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Current Rheumatology Reports
Published in: Current Rheumatology Reports 10/2014

01-10-2014 | Osteoarthritis (MB Goldring, Section Editor)

The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis

Authors: Johannah Sanchez-Adams, Holly A. Leddy, Amy L. McNulty, Christopher J. O’Conor, Farshid Guilak

Published in: Current Rheumatology Reports | Issue 10/2014

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Abstract

Articular cartilage injuries and degenerative joint diseases are responsible for progressive pain and disability in millions of people worldwide, yet there is currently no treatment available to restore full joint functionality. As the tissue functions under mechanical load, an understanding of the physiologic or pathologic effects of biomechanical factors on cartilage physiology is of particular interest. Here, we highlight studies that have measured cartilage deformation at scales ranging from the macroscale to the microscale, as well as the responses of the resident cartilage cells, chondrocytes, to mechanical loading using in vitro and in vivo approaches. From these studies, it is clear that there exists a complex interplay among mechanical, inflammatory, and biochemical factors that can either support or inhibit cartilage matrix homeostasis under normal or pathologic conditions. Understanding these interactions is an important step toward developing tissue engineering approaches and therapeutic interventions for cartilage pathologies, such as osteoarthritis.
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Metadata
Title
The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis
Authors
Johannah Sanchez-Adams
Holly A. Leddy
Amy L. McNulty
Christopher J. O’Conor
Farshid Guilak
Publication date
01-10-2014
Publisher
Springer US
Published in
Current Rheumatology Reports / Issue 10/2014
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-014-0451-6

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