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Neurocritical Care

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01-10-2009 | Original Article

Near-Infrared Spectroscopy for Evaluation of Cerebral Autoregulation During Orthotopic Liver Transplantation

Authors: Peter Nissen, Heidi Pacino, Hans J. Frederiksen, Srdan Novovic, Niels H. Secher

Published in: Neurocritical Care | Issue 2/2009

Abstract

Introduction

The present study evaluated whether frontal lobe cerebral oxygenation (S_cO₂), as assessed by near-infrared spectroscopy (NIRS), can detect cerebral autoregulation in patients undergoing orthotopic liver transplantation.

Methods

We studied changes in frontal lobe S_cO₂ assessed in 33 patients, 19 females, who underwent orthotopic liver transplantation (OLT). We evaluated whether S_cO₂ would remain stable over a wide range of MAP and whether an eventual drop in S_cO₂ could be related to a low MAP.

Results

Among the 31 of 33 patients for whom a NIRS signal could be detected, S_cO₂ varied in parallel with mean arterial pressure (MAP) for 3 patients and, therefore, an autoregulation curve could not be established and yet, there was detected no change in S_cO₂ to a lowest MAP ranging from 42 to 66 mmHg for 20 patients, while for 8 patients a decrease in S_cO₂ was detected at a MAP of 69 (50–90) mmHg; (median and range). As detected by NIRS, the present study confirms that some patients undergoing liver transplantation do not demonstrate cerebral autoregulation but for the majority of the patients, S_cO₂ was stable over a wide range of MAP suggesting that S_cO₂ detects cerebral autoregulation.

Conclusion

We find that NIRS is a ready available non-invasive technology for evaluation of cerebral autoregulation in patients undergoing orthotopic liver transplantation.

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Title: Near-Infrared Spectroscopy for Evaluation of Cerebral Autoregulation During Orthotopic Liver Transplantation
Authors: Peter Nissen
Heidi Pacino
Hans J. Frederiksen
Srdan Novovic
Niels H. Secher
Publication date: 01-10-2009
Publisher: Humana Press Inc
Published in: Neurocritical Care / Issue 2/2009
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-009-9226-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Near-Infrared Spectroscopy for Evaluation of Cerebral Autoregulation During Orthotopic Liver Transplantation

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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