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Published in: Current Treatment Options in Gastroenterology 1/2015

01-03-2015 | Inflammatory Bowel Disease (G Lichtenstein, Section Editor)

Drug Management in the Elderly IBD Patient

Authors: Marina Kim, DO, Seymour Katz, MD FACP MACP, Jesse Green, MD FACG

Published in: Current Treatment Options in Gastroenterology | Issue 1/2015

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Opinion statement

Managing inflammatory bowel disease (IBD) in a world of immunomodulators and biologics is complex enough, but managing the elderly IBD patient is further confounded by multiple comorbidities, polypharmacy with drug–drug interactions, and cognitive mobility/motility disturbances. Social and insurance coverage issues also always lurk in the background. All of these factors summate into a daunting challenge for the clinician. In this review, we aim to describe important considerations when prescribing to an elderly patient with IBD, taking into account costs of medications, drug interactions, the aging body’s effect on pharmacokinetics, and the effect of aging on the immune system. Adverse effects and drug–drug interactions are expounded upon in detail specific for the aging adult with IBD in an effort to assist the clinician in the decision-making process.
Literature
2.
go back to reference Molodecky NA et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46–54. e42; quiz e30.CrossRefPubMed Molodecky NA et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46–54. e42; quiz e30.CrossRefPubMed
3.
4.
go back to reference Loftus Jr EV et al. Crohn's disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gastroenterology. 1998;114(6):1161–8.CrossRefPubMed Loftus Jr EV et al. Crohn's disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gastroenterology. 1998;114(6):1161–8.CrossRefPubMed
5.••
go back to reference Katz S, Surawicz C, Pardi DS. Management of the elderly patients with inflammatory bowel disease: practical considerations. Inflamm Bowel Dis. 2013;19(10):2257–72. This article discusses how the decline in immune function requires consideration of medical therapy in IBD.CrossRefPubMed Katz S, Surawicz C, Pardi DS. Management of the elderly patients with inflammatory bowel disease: practical considerations. Inflamm Bowel Dis. 2013;19(10):2257–72. This article discusses how the decline in immune function requires consideration of medical therapy in IBD.CrossRefPubMed
6.
go back to reference Manosa M, Calafat M, de Francisco R, et al. Phenotypic characteristics and use of therapeutic resources in elderly-onset inflammatory bowel disease: a multicenter, case-control study. In Digestive Disease Week 2014. Manosa M, Calafat M, de Francisco R, et al. Phenotypic characteristics and use of therapeutic resources in elderly-onset inflammatory bowel disease: a multicenter, case-control study. In Digestive Disease Week 2014.
7.
go back to reference Loftus CG et al. Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940-2000. Inflamm Bowel Dis. 2007;13(3):254–61.CrossRefPubMed Loftus CG et al. Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940-2000. Inflamm Bowel Dis. 2007;13(3):254–61.CrossRefPubMed
8.
go back to reference Charpentier C et al. Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study. Gut. 2014;63(3):423–32.CrossRefPubMed Charpentier C et al. Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study. Gut. 2014;63(3):423–32.CrossRefPubMed
9.
go back to reference Ha CY et al. Patients with late-adult-onset ulcerative colitis have better outcomes than those with early onset disease. Clin Gastroenterol Hepatol. 2010;8(8):682–7. e1.CrossRefPubMedCentralPubMed Ha CY et al. Patients with late-adult-onset ulcerative colitis have better outcomes than those with early onset disease. Clin Gastroenterol Hepatol. 2010;8(8):682–7. e1.CrossRefPubMedCentralPubMed
10.
go back to reference Nguyen GC, Bernstein C, Benchimol EI. Risks of Hospitalizations and Surgery in Elderly-Onset Inflammatory Bowel Disease: A Population Based Study. In Digestive Disease Week 2014. Nguyen GC, Bernstein C, Benchimol EI. Risks of Hospitalizations and Surgery in Elderly-Onset Inflammatory Bowel Disease: A Population Based Study. In Digestive Disease Week 2014.
11.
