Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Endocrine
Published in: Endocrine 2/2018

01-02-2018 | Research Letter

Is levothyroxine requirement the same for tablet and soft gel formulations?

Authors: Vincenzo Di Donna, Rosa Maria Paragliola, Chiara de Waure, Giampaolo Papi, Alfredo Pontecorvi, Salvatore Maria Corsello

Published in: Endocrine | Issue 2/2018

Login to get access

Excerpt

Synthetic levothyroxine (LT4) sodium is the gold standard for the treatment of hypothyroidism, but finding the individually tailored LT4 dose level is still challenging [1, 2]. …
Literature
1.
A.M. Formenti, G. Mazziotti, R. Giubbini, A. Giustina, Treatment of hypothyroidism: all that glitters is gold? Endocrine 52, 411–413 (2016)CrossRefPubMed
2.
P. Colucci, C. Seng Yue, M. Ducharme, S. Benvenga, A review of the pharmacokinetics of levothyroxine for the treatment of hypothyroidism. Eur. Endocrinol. 9, 40–47 (2013)CrossRef
3.
R. Vita, P. Fallahi, A. Antonelli, S. Benvenga, The administration of L-thyroxine as soft gel capsule or liquid solution. Expert Opin. Drug Deliv. 11, 1103–1011 (2014)CrossRefPubMed
4.
V. Di Donna, M.G. Santoro, C. de Waure, M.P. Ricciato, R.M. Paragliola, A. Pontecorvi, S.M. Corsello, A new strategy to estimate levothyroxine requirement after total thyroidectomy for benign thyroid disease. Thyroid 24, 1759–1764 (2014)CrossRefPubMed
5.
D. Mistry, S. Atkin, H. Atkinson, S. Gunasekaran, D. Sylvester, A.S. Rigby, R.J. England, Predicting thyroxine requirements following total thyroidectomy. Clin. Endocrinol. 74, 384–387 (2011)CrossRef
6.
F. Santini, A. Pinchera, A. Marsili, G. Ceccarini, M.G. Castagna, R. Valeriano, M. Giannetti, D. Taddei, R. Centoni, G. Scartabelli, T. Rago, C. Mammoli, R. Elisei, P. Vitti, Lean body mass is a major determinant of levothyroxine dosage in the treatment of thyroid disease. J. Clin. Endocrinol. Metab. 90, 124–127 (2005)CrossRefPubMed
7.
C. Virili, P. Trimboli, F. Romanelli, M. Centanni, Liquid and softgel levothyroxine use in clinical practice: state of the art. Endocrine 54, 3–14 (2016)CrossRefPubMed
8.
D. Al-Numani, C. Scarsi, M.P. Ducharme, Levothyroxine soft capsules demonstrate bioequivalent pharmacokinetic exposure with the European reference tablets in healthy volunteers under fasting conditions. Int. J. Clin. Pharmacol. Ther. 54, 135–143 (2016)CrossRefPubMed
9.
R. Vita, G. Saraceno, F. Trimarchi, S. Benvenga, A novel formulation of L-thyroxine (L-T4) reduces the problem of L-T4 malabsorption by coffee observed with traditional tablet formulations. Endocrine 43, 154–160 (2013)CrossRefPubMed
10.
M.G. Santaguida, C. Virili, S.C. Duca, M. Cellini, I. Gatto, N. Brusca, C. De Vito, L. Gargano, M. Centanni, Thyroxine softgel capsule in patients with gastric-related T4 malabsorption. Endocrine 49, 51–57 (2015)CrossRefPubMed
11.
C. Cappelli, I. Pirola, E. Gandossi, A. Cristiano, L. Daffini, B. Agosti, C. Casella, M. Castellano, Hormone profile in patients ingesting soft gel capsule or liquid levothyroxine formulations with breakfast. Int. J. Endocrinol. (2016). doi:10.​1155/​2016/​9043450
12.
P. Fallahi, S.M. Ferrari, A. Antonelli, Oral L-thyroxine liquid versus tablet in patients with hypothyroidism without malabsorption: a prospective study. Endocrine 52, 597–560 (2016)CrossRefPubMed
13.
D. Brancato, A. Scorsone, G. Saura, L. Ferrara, A. Di Noto, V. Aiello, M. Fleres, V. Provenzano, Comparison of TSH levels with liquid formulation versus tablet formulations of levothyroxine in the treatment of adult hypothyroidism. Endocr. Pract. 20, 657–662 (2014)CrossRefPubMed
14.
R. Negro, R. Valcavi, D. Agrimi, K.A. Toulis, Levothyroxine liquid solution versus tablet for replacement treatment in hypothyroid patients. Endocr. Pract. 20, 901–906 (2014)CrossRefPubMed
15.
C.P. Lombardi, R. Bocale, A. Barini, A. Barini, A. D’Amore, M. Boscherini, R. Bellantone, Comparative study between the effects of replacement therapy with liquid and tablet ormulations of levothyroxine on mood states, self-perceived psychological well-being and thyroid hormone profile in recently thyroidectomized patients. Endocrine 55, 51–59 (2016)CrossRefPubMed
16.
A. Cassio, S. Monti, A. Rizzello, I. Bettocchi, F. Baronio, G. D’Addabbo, M.O. Bal, A. Balsamo, Comparison between liquid and tablet formulations of levothyroxine in the initial treatment of congenital hypothyroidism. J. Pediatr. 162, 1264–1269 (2013)CrossRefPubMed
17.
E. Peroni, M.C. Vigone, S. Mora, L.A. Bassi, C. Pozzi, A. Passoni, G. Weber, Congenital hypothyroidism treatment in infants: a comparative study between liquid and tablet formulations of levothyroxine. Horm. Res. Paediatr. 81, 50–54 (2014)CrossRefPubMed
18.
L. Chaker, M.E. van den Berg, M.N. Niemeijer, O.H. Franco, A. Dehghan, A. Hofman, P.R. Rijnbeek, J.W. Deckers, M. Eijgelsheim, B.H. Stricker, R.P. Peeters, Thyroid function and sudden cardiac death: a prospective population-based cohort study. Circulation 134, 713–722 (2016)CrossRefPubMed
Metadata
Title
Is levothyroxine requirement the same for tablet and soft gel formulations?
Authors
Vincenzo Di Donna
Rosa Maria Paragliola
Chiara de Waure
Giampaolo Papi
Alfredo Pontecorvi
Salvatore Maria Corsello
Publication date
01-02-2018
Publisher
Springer US
Published in
Endocrine / Issue 2/2018
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-017-1311-8

Other articles of this Issue 2/2018

Endocrine 2/2018 Go to the issue

Original Article

Bone marrow fat contributes to insulin sensitivity and adiponectin secretion in premenopausal women

Original Article

Effects of chronic endurance exercise training on serum 25(OH)D concentrations in elderly Japanese men

Original Article

Quality of life and growth after childhood craniopharyngioma: results of the multinational trial KRANIOPHARYNGEOM 2007

Endocrine Surgery

Parathyroid hormone in surgery-induced weight loss: no glucometabolic effects but potential adaptive response to skeletal loading

Review

Irisin in metabolic diseases

Original Article

Vertebral fractures assessed with dual-energy X-ray absorptiometry in patients with Addison’s disease on glucocorticoid and mineralocorticoid replacement therapy
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits