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Published in: Current Treatment Options in Gastroenterology 3/2015

01-09-2015 | Geriatrics (S Katz, Section Editor)

Challenges in the Diagnosis and Management of Inflammatory Bowel Disease in the Elderly

Author: Sasha Taleban, MD

Published in: Current Treatment Options in Gastroenterology | Issue 3/2015

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Opinion statement

Among inflammatory bowel disease (IBD) patients, 4–12 % is diagnosed after the age of 60. Both the rates of elderly and IBD are increasing worldwide. In older patients, the diagnosis of Crohn’s disease (CD) and ulcerative colitis (UC) is made more difficult due to polypharmacy and multimorbidity along with disease processes that mimic IBD. The clinical presentation in older-onset IBD differs from younger patients, and there is minimal disease progression over time. The management of the older IBD patient involves a combination of medical and surgical strategies. Few treatment efficacy studies exist in elderly IBD as most authors have focused on the adverse events related to therapy. A vast number of incident CD and UC cases in elderly have been treated with 5-aminosalicylic acid agents and do not require the use of immune modifying agents or biologics. Many other older IBD patients are prescribed long-term corticosteroids despite guidelines recommending more effective and safer maintenance therapy regimens. Serious infections, malignancy, and drug interactions are the most concerning complications of medical therapy. There are particularly important health care maintenance issues in older IBD patients including vaccinations, colorectal cancer screening, and bone loss prevention.
Literature
1.
go back to reference Banks BM, Klayman MI. Idiopathic ulcerative colitis beginning after the age of fifty. N Engl J Med. 1953;249:91–6.PubMedCrossRef Banks BM, Klayman MI. Idiopathic ulcerative colitis beginning after the age of fifty. N Engl J Med. 1953;249:91–6.PubMedCrossRef
2.
go back to reference Law DH, Steinberg H, Sleisenger MH. Ulcerative colitis with onset after the age fifty. Gastroenterology. 1961;41:457–64.PubMedCrossRef Law DH, Steinberg H, Sleisenger MH. Ulcerative colitis with onset after the age fifty. Gastroenterology. 1961;41:457–64.PubMedCrossRef
3.
go back to reference Nugent FW. Regional ileitis with onset in patients over fifty years of age. Gastroenterology. 1958;35:418–9.PubMedCrossRef Nugent FW. Regional ileitis with onset in patients over fifty years of age. Gastroenterology. 1958;35:418–9.PubMedCrossRef
5.
6.
go back to reference Katz S, Feldstein R. Inflammatory bowel disease of the elderly: a wake-up call. Gastroenterol Hepatol. 2008;4:337–47. Katz S, Feldstein R. Inflammatory bowel disease of the elderly: a wake-up call. Gastroenterol Hepatol. 2008;4:337–47.
7.
go back to reference Katz S, Pardi DS. Inflammatory bowel disease of the elderly: frequently asked questions (FAQs). Am J Gastroenterol. 2011;106:1889–97.PubMedCrossRef Katz S, Pardi DS. Inflammatory bowel disease of the elderly: frequently asked questions (FAQs). Am J Gastroenterol. 2011;106:1889–97.PubMedCrossRef
8.
go back to reference Ruel J, Ruane D, Mehandru S, et al. IBD across the age spectrum: is it the same disease? Nat Rev Gastroenterol Hepatol. 2014;11:88–98.PubMedCrossRef Ruel J, Ruane D, Mehandru S, et al. IBD across the age spectrum: is it the same disease? Nat Rev Gastroenterol Hepatol. 2014;11:88–98.PubMedCrossRef
9.••
go back to reference Charpentier C, Salleron J, Savoye G, et al. Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study. Gut. 2014;63:423–32. Population-based French study using EPIMAD registry between 1988–2006 that leads to many of the conclusions about the natural history and approach to treatment in older-onset IBD.PubMedCrossRef Charpentier C, Salleron J, Savoye G, et al. Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study. Gut. 2014;63:423–32. Population-based French study using EPIMAD registry between 1988–2006 that leads to many of the conclusions about the natural history and approach to treatment in older-onset IBD.PubMedCrossRef
10.•
go back to reference Lakatos PL, David G, Pandur T, et al. IBD in the elderly population: results from a population-based study in Western Hungary, 1977–2008. J Crohns Colitis. 2011;5:5–13. Population-based Hungarian study between 1977–2008 that leads to many of the conclusions about the natural history and approach to treatment in older-onset IBD.PubMedCrossRef Lakatos PL, David G, Pandur T, et al. IBD in the elderly population: results from a population-based study in Western Hungary, 1977–2008. J Crohns Colitis. 2011;5:5–13. Population-based Hungarian study between 1977–2008 that leads to many of the conclusions about the natural history and approach to treatment in older-onset IBD.PubMedCrossRef
12.
go back to reference Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142:46–54.PubMedCrossRef Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142:46–54.PubMedCrossRef
13.
go back to reference Nilsen T, Sundström J, Lind L, et al. Serum calprotectin levels in elderly males and females without bacterial or viral infections. Clin Biochem. 2014;47:1065–8.PubMedCrossRef Nilsen T, Sundström J, Lind L, et al. Serum calprotectin levels in elderly males and females without bacterial or viral infections. Clin Biochem. 2014;47:1065–8.PubMedCrossRef
14.
