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Published in: Current Psychiatry Reports 9/2013

01-09-2013 | Complex Medical-Psychiatric Issues (MB Riba, Section Editor)

The Comorbidity between Depression and Diabetes

Authors: Bibilola D. Oladeji, Oye Gureje

Published in: Current Psychiatry Reports | Issue 9/2013

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Abstract

Comorbidity of depression and diabetes is common, and each disorder has a negative impact on the outcome of the other. The direction of causality is not certain as each disorder seems to act as both a risk factor and consequence for the other in longitudinal studies. This bidirectional association is possibly mediated by shared environmental and genetic risk factors. Comorbid depression is associated with reduced adherence to medication and self-care management, poor glycaemic control, increased health care utilization, increased costs and elevated risk of complications, as well as mortality in patients with diabetes. Psychological and pharmacological interventions are shown to be effective in improving depression symptoms; however, collaborative care programs that simultaneously manage both disorders seem to be most effective in improving diabetes-related outcomes.
Literature
1.
go back to reference Harter M, Baumeister H, Reuter K, et al. Increased 12-month prevalence rates of mental disorders in patients with chronic somatic diseases. Psychother Psychosom. 2007;76:354–60.PubMedCrossRef Harter M, Baumeister H, Reuter K, et al. Increased 12-month prevalence rates of mental disorders in patients with chronic somatic diseases. Psychother Psychosom. 2007;76:354–60.PubMedCrossRef
2.
go back to reference Gili M, Comas A, Garcia-Garcia M, et al. Comorbidity between common mental disorders and chronic somatic disease in primary care patients. Gen Hosp Psychiatry. 2010;32:240–5.PubMedCrossRef Gili M, Comas A, Garcia-Garcia M, et al. Comorbidity between common mental disorders and chronic somatic disease in primary care patients. Gen Hosp Psychiatry. 2010;32:240–5.PubMedCrossRef
3.
go back to reference International Diabetes Federation. Diabetes Atlas 5th ed. In. Brussels: International Diabetes Federation; 2012. International Diabetes Federation. Diabetes Atlas 5th ed. In. Brussels: International Diabetes Federation; 2012.
4.
go back to reference World Health Organization. WHO Global status report on noncommunicable diseases 2010: description of the global burden of NCDs, their risk factors and determinants. In. Geneva: World Health Organization; 2011. World Health Organization. WHO Global status report on noncommunicable diseases 2010: description of the global burden of NCDs, their risk factors and determinants. In. Geneva: World Health Organization; 2011.
5.
go back to reference Roy T, Lloyd CE. Epidemiology of depression and diabetes: A systematic review. J Affect Disord. 2012;142(S1):S8–S21.PubMedCrossRef Roy T, Lloyd CE. Epidemiology of depression and diabetes: A systematic review. J Affect Disord. 2012;142(S1):S8–S21.PubMedCrossRef
6.
go back to reference Nouwen A, Winkley K, Twisk J, et al. Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia. 2010;53(12):2480–6.PubMedCrossRef Nouwen A, Winkley K, Twisk J, et al. Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia. 2010;53(12):2480–6.PubMedCrossRef
7.
go back to reference •• Chen PC, Chan YT, Chen HF, Ko MC, Li CY. Population-Based Cohort Analyses of the Bidirectional Relationship Between Type 2 Diabetes and Depression. Diabetes Care. 2013;36:376–82. Prospective cohort study demostrated bidirectional associations between diabetes and depression.PubMedCrossRef •• Chen PC, Chan YT, Chen HF, Ko MC, Li CY. Population-Based Cohort Analyses of the Bidirectional Relationship Between Type 2 Diabetes and Depression. Diabetes Care. 2013;36:376–82. Prospective cohort study demostrated bidirectional associations between diabetes and depression.PubMedCrossRef
8.
go back to reference Golden SH, Lazo M, Carnethon M, et al. Examining a Bidirectional Association Between Depressive Symptoms and Diabetes. JAMA. 2008;299:2751–9.PubMedCrossRef Golden SH, Lazo M, Carnethon M, et al. Examining a Bidirectional Association Between Depressive Symptoms and Diabetes. JAMA. 2008;299:2751–9.PubMedCrossRef
9.
go back to reference Murray CJL, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197–223.PubMedCrossRef Murray CJL, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197–223.PubMedCrossRef
10.
go back to reference Egede LE, Ellis C. Diabetes and depression: Global perspectives. Diabetes Res Clin Pract. 2010;87:302–12.PubMedCrossRef Egede LE, Ellis C. Diabetes and depression: Global perspectives. Diabetes Res Clin Pract. 2010;87:302–12.PubMedCrossRef
11.