12.
go back to reference Nelson DR et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 1993;12(1):1–51.CrossRefPubMed Nelson DR et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 1993;12(1):1–51.CrossRefPubMed
13.
go back to reference Peterson JA, Graham SE. A close family resemblance: the importance of structure in understanding cytochromes P450. Structure. 1998;6(9):1079–85.CrossRefPubMed Peterson JA, Graham SE. A close family resemblance: the importance of structure in understanding cytochromes P450. Structure. 1998;6(9):1079–85.CrossRefPubMed
14.
go back to reference Smith G et al. Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica. 1998;28(12):1129–65.CrossRefPubMed Smith G et al. Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica. 1998;28(12):1129–65.CrossRefPubMed
15.
go back to reference Werck-Reichhart D, Feyereisen R. Cytochromes P450: a success story. Genome Biol. 2000;1(6): p. REVIEWS3003. Werck-Reichhart D, Feyereisen R. Cytochromes P450: a success story. Genome Biol. 2000;1(6): p. REVIEWS3003.
16.
go back to reference Park BK, Pirmohamed M, Kitteringham NR. The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. Pharmacol Ther. 1995;68(3):385–424.CrossRefPubMed Park BK, Pirmohamed M, Kitteringham NR. The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. Pharmacol Ther. 1995;68(3):385–424.CrossRefPubMed
17.
go back to reference Murray M. Mechanisms and significance of inhibitory drug interactions involving cytochrome P450 enzymes (review). Int J Mol Med. 1999;3(3):227–38.PubMed Murray M. Mechanisms and significance of inhibitory drug interactions involving cytochrome P450 enzymes (review). Int J Mol Med. 1999;3(3):227–38.PubMed
18.
go back to reference Swedko PJ et al. Serum creatinine is an inadequate screening test for renal failure in elderly patients. Arch Intern Med. 2003;163(3):356–60.CrossRefPubMed Swedko PJ et al. Serum creatinine is an inadequate screening test for renal failure in elderly patients. Arch Intern Med. 2003;163(3):356–60.CrossRefPubMed
19.
go back to reference Sawhney R, Sehl M, Naeim A. Physiologic aspects of aging: impact on cancer management and decision making, part I. Cancer J. 2005;11(6):449–60.CrossRefPubMed Sawhney R, Sehl M, Naeim A. Physiologic aspects of aging: impact on cancer management and decision making, part I. Cancer J. 2005;11(6):449–60.CrossRefPubMed
20.
go back to reference Aymanns C et al. Review on pharmacokinetics and pharmacodynamics and the aging kidney. Clin J Am Soc Nephrol. 2010;5(2):314–27.CrossRefPubMed Aymanns C et al. Review on pharmacokinetics and pharmacodynamics and the aging kidney. Clin J Am Soc Nephrol. 2010;5(2):314–27.CrossRefPubMed
21.
go back to reference Cooper E, Zhang Z, Raftos DA, Habicht GS, Beck G, Connors V, et al. When did communication in the immune-system begin. Int J Immunopathol Pharmacol. 1994;7(3):203–17. Cooper E, Zhang Z, Raftos DA, Habicht GS, Beck G, Connors V, et al. When did communication in the immune-system begin. Int J Immunopathol Pharmacol. 1994;7(3):203–17.
22.
go back to reference Cakman I et al. Dysregulation between TH1 and TH2 T cell subpopulations in the elderly. Mech Ageing Dev. 1996;87(3):197–209.CrossRefPubMed Cakman I et al. Dysregulation between TH1 and TH2 T cell subpopulations in the elderly. Mech Ageing Dev. 1996;87(3):197–209.CrossRefPubMed
24.
go back to reference Gellad WF, Grenard JL, Marcum ZA. A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity. Am J Geriatr Pharmacother. 2011;9(1):11–23.CrossRefPubMedCentralPubMed Gellad WF, Grenard JL, Marcum ZA. A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity. Am J Geriatr Pharmacother. 2011;9(1):11–23.CrossRefPubMedCentralPubMed
25.
go back to reference Chapman RH et al. Predictors of adherence to concomitant antihypertensive and lipid-lowering medications in older adults: a retrospective, cohort study. Drugs Aging. 2008;25(10):885–92.CrossRefPubMed Chapman RH et al. Predictors of adherence to concomitant antihypertensive and lipid-lowering medications in older adults: a retrospective, cohort study. Drugs Aging. 2008;25(10):885–92.CrossRefPubMed
26.
go back to reference Parlan AH, Ha C. Severe polypharmacy and major medication interactions are associated with increasing age and comorbidities among IBD patients. Gastroenterology. 2013;144(suppl.1)( S11 Abstract Su1130). Parlan AH, Ha C. Severe polypharmacy and major medication interactions are associated with increasing age and comorbidities among IBD patients. Gastroenterology. 2013;144(suppl.1)( S11 Abstract Su1130).
