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Published in: Neurocritical Care 1/2013

01-02-2013 | Review Article

Influenza-Associated Neurological Complications

Authors: Jenny P. Tsai, Andrew J. Baker

Published in: Neurocritical Care | Issue 1/2013

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Abstract

While mostly diagnosed in the pediatric population, neurological complications of pandemic influenza A infection may affect young and previously healthy adults, and may follow a fulminant, severe, and occasionally fatal course. We reviewed severe neurological complications secondary to influenza infection reported in the literature, in attempt to outline recurrent syndromes that may assist the clinician in making a timely diagnosis. Vigilance and awareness of these clinical entities are key in the neurologist and intensivist’s role in surveillance and early recognition of pandemic influenza, and in ensuring improved survival for affected patients.
Literature
1.
go back to reference Agyeman P, Duppenthaler A, Heininger U, Aebi C. Influenza-associated myositis in children. Infection. 2004;32(4):199–203.PubMedCrossRef Agyeman P, Duppenthaler A, Heininger U, Aebi C. Influenza-associated myositis in children. Infection. 2004;32(4):199–203.PubMedCrossRef
2.
go back to reference Aiba H, Mochizuki M, Kimura M, Hojo H. Predictive value of serum interleukin-6 level in influenza virus-associated encephalopathy. Neurology. 2001;57(2):295–9.PubMedCrossRef Aiba H, Mochizuki M, Kimura M, Hojo H. Predictive value of serum interleukin-6 level in influenza virus-associated encephalopathy. Neurology. 2001;57(2):295–9.PubMedCrossRef
3.
go back to reference Akins PT, Belko J, Uyeki TM, Axelrod Y, Lee KK, Silverthorn J. H1N1 encephalitis with malignant edema and review of neurologic complications from influenza. Neurocrit Care. 2010;13(3):396–406.PubMedCrossRef Akins PT, Belko J, Uyeki TM, Axelrod Y, Lee KK, Silverthorn J. H1N1 encephalitis with malignant edema and review of neurologic complications from influenza. Neurocrit Care. 2010;13(3):396–406.PubMedCrossRef
4.
go back to reference Amin R, Ford-Jones E, Richardson SE, MacGregor D, Tellier R, Heurter H, Fearon M, Bitnun A. Acute childhood encephalitis and encephalopathy associated with influenza: a prospective 11 year review. Pediatr Infect Dis J. 2008;27(5):390–5.PubMedCrossRef Amin R, Ford-Jones E, Richardson SE, MacGregor D, Tellier R, Heurter H, Fearon M, Bitnun A. Acute childhood encephalitis and encephalopathy associated with influenza: a prospective 11 year review. Pediatr Infect Dis J. 2008;27(5):390–5.PubMedCrossRef
5.
go back to reference Auriel E, Gadoth A, Regev K, et al. Seasonal and H1N1v influenza vaccines in MS: safety and compliance. J Neurol Sci. 2012;314(1–2):102–3.PubMedCrossRef Auriel E, Gadoth A, Regev K, et al. Seasonal and H1N1v influenza vaccines in MS: safety and compliance. J Neurol Sci. 2012;314(1–2):102–3.PubMedCrossRef
6.
go back to reference Bacon CJ, Hall SM. Haemorrhagic shock encephalopathy syndrome in the British Isles. Arch Dis Child. 1992;67(8):985–93.PubMedCrossRef Bacon CJ, Hall SM. Haemorrhagic shock encephalopathy syndrome in the British Isles. Arch Dis Child. 1992;67(8):985–93.PubMedCrossRef
7.
go back to reference Bardage C, Persson I, Ortgvist A, et al. Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm. Sweden BMJ. 2011;343:d5956.CrossRef Bardage C, Persson I, Ortgvist A, et al. Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm. Sweden BMJ. 2011;343:d5956.CrossRef
8.
go back to reference Bautista E, Chotpitayasunondh T, Gao Z, Harper SA, Shaw M, Uyeki TM, Zaki SR, Hayden FG, Hui DS, Kettner JD, et al. Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med. 2010;362(18):1708–19.PubMedCrossRef Bautista E, Chotpitayasunondh T, Gao Z, Harper SA, Shaw M, Uyeki TM, Zaki SR, Hayden FG, Hui DS, Kettner JD, et al. Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med. 2010;362(18):1708–19.PubMedCrossRef
9.
go back to reference Berger JR, Houff SA. Neurological infections: the year of PML and influenza. Lancet Neurol. 2010;9(1):14–7.PubMedCrossRef Berger JR, Houff SA. Neurological infections: the year of PML and influenza. Lancet Neurol. 2010;9(1):14–7.PubMedCrossRef
10.
go back to reference Black S, Eskola J, Siegrist CA, Halsey N, Macdonald N, Law B, Miller E, Andrews N, Stowe J, Salmon D, et al. Importance of background rates of disease in assessment of vaccine safety during mass immunisation with pandemic H1N1 influenza vaccines. Lancet. 2009;374(9707):2115–22.PubMedCrossRef Black S, Eskola J, Siegrist CA, Halsey N, Macdonald N, Law B, Miller E, Andrews N, Stowe J, Salmon D, et al. Importance of background rates of disease in assessment of vaccine safety during mass immunisation with pandemic H1N1 influenza vaccines. Lancet. 2009;374(9707):2115–22.PubMedCrossRef
11.
go back to reference Chen YC, Lo CP, Chang TP. Novel influenza A (H1N1)-associated encephalopathy/encephalitis with severe neurological sequelae and unique image features–a case report. J Neurol Sci. 2010;298(1–2):110–3.PubMedCrossRef Chen YC, Lo CP, Chang TP. Novel influenza A (H1N1)-associated encephalopathy/encephalitis with severe neurological sequelae and unique image features–a case report. J Neurol Sci. 2010;298(1–2):110–3.PubMedCrossRef
12.
go back to reference Davis LE. Neurologic and muscular complications of the 2009 influenza A (H1N1) pandemic. Curr Neurol Neurosci Rep. 2010;10(6):476–83.PubMedCrossRef Davis LE. Neurologic and muscular complications of the 2009 influenza A (H1N1) pandemic. Curr Neurol Neurosci Rep. 2010;10(6):476–83.PubMedCrossRef
13.