go back to reference Park M, Katon WJ, Wolf FM. Depression and risk of mortality in individuals with diabetes: a meta-analysis and systematic review. Gen Hosp Psychiatry. 2013;35:217–25.PubMedCrossRef Park M, Katon WJ, Wolf FM. Depression and risk of mortality in individuals with diabetes: a meta-analysis and systematic review. Gen Hosp Psychiatry. 2013;35:217–25.PubMedCrossRef
12.
go back to reference Scott KM. The joint association of mental and physical conditions with disability. In: von Korff M, Scott KM, Gureje O, editors. Global Perspectives on Mental-Physical Comorbidity in the WHO World Mental Health Surveys. Cambridge: Cambridge University Press; 2009. Scott KM. The joint association of mental and physical conditions with disability. In: von Korff M, Scott KM, Gureje O, editors. Global Perspectives on Mental-Physical Comorbidity in the WHO World Mental Health Surveys. Cambridge: Cambridge University Press; 2009.
13.
go back to reference Gonzalez JS, Peyrot M, McCarl LA, et al. Depression and diabetes treatment nonadherence: a meta-analysis. Diabetes Care. 2008;31(12):2398–403.PubMedCrossRef Gonzalez JS, Peyrot M, McCarl LA, et al. Depression and diabetes treatment nonadherence: a meta-analysis. Diabetes Care. 2008;31(12):2398–403.PubMedCrossRef
14.
go back to reference Lloyd CE, Hermanns N, Nouwen A, et al. The epidemiology of depression and diabetes. In: Katon W, Maj M, Sartorius N, editors. Depression and Diabetes. UK: Wiley-Blackwell; 2010. Lloyd CE, Hermanns N, Nouwen A, et al. The epidemiology of depression and diabetes. In: Katon W, Maj M, Sartorius N, editors. Depression and Diabetes. UK: Wiley-Blackwell; 2010.
15.
go back to reference Molosankwe I, Patel A, Gagliardino JJ, Knapp M, McDaid D. Economic aspects of the association between diabetes and depression: A systematic review. J Affect Disord. 2012;142(S1):S42–55.PubMedCrossRef Molosankwe I, Patel A, Gagliardino JJ, Knapp M, McDaid D. Economic aspects of the association between diabetes and depression: A systematic review. J Affect Disord. 2012;142(S1):S42–55.PubMedCrossRef
16.
go back to reference Shrestha SS, Zhang P, Li R, et al. Medical expenditures associated with major depressive disorder among privately insured working-age adults with diagnosed diabetes in the United States, 2008. Diabetes Res Clin Pract. 2013;100(1):102–10.PubMedCrossRef Shrestha SS, Zhang P, Li R, et al. Medical expenditures associated with major depressive disorder among privately insured working-age adults with diagnosed diabetes in the United States, 2008. Diabetes Res Clin Pract. 2013;100(1):102–10.PubMedCrossRef
17.
go back to reference Pan A, Lucas M, Sun Q, et al. Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med. 2010;170(21):1884–91.PubMedCrossRef Pan A, Lucas M, Sun Q, et al. Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med. 2010;170(21):1884–91.PubMedCrossRef
18.
go back to reference Shehatah A, Rabie MA, Al-Shahry A. Prevalence and correlates of depressive disorders in elderly with type 2 diabetes in primary health care settings. J Affect Disord. 2010;123:197–201.PubMedCrossRef Shehatah A, Rabie MA, Al-Shahry A. Prevalence and correlates of depressive disorders in elderly with type 2 diabetes in primary health care settings. J Affect Disord. 2010;123:197–201.PubMedCrossRef
19.
go back to reference Barnard KD, Skinner TC, Peveler R. The prevalence of co-morbid depression in adults with Type 1 diabetes: systematic literature review. Diabet Med. 2006;23:445–8.PubMedCrossRef Barnard KD, Skinner TC, Peveler R. The prevalence of co-morbid depression in adults with Type 1 diabetes: systematic literature review. Diabet Med. 2006;23:445–8.PubMedCrossRef
20.
go back to reference Gendelman N, Snell-Bergeon JK, Mcfann K, et al. Prevalence and correlates of depression in individuals with and without Type 1 diabetes. Diabetes Care. 2009;32:575–9.PubMedCrossRef Gendelman N, Snell-Bergeon JK, Mcfann K, et al. Prevalence and correlates of depression in individuals with and without Type 1 diabetes. Diabetes Care. 2009;32:575–9.PubMedCrossRef
21.
