Top

Published in:

Open Access 01-02-2011

Stem Cells for the Treatment of Urinary Incontinence

Authors: Andrea Staack, Larissa V. Rodríguez

Published in: Current Urology Reports | Issue 1/2011

Abstract

Stress urinary incontinence (SUI) is highly prevalent. As of now, there is no minimally invasive long-term treatment available. Adult stem cells are nonimmunogenic and have the ability to self-renew and to differentiate into multiple cell types. Over the past decade, in vivo studies have described periurethral injections of adult-derived stem cells for the treatment of SUI. The ultimate goal has been to achieve a permanent cure for SUI by restoration of the intrinsic and extrinsic urethral sphincter and the surrounding connective tissue, including peripheral nerves and blood vessels. For this purpose, future studies need to focus on delivery systems, cell survival, and functional improvement of the urethral closure mechanism, including improvement of innervation and vascularization.

Levy R, Muller N: Urinary incontinence: economic burden and new choices in pharmaceutical treatment. Adv Ther 2006, 23:556–573.CrossRefPubMed

Buckley BS, Lapitan MC: Prevalence of urinary incontinence in men, women, and children: current evidence: findings of the Fourth International Consultation on Incontinence. Urology 2010, 76:265–270.CrossRefPubMed

Wilson L, Brown JS, Shin GP, et al.: Annual direct cost of urinary incontinence. Obstet Gynecol 2001, 98:398–406.CrossRefPubMed

Macura KJ, Genadry RR: Female urinary incontinence: pathophysiology, methods of evaluation and role of mr imaging. Abdom Imaging 2008, 33:371–380.CrossRefPubMed

Prantil RL, Jankowski RJ, Kaiho Y, et al.: Ex vivo biomechanical properties of the female urethra in a rat model of birth trauma. Am J Physiol Renal Physiol 2007, 292:F1229–F1237.CrossRefPubMed

Lifford KL, Townsend MK, Curhan GC, et al.: The epidemiology of urinary incontinence in older women: Incidence, progression, and remission. J Am Geriatr Soc 2008, 56:1191–1198.CrossRefPubMed

Sharifi-Aghdas F: Surgical management of stress urinary incontinence. Urol J 2005, 2:175–182.PubMed

Lin AS, Carrier S, Morgan DM, Lue TF: Effect of simulated birth trauma on the urinary continence mechanism in the rat. Urology 1998, 52:143–151.CrossRefPubMed

Damaser MS, Broxton-King C, Ferguson C, et al.: Functional and neuroanatomical effects of vaginal distention and pudendal nerve crush in the female rat. J Urol 2003, 170:1027–1031.CrossRefPubMed

10.

Kerns JM, Damaser MS, Kane JM, et al.: Effects of pudendal nerve injury in the female rat. Neurourol Urodyn 2000, 19:53–69.CrossRefPubMed

11.

Smith CP, Somogyi GT, Bird ET, et al.: Neurogenic bladder model for spinal cord injury: Spinal cord microdialysis and chronic urodynamics. Brain Res Brain Res Protoc 2002, 9:57–64.CrossRefPubMed

12.

Rodríguez LV, Chen S, Jack GS, et al.: New objective measures to quantify stress urinary incontinence in a novel durable animal model of intrinsic sphincter deficiency. Am J Physiol Regul Integr Comp Physiol 2005, 288:R1332–R1338.PubMed

13.

Wu Y, Chen L, Scott PG, Tredget EE: Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 2007, 25:2648–2659.CrossRefPubMed

14.

Lin Y, Yan Z, Liu L, et al.: Proliferation and pluripotency potential of ectomesenchymal cells derived from first branchial arch. Cell Prolif 2006, 39:79–92.CrossRefPubMed

15.

Jang HJ, Cho KS, Park HY, Roh HJ: Adipose tissue-derived stem cells for cell therapy of airway allergic diseases in mouse. Acta Histochem 2010 Jun 30 (Epub ahead of print).

16.

Sadek HA, Martin CM, Latif SS, et al.: Bone-marrow-derived side population cells for myocardial regeneration. J Cardiovasc Transl Res 2009, 2:173–181.CrossRefPubMed

17.

Kanematsu A, Yamamoto S, Iwai-Kanai E, et al.: Induction of smooth muscle cell-like phenotype in marrow-derived cells among regenerating urinary bladder smooth muscle cells. Am J Pathol 2005, 166:565–573.PubMed

18.

Lorenzi B, Pessina F, Lorenzoni P, et al.: Treatment of experimental injury of anal sphincters with primary surgical repair and injection of bone marrow-derived mesenchymal stem cells. Dis Colon Rectum 2008, 51:411–420.CrossRefPubMed

19.

El Backly RM, Cancedda R: Bone marrow stem cells in clinical application: harnessing paracrine roles and niche mechanisms. Adv Biochem Eng Biotechnol 2010 Aug 27 (Epub ahead of print).

20.