go back to reference de Jong MD, Bach VC, Phan TQ, Vo MH, Tran TT, Nguyen BH, Beld M, Le TP, Truong HK, Nguyen VV, et al. Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma. N Engl J Med. 2005;352(7):686–91.PubMedCrossRef de Jong MD, Bach VC, Phan TQ, Vo MH, Tran TT, Nguyen BH, Beld M, Le TP, Truong HK, Nguyen VV, et al. Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma. N Engl J Med. 2005;352(7):686–91.PubMedCrossRef
14.
go back to reference de Jong MD, Simmons CP, Thanh TT, Hien VM, Smith GJ, Chau TN, Hoang DM, Chau NV, Khanh TH, Dong VC, et al. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med. 2006;12(10):1203–7.PubMedCrossRef de Jong MD, Simmons CP, Thanh TT, Hien VM, Smith GJ, Chau TN, Hoang DM, Chau NV, Khanh TH, Dong VC, et al. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med. 2006;12(10):1203–7.PubMedCrossRef
15.
go back to reference Destefano F, Tokars J. H1N1 vaccine safety monitoring: beyond background rates. Lancet. 2010;375(9721):1146–7.PubMedCrossRef Destefano F, Tokars J. H1N1 vaccine safety monitoring: beyond background rates. Lancet. 2010;375(9721):1146–7.PubMedCrossRef
16.
go back to reference Drago L, Attia MW, DePiero A, Bean C. Influenza A-associated meningoencephalitis. Pediatr Emerg Care. 2005;21(7):437–9.PubMedCrossRef Drago L, Attia MW, DePiero A, Bean C. Influenza A-associated meningoencephalitis. Pediatr Emerg Care. 2005;21(7):437–9.PubMedCrossRef
17.
go back to reference Eisen DP, McBryde ES. Avoiding Guillan-Barre Syndrome following swine origin pandemic H1N1 2009 influenza vaccination. J Infect Dis. 2009;200(10):1627–8.PubMedCrossRef Eisen DP, McBryde ES. Avoiding Guillan-Barre Syndrome following swine origin pandemic H1N1 2009 influenza vaccination. J Infect Dis. 2009;200(10):1627–8.PubMedCrossRef
18.
go back to reference Evans D, Cauchemez S, Hayden FG. “Prepandemic” immunization for novel influenza viruses, “swine flu” vaccine, Guillain-Barre syndrome, and the detection of rare severe adverse events. J Infect Dis. 2009;200(3):321–8.PubMedCrossRef Evans D, Cauchemez S, Hayden FG. “Prepandemic” immunization for novel influenza viruses, “swine flu” vaccine, Guillain-Barre syndrome, and the detection of rare severe adverse events. J Infect Dis. 2009;200(3):321–8.PubMedCrossRef
19.
go back to reference Finsterer J, Artner C, Kladosek A, Kalchmayr R, Redtenbacher S. Cavernous sinus syndrome due to vaccination-induced giant cell arteritis. Arch Intern Med. 2001;161(7):1008–9.PubMedCrossRef Finsterer J, Artner C, Kladosek A, Kalchmayr R, Redtenbacher S. Cavernous sinus syndrome due to vaccination-induced giant cell arteritis. Arch Intern Med. 2001;161(7):1008–9.PubMedCrossRef
20.
go back to reference Fluss J, Ferey S, Menache-Starobinski C, Delavelle J, Van Bogaert P, Vargas MI. Mild influenza-associated encephalopathy/encephalitis with a reversible splenial lesion in a Caucasian child with additional cerebellar features. Eur J Paediatr Neurol. 2010;14(1):97–100.PubMedCrossRef Fluss J, Ferey S, Menache-Starobinski C, Delavelle J, Van Bogaert P, Vargas MI. Mild influenza-associated encephalopathy/encephalitis with a reversible splenial lesion in a Caucasian child with additional cerebellar features. Eur J Paediatr Neurol. 2010;14(1):97–100.PubMedCrossRef
21.
go back to reference Foley PB. Encephalitis lethargica and the influenza virus. II. The influenza pandemic of 1918/19 and encephalitis lethargica: epidemiology and symptoms. J Neural Transm. 2009;116(10):1295–308.PubMedCrossRef Foley PB. Encephalitis lethargica and the influenza virus. II. The influenza pandemic of 1918/19 and encephalitis lethargica: epidemiology and symptoms. J Neural Transm. 2009;116(10):1295–308.PubMedCrossRef
22.
go back to reference Foley PB. Encephalitis lethargica and the influenza virus. III. The influenza pandemic of 1918/19 and encephalitis lethargica: neuropathology and discussion. J Neural Transm. 2009;116(10):1309–21.PubMedCrossRef Foley PB. Encephalitis lethargica and the influenza virus. III. The influenza pandemic of 1918/19 and encephalitis lethargica: neuropathology and discussion. J Neural Transm. 2009;116(10):1309–21.PubMedCrossRef
23.
go back to reference Fugate JE, Lam EM, Rabinstein AA, Wijdicks EF. Acute hemorrhagic leukoencephalitis and hypoxic brain injury associated with H1N1 influenza. Arch Neurol. 2010;67(6):756–8.PubMedCrossRef Fugate JE, Lam EM, Rabinstein AA, Wijdicks EF. Acute hemorrhagic leukoencephalitis and hypoxic brain injury associated with H1N1 influenza. Arch Neurol. 2010;67(6):756–8.PubMedCrossRef
24.
go back to reference Fujimoto S, Kobayashi M, Uemura O, Iwasa M, Ando T, Katoh T, Nakamura C, Maki N, Togari H, Wada Y. PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis. Lancet. 1998;352(9131):873–5.PubMedCrossRef Fujimoto S, Kobayashi M, Uemura O, Iwasa M, Ando T, Katoh T, Nakamura C, Maki N, Togari H, Wada Y. PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis. Lancet. 1998;352(9131):873–5.PubMedCrossRef
25.
go back to reference Ganapathy S, Ey EH, Wolfson BJ, Khan N. Transient isolated lesion of the splenium associated with clinically mild influenza encephalitis. Pediatr Radiol. 2008;38(11):1243–5.PubMedCrossRef Ganapathy S, Ey EH, Wolfson BJ, Khan N. Transient isolated lesion of the splenium associated with clinically mild influenza encephalitis. Pediatr Radiol. 2008;38(11):1243–5.PubMedCrossRef
26.
go back to reference Gefen R, Eshel G, Abu-Kishk I, Lahat E, Youngster I, Rosenbloom E, Kozer E. Hemorrhagic shock and encephalopathy syndrome: clinical course and neurological outcome. J Child Neurol. 2008;23(5):589–92.PubMedCrossRef Gefen R, Eshel G, Abu-Kishk I, Lahat E, Youngster I, Rosenbloom E, Kozer E. Hemorrhagic shock and encephalopathy syndrome: clinical course and neurological outcome. J Child Neurol. 2008;23(5):589–92.PubMedCrossRef
27.
go back to reference Gika AD, Rich P, Gupta S, Neilson DE, Clarke A. Recurrent acute necrotizing encephalopathy following influenza A in a genetically predisposed family. Dev Med Child Neurol. 2010;52(1):99–102.PubMedCrossRef Gika AD, Rich P, Gupta S, Neilson DE, Clarke A. Recurrent acute necrotizing encephalopathy following influenza A in a genetically predisposed family. Dev Med Child Neurol. 2010;52(1):99–102.PubMedCrossRef
28.
go back to reference Gooskens J, Kuiken T, Claas EC, Harinck HI, Thijssen JC, Baelde HJ, Kroes AC. Severe influenza resembling hemorrhagic shock and encephalopathy syndrome. J Clin Virol. 2007;39(2):136–40.PubMedCrossRef Gooskens J, Kuiken T, Claas EC, Harinck HI, Thijssen JC, Baelde HJ, Kroes AC. Severe influenza resembling hemorrhagic shock and encephalopathy syndrome. J Clin Virol. 2007;39(2):136–40.PubMedCrossRef
29.
go back to reference Hidaka F, Matsuo S, Muta T, Takeshige K, Mizukami T, Nunoi H. A missense mutation of the Toll-like receptor 3 gene in a patient with influenza-associated encephalopathy. Clin Immunol. 2006;119(2):188–94.PubMedCrossRef Hidaka F, Matsuo S, Muta T, Takeshige K, Mizukami T, Nunoi H. A missense mutation of the Toll-like receptor 3 gene in a patient with influenza-associated encephalopathy. Clin Immunol. 2006;119(2):188–94.PubMedCrossRef
30.
go back to reference Honorat R, Tison C, Sevely A, et al. Influenza A(H1N1)-associated ischemic stroke in a 9-month-old child. Pediatr Emerg Care. 2012;28(4):368–9.PubMedCrossRef Honorat R, Tison C, Sevely A, et al. Influenza A(H1N1)-associated ischemic stroke in a 9-month-old child. Pediatr Emerg Care. 2012;28(4):368–9.PubMedCrossRef
31.
go back to reference Hosoya M, Kawasaki Y, Katayose M, Sakuma H, Watanabe M, Igarashi E, Aoyama M, Nunoi H, Suzuki H. Prognostic predictive values of serum cytochrome c, cytokines, and other laboratory measurements in acute encephalopathy with multiple organ failure. Arch Dis Child. 2006;91(6):469–72.PubMedCrossRef Hosoya M, Kawasaki Y, Katayose M, Sakuma H, Watanabe M, Igarashi E, Aoyama M, Nunoi H, Suzuki H. Prognostic predictive values of serum cytochrome c, cytokines, and other laboratory measurements in acute encephalopathy with multiple organ failure. Arch Dis Child. 2006;91(6):469–72.PubMedCrossRef
32.
go back to reference Hosoya M, Nunoi H, Aoyama M, Kawasaki Y, Suzuki H. Cytochrome c and tumor necrosis factor-alpha values in serum and cerebrospinal fluid of patients with influenza-associated encephalopathy. Pediatr Infect Dis J. 2005;24(5):467–70.PubMedCrossRef Hosoya M, Nunoi H, Aoyama M, Kawasaki Y, Suzuki H. Cytochrome c and tumor necrosis factor-alpha values in serum and cerebrospinal fluid of patients with influenza-associated encephalopathy. Pediatr Infect Dis J. 2005;24(5):467–70.PubMedCrossRef
33.
go back to reference Huang YC, Lin TY, Wu SL, Tsao KC. Influenza A-associated central nervous system dysfunction in children presenting as transient visual hallucination. Pediatr Infect Dis J. 2003;22(4):366–8.PubMed Huang YC, Lin TY, Wu SL, Tsao KC. Influenza A-associated central nervous system dysfunction in children presenting as transient visual hallucination. Pediatr Infect Dis J. 2003;22(4):366–8.PubMed
34.
go back to reference Hull JH, Mead SH, Foster OJ, Modarres-Sadeghi H. Severe vasculitic neuropathy following influenza vaccination. J Neurol Neurosurg Psychiatry. 2004;75(10):1507–8.PubMedCrossRef Hull JH, Mead SH, Foster OJ, Modarres-Sadeghi H. Severe vasculitic neuropathy following influenza vaccination. J Neurol Neurosurg Psychiatry. 2004;75(10):1507–8.PubMedCrossRef
35.
go back to reference Huynh W, Cordato DJ, Kehdi E, Masters LT, Dedousis C. Post-vaccination encephalomyelitis: literature review and illustrative case. J Clin Neurosci. 2008;15(12):1315–22.PubMedCrossRef Huynh W, Cordato DJ, Kehdi E, Masters LT, Dedousis C. Post-vaccination encephalomyelitis: literature review and illustrative case. J Clin Neurosci. 2008;15(12):1315–22.PubMedCrossRef
36.
go back to reference Ichiyama T, Isumi H, Ozawa H, Matsubara T, Morishima T, Furukawa S. Cerebrospinal Fluid and Serum Levels of Cytokines and Soluble Tumor Necrosis Factor Receptor in Influenza Virus-associated Encephalopathy. Scand J Infect Dis. 2003;35(1):59–61.PubMedCrossRef Ichiyama T, Isumi H, Ozawa H, Matsubara T, Morishima T, Furukawa S. Cerebrospinal Fluid and Serum Levels of Cytokines and Soluble Tumor Necrosis Factor Receptor in Influenza Virus-associated Encephalopathy. Scand J Infect Dis. 2003;35(1):59–61.PubMedCrossRef
37.