go back to reference Collins MM, Corcoran P, Perry IJ. Anxiety and depression symptoms in patients with diabetes. Diabet Med. 2009;26(2):153–61.PubMedCrossRef Collins MM, Corcoran P, Perry IJ. Anxiety and depression symptoms in patients with diabetes. Diabet Med. 2009;26(2):153–61.PubMedCrossRef
22.
go back to reference • Pouwer F, Geelhoed-Duijvestijn PH, Tack CJ, et al. Prevalence of comorbid depresssion is high in out-patients with type 1 or type 2 diabetes mellitus. Results from three out-patient clinics in the Netherlands. Diabet Med. 2010;27(2):217–24. Even though the rates of depression were similar in types 1 and 2 diabetes, the risk factors associated with depression were different in patients with type 1 and 2 diabetes.PubMedCrossRef • Pouwer F, Geelhoed-Duijvestijn PH, Tack CJ, et al. Prevalence of comorbid depresssion is high in out-patients with type 1 or type 2 diabetes mellitus. Results from three out-patient clinics in the Netherlands. Diabet Med. 2010;27(2):217–24. Even though the rates of depression were similar in types 1 and 2 diabetes, the risk factors associated with depression were different in patients with type 1 and 2 diabetes.PubMedCrossRef
23.
go back to reference Engum A, Mykletun A, Midthjell K, Holen A, Dahl AA. A large population-based study of sociodemographic, lifestyle, and clinical factors associated with depresssion in type 1 and type 2 diabetes. Diabetes Care. 2005;28:1904–9.PubMedCrossRef Engum A, Mykletun A, Midthjell K, Holen A, Dahl AA. A large population-based study of sociodemographic, lifestyle, and clinical factors associated with depresssion in type 1 and type 2 diabetes. Diabetes Care. 2005;28:1904–9.PubMedCrossRef
24.
go back to reference Ali S, Davies MJ, Taub NA, Stone MA, Khunti K. Prevalence of diagnosed depression in South Asian and white European people with type 1 and type 2 diabetes mellitus in a UK secondary care population. Postgrad Med J. 2009;85(1003):238–43.PubMedCrossRef Ali S, Davies MJ, Taub NA, Stone MA, Khunti K. Prevalence of diagnosed depression in South Asian and white European people with type 1 and type 2 diabetes mellitus in a UK secondary care population. Postgrad Med J. 2009;85(1003):238–43.PubMedCrossRef
25.
go back to reference Moussavi S, Chatterji S, Verdes E, et al. Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet. 2007;370:851–8.PubMedCrossRef Moussavi S, Chatterji S, Verdes E, et al. Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet. 2007;370:851–8.PubMedCrossRef
26.
go back to reference Li C, Ford ES, Strine TW, Mokdad AH. Prevalence of depression among US adults with diabetes: findings from the 2006 behavioural risk factor surveillance system. Diabetes Care. 2008;31(1):105–7.PubMedCrossRef Li C, Ford ES, Strine TW, Mokdad AH. Prevalence of depression among US adults with diabetes: findings from the 2006 behavioural risk factor surveillance system. Diabetes Care. 2008;31(1):105–7.PubMedCrossRef
27.
go back to reference Lloyd CE, Roy T, Nouwen A, Chauhan AM. Epidemiology of depression in diabetes: International and cross-cultural issues. J Affect Disord. 2012;142(S1):S22–9.PubMedCrossRef Lloyd CE, Roy T, Nouwen A, Chauhan AM. Epidemiology of depression in diabetes: International and cross-cultural issues. J Affect Disord. 2012;142(S1):S22–9.PubMedCrossRef
28.
go back to reference Al-Amer RM, Sobeh MM, Zayed AA, Al-Domi HA. Depression among adults with diabetes in Jordan: risk factors and relationship to blood sugar control. J Diabetes Compl. 2011;25:247–52.CrossRef Al-Amer RM, Sobeh MM, Zayed AA, Al-Domi HA. Depression among adults with diabetes in Jordan: risk factors and relationship to blood sugar control. J Diabetes Compl. 2011;25:247–52.CrossRef
29.
go back to reference Chien IC, Wu EL, Lin CH, Chou P. Prevalence of diabetes in patients with major depression: a population based study. Comp Psychaitry. 2012;53:569–75.CrossRef Chien IC, Wu EL, Lin CH, Chou P. Prevalence of diabetes in patients with major depression: a population based study. Comp Psychaitry. 2012;53:569–75.CrossRef
30.