27.
go back to reference Parian AM, Ha CY. Severe polypharmacy and major medication interactions are associated with increasing age and comorbidity among inflammatory bowel disease patients. Gastroenterology. 2013;144(5, Supplement 1): p. S-406. Parian AM, Ha CY. Severe polypharmacy and major medication interactions are associated with increasing age and comorbidity among inflammatory bowel disease patients. Gastroenterology. 2013;144(5, Supplement 1): p. S-406.
28.
go back to reference "Prices, Coupons and Information - GoodRx." Prices, Coupons and Information. N.p., n.d. Web. 06 Nov. 2014. "Prices, Coupons and Information - GoodRx." Prices, Coupons and Information. N.p., n.d. Web. 06 Nov. 2014.
29.
30.
go back to reference Prescribing information. Apriso (mesalamine). Morrisville, NC: Salix Pharmaceuticals, Inc., 2008. Prescribing information. Apriso (mesalamine). Morrisville, NC: Salix Pharmaceuticals, Inc., 2008.
31.
go back to reference Prescribing information. Asacol (mesalamine). Cincinnati, OH: Procter & Gamble Pharmaceuticals, Inc., October 2007. Prescribing information. Asacol (mesalamine). Cincinnati, OH: Procter & Gamble Pharmaceuticals, Inc., October 2007.
32.
go back to reference Prescribing information. Lialda (mesalamine). Wayne, PA: Shire US Inc., January 2007. Prescribing information. Lialda (mesalamine). Wayne, PA: Shire US Inc., January 2007.
33.
go back to reference Ford AC, Khan K, Sandborn WJ, et al. Once-daily dosing vs. conventional dosing schedule of mesalamine and relapse of quiescent ulcerative colitis: systematic review and meta-analysis. Am J Gastroentrol. 2011;106:2070–7.CrossRef Ford AC, Khan K, Sandborn WJ, et al. Once-daily dosing vs. conventional dosing schedule of mesalamine and relapse of quiescent ulcerative colitis: systematic review and meta-analysis. Am J Gastroentrol. 2011;106:2070–7.CrossRef
34.
go back to reference Kane SV, Summer M, Solomon D, et al. Twelve-month persistency with oral 5-aminosalicylic acid therapy for ulcerative colitis: results from a large pharmacy prescriptions database. Dig Dis Sci. 2011;56:3463–70.CrossRefPubMed Kane SV, Summer M, Solomon D, et al. Twelve-month persistency with oral 5-aminosalicylic acid therapy for ulcerative colitis: results from a large pharmacy prescriptions database. Dig Dis Sci. 2011;56:3463–70.CrossRefPubMed
35.
go back to reference Sandborn WJ et al. Once-daily dosing of delayed-release oral mesalamine (400-mg tablet) is as effective as twice-daily dosing for maintenance of remission of ulcerative colitis. Gastroenterology. 2010;138(4):1286–96. 1296 e1-3.CrossRefPubMed Sandborn WJ et al. Once-daily dosing of delayed-release oral mesalamine (400-mg tablet) is as effective as twice-daily dosing for maintenance of remission of ulcerative colitis. Gastroenterology. 2010;138(4):1286–96. 1296 e1-3.CrossRefPubMed
36.
go back to reference Reguiero M, Loftus Jr E, Steinhart AH, et al. Medical management of left-sided ulcerative colitis and ulcerative proctitis: critical evaluation of therapeutic trials. Inflamm Bowel Dis. 2006;12:979–94.CrossRef Reguiero M, Loftus Jr E, Steinhart AH, et al. Medical management of left-sided ulcerative colitis and ulcerative proctitis: critical evaluation of therapeutic trials. Inflamm Bowel Dis. 2006;12:979–94.CrossRef
37.