go back to reference Ichiyama T, Morishima T, Kajimoto M, Matsushige T, Matsubara T, Furukawa S. Matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in influenza-associated encephalopathy. Pediatr Infect Dis J. 2007;26(6):542–4.PubMedCrossRef Ichiyama T, Morishima T, Kajimoto M, Matsushige T, Matsubara T, Furukawa S. Matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in influenza-associated encephalopathy. Pediatr Infect Dis J. 2007;26(6):542–4.PubMedCrossRef
38.
go back to reference Ichiyama T, Morishima T, Suenaga N, Kajimoto M, Matsubara T, Furukawa S. Analysis of serum soluble CD40 ligand in patients with influenza virus-associated encephalopathy. J Neurol Sci. 2005;239(1):53–7.PubMedCrossRef Ichiyama T, Morishima T, Suenaga N, Kajimoto M, Matsubara T, Furukawa S. Analysis of serum soluble CD40 ligand in patients with influenza virus-associated encephalopathy. J Neurol Sci. 2005;239(1):53–7.PubMedCrossRef
39.
go back to reference Ishigami A, Kubo S, Ikematsu K, Kitamura O, Tokunaga I, Gotohda T, Nakasono I. An adult autopsy case of acute encephalopathy associated with influenza A virus. Leg Med (Tokyo). 2004;6(4):252–5.CrossRef Ishigami A, Kubo S, Ikematsu K, Kitamura O, Tokunaga I, Gotohda T, Nakasono I. An adult autopsy case of acute encephalopathy associated with influenza A virus. Leg Med (Tokyo). 2004;6(4):252–5.CrossRef
40.
go back to reference Ito Y, Ichiyama T, Kimura H, Shibata M, Ishiwada N, Kuroki H, Furukawa S, Morishima T. Detection of influenza virus RNA by reverse transcription-PCR and proinflammatory cytokines in influenza-virus-associated encephalopathy. J Med Virol. 1999;58(4):420–5.PubMedCrossRef Ito Y, Ichiyama T, Kimura H, Shibata M, Ishiwada N, Kuroki H, Furukawa S, Morishima T. Detection of influenza virus RNA by reverse transcription-PCR and proinflammatory cytokines in influenza-virus-associated encephalopathy. J Med Virol. 1999;58(4):420–5.PubMedCrossRef
41.
go back to reference Iwata A, Matsubara K, Nigami H, Kamimura K, Fukaya T. Reversible splenial lesion associated with novel influenza A (H1N1) viral infection. Pediatr Neurol. 2010;42(6):447–50.PubMedCrossRef Iwata A, Matsubara K, Nigami H, Kamimura K, Fukaya T. Reversible splenial lesion associated with novel influenza A (H1N1) viral infection. Pediatr Neurol. 2010;42(6):447–50.PubMedCrossRef
42.
go back to reference Juurlink DN, Stukel TA, Kwong J, Kopp A, McGeer A, Upshur RE, Manuel DG, Moineddin R, Wilson K. Guillain-Barre syndrome after influenza vaccination in adults: a population-based study. Arch Intern Med. 2006;166(20):2217–21.PubMedCrossRef Juurlink DN, Stukel TA, Kwong J, Kopp A, McGeer A, Upshur RE, Manuel DG, Moineddin R, Wilson K. Guillain-Barre syndrome after influenza vaccination in adults: a population-based study. Arch Intern Med. 2006;166(20):2217–21.PubMedCrossRef
43.
go back to reference Kao CD, Chen JT, Lin KP, Shan DE, Wu ZA, Liao KK. Guillain-Barre syndrome coexisting with pericarditis or nephrotic syndrome after influenza vaccination. Clin Neurol Neurosurg. 2004;106(2):136–8.PubMedCrossRef Kao CD, Chen JT, Lin KP, Shan DE, Wu ZA, Liao KK. Guillain-Barre syndrome coexisting with pericarditis or nephrotic syndrome after influenza vaccination. Clin Neurol Neurosurg. 2004;106(2):136–8.PubMedCrossRef
44.
go back to reference Kasai T, Togashi T, Morishima T. Encephalopathy associated with influenza epidemics. Lancet. 2000;355(9214):1558–9.PubMedCrossRef Kasai T, Togashi T, Morishima T. Encephalopathy associated with influenza epidemics. Lancet. 2000;355(9214):1558–9.PubMedCrossRef
45.
go back to reference Kawada J, Kimura H, Hara S, Ito Y, Kawashima H, Okuno T, Morishima T. Absence of associations between influenza-associated encephalopathy and human herpesvirus 6 or human herpesvirus 7. Pediatr Infect Dis J. 2003;22(2):115–9.PubMed Kawada J, Kimura H, Hara S, Ito Y, Kawashima H, Okuno T, Morishima T. Absence of associations between influenza-associated encephalopathy and human herpesvirus 6 or human herpesvirus 7. Pediatr Infect Dis J. 2003;22(2):115–9.PubMed
46.
go back to reference Kawada J, Kimura H, Ito Y, Hara S, Iriyama M, Yoshikawa T, Morishima T. Systemic cytokine responses in patients with influenza-associated encephalopathy. J Infect Dis. 2003;188(5):690–8.PubMedCrossRef Kawada J, Kimura H, Ito Y, Hara S, Iriyama M, Yoshikawa T, Morishima T. Systemic cytokine responses in patients with influenza-associated encephalopathy. J Infect Dis. 2003;188(5):690–8.PubMedCrossRef
47.
go back to reference Kawashima H, Togashi T, Yamanaka G, Nakajima M, Nagai M, Aritaki K, Kashiwagi Y, Takekuma K, Hoshika A. Efficacy of plasma exchange and methylprednisolone pulse therapy on influenza-associated encephalopathy. J Infect. 2005;51(2):E53–6.PubMedCrossRef Kawashima H, Togashi T, Yamanaka G, Nakajima M, Nagai M, Aritaki K, Kashiwagi Y, Takekuma K, Hoshika A. Efficacy of plasma exchange and methylprednisolone pulse therapy on influenza-associated encephalopathy. J Infect. 2005;51(2):E53–6.PubMedCrossRef
48.