go back to reference Asghar S, Hussain A, Ali SM, Khan AK, Magnusson A. Prevalence of depression and diabetes: a population-based study from rural Bangladesh. Diabet Med. 2007;24(8):872–7.PubMedCrossRef Asghar S, Hussain A, Ali SM, Khan AK, Magnusson A. Prevalence of depression and diabetes: a population-based study from rural Bangladesh. Diabet Med. 2007;24(8):872–7.PubMedCrossRef
31.
go back to reference Holt RIG, Phillips DIW, Jameson KA, et al. The Hertfordshire Cohort Study G: The relationship between depression and diabetes mellitus: findings from the Hertfordshire Cohort Study. Diabetic Med. 2009;26(6):641–8.PubMedCrossRef Holt RIG, Phillips DIW, Jameson KA, et al. The Hertfordshire Cohort Study G: The relationship between depression and diabetes mellitus: findings from the Hertfordshire Cohort Study. Diabetic Med. 2009;26(6):641–8.PubMedCrossRef
32.
go back to reference Khamseh ME, Baradaran HR, Rajabali H. Depression and diabetes in Iranian patients: a comparative study. Int J Psychiatry Med. 2007;37(1):81–6.PubMedCrossRef Khamseh ME, Baradaran HR, Rajabali H. Depression and diabetes in Iranian patients: a comparative study. Int J Psychiatry Med. 2007;37(1):81–6.PubMedCrossRef
33.
go back to reference Rotella F, Mannucci E. Diabetes mellitus as a risk factor for depression. A meta-analysis of longitudinal studies. Diabetes Res Clin Pract. 2013;99:98–104.PubMedCrossRef Rotella F, Mannucci E. Diabetes mellitus as a risk factor for depression. A meta-analysis of longitudinal studies. Diabetes Res Clin Pract. 2013;99:98–104.PubMedCrossRef
34.
go back to reference Rotella F, Mannucci E. Depression as a risk factor for diabetes: a meta-analysis of longitudinal studies. J Clin Psychiatry. 2013;74(1):31–7.PubMedCrossRef Rotella F, Mannucci E. Depression as a risk factor for diabetes: a meta-analysis of longitudinal studies. J Clin Psychiatry. 2013;74(1):31–7.PubMedCrossRef
35.
go back to reference Gureje O. The pattern and nature of mental physical comorbidity: Specific or general. In: von Korff M, Scott KM, Gureje O, editors. Global Perspectives on Mental-Physical Comorbidity In the WHO World Mental Health Surveys. Cambridge: Cambridge University Press; 2009. Gureje O. The pattern and nature of mental physical comorbidity: Specific or general. In: von Korff M, Scott KM, Gureje O, editors. Global Perspectives on Mental-Physical Comorbidity In the WHO World Mental Health Surveys. Cambridge: Cambridge University Press; 2009.
36.
go back to reference Leone T, Coast E, Narayanan S, de Graft Aikins A. Diabetes and depression comorbidity and socio-economic status in low and middle income countries (LMICs): a mapping of the evidence. Globalization and Health. 2012;8(1):39.PubMedCrossRef Leone T, Coast E, Narayanan S, de Graft Aikins A. Diabetes and depression comorbidity and socio-economic status in low and middle income countries (LMICs): a mapping of the evidence. Globalization and Health. 2012;8(1):39.PubMedCrossRef
37.
go back to reference Mast BT, Miles T, Penninx BW, et al. Vascular Disease and Future Risk of Depressive Symptomatology in Older Adults: Findings from the Health, Aging, and Body Composition Study. Biol Psychiatry. 2008;64(4):320–6.PubMedCrossRef Mast BT, Miles T, Penninx BW, et al. Vascular Disease and Future Risk of Depressive Symptomatology in Older Adults: Findings from the Health, Aging, and Body Composition Study. Biol Psychiatry. 2008;64(4):320–6.PubMedCrossRef
38.
go back to reference Katon W, Russo J, Lin EH, et al. Depression and diabetes: factors associated with major depression at five-year follow-up. Psychosomatics. 2009;50:570–9.PubMed Katon W, Russo J, Lin EH, et al. Depression and diabetes: factors associated with major depression at five-year follow-up. Psychosomatics. 2009;50:570–9.PubMed
39.
go back to reference • Mantyselka P, Korniloff K, Saaristo T, et al. Association of depressive symptoms with impaired glucose regulation, screen-detected, and previously known Type 2 diabetes. Diabetes Care. 2011;34:71–6. Patients with previous diagnosis of depression had significantly higher rates of depression compared to those with normal glucose levels or previously undiagnosed diabetes.PubMedCrossRef • Mantyselka P, Korniloff K, Saaristo T, et al. Association of depressive symptoms with impaired glucose regulation, screen-detected, and previously known Type 2 diabetes. Diabetes Care. 2011;34:71–6. Patients with previous diagnosis of depression had significantly higher rates of depression compared to those with normal glucose levels or previously undiagnosed diabetes.PubMedCrossRef
40.
