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Keynote webinar | Spotlight on medication adherence

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Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
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Endocrine
Published in: Endocrine 1/2014

01-09-2014 | Editorial

Lower 25-hydroxyvitamin D3 levels and increased risk of liver diseases: is there a causal link?

Authors: Giovanni Targher, Christopher D. Byrne

Published in: Endocrine | Issue 1/2014

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Excerpt

Vitamin D deficiency is a highly prevalent condition worldwide, reportedly present in approximately 30–60 % of the general adult population [1, 2]. This worldwide pandemic remains generally unrecognized and untreated. …
Literature
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2.
G. Targher, I. Pichiri, G. Lippi, Vitamin D, thrombosis, and hemostasis: more than skin deep. Semin. Thromb. Hemost. 38, 114–124 (2012)PubMedCrossRef
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Skaaby T, Husemoen LL, Borglykke A, Jørgensen T, Thuesen BH, Pisinger C, Schmidt LE, Linneberg A (2013) Vitamin D status, liver enzymes, and incident liver disease and mortality: a general population study. Endocrine. 2013 Nov 23 [Epub ahead of print]. DOI: 10.​1007/​s12020-013-0107-8
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J.B. Wang, C.C. Abnet, W. Chen, S.M. Dawsey, J.H. Fan, L.Y. Yin et al., Association between serum 25(OH) vitamin D, incident liver cancer and chronic liver disease mortality in the Linxian nutrition intervention trials: a nested case-control study. Br. J. Cancer 109, 1997–2004 (2013)PubMedCrossRef
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I. Barchetta, F. Angelico, M. Del Ben, M.G. Baroni, P. Pozzilli, S. Morini et al., Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes. BMC Med. 9, 85 (2011)PubMedCentralPubMedCrossRef
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K.L. Jablonski, A. Jovanovich, J. Holmen, G. Targher, K. McFann, J. Kendrick et al., Low 25-hydroxyvitamin D level is independently associated with non-alcoholic fatty liver disease. Nutr. Metab. Cardiovasc. Dis. 23, 792–798 (2013)PubMedCentralPubMedCrossRef
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E.J. Rhee, M.K. Kim, S.E. Park, C.Y. Park, K.H. Baek, W.Y. Lee et al., High serum vitamin D levels reduce the risk for nonalcoholic fatty liver disease in healthy men independent of metabolic syndrome. Endocr. J. 60, 743–752 (2013)PubMedCrossRef
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G. Targher, L. Bertolini, L. Scala, M. Cigolini, L. Zenari, G. Falezza et al., Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutr. Metab. Cardiovasc. Dis. 17, 517–524 (2007)PubMedCrossRef
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G. Targher, E. Scorletti, A. Mantovani, C.D. Byrne, Nonalcoholic fatty liver disease and reduced serum vitamin D3 levels. Metab. Syndr. Relat. Disord. 11, 217–228 (2013)PubMedCrossRef
Metadata
Title
Lower 25-hydroxyvitamin D3 levels and increased risk of liver diseases: is there a causal link?
Authors
Giovanni Targher
Christopher D. Byrne
Publication date
01-09-2014
Publisher
Springer US
Published in
Endocrine / Issue 1/2014
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-014-0220-3

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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