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Neurocritical Care
Published in: Neurocritical Care 2/2020

01-04-2020 | Magnetic Resonance Imaging | Original Work

Brain Volume Changes in Patients with Acute Brain Dysfunction Due to Sepsis

Authors: Günseli Orhun, Erdem Tüzün, Başar Bilgiç, Perihan Ergin Özcan, Serra Sencer, Mehmet Barburoğlu, Figen Esen

Published in: Neurocritical Care | Issue 2/2020

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Abstract

Background

Sepsis-induced brain dysfunction (SIBD) is often encountered in sepsis patients and is related to increased morbidity. No specific tests are available for SIBD, and neuroimaging findings are often normal. In this study, our aim was to analyze the diagnostic value of volumetric analysis of the brain structures and to find out its significance as a prognostic measure.

Methods

In this prospective observational study, brain magnetic resonance imaging (MRI) sections of 25 consecutively enrolled SIBD patients (17 with encephalopathy and 8 with coma) and 22 healthy controls underwent volumetric evaluation by an automated segmentation method.

Results

Ten SIBD patients had normal MRI, and 15 patients showed brain lesions or atrophy. The most prominent volume reduction was found in cerebral and cerebellar white matter, cerebral cortex, hippocampus, and amygdala, whereas deep gray matter regions and cerebellar cortex were relatively less affected. SIBD patients with normal MRI showed significantly reduced volumes in hippocampus and cerebral white matter. Caudate nuclei, putamen, and thalamus showed lower volume values in non-survivor SIBD patients, and left putamen and right thalamus showed a more pronounced volume reduction in coma patients.

Conclusions

Volumetric analysis of the brain appears to be a sensitive measure of volumetric changes in SIBD. Volume reduction in specific deep gray matter regions might be an indicator of unfavorable outcome.
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Metadata
Title
Brain Volume Changes in Patients with Acute Brain Dysfunction Due to Sepsis
Authors
Günseli Orhun
Erdem Tüzün
Başar Bilgiç
Perihan Ergin Özcan
Serra Sencer
Mehmet Barburoğlu
Figen Esen
Publication date
01-04-2020
Publisher
Springer US
Published in
Neurocritical Care / Issue 2/2020
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-019-00759-8

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