go back to reference Stoller MA, Stoller EP. Perceived income adequacy among elderly retirees. J Appl Gerontol. 2003;22:230–51.CrossRef Stoller MA, Stoller EP. Perceived income adequacy among elderly retirees. J Appl Gerontol. 2003;22:230–51.CrossRef
15.
go back to reference Page MJ, Poritz LS, Kunselman SJ, et al. Factors affecting surgical risk in elderly patients with inflammatory bowel disease. J Gastrointest Surg. 2002;6:606–13.PubMedCrossRef Page MJ, Poritz LS, Kunselman SJ, et al. Factors affecting surgical risk in elderly patients with inflammatory bowel disease. J Gastrointest Surg. 2002;6:606–13.PubMedCrossRef
16.
go back to reference Collins CE, Ayturk MD, Flahive JM, et al. Epidemiology and outcomes of community-acquired clostridium difficile infections in medicare beneficiaries. J Am Coll Surg. 2014;218:1141–7.PubMedPubMedCentralCrossRef Collins CE, Ayturk MD, Flahive JM, et al. Epidemiology and outcomes of community-acquired clostridium difficile infections in medicare beneficiaries. J Am Coll Surg. 2014;218:1141–7.PubMedPubMedCentralCrossRef
17.
go back to reference Wehling M. Non-steroidal anti-inflammatory drug use in chronic pain conditions with special emphasis on the elderly and patients with relevant comorbidities: management and mitigation of risks and adverse effects. Eur J Clin Pharmacol. 2014;70:1159–72.PubMedCrossRef Wehling M. Non-steroidal anti-inflammatory drug use in chronic pain conditions with special emphasis on the elderly and patients with relevant comorbidities: management and mitigation of risks and adverse effects. Eur J Clin Pharmacol. 2014;70:1159–72.PubMedCrossRef
18.
go back to reference Ng SC, Tang W, Ching JY, et al. Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn’s and colitis epidemiology study. Gastroenterology. 2013;145:158–65.PubMedCrossRef Ng SC, Tang W, Ching JY, et al. Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn’s and colitis epidemiology study. Gastroenterology. 2013;145:158–65.PubMedCrossRef
19.
go back to reference Parian AM, Ha CY. Su1130 severe polypharmacy and major medication interactions are associated with increasing age and comorbidity among inflammatory bowel disease patients. Gastroenterology. 2013;144:S-406.CrossRef Parian AM, Ha CY. Su1130 severe polypharmacy and major medication interactions are associated with increasing age and comorbidity among inflammatory bowel disease patients. Gastroenterology. 2013;144:S-406.CrossRef
20.
go back to reference Singh S, Kullo IJ, Pardi DS, et al. Epidemiology, risk factors and management of cardiovascular diseases in IBD. Nat Rev Gastroenterol Hepatol. 2015;12:26–35.PubMedCrossRef Singh S, Kullo IJ, Pardi DS, et al. Epidemiology, risk factors and management of cardiovascular diseases in IBD. Nat Rev Gastroenterol Hepatol. 2015;12:26–35.PubMedCrossRef
21.
go back to reference Long MD, Kappelman MD, Martin CF, et al. Risk factors for depression in the elderly inflammatory bowel disease population. J Crohns Colitis. 2014;8:113–9.PubMedCrossRef Long MD, Kappelman MD, Martin CF, et al. Risk factors for depression in the elderly inflammatory bowel disease population. J Crohns Colitis. 2014;8:113–9.PubMedCrossRef
22.
go back to reference Graham JE, Rockwood K, Beattie BL, et al. Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet. 1997;349:1793–6.PubMedCrossRef Graham JE, Rockwood K, Beattie BL, et al. Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet. 1997;349:1793–6.PubMedCrossRef
23.
go back to reference Amati L, Passeri M, Selicato F, et al. New insights into the biological and clinical significance of fecal calprotectin in inflammatory bowel disease. Immunopharmacol Immunotoxicol. 2006;28:665–81.PubMedCrossRef Amati L, Passeri M, Selicato F, et al. New insights into the biological and clinical significance of fecal calprotectin in inflammatory bowel disease. Immunopharmacol Immunotoxicol. 2006;28:665–81.PubMedCrossRef
24.
go back to reference Joshi S, Lewis SJ, Creanor S, et al. Age-related faecal calprotectin, lactoferrin and tumour M2-PK concentrations in healthy volunteers. Ann Clin Biochem. 2010;47:259–63.PubMedCrossRef Joshi S, Lewis SJ, Creanor S, et al. Age-related faecal calprotectin, lactoferrin and tumour M2-PK concentrations in healthy volunteers. Ann Clin Biochem. 2010;47:259–63.PubMedCrossRef
25.
go back to reference Greenwald DA, Brandt LJ. Inflammatory bowel disease after age 60. Curr Treat Options Gastroenterol. 2003;6:213–25.PubMedCrossRef Greenwald DA, Brandt LJ. Inflammatory bowel disease after age 60. Curr Treat Options Gastroenterol. 2003;6:213–25.PubMedCrossRef
26.•
go back to reference Cottone M, Kohn A, Daperno M, et al. Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease. Clin Gastroenterol Hepatol. 2011;9:30–5. Multicenter retrospective Italian study from 2000–2009 evaluating the safety of infliximab and adalimumab in patients >65 years old is responsible for several of the conclusions drawn regarding efficacy and safety profile of biologic use in elderly.PubMedCrossRef Cottone M, Kohn A, Daperno M, et al. Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease. Clin Gastroenterol Hepatol. 2011;9:30–5. Multicenter retrospective Italian study from 2000–2009 evaluating the safety of infliximab and adalimumab in patients >65 years old is responsible for several of the conclusions drawn regarding efficacy and safety profile of biologic use in elderly.PubMedCrossRef
27.
go back to reference Vermeire S, Schreiber S, Sandborn WJ, et al. Correlation between the Crohn’s disease activity and Harvey-Bradshaw indices in assessing Crohn’s disease severity. Clin Gastroenterol Hepatol. 2010;8:357–63.PubMedCrossRef Vermeire S, Schreiber S, Sandborn WJ, et al. Correlation between the Crohn’s disease activity and Harvey-Bradshaw indices in assessing Crohn’s disease severity. Clin Gastroenterol Hepatol. 2010;8:357–63.PubMedCrossRef
28.
29.
go back to reference Marteau P, Probert CS, Lindgren S, et al. Combined oral and enema treatment with Pentasa (mesalazine) is superior to oral therapy alone in patients with extensive mild/moderate active ulcerative colitis: a randomised, double blind, placebo controlled study. Gut. 2005;54:960–5.PubMedPubMedCentralCrossRef Marteau P, Probert CS, Lindgren S, et al. Combined oral and enema treatment with Pentasa (mesalazine) is superior to oral therapy alone in patients with extensive mild/moderate active ulcerative colitis: a randomised, double blind, placebo controlled study. Gut. 2005;54:960–5.PubMedPubMedCentralCrossRef
30.
go back to reference Kane SV, Cohen RD, Aikens JE, et al. Prevalence of nonadherence with maintenance mesalamine in quiescent ulcerative colitis. Am J Gastroenterol. 2001;96:2929–33.PubMedCrossRef Kane SV, Cohen RD, Aikens JE, et al. Prevalence of nonadherence with maintenance mesalamine in quiescent ulcerative colitis. Am J Gastroenterol. 2001;96:2929–33.PubMedCrossRef
31.
go back to reference Hawthorne AB, Stenson R, Gillespie D, et al. One-year investigator-blind randomized multicenter trial comparing Asacol 2.4 g once daily with 800 mg three times daily for maintenance of remission in ulcerative colitis. Inflamm Bowel Dis. 2012;18:1885–93.PubMedCrossRef Hawthorne AB, Stenson R, Gillespie D, et al. One-year investigator-blind randomized multicenter trial comparing Asacol 2.4 g once daily with 800 mg three times daily for maintenance of remission in ulcerative colitis. Inflamm Bowel Dis. 2012;18:1885–93.PubMedCrossRef
32.
go back to reference Kane SV, Sumner M, Solomon D, et al. Twelve-month persistency with oral 5-aminosalicylic acid therapy for ulcerative colitis: results from a large pharmacy prescriptions database. Dig Dis Sci. 2011;56:3463–70.PubMedCrossRef Kane SV, Sumner M, Solomon D, et al. Twelve-month persistency with oral 5-aminosalicylic acid therapy for ulcerative colitis: results from a large pharmacy prescriptions database. Dig Dis Sci. 2011;56:3463–70.PubMedCrossRef
33.
go back to reference Ford AC, Kane SV, Khan KJ, et al. Efficacy of 5-aminosalicylates in Crohn’s disease: systematic review and meta-analysis. Am J Gastroenterol. 2011;106:617–29.PubMedCrossRef Ford AC, Kane SV, Khan KJ, et al. Efficacy of 5-aminosalicylates in Crohn’s disease: systematic review and meta-analysis. Am J Gastroenterol. 2011;106:617–29.PubMedCrossRef
34.
go back to reference Lim WC, Hanauer S. Aminosalicylates for induction of remission or response in Crohn’s disease. Cochrane Database Syst Rev 2010:Cd008870. Lim WC, Hanauer S. Aminosalicylates for induction of remission or response in Crohn’s disease. Cochrane Database Syst Rev 2010:Cd008870.
35.•
go back to reference Lichtenstein GR, Hanauer SB, Sandborn WJ. Management of Crohn’s disease in adults. Am J Gastroenterol. 2009;104:465–83. The American College of Gastroenterology guidelines for the management of adult CD.PubMedCrossRef Lichtenstein GR, Hanauer SB, Sandborn WJ. Management of Crohn’s disease in adults. Am J Gastroenterol. 2009;104:465–83. The American College of Gastroenterology guidelines for the management of adult CD.PubMedCrossRef
36.
go back to reference Sandborn WJ, Travis S, Moro L, et al. Once-daily budesonide MMX® extended-release tablets induce remission in patients with mild to moderate ulcerative colitis: results from the CORE I study. Gastroenterology. 2012;143:1218–26.PubMedCrossRef Sandborn WJ, Travis S, Moro L, et al. Once-daily budesonide MMX® extended-release tablets induce remission in patients with mild to moderate ulcerative colitis: results from the CORE I study. Gastroenterology. 2012;143:1218–26.PubMedCrossRef
37.
go back to reference Khan KJ, Ullman TA, Ford AC, et al. Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis. Am J Gastroenterol. 2011;106:661–73.PubMedCrossRef Khan KJ, Ullman TA, Ford AC, et al. Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis. Am J Gastroenterol. 2011;106:661–73.PubMedCrossRef
38.
go back to reference Van Staa TP, Travis S, Leufkens HG, et al. 5-Aminosalicylic acids and the risk of renal disease: a large British epidemiologic study. Gastroenterology. 2004;126:1733–9.PubMedCrossRef Van Staa TP, Travis S, Leufkens HG, et al. 5-Aminosalicylic acids and the risk of renal disease: a large British epidemiologic study. Gastroenterology. 2004;126:1733–9.PubMedCrossRef
39.
go back to reference Gisbert JP, Gonzalez-Lama Y, Mate J. 5-Aminosalicylates and renal function in inflammatory bowel disease: a systematic review. Inflamm Bowel Dis. 2007;13:629–38.PubMedCrossRef Gisbert JP, Gonzalez-Lama Y, Mate J. 5-Aminosalicylates and renal function in inflammatory bowel disease: a systematic review. Inflamm Bowel Dis. 2007;13:629–38.PubMedCrossRef
40.
go back to reference de Graaf P, de Boer NK, Wong DR, et al. Influence of 5-aminosalicylic acid on 6-thioguanosine phosphate metabolite levels: a prospective study in patients under steady thiopurine therapy. Br J Pharmacol. 2010;160:1083–91.PubMedPubMedCentralCrossRef de Graaf P, de Boer NK, Wong DR, et al. Influence of 5-aminosalicylic acid on 6-thioguanosine phosphate metabolite levels: a prospective study in patients under steady thiopurine therapy. Br J Pharmacol. 2010;160:1083–91.PubMedPubMedCentralCrossRef
41.
go back to reference Cino M, Greenberg GR. Bone mineral density in Crohn’s disease: a longitudinal study of budesonide, prednisone, and nonsteroid therapy. Am J Gastroenterol. 2002;97:915–21.PubMedCrossRef Cino M, Greenberg GR. Bone mineral density in Crohn’s disease: a longitudinal study of budesonide, prednisone, and nonsteroid therapy. Am J Gastroenterol. 2002;97:915–21.PubMedCrossRef
42.
go back to reference Rutgeerts P, Lofberg R, Malchow H, et al. A comparison of budesonide with prednisolone for active Crohn’s disease. N Engl J Med. 1994;331:842–5.PubMedCrossRef Rutgeerts P, Lofberg R, Malchow H, et al. A comparison of budesonide with prednisolone for active Crohn’s disease. N Engl J Med. 1994;331:842–5.PubMedCrossRef
43.
go back to reference Ananthakrishnan AN, McGinley EL, Binion DG. Inflammatory bowel disease in the elderly is associated with worse outcomes: a national study of hospitalizations. Inflamm Bowel Dis. 2009;15:182–9.PubMedCrossRef Ananthakrishnan AN, McGinley EL, Binion DG. Inflammatory bowel disease in the elderly is associated with worse outcomes: a national study of hospitalizations. Inflamm Bowel Dis. 2009;15:182–9.PubMedCrossRef
44.•
go back to reference Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adults: American college of gastroenterology, practice parameters committee. Am J Gastroenterol. 2010;105:501–23. The American College of Gastroenterology guidelines for the management of adult UC.PubMedCrossRef Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adults: American college of gastroenterology, practice parameters committee. Am J Gastroenterol. 2010;105:501–23. The American College of Gastroenterology guidelines for the management of adult UC.PubMedCrossRef
45.•
go back to reference Desai A, Zator ZA, de Silva P, et al. Older age is associated with higher rate of discontinuation of anti-TNF therapy in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013;19:309–15. Along with [26], this retrospective single-center study evaluated the efficacy of ant-TNF agents in the elderly.PubMedCrossRef Desai A, Zator ZA, de Silva P, et al. Older age is associated with higher rate of discontinuation of anti-TNF therapy in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013;19:309–15. Along with [26], this retrospective single-center study evaluated the efficacy of ant-TNF agents in the elderly.PubMedCrossRef
46.
go back to reference Feagan BG, Rutgeerts P, Sands BE, et al. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2013;369:699–710.PubMedCrossRef Feagan BG, Rutgeerts P, Sands BE, et al. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2013;369:699–710.PubMedCrossRef
47.
go back to reference Sandborn WJ, Feagan BG, Rutgeerts P, et al. Vedolizumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med. 2013;369:711–21.PubMedCrossRef Sandborn WJ, Feagan BG, Rutgeerts P, et al. Vedolizumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med. 2013;369:711–21.PubMedCrossRef
48.
go back to reference Juneja M, Baidoo L, Schwartz MB, et al. Geriatric inflammatory bowel disease: phenotypic presentation, treatment patterns, nutritional status, outcomes, and comorbidity. Dig Dis Sci. 2012;57:2408–15.PubMedCrossRef Juneja M, Baidoo L, Schwartz MB, et al. Geriatric inflammatory bowel disease: phenotypic presentation, treatment patterns, nutritional status, outcomes, and comorbidity. Dig Dis Sci. 2012;57:2408–15.PubMedCrossRef
49.
go back to reference Toruner M, Loftus Jr EV, Harmsen WS, et al. Risk factors for opportunistic infections in patients with inflammatory bowel disease. Gastroenterology. 2008;134:929–36.PubMedCrossRef Toruner M, Loftus Jr EV, Harmsen WS, et al. Risk factors for opportunistic infections in patients with inflammatory bowel disease. Gastroenterology. 2008;134:929–36.PubMedCrossRef
50.
go back to reference Brassard P, Bitton A, Suissa A, et al. Oral corticosteroids and the risk of serious infections in patients with elderly-onset inflammatory bowel diseases. Am J Gastroenterol. 2014;109:1795–802.PubMedCrossRef Brassard P, Bitton A, Suissa A, et al. Oral corticosteroids and the risk of serious infections in patients with elderly-onset inflammatory bowel diseases. Am J Gastroenterol. 2014;109:1795–802.PubMedCrossRef
51.•
go back to reference Lichtenstein GR, Feagan BG, Cohen RD, et al. Serious infection and mortality in patients with Crohn’s disease: more than 5 years of follow-up in the TREAT registry. Am J Gastroenterol. 2012;107:1409–22. Large, prospective, observational registry comparing risk factors for serious infection and mortality among CD patients taking or not taking infliximab.PubMedPubMedCentralCrossRef Lichtenstein GR, Feagan BG, Cohen RD, et al. Serious infection and mortality in patients with Crohn’s disease: more than 5 years of follow-up in the TREAT registry. Am J Gastroenterol. 2012;107:1409–22. Large, prospective, observational registry comparing risk factors for serious infection and mortality among CD patients taking or not taking infliximab.PubMedPubMedCentralCrossRef
52.
go back to reference Beaugerie L, Carrat F, Colombel JF, et al. Risk of new or recurrent cancer under immunosuppressive therapy in patients with IBD and previous cancer. Gut. 2013;63:1416–23.PubMedCrossRef Beaugerie L, Carrat F, Colombel JF, et al. Risk of new or recurrent cancer under immunosuppressive therapy in patients with IBD and previous cancer. Gut. 2013;63:1416–23.PubMedCrossRef
53.
go back to reference Khan N, Abbas AM, Lichtenstein GR, et al. Risk of lymphoma in patients with ulcerative colitis treated with thiopurines: a nationwide retrospective cohort study. Gastroenterology. 2013;145:1007–15.PubMedCrossRef Khan N, Abbas AM, Lichtenstein GR, et al. Risk of lymphoma in patients with ulcerative colitis treated with thiopurines: a nationwide retrospective cohort study. Gastroenterology. 2013;145:1007–15.PubMedCrossRef
54.•
go back to reference Lichtenstein GR, Feagan BG, Cohen RD, et al. Drug therapies and the risk of malignancy in Crohn’s disease: results from the TREAT Registry. Am J Gastroenterol. 2014;109:212–23. Large, prospective, observational registry comparing risk factors for various malignancies among CD patients taking or not taking infliximab.PubMedCrossRef Lichtenstein GR, Feagan BG, Cohen RD, et al. Drug therapies and the risk of malignancy in Crohn’s disease: results from the TREAT Registry. Am J Gastroenterol. 2014;109:212–23. Large, prospective, observational registry comparing risk factors for various malignancies among CD patients taking or not taking infliximab.PubMedCrossRef
55.
go back to reference Mariette X, Cazals-Hatem D, Warszawki J, et al. Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France. Blood. 2002;99:3909–15.PubMedCrossRef Mariette X, Cazals-Hatem D, Warszawki J, et al. Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France. Blood. 2002;99:3909–15.PubMedCrossRef
56.
go back to reference Wolfe F, Michaud K. Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients. Arthritis Rheum. 2004;50:1740–51.PubMedCrossRef Wolfe F, Michaud K. Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients. Arthritis Rheum. 2004;50:1740–51.PubMedCrossRef
57.
go back to reference Siegel CA, Marden SM, Persing SM, et al. Risk of lymphoma associated with combination anti-tumor necrosis factor and immunomodulator therapy for the treatment of Crohn’s disease: a meta-analysis. Clin Gastroenterol Hepatol. 2009;7:874–81.PubMedPubMedCentralCrossRef Siegel CA, Marden SM, Persing SM, et al. Risk of lymphoma associated with combination anti-tumor necrosis factor and immunomodulator therapy for the treatment of Crohn’s disease: a meta-analysis. Clin Gastroenterol Hepatol. 2009;7:874–81.PubMedPubMedCentralCrossRef
58.
go back to reference Long MD, Herfarth HH, Pipkin CA, et al. Increased risk for non-melanoma skin cancer in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2010;8:268–74.PubMedPubMedCentralCrossRef Long MD, Herfarth HH, Pipkin CA, et al. Increased risk for non-melanoma skin cancer in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2010;8:268–74.PubMedPubMedCentralCrossRef
59.
go back to reference Peyrin-Biroulet L, Khosrotehrani K, Carrat F, et al. Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease. Gastroenterology. 2011;141:1621–8.PubMedCrossRef Peyrin-Biroulet L, Khosrotehrani K, Carrat F, et al. Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease. Gastroenterology. 2011;141:1621–8.PubMedCrossRef
60.
go back to reference Syrigos KN, Tzannou I, Katirtzoglou N, et al. Skin cancer in the elderly. In Vivo. 2005;19:643–52.PubMed Syrigos KN, Tzannou I, Katirtzoglou N, et al. Skin cancer in the elderly. In Vivo. 2005;19:643–52.PubMed
61.
go back to reference Long MD, Martin CF, Pipkin CA, et al. Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease. Gastroenterology. 2012;143:390–9.PubMedCrossRef Long MD, Martin CF, Pipkin CA, et al. Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease. Gastroenterology. 2012;143:390–9.PubMedCrossRef
62.
go back to reference Mariette X, Matucci-Cerinic M, Pavelka K, et al. Malignancies associated with tumour necrosis factor inhibitors in registries and prospective observational studies: a systematic review and meta-analysis. Ann Rheum Dis. 2011;70:1895–904.PubMedCrossRef Mariette X, Matucci-Cerinic M, Pavelka K, et al. Malignancies associated with tumour necrosis factor inhibitors in registries and prospective observational studies: a systematic review and meta-analysis. Ann Rheum Dis. 2011;70:1895–904.PubMedCrossRef
63.
go back to reference Peyrin-Biroulet L, Chevaux JB, Bouvier AM, et al. Risk of melanoma in patients who receive thiopurines for inflammatory bowel disease is not increased. Am J Gastroenterol. 2012;107:1443–4.PubMedCrossRef Peyrin-Biroulet L, Chevaux JB, Bouvier AM, et al. Risk of melanoma in patients who receive thiopurines for inflammatory bowel disease is not increased. Am J Gastroenterol. 2012;107:1443–4.PubMedCrossRef
64.
go back to reference Hoentjen F, Seinen ML, Hanauer SB, et al. Safety and effectiveness of long-term allopurinol-thiopurine maintenance treatment in inflammatory bowel disease. Inflamm Bowel Dis. 2013;19:363–9.PubMedCrossRef Hoentjen F, Seinen ML, Hanauer SB, et al. Safety and effectiveness of long-term allopurinol-thiopurine maintenance treatment in inflammatory bowel disease. Inflamm Bowel Dis. 2013;19:363–9.PubMedCrossRef
65.
go back to reference Irving PM, Shanahan F, Rampton DS. Drug interactions in inflammatory bowel disease. Am J Gastroenterol. 2008;103:207–19.PubMedCrossRef Irving PM, Shanahan F, Rampton DS. Drug interactions in inflammatory bowel disease. Am J Gastroenterol. 2008;103:207–19.PubMedCrossRef
66.
go back to reference Bourre-Tessier J, Haraoui B. Methotrexate drug interactions in the treatment of rheumatoid arthritis: a systematic review. J Rheumatol. 2010;37:1416–21.PubMedCrossRef Bourre-Tessier J, Haraoui B. Methotrexate drug interactions in the treatment of rheumatoid arthritis: a systematic review. J Rheumatol. 2010;37:1416–21.PubMedCrossRef
67.
go back to reference Teml A, Schaeffeler E, Herrlinger KR, et al. Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing. Clin Pharmacokinet. 2007;46:187–208.PubMedCrossRef Teml A, Schaeffeler E, Herrlinger KR, et al. Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing. Clin Pharmacokinet. 2007;46:187–208.PubMedCrossRef
68.
go back to reference Kim M, Dam A, Green J. Common GI drug interactions in the elderly. Curr Treat Options Gastroenterol. 2014;12:292–309.PubMedCrossRef Kim M, Dam A, Green J. Common GI drug interactions in the elderly. Curr Treat Options Gastroenterol. 2014;12:292–309.PubMedCrossRef
69.
go back to reference Kaplan GG, Hubbard J, Panaccione R, et al. Risk of comorbidities on postoperative outcomes in patients with inflammatory bowel disease. Arch Surg. 2011;146:959–64.PubMedCrossRef Kaplan GG, Hubbard J, Panaccione R, et al. Risk of comorbidities on postoperative outcomes in patients with inflammatory bowel disease. Arch Surg. 2011;146:959–64.PubMedCrossRef
70.
go back to reference Fries W, Viola A, Mannetti N, et al. P303 ulcerative colitis (UC) in the elderly–moderate at onset but then a milder course? An IG-IBD study. J Crohns Colitis. 2014;8:S190–1.CrossRef Fries W, Viola A, Mannetti N, et al. P303 ulcerative colitis (UC) in the elderly–moderate at onset but then a milder course? An IG-IBD study. J Crohns Colitis. 2014;8:S190–1.CrossRef
71.
go back to reference Viola A, Cantoro L, Monterubbianesi R, et al. P542 Crohn’s disease (CD) in the elderly – an IG-IBD study. J Crohns Colitis. 2014;8:S293–4.CrossRef Viola A, Cantoro L, Monterubbianesi R, et al. P542 Crohn’s disease (CD) in the elderly – an IG-IBD study. J Crohns Colitis. 2014;8:S293–4.CrossRef
72.