go back to reference Kawashima H, Watanabe Y, Ichiyama T, Mizuguchi M, Yamada N, Kashiwagi Y, Takekuma K, Hoshika A, Mori T. High concentration of serum nitrite/nitrate obtained from patients with influenza-associated encephalopathy. Pediatr Int. 2002;44(6):705–7.PubMedCrossRef Kawashima H, Watanabe Y, Ichiyama T, Mizuguchi M, Yamada N, Kashiwagi Y, Takekuma K, Hoshika A, Mori T. High concentration of serum nitrite/nitrate obtained from patients with influenza-associated encephalopathy. Pediatr Int. 2002;44(6):705–7.PubMedCrossRef
49.
go back to reference Kawashima H, Watanabe Y, Morishima T, Togashi T, Yamada N, Kashiwagi Y, Takekuma K, Hoshika A, Mori T. NOx (nitrite/nitrate) in cerebral spinal fluids obtained from patients with influenza-associated encephalopathy. Neuropediatrics. 2003;34(3):137–40.PubMedCrossRef Kawashima H, Watanabe Y, Morishima T, Togashi T, Yamada N, Kashiwagi Y, Takekuma K, Hoshika A, Mori T. NOx (nitrite/nitrate) in cerebral spinal fluids obtained from patients with influenza-associated encephalopathy. Neuropediatrics. 2003;34(3):137–40.PubMedCrossRef
50.
go back to reference Kostianovsky A, Charles P, Alves JF, et al. Immunogenicity and safety of seasonal and 2009 pandemic A/H1N1 influenza vaccines for patients with autoimmune diseases: a prospective, monocentre trial on 199 patients. Clin Exp Rheumatol. 2012;30(1 Suppl 70):S83–9.PubMed Kostianovsky A, Charles P, Alves JF, et al. Immunogenicity and safety of seasonal and 2009 pandemic A/H1N1 influenza vaccines for patients with autoimmune diseases: a prospective, monocentre trial on 199 patients. Clin Exp Rheumatol. 2012;30(1 Suppl 70):S83–9.PubMed
51.
go back to reference Lee N. Acute Encephalopathy Associated with Influenza A Infection in Adults. Emerging Infectious Diseases 2010;16(1). Lee N. Acute Encephalopathy Associated with Influenza A Infection in Adults. Emerging Infectious Diseases 2010;16(1).
52.
go back to reference Lehmann HC, Hartung HP, Kieseier BC, Hughes RA. Guillain-Barre syndrome after exposure to influenza virus. Lancet Infect Dis. 2010;10(9):643–51.PubMedCrossRef Lehmann HC, Hartung HP, Kieseier BC, Hughes RA. Guillain-Barre syndrome after exposure to influenza virus. Lancet Infect Dis. 2010;10(9):643–51.PubMedCrossRef
53.
go back to reference Lyon JB, Remigio C, Milligan T, Deline C. Acute necrotizing encephalopathy in a child with H1N1 influenza infection. Pediatr Radiol. 2010;40(2):200–5.PubMedCrossRef Lyon JB, Remigio C, Milligan T, Deline C. Acute necrotizing encephalopathy in a child with H1N1 influenza infection. Pediatr Radiol. 2010;40(2):200–5.PubMedCrossRef
54.
go back to reference Martin A, Reade EP. Acute necrotizing encephalopathy progressing to brain death in a pediatric patient with novel influenza A (H1N1) infection. Clin Infect Dis. 2010;50(8):e50–2.PubMedCrossRef Martin A, Reade EP. Acute necrotizing encephalopathy progressing to brain death in a pediatric patient with novel influenza A (H1N1) infection. Clin Infect Dis. 2010;50(8):e50–2.PubMedCrossRef
55.
go back to reference Maurizi CP. Influenza caused epidemic encephalitis (encephalitis lethargica): the circumstantial evidence and a challenge to the nonbelievers. Med Hypotheses. 2010;74(5):798–801.PubMedCrossRef Maurizi CP. Influenza caused epidemic encephalitis (encephalitis lethargica): the circumstantial evidence and a challenge to the nonbelievers. Med Hypotheses. 2010;74(5):798–801.PubMedCrossRef
56.
go back to reference Mizuguchi M. Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan. Brain Dev. 1997;19(2):81–92.PubMedCrossRef Mizuguchi M. Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan. Brain Dev. 1997;19(2):81–92.PubMedCrossRef
57.
go back to reference Mizuguchi M, Yamanouchi H, Ichiyama T, Shiomi M. Acute encephalopathy associated with influenza and other viral infections. Acta Neurol Scand. 2007;115(4 Suppl):45–56.PubMedCrossRef Mizuguchi M, Yamanouchi H, Ichiyama T, Shiomi M. Acute encephalopathy associated with influenza and other viral infections. Acta Neurol Scand. 2007;115(4 Suppl):45–56.PubMedCrossRef
58.
go back to reference Moro PL, Tepper NK, Grohskopf LA, et al. Safety of seasonal influenza and influenza A (H1N1) 2009 monovalent vaccines in pregnancy. Expert Rev Vaccines. 2012;11(8):911–21.PubMedCrossRef Moro PL, Tepper NK, Grohskopf LA, et al. Safety of seasonal influenza and influenza A (H1N1) 2009 monovalent vaccines in pregnancy. Expert Rev Vaccines. 2012;11(8):911–21.PubMedCrossRef
59.
go back to reference Mortimer PP. Was encephalitis lethargica a post-influenzal or some other phenomenon? Time to re-examine the problem. Epidemiol Infect. 2009;137(4):449–55.PubMedCrossRef Mortimer PP. Was encephalitis lethargica a post-influenzal or some other phenomenon? Time to re-examine the problem. Epidemiol Infect. 2009;137(4):449–55.PubMedCrossRef
60.
go back to reference Muhammad S, Haasbach E, Kotchourko M, Strigli A, Krenz A, Ridder DA, Vogel AB, Marti HH, Al-Abed Y, Planz O, et al. Influenza virus infection aggravates stroke outcome. Stroke. 2011;42(3):783–91.PubMedCrossRef Muhammad S, Haasbach E, Kotchourko M, Strigli A, Krenz A, Ridder DA, Vogel AB, Marti HH, Al-Abed Y, Planz O, et al. Influenza virus infection aggravates stroke outcome. Stroke. 2011;42(3):783–91.PubMedCrossRef
61.
go back to reference Nakamura N, Nokura K, Zettsu T, Koga H, Tachi M, Terada M, Katoh H, Itoh Y, Osawa H, Ozeki T, et al. Neurologic complications associated with influenza vaccination: two adult cases. Intern Med. 2003;42(2):191–4.PubMedCrossRef Nakamura N, Nokura K, Zettsu T, Koga H, Tachi M, Terada M, Katoh H, Itoh Y, Osawa H, Ozeki T, et al. Neurologic complications associated with influenza vaccination: two adult cases. Intern Med. 2003;42(2):191–4.PubMedCrossRef
62.
go back to reference Neurologic complications associated with novel influenza A (H1N1) virus infection in children - Dallas, Texas, May 2009. MMWR Morb Mortal Wkly Rep 2009, 58(28):773-778. Neurologic complications associated with novel influenza A (H1N1) virus infection in children - Dallas, Texas, May 2009. MMWR Morb Mortal Wkly Rep 2009, 58(28):773-778.