Drost AC, Weng S, Feil G, et al.: In vitro myogenic differentiation of human bone marrow-derived mesenchymal stem cells as a potential treatment for urethral sphincter muscle repair. Ann N Y Acad Sci 2009, 1176:135–143.CrossRefPubMed

21.

• Kinebuchi Y, Aizawa N, Imamura T, et al.: Autologous bone-marrow-derived mesenchymal stem cell transplantation into injured rat urethral sphincter. Int J Urol 2010, 17:359–368. This article demonstrated differentiation of autologous BMSCs into striated muscle and peripheral nerves.CrossRefPubMed

22.

Seale P, Rudnicki MA: A new look at the origin, function, and “stem-cell” status of muscle satellite cells. Dev Biol 2000, 218:115–124.CrossRefPubMed

23.

Chancellor MB, Yokoyama T, Tirney S, et al.: Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the treatment of stress urinary incontinence and impaired detrusor contractility. Neurourol Urodyn 2000, 19:279–287.CrossRefPubMed

24.

Yokoyama T, Huard J, Pruchnic R, et al.: Muscle-derived cell transplantation and differentiation into lower urinary tract smooth muscle. Urology 2001, 57:826–831.CrossRefPubMed

25.

Yiou R, Lefaucheur JP, Atala A: The regeneration process of the striated urethral sphincter involves activation of intrinsic satellite cells. Anat Embryol (Berl) 2003, 206:429–435.

26.

Cannon TW, Lee JY, Somogyi G, et al.: Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra. Urology 2003, 62:958–963.CrossRefPubMed

27.

Kwon D, Minnery B, Kim Y, et al.: Neurologic recovery and improved detrusor contractility using muscle-derived cells in rat model of unilateral pelvic nerve transection. Urology 2005, 65:1249–1253.CrossRefPubMed

28.

Hoshi A, Tamaki T, Tono K, et al.: Reconstruction of radical prostatectomy-induced urethral damage using skeletal muscle-derived multipotent stem cells. Transplantation 2008, 85:1617–1624.CrossRefPubMed

29.

Tamaki T, Uchiyama Y, Okada Y, et al.: Functional recovery of damaged skeletal muscle through synchronized vasculogenesis, myogenesis, and neurogenesis by muscle-derived stem cells. Circulation 2005, 112:2857–2866.CrossRefPubMed

30.

•• Nitta M, Tamaki T, Tono K, et al.: Reconstitution of experimental neurogenic bladder dysfunction using skeletal muscle-derived multipotent stem cells. Transplantation 2010, 89:1043–1049. This article states that MDSCs have the capability to differentiate into Schwann cells, perineural cells, vascular smooth muscle cells, pericytes, and fibroblasts, and contribute to functional recovery of neurogenic bladder dysfunction.CrossRefPubMed

31.

Mitterberger M, Pinggera GM, Marksteiner R, et al.: Functional and histological changes after myoblast injections in the porcine rhabdosphincter. Eur Urol 2007, 52:1736–1743. (Published erratum appears in Eur Urol 2008, 54:1208.)CrossRefPubMed

32.

Roche R, Festy F, Fritel X: Stem cells for stress urinary incontinence: The adipose promise. J Cell Mol Med 2010, 14:135–142.CrossRefPubMed

33.

Zuk PA, Zhu M, Ashjian P, et al.: Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002, 13:4279–4295.CrossRefPubMed

34.

Lin CS, Xin ZC, Deng CH, et al.: Defining adipose tissue-derived stem cells in tissue and in culture. Histol Histopathol, 25:807–815.

35.

Fu Q, Song XF, Liao GL, et al.: Myoblasts differentiated from adipose-derived stem cells to treat stress urinary incontinence. Urology 2010, 75:718–723.CrossRefPubMed

36.

Rodríguez L, Alfonso Z, Zhang R, et al.: Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells. Proc Natl Acad Sci U S A 2006, 103:12167–12172.CrossRefPubMed

37.

Xue S, Zhang HT, Zhang P, et al.: Functional endothelial progenitor cells derived from adipose tissue show beneficial effect on cell therapy of traumatic brain injury. Neurosci Lett 2010, 473:186–191.CrossRefPubMed

38.

Bacou F, el Andalousi RB, Daussin PA, et al.: Transplantation of adipose tissue-derived stromal cells increases mass and functional capacity of damaged skeletal muscle. Cell Transplant 2004, 13:103–111.PubMed

39.

Zhang Y, Luo H, Zhang Z, et al.: A nerve graft constructed with xenogeneic acellular nerve matrix and autologous adipose-derived mesenchymal stem cells. Biomaterials 2010, 31:5312–5324.CrossRefPubMed

40.

Lin G, Wang G, Banie L, et al.: Treatment of stress urinary incontinence with adipose tissue-derived stem cells. Cytotherapy 2010, 12:88–95.CrossRefPubMed

41.

Jack G, Almeida F, Zhang R, et al.: Processed lipoaspirate cells for tissue engineering of the lower urinary tract: Implications for the treatment of stress urinary incontinence and bladder reconstruction. J Urol 2005, 174:2041–2045.CrossRefPubMed

42.