go back to reference Safdi M, DeMicco M, Sninsky C, et al. A double blind comparison of oral versus rectal mesalamine versus combination therapy in the treatment of distal ulcerative colitis. Am J Gastroenterol. 1997;92:1867–71.PubMed Safdi M, DeMicco M, Sninsky C, et al. A double blind comparison of oral versus rectal mesalamine versus combination therapy in the treatment of distal ulcerative colitis. Am J Gastroenterol. 1997;92:1867–71.PubMed
38.
go back to reference Marshall JK et al. Rectal 5-aminosalicylic acid for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2010;1, CD004115.PubMed Marshall JK et al. Rectal 5-aminosalicylic acid for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2010;1, CD004115.PubMed
39.
go back to reference Rao SS, C American College of Gastroenterology Practice Parameters. Diagnosis and management of fecal incontinence. American College of Gastroenterology Practice Parameters Committee. Am J Gastroenterol. 2004;99(8):1585–604.CrossRefPubMed Rao SS, C American College of Gastroenterology Practice Parameters. Diagnosis and management of fecal incontinence. American College of Gastroenterology Practice Parameters Committee. Am J Gastroenterol. 2004;99(8):1585–604.CrossRefPubMed
40.
go back to reference Boyle DJ et al. The effects of age and childbirth on anal sphincter function and morphology in 999 symptomatic female patients with colorectal dysfunction. Dis Colon Rectum. 2012;55(3):286–93.CrossRefPubMed Boyle DJ et al. The effects of age and childbirth on anal sphincter function and morphology in 999 symptomatic female patients with colorectal dysfunction. Dis Colon Rectum. 2012;55(3):286–93.CrossRefPubMed
41.
go back to reference Hall S, Rindone JP. A case of sulphasalazine potentiating the hypoprothombinemic effect of warfarin resulting in bleeding. J Clin Pharm Ther. 2011;36(2):246–8.CrossRefPubMed Hall S, Rindone JP. A case of sulphasalazine potentiating the hypoprothombinemic effect of warfarin resulting in bleeding. J Clin Pharm Ther. 2011;36(2):246–8.CrossRefPubMed
42.
go back to reference Teefy AM, Martin JE, Kovacs MJ. Warfarin resistance due to sulfasalazine. Ann Pharmacother. 2000;34(11):1265–8.CrossRefPubMed Teefy AM, Martin JE, Kovacs MJ. Warfarin resistance due to sulfasalazine. Ann Pharmacother. 2000;34(11):1265–8.CrossRefPubMed
43.
go back to reference Feagan BG et al. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators. N Engl J Med. 2000;342(22):1627–32.CrossRefPubMed Feagan BG et al. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators. N Engl J Med. 2000;342(22):1627–32.CrossRefPubMed
44.
45.
go back to reference Gisbert JP, Gonzalez-Lama Y, Mate J. 5-Aminosalicylates and renal function in inflammatory bowel disease: a systematic review. Inflamm Bowel Dis. 2007;13(5):629–38.CrossRefPubMed Gisbert JP, Gonzalez-Lama Y, Mate J. 5-Aminosalicylates and renal function in inflammatory bowel disease: a systematic review. Inflamm Bowel Dis. 2007;13(5):629–38.CrossRefPubMed
46.
go back to reference Firwana BM et al. Nephrotic syndrome after treatment of Crohn's disease with mesalamine: case report and literature review. Avicenna J Med. 2012;2(1):9–11.CrossRefPubMedCentralPubMed Firwana BM et al. Nephrotic syndrome after treatment of Crohn's disease with mesalamine: case report and literature review. Avicenna J Med. 2012;2(1):9–11.CrossRefPubMedCentralPubMed
47.
go back to reference Singh M et al. Gastrointestinal drug interactions affecting the elderly. Clin Geriatr Med. 2014;30(1):1–15.CrossRefPubMed Singh M et al. Gastrointestinal drug interactions affecting the elderly. Clin Geriatr Med. 2014;30(1):1–15.CrossRefPubMed
48.
go back to reference Kornbluth A, Sachar DB, G. Practice Parameters Committee of the American College of. Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol. 2010;105(3):501–23. quiz 524.CrossRefPubMed Kornbluth A, Sachar DB, G. Practice Parameters Committee of the American College of. Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol. 2010;105(3):501–23. quiz 524.CrossRefPubMed
49.