63.
go back to reference Newland JG, Laurich VM, Rosenquist AW, Heydon K, Licht DJ, Keren R, Zaoutis TE, Watson B, Hodinka RL, Coffin SE. Neurologic complications in children hospitalized with influenza: characteristics, incidence, and risk factors. J Pediatr. 2007;150(3):306–10.PubMedCrossRef Newland JG, Laurich VM, Rosenquist AW, Heydon K, Licht DJ, Keren R, Zaoutis TE, Watson B, Hodinka RL, Coffin SE. Neurologic complications in children hospitalized with influenza: characteristics, incidence, and risk factors. J Pediatr. 2007;150(3):306–10.PubMedCrossRef
64.
go back to reference Ng WF, Chiu SC, Lam DS, Wong YC, Tam S, Kwong NS, Loo KT, Yuen KY. A 7-year-old boy dying of acute encephalopathy. Brain Pathol. 2010;20(1):261–4.PubMedCrossRef Ng WF, Chiu SC, Lam DS, Wong YC, Tam S, Kwong NS, Loo KT, Yuen KY. A 7-year-old boy dying of acute encephalopathy. Brain Pathol. 2010;20(1):261–4.PubMedCrossRef
65.
go back to reference Nichol KL, Nordin J, Mullooly J, Lask R, Fillbrandt K, Iwane M. Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly. N Engl J Med. 2003;348(14):1322–32.PubMedCrossRef Nichol KL, Nordin J, Mullooly J, Lask R, Fillbrandt K, Iwane M. Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly. N Engl J Med. 2003;348(14):1322–32.PubMedCrossRef
66.
go back to reference Nunoi H, Mercado MR, Mizukami T, Okajima K, Morishima T, Sakata H, Nakayama S, Mori S, Hayashi M, Mori H, et al. Apoptosis under hypercytokinemia is a possible pathogenesis in influenza-associated encephalopathy. Pediatr Int. 2005;47(2):175–9.PubMedCrossRef Nunoi H, Mercado MR, Mizukami T, Okajima K, Morishima T, Sakata H, Nakayama S, Mori S, Hayashi M, Mori H, et al. Apoptosis under hypercytokinemia is a possible pathogenesis in influenza-associated encephalopathy. Pediatr Int. 2005;47(2):175–9.PubMedCrossRef
67.
go back to reference Okabe N, Yamashita K, Taniguchi K, Inouye S. Influenza surveillance system of Japan and acute encephalitis and encephalopathy in the influenza season. Pediatr Int. 2000;42(2):187–91.PubMedCrossRef Okabe N, Yamashita K, Taniguchi K, Inouye S. Influenza surveillance system of Japan and acute encephalitis and encephalopathy in the influenza season. Pediatr Int. 2000;42(2):187–91.PubMedCrossRef
68.
go back to reference Okumura A, Abe S, Kidokoro H, Mizuguchi M. Acute necrotizing encephalopathy: a comparison between influenza and non-influenza cases. Microbiol Immunol. 2009;53(5):277–80.PubMedCrossRef Okumura A, Abe S, Kidokoro H, Mizuguchi M. Acute necrotizing encephalopathy: a comparison between influenza and non-influenza cases. Microbiol Immunol. 2009;53(5):277–80.PubMedCrossRef
69.
go back to reference Okumura A, Mizuguchi M, Kidokoro H, Tanaka M, Abe S, Hosoya M, Aiba H, Maegaki Y, Yamamoto H, Tanabe T, et al. Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin. Brain Dev. 2009;31(3):221–7.PubMedCrossRef Okumura A, Mizuguchi M, Kidokoro H, Tanaka M, Abe S, Hosoya M, Aiba H, Maegaki Y, Yamamoto H, Tanabe T, et al. Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin. Brain Dev. 2009;31(3):221–7.PubMedCrossRef
70.
go back to reference Olgar S, Ertugrul T, Nisli K, Aydin K, Caliskan M. Influenza a-associated acute necrotizing encephalopathy. Neuropediatrics. 2006;37(3):166–8.PubMedCrossRef Olgar S, Ertugrul T, Nisli K, Aydin K, Caliskan M. Influenza a-associated acute necrotizing encephalopathy. Neuropediatrics. 2006;37(3):166–8.PubMedCrossRef
71.
go back to reference Pandemic influenza: a priority for the neurological community. Lancet Neurol 2009; 8(10):869. Pandemic influenza: a priority for the neurological community. Lancet Neurol 2009; 8(10):869.
72.
go back to reference Parikh M, Dolson G, Ramanathan V, Sangsiraprapha W. Novel H1N1-associated rhabdomyolysis leading to acute renal failure. Clin Microbiol Infect. 2010;16(4):330–2.PubMedCrossRef Parikh M, Dolson G, Ramanathan V, Sangsiraprapha W. Novel H1N1-associated rhabdomyolysis leading to acute renal failure. Clin Microbiol Infect. 2010;16(4):330–2.PubMedCrossRef
73.
go back to reference Partinen M, Saarenpaa-Heikkila O, Ilveskoski I, et al. Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland. PLoS ONE. 2012;7(3):33723.CrossRef Partinen M, Saarenpaa-Heikkila O, Ilveskoski I, et al. Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland. PLoS ONE. 2012;7(3):33723.CrossRef
74.
go back to reference Perez C, Loza E, Tinture T. Giant cell arteritis after influenza vaccination. Arch Intern Med. 2000;160(17):2677.PubMedCrossRef Perez C, Loza E, Tinture T. Giant cell arteritis after influenza vaccination. Arch Intern Med. 2000;160(17):2677.PubMedCrossRef
75.
go back to reference Preliminary results: surveillance for Guillain-Barre syndrome after receipt of influenza A (H1N1) 2009 monovalent vaccine - United States, 2009-2010. MMWR Morb Mortal Wkly Rep 2010, 59(21):657-661. Preliminary results: surveillance for Guillain-Barre syndrome after receipt of influenza A (H1N1) 2009 monovalent vaccine - United States, 2009-2010. MMWR Morb Mortal Wkly Rep 2010, 59(21):657-661.
