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Published in:

01-06-2013

Protective Effect of Neferine Against Isoproterenol-Induced Cardiac Toxicity

Authors: Gurusamy Lalitha, Paramasivan Poornima, Arjunan Archanah, Viswanadha Vijaya Padma

Published in: Cardiovascular Toxicology | Issue 2/2013

Abstract

The present study was designed to investigate the cardioprotective effect of neferine against isoproterenol-induced myocardial infarction. Neferine was given orally for 30 days, and isoproterenol was injected subcutaneously for 2 days. Histopathological examination of heart tissue of isoproterenol-treated rats showed myocardial necrosis. Biochemical analysis of isoproterenol-treated rats showed significant increase in the serum marker enzymes—creatine kinase, lactate dehydrogenase, and aspartate transaminase and increased serum glycoprotein components with a concomitant decrease in the heart tissue homogenate when compared to control. Increased lipid peroxidation and decreased antioxidants reduced glutathione, superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase and altered lipid profile in serum and tissue was also recorded in the isoproterenol-treated rats, whereas the rats which received neferine pre-treatment followed by isoproterenol injection showed minimal histological changes, absence of inflammation, and a significant decrease in the serum marker enzymes and serum glycoprotein components with a concomitant increase in the heart tissue homogenate when compared to isoproterenol group. Neferine pre-treatment restored the altered biochemical parameters and lipid profile to near normal. The results of the present study showed that neferine exerts strong antioxidant property against isoproterenol-induced oxidative stress and can be used as a potent cardioprotective agent against isoproterenol-induced myocardial infarction.

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Title: Protective Effect of Neferine Against Isoproterenol-Induced Cardiac Toxicity
Authors: Gurusamy Lalitha
Paramasivan Poornima
Arjunan Archanah
Viswanadha Vijaya Padma
Publication date: 01-06-2013
Publisher: Humana Press Inc
Published in: Cardiovascular Toxicology / Issue 2/2013
Print ISSN: 1530-7905
Electronic ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-012-9196-5

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