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Immunologic Research
Published in: Immunologic Research 1-3/2015

Open Access 01-12-2015 | NEUROIMMUNOLOGY

Circulating T cell subsets are altered in individuals with chronic spinal cord injury

Authors: Rachel Monahan, Adam Stein, Katie Gibbs, Matthew Bank, Ona Bloom

Published in: Immunologic Research | Issue 1-3/2015

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Abstract

Traumatic spinal cord injury (SCI) induces changes in the immune system, both acutely and chronically. To better understand changes in the chronic phase of SCI, we performed a prospective, observational study in a research institute and Department of Physical Medicine and Rehabilitation of an academic medical center to examine immune system parameters, including peripheral immune cell populations, in individuals with chronic SCI as compared to uninjured individuals. Here, we describe the relative frequencies of T cell populations in individuals with chronic SCI as compared to uninjured individuals. We show that the frequency of CD3+ and CD3+ CD4+ T cells are decreased in individuals with chronic SCI, although activated (HLA-DR+) CD4+ T cells are elevated in chronic SCI. We also examined regulatory T cells (Tregs), defined as CD3+ CD4+ CD25+ CD127lo and CCR4+, HLA-DR+ or CCR4+ HLA-DR+. To our knowledge, we provide the first evidence that CCR4+, HLA-DR+ or CCR4+ HLA-DR+ Tregs are expanded in individuals with SCI. These data support additional functional studies of T cells isolated from individuals with chronic SCI, where alterations in T cell homeostasis may contribute to immune dysfunction, such as immunity against infections or the persistence of chronic inflammation.
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Metadata
Title
Circulating T cell subsets are altered in individuals with chronic spinal cord injury
Authors
Rachel Monahan
Adam Stein
Katie Gibbs
Matthew Bank
Ona Bloom
Publication date
01-12-2015
Publisher
Springer US
Published in
Immunologic Research / Issue 1-3/2015
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-015-8698-1

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