go back to reference Almogy G, Sachar DB, Bodian CA, et al. Surgery for ulcerative colitis in elderly persons: changes in indications for surgery and outcome over time. Arch Surg. 2001;136:1396–400.PubMedCrossRef Almogy G, Sachar DB, Bodian CA, et al. Surgery for ulcerative colitis in elderly persons: changes in indications for surgery and outcome over time. Arch Surg. 2001;136:1396–400.PubMedCrossRef
73.
go back to reference Ikeuchi H, Uchino M, Matsuoka H, et al. Prognosis following emergency surgery for ulcerative colitis in elderly patients. Surg Today. 2014;44:39–43.PubMedCrossRef Ikeuchi H, Uchino M, Matsuoka H, et al. Prognosis following emergency surgery for ulcerative colitis in elderly patients. Surg Today. 2014;44:39–43.PubMedCrossRef
74.
go back to reference Chapman JR, Larson DW, Wolff BG, et al. Ileal pouch-anal anastomosis: does age at the time of surgery affect outcome? Arch Surg. 2005;140:534–9.PubMedCrossRef Chapman JR, Larson DW, Wolff BG, et al. Ileal pouch-anal anastomosis: does age at the time of surgery affect outcome? Arch Surg. 2005;140:534–9.PubMedCrossRef
75.
go back to reference Delaney CP, Fazio VW, Remzi FH, et al. Prospective, age-related analysis of surgical results, functional outcome, and quality of life after ileal pouch-anal anastomosis. Ann Surg. 2003;238:221–8.PubMedPubMedCentral Delaney CP, Fazio VW, Remzi FH, et al. Prospective, age-related analysis of surgical results, functional outcome, and quality of life after ileal pouch-anal anastomosis. Ann Surg. 2003;238:221–8.PubMedPubMedCentral
76.
go back to reference Longo WE, Virgo KS, Bahadursingh AN, et al. Patterns of disease and surgical treatment among United States veterans more than 50 years of age with ulcerative colitis. Am J Surg. 2003;186:514–8.PubMedCrossRef Longo WE, Virgo KS, Bahadursingh AN, et al. Patterns of disease and surgical treatment among United States veterans more than 50 years of age with ulcerative colitis. Am J Surg. 2003;186:514–8.PubMedCrossRef
77.
go back to reference Lakatos PL, Vegh Z, Lovasz BD, et al. Is current smoking still an important environmental factor in inflammatory bowel diseases? Results from a population-based incident cohort. Inflamm Bowel Dis. 2013;19:1010–7.PubMedCrossRef Lakatos PL, Vegh Z, Lovasz BD, et al. Is current smoking still an important environmental factor in inflammatory bowel diseases? Results from a population-based incident cohort. Inflamm Bowel Dis. 2013;19:1010–7.PubMedCrossRef
78.
go back to reference Triantafillidis JK, Mantzaris G, Karagiannis J, et al. Similar response to adalimumab in patients with active Crohn’s disease either naive to biologic agents or with prior loss of response or intolerance to infliximab. Rev Med Chir Soc Med Nat Iasi. 2010;114:85–90.PubMed Triantafillidis JK, Mantzaris G, Karagiannis J, et al. Similar response to adalimumab in patients with active Crohn’s disease either naive to biologic agents or with prior loss of response or intolerance to infliximab. Rev Med Chir Soc Med Nat Iasi. 2010;114:85–90.PubMed
79.
go back to reference Meyer AM, Ramzan NN, Heigh RI, et al. Relapse of inflammatory bowel disease associated with use of nonsteroidal anti-inflammatory drugs. Dig Dis Sci. 2006;51:168–72.PubMedCrossRef Meyer AM, Ramzan NN, Heigh RI, et al. Relapse of inflammatory bowel disease associated with use of nonsteroidal anti-inflammatory drugs. Dig Dis Sci. 2006;51:168–72.PubMedCrossRef
80.
go back to reference Miao XP, Li JS, Ouyang Q, et al. Tolerability of selective cyclooxygenase 2 inhibitors used for the treatment of rheumatological manifestations of inflammatory bowel disease. Cochrane Database Syst Rev 2014;10:Cd007744. Miao XP, Li JS, Ouyang Q, et al. Tolerability of selective cyclooxygenase 2 inhibitors used for the treatment of rheumatological manifestations of inflammatory bowel disease. Cochrane Database Syst Rev 2014;10:Cd007744.
81.
go back to reference Martin TD, Chan SS, Hart AR. Environmental factors in the relapse and recurrence of inflammatory bowel disease: a review of the literature. Dig Dis Sci 2014 Martin TD, Chan SS, Hart AR. Environmental factors in the relapse and recurrence of inflammatory bowel disease: a review of the literature. Dig Dis Sci 2014
82.
go back to reference Mowat C, Cole A, Windsor A, et al. Guidelines for the management of inflammatory bowel disease in adults. Gut. 2011;60:571–607.PubMedCrossRef Mowat C, Cole A, Windsor A, et al. Guidelines for the management of inflammatory bowel disease in adults. Gut. 2011;60:571–607.PubMedCrossRef
83.
go back to reference Kugelberg E. T cell memory: the effect of ageing on CD8+ T cells. Nat Rev Immunol. 2014;14:3–3. Kugelberg E. T cell memory: the effect of ageing on CD8+ T cells. Nat Rev Immunol. 2014;14:3–3.