go back to reference Shen B et al. A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflamm Bowel Dis. 2001;7(4):301–5.CrossRefPubMed Shen B et al. A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflamm Bowel Dis. 2001;7(4):301–5.CrossRefPubMed
50.
go back to reference Bito M et al. The mechanisms of insulin secretion and calcium signaling in pancreatic beta-cells exposed to fluoroquinolones. Biol Pharm Bull. 2013;36(1):31–5.CrossRefPubMed Bito M et al. The mechanisms of insulin secretion and calcium signaling in pancreatic beta-cells exposed to fluoroquinolones. Biol Pharm Bull. 2013;36(1):31–5.CrossRefPubMed
51.
go back to reference Chou HW et al. Risk of severe dysglycemia among diabetic patients receiving levofloxacin, ciprofloxacin, or moxifloxacin in Taiwan. Clin Infect Dis. 2013;57(7):971–80.CrossRefPubMed Chou HW et al. Risk of severe dysglycemia among diabetic patients receiving levofloxacin, ciprofloxacin, or moxifloxacin in Taiwan. Clin Infect Dis. 2013;57(7):971–80.CrossRefPubMed
52.
go back to reference Lexi-Comp OnlineTM, Hudson, Ohio: Lexi-Comp, Inc.; April 2014. Lexi-Comp OnlineTM, Hudson, Ohio: Lexi-Comp, Inc.; April 2014.
53.
go back to reference Howard-Thompson A et al. Intracerebral hemorrhage secondary to a warfarin-metronidazole interaction. Am J Geriatr Pharmacother. 2008;6(1):33–6.CrossRefPubMed Howard-Thompson A et al. Intracerebral hemorrhage secondary to a warfarin-metronidazole interaction. Am J Geriatr Pharmacother. 2008;6(1):33–6.CrossRefPubMed
54.
go back to reference Juneja M et al. Geriatric inflammatory bowel disease: phenotypic presentation, treatment patterns, nutritional status, outcomes, and comorbidity. Dig Dis Sci. 2012;57(9):2408–15.CrossRefPubMed Juneja M et al. Geriatric inflammatory bowel disease: phenotypic presentation, treatment patterns, nutritional status, outcomes, and comorbidity. Dig Dis Sci. 2012;57(9):2408–15.CrossRefPubMed
55.
go back to reference Lichtenstein GR et al. Serious infection and mortality in patients with Crohn's disease: more than 5 years of follow-up in the TREAT registry. Am J Gastroenterol. 2012;107(9):1409–22.CrossRefPubMedCentralPubMed Lichtenstein GR et al. Serious infection and mortality in patients with Crohn's disease: more than 5 years of follow-up in the TREAT registry. Am J Gastroenterol. 2012;107(9):1409–22.CrossRefPubMedCentralPubMed
56.
go back to reference Ha CY, Katz S. Clinical implications of ageing for the management of IBD. Nat Rev Gastroenterol Hepatol. 2014;11(2):128–38.CrossRefPubMed Ha CY, Katz S. Clinical implications of ageing for the management of IBD. Nat Rev Gastroenterol Hepatol. 2014;11(2):128–38.CrossRefPubMed
57.
go back to reference Brassard P, et al. "Oral corticosteroids and the risk of serious infections in patients with elderly-onset inflammatory bowel diseases." Am J Gastroenterol. 2014;109(11):1795–802. Brassard P, et al. "Oral corticosteroids and the risk of serious infections in patients with elderly-onset inflammatory bowel diseases." Am J Gastroenterol. 2014;109(11):1795–802.
