 1-year mortality in Medicare patients after acute myocardial infarction: the American College of Cardiology’s guidelines applied in practice (GAP) initiative in Michigan. Am Heart J. 2007;154:461–9.PubMedCrossRef Rogers AM, Ramanath VS, Grzybowski M, et al. The association between guideline-based treatment instructions at the point of discharge and lower 1-year mortality in Medicare patients after acute myocardial infarction: the American College of Cardiology’s guidelines applied in practice (GAP) initiative in Michigan. Am Heart J. 2007;154:461–9.PubMedCrossRef
27.
go back to reference Blaauwbroek R, Tuinier W, Meyboom-de Jong B, et al. Shared care by paediatric oncologists and family doctors for long-term follow-up of adult childhood cancer survivors: a pilot study. Lancet Oncol. 2008;9:232–8.PubMedCrossRef Blaauwbroek R, Tuinier W, Meyboom-de Jong B, et al. Shared care by paediatric oncologists and family doctors for long-term follow-up of adult childhood cancer survivors: a pilot study. Lancet Oncol. 2008;9:232–8.PubMedCrossRef
28.
go back to reference Parish RC, Miller LJ. Adverse effects of angiotensin converting enzyme (ACE) inhibitors. An update. Drug Saf. 1992;7:14–31.PubMedCrossRef Parish RC, Miller LJ. Adverse effects of angiotensin converting enzyme (ACE) inhibitors. An update. Drug Saf. 1992;7:14–31.PubMedCrossRef
30.
go back to reference Rehman A, Schiffrin EL. Vascular effects of antihypertensive drug therapy. Curr Hypertens Rep. 2010;12:226–32.PubMedCrossRef Rehman A, Schiffrin EL. Vascular effects of antihypertensive drug therapy. Curr Hypertens Rep. 2010;12:226–32.PubMedCrossRef
31.
go back to reference Lees J, Chan A. Polypharmacy in elderly patients with cancer: clinical implications and management. Lancet Oncol. 2011;12:1249–57.PubMedCrossRef Lees J, Chan A. Polypharmacy in elderly patients with cancer: clinical implications and management. Lancet Oncol. 2011;12:1249–57.PubMedCrossRef
32.
go back to reference Grunfeld E, Earle CC. The interface between primary and oncology specialty care: treatment through survivorship. J Natl Cancer Inst Monogr. 2010;40:25–30.CrossRef Grunfeld E, Earle CC. The interface between primary and oncology specialty care: treatment through survivorship. J Natl Cancer Inst Monogr. 2010;40:25–30.CrossRef
Metadata
Title
Appropriateness of cardiovascular care in elderly adult cancer survivors
Authors
Winson Y. Cheung
Raisa Levin
Soko Setoguchi
Publication date
01-06-2013
Publisher
Springer US
Published in
Medical Oncology / Issue 2/2013
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-013-0561-4

Other articles of this Issue 2/2013

Medical Oncology 2/2013 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.