84.
go back to reference Horton HA, Kim H, Melmed GY. Vaccinations in older adults with gastrointestinal diseases. Clin Geriatr Med. 2014;30:17–28.PubMedCrossRef Horton HA, Kim H, Melmed GY. Vaccinations in older adults with gastrointestinal diseases. Clin Geriatr Med. 2014;30:17–28.PubMedCrossRef
85.
go back to reference Cossio-Gil Y, Martinez-Gomez X, Campins-Marti M, et al. Immunogenicity of hepatitis B vaccine in patients with inflammatory bowel disease and the benefits of revaccination. J Gastroenterol Hepatol. 2015;30:92–8.PubMedCrossRef Cossio-Gil Y, Martinez-Gomez X, Campins-Marti M, et al. Immunogenicity of hepatitis B vaccine in patients with inflammatory bowel disease and the benefits of revaccination. J Gastroenterol Hepatol. 2015;30:92–8.PubMedCrossRef
86.
go back to reference Melmed GY. Vaccination strategies for patients with inflammatory bowel disease on immunomodulators and biologics. Inflamm Bowel Dis. 2009;15:1410–6.PubMedCrossRef Melmed GY. Vaccination strategies for patients with inflammatory bowel disease on immunomodulators and biologics. Inflamm Bowel Dis. 2009;15:1410–6.PubMedCrossRef
87.
go back to reference Mattar MC, Lough D, Pishvaian MJ, et al. Current management of inflammatory bowel disease and colorectal cancer. Gastrointest Cancer Res. 2011;4:53–61.PubMedPubMedCentral Mattar MC, Lough D, Pishvaian MJ, et al. Current management of inflammatory bowel disease and colorectal cancer. Gastrointest Cancer Res. 2011;4:53–61.PubMedPubMedCentral
88.
go back to reference Crispin A, Birkner B, Munte A, et al. Process quality and incidence of acute complications in a series of more than 230,000 outpatient colonoscopies. Endoscopy. 2009;41:1018–25.PubMedCrossRef Crispin A, Birkner B, Munte A, et al. Process quality and incidence of acute complications in a series of more than 230,000 outpatient colonoscopies. Endoscopy. 2009;41:1018–25.PubMedCrossRef
89.
go back to reference Gatto NM, Frucht H, Sundararajan V, et al. Risk of perforation after colonoscopy and sigmoidoscopy: a population-based study. J Natl Cancer Inst. 2003;95:230–6.PubMedCrossRef Gatto NM, Frucht H, Sundararajan V, et al. Risk of perforation after colonoscopy and sigmoidoscopy: a population-based study. J Natl Cancer Inst. 2003;95:230–6.PubMedCrossRef
90.
go back to reference Ko CW, Riffle S, Michaels L, et al. Serious complications within 30 days of screening and surveillance colonoscopy are uncommon. Clin Gastroenterol Hepatol. 2010;8:166–73.PubMedCrossRef Ko CW, Riffle S, Michaels L, et al. Serious complications within 30 days of screening and surveillance colonoscopy are uncommon. Clin Gastroenterol Hepatol. 2010;8:166–73.PubMedCrossRef
91.
go back to reference Bernstein CN, Blanchard JF, Leslie W, et al. The incidence of fracture among patients with inflammatory bowel disease. A population-based cohort study. Ann Intern Med. 2000;133:795–9.PubMedCrossRef Bernstein CN, Blanchard JF, Leslie W, et al. The incidence of fracture among patients with inflammatory bowel disease. A population-based cohort study. Ann Intern Med. 2000;133:795–9.PubMedCrossRef
92.
go back to reference Etzel JP, Larson MF, Anawalt BD, et al. Assessment and management of low bone density in inflammatory bowel disease and performance of professional society guidelines. Inflamm Bowel Dis. 2011;17:2122–9.PubMedCrossRef Etzel JP, Larson MF, Anawalt BD, et al. Assessment and management of low bone density in inflammatory bowel disease and performance of professional society guidelines. Inflamm Bowel Dis. 2011;17:2122–9.PubMedCrossRef
93.
go back to reference Lau AN, Adachi JD. Bone aging. In: Geriatric rheumatology. Springer; 2011. p. 11–16. Lau AN, Adachi JD. Bone aging. In: Geriatric rheumatology. Springer; 2011. p. 11–16.
94.
go back to reference Bernstein CN, Leslie WD, Leboff MS. AGA technical review on osteoporosis in gastrointestinal diseases. Gastroenterology. 2003;124:795–841.PubMedCrossRef Bernstein CN, Leslie WD, Leboff MS. AGA technical review on osteoporosis in gastrointestinal diseases. Gastroenterology. 2003;124:795–841.PubMedCrossRef
Metadata
Title
Challenges in the Diagnosis and Management of Inflammatory Bowel Disease in the Elderly
Author
Sasha Taleban, MD
Publication date
01-09-2015
Publisher
Springer US
Published in
Current Treatment Options in Gastroenterology / Issue 3/2015
Print ISSN: 1092-8472
Electronic ISSN: 1534-309X
DOI
https://doi.org/10.1007/s11938-015-0059-6

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