58.
go back to reference Suzuki Y et al. Efficacy and tolerability of oral budesonide in Japanese patients with active Crohn's disease: a multicentre, double-blind, randomized, parallel-group Phase II study. J Crohn’s Colitis. 2013;7(3):239–47.CrossRef Suzuki Y et al. Efficacy and tolerability of oral budesonide in Japanese patients with active Crohn's disease: a multicentre, double-blind, randomized, parallel-group Phase II study. J Crohn’s Colitis. 2013;7(3):239–47.CrossRef
59.
go back to reference Ford AC et al. Glucocorticosteroid therapy in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol. 2011;106(4):590–9. quiz 600.CrossRefPubMed Ford AC et al. Glucocorticosteroid therapy in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol. 2011;106(4):590–9. quiz 600.CrossRefPubMed
60.
go back to reference Thomas TP. The complications of systemic corticosteroid therapy in the elderly. A retrospective study. Gerontology. 1984;30(1):60–5.CrossRefPubMed Thomas TP. The complications of systemic corticosteroid therapy in the elderly. A retrospective study. Gerontology. 1984;30(1):60–5.CrossRefPubMed
61.
go back to reference Akerkar GA et al. Corticosteroid-associated complications in elderly Crohn's disease patients. Am J Gastroenterol. 1997;92(3):461–4.PubMed Akerkar GA et al. Corticosteroid-associated complications in elderly Crohn's disease patients. Am J Gastroenterol. 1997;92(3):461–4.PubMed
62.
go back to reference Ananthakrishnan AN et al. Fracture-associated hospitalizations in patients with inflammatory bowel disease. Dig Dis Sci. 2011;56(1):176–82.CrossRefPubMed Ananthakrishnan AN et al. Fracture-associated hospitalizations in patients with inflammatory bowel disease. Dig Dis Sci. 2011;56(1):176–82.CrossRefPubMed
63.
go back to reference Bernstein CN. Osteoporosis and other complications of inflammatory bowel disease. Curr Opin Gastroenterol. 2002;18(4):428–34.CrossRefPubMed Bernstein CN. Osteoporosis and other complications of inflammatory bowel disease. Curr Opin Gastroenterol. 2002;18(4):428–34.CrossRefPubMed
64.
go back to reference Dilger K, Schwab M, Fromm MF. Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein. Inflamm Bowel Dis. 2004;10(5):578–83.CrossRefPubMed Dilger K, Schwab M, Fromm MF. Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein. Inflamm Bowel Dis. 2004;10(5):578–83.CrossRefPubMed
65.
go back to reference Greenwald DA, Brandt LJ. Inflammatory bowel disease after age 60. Curr Treat Options Gastroenterol. 2003;6(3):213–25.CrossRefPubMed Greenwald DA, Brandt LJ. Inflammatory bowel disease after age 60. Curr Treat Options Gastroenterol. 2003;6(3):213–25.CrossRefPubMed
66.
go back to reference Rodriguez-D'Jesus A, Casellas F, Malagelada JR. [Epidemiology of inflammatory bowel disease in the elderly]. Gastroenterol Hepatol. 2008;31(5):269–73.CrossRefPubMed Rodriguez-D'Jesus A, Casellas F, Malagelada JR. [Epidemiology of inflammatory bowel disease in the elderly]. Gastroenterol Hepatol. 2008;31(5):269–73.CrossRefPubMed
67.
go back to reference Neurath MF et al. 6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease. Clin Gastroenterol Hepatol. 2005;3(10):1007–14.CrossRefPubMed Neurath MF et al. 6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease. Clin Gastroenterol Hepatol. 2005;3(10):1007–14.CrossRefPubMed
68.
go back to reference Dubinsky MC et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology. 2000;118(4):705–13.CrossRefPubMed Dubinsky MC et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology. 2000;118(4):705–13.CrossRefPubMed
69.
go back to reference Smith MA et al. Optimising outcome on thiopurines in inflammatory bowel disease by co-prescription of allopurinol. J Crohn’s Colitis. 2012;6(9):905–12.CrossRef Smith MA et al. Optimising outcome on thiopurines in inflammatory bowel disease by co-prescription of allopurinol. J Crohn’s Colitis. 2012;6(9):905–12.CrossRef
70.
go back to reference Blaker PA et al. Mechanism of allopurinol induced TPMT inhibition. Biochem Pharmacol. 2013;86(4):539–47.CrossRefPubMed Blaker PA et al. Mechanism of allopurinol induced TPMT inhibition. Biochem Pharmacol. 2013;86(4):539–47.CrossRefPubMed
71.
go back to reference Govani SM, Higgins PD. Combination of thiopurines and allopurinol: adverse events and clinical benefit in IBD. J Crohn’s Colitis. 2010;4(4):444–9.CrossRef Govani SM, Higgins PD. Combination of thiopurines and allopurinol: adverse events and clinical benefit in IBD. J Crohn’s Colitis. 2010;4(4):444–9.CrossRef
72.