Zeng X, Jack GS, Zhang R: Treatment of SUI using adipose-derived stem cells: restoration of urethral function [abstract 900]. J Urol 2006, 175:291.

43.

Strasser H, Marksteiner R, Margreiter E, et al.: Transurethral ultrasonography-guided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence. World J Urol 2007, 25:385–392.CrossRefPubMed

44.

Strasser H, Marksteiner R, Margreiter E, et al.: Autologous myoblasts and fibroblasts versus collagen for treatment of stress urinary incontinence in women: A randomised controlled trial. Lancet 2007, 369:2179–2186. (Published erratum appears in Lancet 2008, 371:474.)CrossRefPubMed

45.

Kleinert S, Horton R: Retraction: Autologous myoblasts and fibroblasts versus collagen [corrected] for treatment of stress urinary incontinence in women: a [corrected] randomised controlled trial. Lancet 2008, 372:789–790. (Published erratum appears in Lancet 2008, 372:1302.)CrossRefPubMed

46.

•• Carr LK, Steele D, Steele S, et al.: 1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 2008, 19:881–883. In this pilot human study, patients with SUI were treated with autologous MDSCs injections; onset of improvement was achieved between 3 and 8 months.CrossRefPubMed

47.

Herschorn S, Carr L, Birch C, et al.: Autologous muscle-derived cells as therapy for stress urinary incontinence: A randomized blinded trial. Neurourol Urodyn 2010, 29:243–326 [abstract].CrossRef

48.

Assis AC, Carvalho JL, Jacoby BA, et al.: Time-dependent migration of systemically delivered bone marrow mesenchymal stem cells to the infarcted heart. Cell Transplant 2010, 19:219–230.CrossRefPubMed

49.

Bai X, Yan Y, Coleman M, et al.: Tracking long-term survival of intramyocardially delivered human adipose tissue-derived stem cells using bioluminescence imaging. Mol Imaging Biol 2010 Aug 21 (Epub ahead of print).

50.

Huard J, Yokoyama T, Pruchnic R, et al.: Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction. Gene Ther 2002, 9:1617–1626.CrossRefPubMed

51.

Yiou R, Dreyfus P, Chopin DK, et al.: Muscle precursor cell autografting in a murine model of urethral sphincter injury. BJU Int 2002, 89:298–302.CrossRefPubMed

52.

Lee JY, Cannon TW, Pruchnic R, et al.: The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 2003, 14:31–37.CrossRefPubMed

53.

Lee J, Paik S, Yuk S, et al.: Long term effects of muscle-derived stem cells on leak point pressure and closing pressure in rats with transected pudendal nerves. Mol Cells 2004, 18:309–313.PubMed

54.

Peyromaure M, Sebe P, Praud C, et al.: Fate of implanted syngenic muscle precursor cells in striated urethral sphincter of female rats: Perspectives for treatment of urinary incontinence. Urology 2004, 64:1037–1041.CrossRefPubMed

55.

Chermansky CJ, Tarin T, Kwon DD, et al.: Intraurethral muscle-derived cell injections increase leak point pressure in a rat model of intrinsic sphincter deficiency. Urology 2004, 63:780–785.CrossRefPubMed

56.

Kwon D, Kim Y, Pruchnic R, et al.: Periurethral cellular injection: comparison of muscle-derived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence. Urology 2006, 68:449–454.CrossRefPubMed

57.

Mitterberger M, Marksteiner R, Margreiter E, et al.: Myoblast and fibroblast therapy for post-prostatectomy urinary incontinence: 1-year followup of 63 patients. J Urol 2008, 179:226–231.CrossRefPubMed

58.

Yamamoto T, Gotoh M, Hattori R, et al.: Periurethral injection of autologous adipose-derived stem cells for the treatment of stress urinary incontinence in patients undergoing radical prostatectomy: report of initial two cases. Int J Urol 2010, 17:75–82. (Retraction in Int J Urol 2010, 17:896.)CrossRefPubMed

Title: Stem Cells for the Treatment of Urinary Incontinence
Authors: Andrea Staack
Larissa V. Rodríguez
Publication date: 01-02-2011
Publisher: Current Science Inc.
Published in: Current Urology Reports / Issue 1/2011
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI: https://doi.org/10.1007/s11934-010-0155-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Stem Cells for the Treatment of Urinary Incontinence

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2011

Impact of Genetics on the Diagnosis and Treatment of Renal Cancer

Surgical Management of Renal Cystic Disease

Renal Imaging in Patients with Renal Impairment

A Randomized, Double-Blind, Placebo-Controlled Trial of Anticholinergic Medication for Nonresponders to Desmopressin for Monosymptomatic Nocturnal Enuresis

Emerging Concepts for Pelvic Organ Prolapse Surgery: What is Cure?

New Advances in Benign Prostatic Hyperplasia: Laser Therapy