76.
go back to reference Reid AH, McCall S, Henry JM, Taubenberger JK. Experimenting on the past: the enigma of von Economo’s encephalitis lethargica. J Neuropathol Exp Neurol. 2001;60(7):663–70.PubMed Reid AH, McCall S, Henry JM, Taubenberger JK. Experimenting on the past: the enigma of von Economo’s encephalitis lethargica. J Neuropathol Exp Neurol. 2001;60(7):663–70.PubMed
77.
go back to reference Ryan MM, Procopis PG, Ouvrier RA. Influenza A encephalitis with movement disorder. Pediatr Neurol. 1999;21(3):669–73.PubMedCrossRef Ryan MM, Procopis PG, Ouvrier RA. Influenza A encephalitis with movement disorder. Pediatr Neurol. 1999;21(3):669–73.PubMedCrossRef
78.
go back to reference Safety of influenza A (H1N1) 2009 monovalent vaccines - United States, October 1-November 24, 2009. MMWR Morb Mortal Wkly Rep 2009, 58(48):1351-1356. Safety of influenza A (H1N1) 2009 monovalent vaccines - United States, October 1-November 24, 2009. MMWR Morb Mortal Wkly Rep 2009, 58(48):1351-1356.
79.
go back to reference Sakurai T, Kimura A, Tanaka Y, Hozumi I, Ogura S, Inuzuka T. Case of adult influenza type A virus-associated encephalopathy successfully treated with primary multidisciplinary treatments. Rinsho Shinkeigaku. 2007;47(10):639–43.PubMed Sakurai T, Kimura A, Tanaka Y, Hozumi I, Ogura S, Inuzuka T. Case of adult influenza type A virus-associated encephalopathy successfully treated with primary multidisciplinary treatments. Rinsho Shinkeigaku. 2007;47(10):639–43.PubMed
80.
go back to reference Sanchez-Torrent L, Trivino-Rodriguez M, Suero-Toledano P, Claret-Teruel G, Munoz-Almagro C, Martinez-Sanchez L, Jordan-Garcia I, Garcia–Garcia JJ. Novel influenza A (H1N1) encephalitis in a 3-month-old infant. Infection. 2010;38(3):227–9.PubMedCrossRef Sanchez-Torrent L, Trivino-Rodriguez M, Suero-Toledano P, Claret-Teruel G, Munoz-Almagro C, Martinez-Sanchez L, Jordan-Garcia I, Garcia–Garcia JJ. Novel influenza A (H1N1) encephalitis in a 3-month-old infant. Infection. 2010;38(3):227–9.PubMedCrossRef
81.
go back to reference Sato S, Kumada S, Koji T, Okaniwa M. Reversible frontal lobe syndrome associated with influenza virus infection in children. Pediatr Neurol. 2000;22(4):318–21.PubMedCrossRef Sato S, Kumada S, Koji T, Okaniwa M. Reversible frontal lobe syndrome associated with influenza virus infection in children. Pediatr Neurol. 2000;22(4):318–21.PubMedCrossRef
82.
go back to reference Shieh WJ, Blau DM, Denison AM, Deleon-Carnes M, Adem P, Bhatnagar J, Sumner J, Liu L, Patel M, Batten B, et al. 2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States. Am J Pathol. 2010;177(1):166–75.PubMedCrossRef Shieh WJ, Blau DM, Denison AM, Deleon-Carnes M, Adem P, Bhatnagar J, Sumner J, Liu L, Patel M, Batten B, et al. 2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States. Am J Pathol. 2010;177(1):166–75.PubMedCrossRef
83.
go back to reference Shiomi M. Pathogenesis of acute encephalitis and acute encephalopathy. Nippon Rinsho. 2011;69(3):399–408.PubMed Shiomi M. Pathogenesis of acute encephalitis and acute encephalopathy. Nippon Rinsho. 2011;69(3):399–408.PubMed
84.
go back to reference Smeeth L, Thomas SL, Hall AJ, Hubbard R, Farrington P, Vallance P. Risk of myocardial infarction and stroke after acute infection or vaccination. N Engl J Med. 2004;351(25):2611–8.PubMedCrossRef Smeeth L, Thomas SL, Hall AJ, Hubbard R, Farrington P, Vallance P. Risk of myocardial infarction and stroke after acute infection or vaccination. N Engl J Med. 2004;351(25):2611–8.PubMedCrossRef
86.
go back to reference Takanashi J. Two newly proposed infectious encephalitis/encephalopathy syndromes. Brain Dev. 2009;31(7):521–8.PubMedCrossRef Takanashi J. Two newly proposed infectious encephalitis/encephalopathy syndromes. Brain Dev. 2009;31(7):521–8.PubMedCrossRef
87.
go back to reference Takanashi J, Tada H, Kuroki H, Barkovich AJ. Delirious behavior in influenza is associated with a reversible splenial lesion. Brain Dev. 2009;31(6):423–6.PubMedCrossRef Takanashi J, Tada H, Kuroki H, Barkovich AJ. Delirious behavior in influenza is associated with a reversible splenial lesion. Brain Dev. 2009;31(6):423–6.PubMedCrossRef
88.
go back to reference Takanashi J, Tsuji M, Amemiya K, Tada H, Barkovich AJ. Mild influenza encephalopathy with biphasic seizures and late reduced diffusion. J Neurol Sci. 2007;256(1–2):86–9.PubMedCrossRef Takanashi J, Tsuji M, Amemiya K, Tada H, Barkovich AJ. Mild influenza encephalopathy with biphasic seizures and late reduced diffusion. J Neurol Sci. 2007;256(1–2):86–9.PubMedCrossRef
89.