go back to reference de Boer NK et al. Dose-dependent influence of 5-aminosalicylates on thiopurine metabolism. Am J Gastroenterol. 2007;102(12):2747–53.CrossRefPubMed de Boer NK et al. Dose-dependent influence of 5-aminosalicylates on thiopurine metabolism. Am J Gastroenterol. 2007;102(12):2747–53.CrossRefPubMed
73.
go back to reference Gao X, et al. "The potential influence of 5-aminosalicylic acid on the induction of myelotoxicity during thiopurine therapy in inflammatory bowel disease patients." Eur J Gastroenterol Hepatol. 2012;24(8):958–64. Gao X, et al. "The potential influence of 5-aminosalicylic acid on the induction of myelotoxicity during thiopurine therapy in inflammatory bowel disease patients." Eur J Gastroenterol Hepatol. 2012;24(8):958–64.
74.
go back to reference Daperno M et al. Prospective study of the effects of concomitant medications on thiopurine metabolism in inflammatory bowel disease. Aliment Pharmacol Ther. 2009;30(8):843–53.CrossRefPubMed Daperno M et al. Prospective study of the effects of concomitant medications on thiopurine metabolism in inflammatory bowel disease. Aliment Pharmacol Ther. 2009;30(8):843–53.CrossRefPubMed
75.
go back to reference Chisick L, Oleschuk C, Bernstein CN. The utility of thiopurine methyltransferase enzyme testing in inflammatory bowel disease. Can J Gastroenterol. 2013;27(1):39–43.PubMedCentralPubMed Chisick L, Oleschuk C, Bernstein CN. The utility of thiopurine methyltransferase enzyme testing in inflammatory bowel disease. Can J Gastroenterol. 2013;27(1):39–43.PubMedCentralPubMed
76.
go back to reference Smith MA et al. Review article: malignancy on thiopurine treatment with special reference to inflammatory bowel disease. Aliment Pharmacol Ther. 2010;32(2):119–30.CrossRefPubMed Smith MA et al. Review article: malignancy on thiopurine treatment with special reference to inflammatory bowel disease. Aliment Pharmacol Ther. 2010;32(2):119–30.CrossRefPubMed
77.
go back to reference Beaugerie L et al. Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study. Lancet. 2009;374(9701):1617–25.CrossRefPubMed Beaugerie L et al. Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study. Lancet. 2009;374(9701):1617–25.CrossRefPubMed
78.
79.
go back to reference Peyrin-Biroulet L et al. Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease. Gastroenterology. 2011;141(5):1621–8. e1-5.CrossRefPubMed Peyrin-Biroulet L et al. Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease. Gastroenterology. 2011;141(5):1621–8. e1-5.CrossRefPubMed
80.••
go back to reference Cottone M et al. Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease. Clin Gastroenterol Hepatol. 2011;9(1):30–5. An Italian study from 2000-2009 found an increased rate of severe infections in elderly patients with IBD with a 10% mortality rate as compared to younger patients treated with biologics.CrossRefPubMed Cottone M et al. Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease. Clin Gastroenterol Hepatol. 2011;9(1):30–5. An Italian study from 2000-2009 found an increased rate of severe infections in elderly patients with IBD with a 10% mortality rate as compared to younger patients treated with biologics.CrossRefPubMed
81.
go back to reference Billioud V, Peyrin-Biroulet L. Can elderly people be treated safely with anti-TNF agents? Inflamm Bowel Dis. 2012;18(3):594–5.CrossRefPubMed Billioud V, Peyrin-Biroulet L. Can elderly people be treated safely with anti-TNF agents? Inflamm Bowel Dis. 2012;18(3):594–5.CrossRefPubMed
82.
go back to reference Shen H, Lipka S, Katz S. Increased hospitalizations in elderly with inflammatory bowel disease on anti-tumor necrosis factor therapy but not increased infections: a community practice experience. J Crohn’s Colitis. 2014;8(8):898–9.CrossRef Shen H, Lipka S, Katz S. Increased hospitalizations in elderly with inflammatory bowel disease on anti-tumor necrosis factor therapy but not increased infections: a community practice experience. J Crohn’s Colitis. 2014;8(8):898–9.CrossRef
83.
go back to reference Ortega TL, Vermeire S, Vallet V, et al. Efficacy and safety of anti-TNF therapy in elderly patients with inflammatory bowel disease. Digestive Disease Week 2014. Abstract Mo1179. Ortega TL, Vermeire S, Vallet V, et al. Efficacy and safety of anti-TNF therapy in elderly patients with inflammatory bowel disease. Digestive Disease Week 2014. Abstract Mo1179.
