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01-12-2012 | Immunology at Mount Sinai

Diverse immune evasion strategies by human cytomegalovirus

Authors: Vanessa Noriega, Veronika Redmann, Thomas Gardner, Domenico Tortorella

Published in: Immunologic Research | Issue 1-3/2012

Abstract

Members of the Herpesviridae family have the capacity to undergo both lytic and latent infection to establish a lifelong relationship with their host. Following primary infection, human cytomegalovirus (HCMV) can persist as a subclinical, recurrent infection for the lifetime of an individual. This quiescent portion of its life cycle is termed latency and is associated with periodic bouts of reactivation during times of immunosuppression, inflammation, or stress. In order to exist indefinitely and establish infection, HCMV encodes a multitude of immune modulatory mechanisms devoted to escaping the host antiviral response. HCMV has become a paradigm for studies of viral immune evasion of antigen presentation by both major histocompatibility complex (MHC) class I and II molecules. By restricting the presentation of viral antigens during both productive and latent infection, HCMV limits elimination by the human immune system. This review will focus on understanding how the virus manipulates the pathways of antigen presentation in order to modulate the host response to infection.

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Title: Diverse immune evasion strategies by human cytomegalovirus
Authors: Vanessa Noriega
Veronika Redmann
Thomas Gardner
Domenico Tortorella
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Immunologic Research / Issue 1-3/2012
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-012-8304-8

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Springer Medicine

Diverse immune evasion strategies by human cytomegalovirus

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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