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Current Treatment Options in Gastroenterology

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01-12-2020 | Systemic Sclerosis | Hot Topics

Managing Gastrointestinal Complications in Patients With Systemic Sclerosis

Authors: Z. H. McMahan, MD, MHS, D. Khanna, MBBS, MSc

Published in: Current Treatment Options in Gastroenterology | Issue 4/2020

Abstract

Objective

We sought to critically evaluate the literature published over the past 3 years on the management of gastrointestinal complications in systemic sclerosis (SSc). We emphasize interesting and important new findings to bring the reader up-to-date. We also discuss controversial discoveries and hypotheses currently of interest.

Methods

We conducted a literature search on PubMed over the last 3 years using the keywords “systemic sclerosis,” “gastrointestinal,” “scleroderma,” and “treatment.” We also screened clinicaltrials.gov for ongoing trials relevant to the gastrointestinal complications of SSc. Reference lists from recent reviews on the management of gastrointestinal complications of SSc to identify articles that might have been missed in the initial search.

Results

One hundred three publications and ongoing clinical trials were identified. We eliminated all case reports and review articles. Ultimately, we had 58 articles remaining and we prioritized what we found to be the strongest and/or novel findings to discuss in this review.

Conclusions

Advances in the management of gastrointestinal disease in SSc continue to evolve. The application of novel therapies and the repurposing of existing therapies for the management of gastrointestinal involvement are shaping the therapeutic arsenal so that we can more effectively manage these complex patients.

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Title: Managing Gastrointestinal Complications in Patients With Systemic Sclerosis
Authors: Z. H. McMahan, MD, MHS
D. Khanna, MBBS, MSc
Publication date: 01-12-2020
Publisher: Springer US
Keywords: Systemic Sclerosis
Gastroesophageal Reflux Disease
Scleroderma
Prucalopride
Published in: Current Treatment Options in Gastroenterology / Issue 4/2020
Print ISSN: 1092-8472
Electronic ISSN: 1534-309X
DOI: https://doi.org/10.1007/s11938-020-00314-x

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Conclusions

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