84.
go back to reference Tofani C, Valentin T, Tierney A, et al. IBD is an independent risk factor for major infections complications in elderly patients. In Digestive Disease Week 2014. 2014. Tofani C, Valentin T, Tierney A, et al. IBD is an independent risk factor for major infections complications in elderly patients. In Digestive Disease Week 2014. 2014.
85.
go back to reference Desai A, Zator ZA, de SIlva P, et al. Older age is associated with higher rate of discontinuation of anti-TNF therapy in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2012;19:309–15.CrossRef Desai A, Zator ZA, de SIlva P, et al. Older age is associated with higher rate of discontinuation of anti-TNF therapy in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2012;19:309–15.CrossRef
86.••
go back to reference Lichtenstein GR et al. A pooled analysis of infections, malignancy, and mortality in infliximab- and immunomodulator-treated adult patients with inflammatory bowel disease. Am J Gastroenterol. 2012;107(7):1051–63. Biologics such as infliximab have been shown to have a safer profile than immunomodulators, not significantly increasing the incidence of infection, mortality, or malignancy. In contrast, patients treated with immunomodulators as opposed to placebo had a higher incidence of malignancy.CrossRefPubMedCentralPubMed Lichtenstein GR et al. A pooled analysis of infections, malignancy, and mortality in infliximab- and immunomodulator-treated adult patients with inflammatory bowel disease. Am J Gastroenterol. 2012;107(7):1051–63. Biologics such as infliximab have been shown to have a safer profile than immunomodulators, not significantly increasing the incidence of infection, mortality, or malignancy. In contrast, patients treated with immunomodulators as opposed to placebo had a higher incidence of malignancy.CrossRefPubMedCentralPubMed
87.
go back to reference Burmester GR et al. Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease. Ann Rheum Dis. 2013;72(4):517–24.CrossRefPubMedCentralPubMed Burmester GR et al. Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease. Ann Rheum Dis. 2013;72(4):517–24.CrossRefPubMedCentralPubMed
88.
89.
go back to reference Keihanian S, Glover S. Ustekinumab for the Treatment of Crohn's Disease, in 79th Annual Scientific Meeting of the American College of Gastroenterology. Am J Gastroenterol. 2014 Keihanian S, Glover S. Ustekinumab for the Treatment of Crohn's Disease, in 79th Annual Scientific Meeting of the American College of Gastroenterology. Am J Gastroenterol. 2014
90.
go back to reference Manten E, Green JA, Bartholomew C. Primary care considerations in the management of inflammatory bowel disease patients. Practical Gastro. 2012;49. Manten E, Green JA, Bartholomew C. Primary care considerations in the management of inflammatory bowel disease patients. Practical Gastro. 2012;49.
91.••
go back to reference Ha C, Katz S. Management of inflammatory bowel disease in the elderly: do biologicals offer a better alternative? Drugs Aging. 2013;30(11):871–6. This article discusses the safety and efficacy of biologics in the treatment of IBD in the elderly patient.CrossRefPubMed Ha C, Katz S. Management of inflammatory bowel disease in the elderly: do biologicals offer a better alternative? Drugs Aging. 2013;30(11):871–6. This article discusses the safety and efficacy of biologics in the treatment of IBD in the elderly patient.CrossRefPubMed
Metadata
Title
Drug Management in the Elderly IBD Patient
Authors
Marina Kim, DO
Seymour Katz, MD FACP MACP
Jesse Green, MD FACG
Publication date
01-03-2015
Publisher
Springer US
Published in
Current Treatment Options in Gastroenterology / Issue 1/2015
Print ISSN: 1092-8472
Electronic ISSN: 1534-309X
DOI
https://doi.org/10.1007/s11938-014-0039-2

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