go back to reference Tokuhira N, Shime N, Inoue M, et al. Mechanically ventilated children with 2009 pandemic influenza A/H1N1: results from the National Pediatric Intensive Care Registry in Japan. Pediatr Crit Care Med. 2012;13(5):e294–8.PubMedCrossRef Tokuhira N, Shime N, Inoue M, et al. Mechanically ventilated children with 2009 pandemic influenza A/H1N1: results from the National Pediatric Intensive Care Registry in Japan. Pediatr Crit Care Med. 2012;13(5):e294–8.PubMedCrossRef
90.
go back to reference Tsuji M, Yoshida T, Miyakoshi C, Haruta T. Is a reversible splenial lesion a sign of encephalopathy? Pediatr Neurol. 2009;41(2):143–5.PubMedCrossRef Tsuji M, Yoshida T, Miyakoshi C, Haruta T. Is a reversible splenial lesion a sign of encephalopathy? Pediatr Neurol. 2009;41(2):143–5.PubMedCrossRef
91.
go back to reference van der Vries E, Stelma FF, Boucher CA. Emergence of a multidrug-resistant pandemic influenza A (H1N1) virus. N Engl J Med. 2010;363(14):1381–2.PubMedCrossRef van der Vries E, Stelma FF, Boucher CA. Emergence of a multidrug-resistant pandemic influenza A (H1N1) virus. N Engl J Med. 2010;363(14):1381–2.PubMedCrossRef
92.
go back to reference Vellozzi C, Broder KR, Haber P, Guh A, Nguyen M, Cano M, Lewis P, McNeil MM, Bryant M, Singleton J, et al. Adverse events following influenza A (H1N1) 2009 monovalent vaccines reported to the Vaccine Adverse Event Reporting System, United States, October 1, 2009-January 31, 2010. Vaccine. 2010;28(45):7248–55.PubMedCrossRef Vellozzi C, Broder KR, Haber P, Guh A, Nguyen M, Cano M, Lewis P, McNeil MM, Bryant M, Singleton J, et al. Adverse events following influenza A (H1N1) 2009 monovalent vaccines reported to the Vaccine Adverse Event Reporting System, United States, October 1, 2009-January 31, 2010. Vaccine. 2010;28(45):7248–55.PubMedCrossRef
93.
go back to reference Watanabe T, Okazaki E, Shibuya H. Influenza A virus-associated encephalopathy with haemophagocytic syndrome. Eur J Pediatr. 2003;162(11):799–800.PubMedCrossRef Watanabe T, Okazaki E, Shibuya H. Influenza A virus-associated encephalopathy with haemophagocytic syndrome. Eur J Pediatr. 2003;162(11):799–800.PubMedCrossRef
94.
go back to reference Yamanouchi H, Kawaguchi N, Mori M, Imataka G, Yamagata T, Hashimoto T, Momoi MY, Eguchi M, Mizuguchi M. Acute infantile encephalopathy predominantly affecting the frontal lobes. Pediatr Neurol. 2006;34(2):93–100.PubMedCrossRef Yamanouchi H, Kawaguchi N, Mori M, Imataka G, Yamagata T, Hashimoto T, Momoi MY, Eguchi M, Mizuguchi M. Acute infantile encephalopathy predominantly affecting the frontal lobes. Pediatr Neurol. 2006;34(2):93–100.PubMedCrossRef
95.
go back to reference Yamanouchi H, Mizuguchi M. Acute infantile encephalopathy predominantly affecting the frontal lobes (AIEF): a novel clinical category and its tentative diagnostic criteria. Epilepsy Res. 2006;70(Suppl 1):S263–8.PubMedCrossRef Yamanouchi H, Mizuguchi M. Acute infantile encephalopathy predominantly affecting the frontal lobes (AIEF): a novel clinical category and its tentative diagnostic criteria. Epilepsy Res. 2006;70(Suppl 1):S263–8.PubMedCrossRef
96.
go back to reference Yang J, Wang Y-G, Xu Y-L, Ren X-L, Mao Y, Li X-W. A (H1N1) Influenza Pneumonia with Acute Disseminated Encephalomyelitis: a Case Report. Biomed Environ Sci. 2010;23(4):323–6.PubMedCrossRef Yang J, Wang Y-G, Xu Y-L, Ren X-L, Mao Y, Li X-W. A (H1N1) Influenza Pneumonia with Acute Disseminated Encephalomyelitis: a Case Report. Biomed Environ Sci. 2010;23(4):323–6.PubMedCrossRef
97.
go back to reference Yao D, Mizuguchi H, Yamaguchi M, Yamada H, Chida J, Shikata K, Kido H. Thermal instability of compound variants of carnitine palmitoyltransferase II and impaired mitochondrial fuel utilization in influenza-associated encephalopathy. Hum Mutat. 2008;29(5):718–27.PubMedCrossRef Yao D, Mizuguchi H, Yamaguchi M, Yamada H, Chida J, Shikata K, Kido H. Thermal instability of compound variants of carnitine palmitoyltransferase II and impaired mitochondrial fuel utilization in influenza-associated encephalopathy. Hum Mutat. 2008;29(5):718–27.PubMedCrossRef
98.
go back to reference Yokota S, Imagawa T, Miyamae T, Ito S, Nakajima S, Nezu A, Mori M. Hypothetical pathophysiology of acute encephalopathy and encephalitis related to influenza virus infection and hypothermia therapy. Pediatr Int. 2000;42(2):197–203.PubMedCrossRef Yokota S, Imagawa T, Miyamae T, Ito S, Nakajima S, Nezu A, Mori M. Hypothetical pathophysiology of acute encephalopathy and encephalitis related to influenza virus infection and hypothermia therapy. Pediatr Int. 2000;42(2):197–203.PubMedCrossRef
99.
go back to reference Zinman L, Thoma J, Kwong JC, Kopp A, Stukel TA, Juurlink DN. Safety of influenza vaccination in patients with myasthenia gravis: a population-based study. Muscle Nerve. 2009;40(6):947–51.PubMedCrossRef Zinman L, Thoma J, Kwong JC, Kopp A, Stukel TA, Juurlink DN. Safety of influenza vaccination in patients with myasthenia gravis: a population-based study. Muscle Nerve. 2009;40(6):947–51.PubMedCrossRef
Metadata
Title
Influenza-Associated Neurological Complications
Authors
Jenny P. Tsai
Andrew J. Baker
Publication date
01-02-2013
Publisher
Humana Press Inc
Published in
Neurocritical Care / Issue 1/2013
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-012-9796-8

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