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Neurocritical Care

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01-02-2009 | Original Article

Near-Infrared Spectroscopy can Monitor Dynamic Cerebral Autoregulation in Adults

Authors: Luzius A. Steiner, David Pfister, Stephan P. Strebel, Danila Radolovich, Peter Smielewski, Marek Czosnyka

Published in: Neurocritical Care | Issue 1/2009

Abstract

Objective

To study the correlation between a dynamic index of cerebral autoregulation assessed with blood flow velocity (FV) using transcranial Doppler, and a tissue oxygenation index (TOI) recorded with near-infrared spectroscopy (NIRS).

Methods

Twenty-three patients with sepsis, severe sepsis, or septic shock were monitored daily on up to four consecutive days. FV, TOI, and mean arterial blood pressure (ABP) were recorded for 60 min every day. An index of autoregulation (Mx) was calculated as the moving correlation coefficient between 10-s averaged values of FV and ABP over moving 5 min time-windows. The index Tox was evaluated as the correlation coefficient between TOI and ABP in the same way. The indices Mx and Tox, ABP and arterial partial pressure of CO₂ were averaged for each patient.

Results

Synchronized slow waves, presenting with periods from 20 s to 2 min, were seen in the TOI and FV of most patients, with a reasonable coherence between the signals in this bandwidth (coherence >0.5). The indices, Mx and Tox, demonstrated good correlation with each other (R = 0.81; P < 0.0001) in the whole group of patients. Both indices showed a significant (P < 0.05) tendency to indicate weaker autoregulation in the state of vasodilatation associated with greater values of arterial partial pressure of CO₂ or lower values of ABP.

Conclusion

NIRS shows promise for the continuous assessment of cerebral autoregulation in adults.

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Title: Near-Infrared Spectroscopy can Monitor Dynamic Cerebral Autoregulation in Adults
Authors: Luzius A. Steiner
David Pfister
Stephan P. Strebel
Danila Radolovich
Peter Smielewski
Marek Czosnyka
Publication date: 01-02-2009
Publisher: Humana Press Inc
Published in: Neurocritical Care / Issue 1/2009
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-008-9140-5

At a glance: The STEP trials

Springer Medicine

Near-Infrared Spectroscopy can Monitor Dynamic Cerebral Autoregulation in Adults

Abstract

Objective

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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