go back to reference Mezuk B, Lee H, Abdou CM, et al. Is ignorance bliss? Depression, antidepresants, and the diagnosis of prediabetes and type 2 diabetes. Health Psychol. 2013;32(3):254–63.PubMedCrossRef Mezuk B, Lee H, Abdou CM, et al. Is ignorance bliss? Depression, antidepresants, and the diagnosis of prediabetes and type 2 diabetes. Health Psychol. 2013;32(3):254–63.PubMedCrossRef
41.
go back to reference Roy T, Lloyd CE, Parvin M, Mohiuddin KG, Rahman M. Prevalence of co-morbid depression in out-patients with type 2 diabetes mellitus in Bangladesh. BMC Psychiatry. 2012;12(1):123.PubMedCrossRef Roy T, Lloyd CE, Parvin M, Mohiuddin KG, Rahman M. Prevalence of co-morbid depression in out-patients with type 2 diabetes mellitus in Bangladesh. BMC Psychiatry. 2012;12(1):123.PubMedCrossRef
42.
go back to reference Mezuk B, Eaton WW, Albrecht S, Golden SH. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care. 2008;31(12):2383–90.PubMedCrossRef Mezuk B, Eaton WW, Albrecht S, Golden SH. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care. 2008;31(12):2383–90.PubMedCrossRef
43.
go back to reference Campayo A, de Jonge P, Roy JF, et al. Depressive disorder and incident diabetes mellitus: the effect of characteristics of depression. Am J Psychiatry. 2010;167(5):580–8.PubMedCrossRef Campayo A, de Jonge P, Roy JF, et al. Depressive disorder and incident diabetes mellitus: the effect of characteristics of depression. Am J Psychiatry. 2010;167(5):580–8.PubMedCrossRef
44.
go back to reference Sambamoorthi U, Ma Y, Findley PA, Rust G. Antidepressant use, depression, and new-onset diabetes among elderly Medicare beneficiaries. J Diabetes. 2012;23. doi: 10.1111/1753-0407.12014. Sambamoorthi U, Ma Y, Findley PA, Rust G. Antidepressant use, depression, and new-onset diabetes among elderly Medicare beneficiaries. J Diabetes. 2012;23. doi: 10.​1111/​1753-0407.​12014.
45.
go back to reference Renn BN, Feliciano L, Segal DL. The bidirectional relationship of depression and diabetes: A systematic review. Clin Psychol Rev. 2011;31(8):1239–46.PubMedCrossRef Renn BN, Feliciano L, Segal DL. The bidirectional relationship of depression and diabetes: A systematic review. Clin Psychol Rev. 2011;31(8):1239–46.PubMedCrossRef
46.
go back to reference Kan C, Silva N, Golden SH, et al. Systematic Review and Meta-analysis of the Association Between Depression and Insulin Resistance. Diabetes Care. 2013;36(2):480–9.PubMedCrossRef Kan C, Silva N, Golden SH, et al. Systematic Review and Meta-analysis of the Association Between Depression and Insulin Resistance. Diabetes Care. 2013;36(2):480–9.PubMedCrossRef
47.
go back to reference Katon W, Russo J, Lin EHB, et al. Diabetes and Poor Disease Control: Is Comorbid Depression Associated With Poor Medication Adherence or Lack of Treatment Intensification? Psychosomatic Med. 2009;71(9):965–72.CrossRef Katon W, Russo J, Lin EHB, et al. Diabetes and Poor Disease Control: Is Comorbid Depression Associated With Poor Medication Adherence or Lack of Treatment Intensification? Psychosomatic Med. 2009;71(9):965–72.CrossRef
48.
go back to reference Andersohn F, Schade R, Suissa S, Garbe E. Long-Term Use of Antidepressants for Depressive Disorders and the Risk of Diabetes Melitus. Am J Psychiatry. 2009;166:591–8.PubMedCrossRef Andersohn F, Schade R, Suissa S, Garbe E. Long-Term Use of Antidepressants for Depressive Disorders and the Risk of Diabetes Melitus. Am J Psychiatry. 2009;166:591–8.PubMedCrossRef
49.
go back to reference Deuschle M. Effects of antidepressants on glucose metabolism and diabetes mellitus type 2 in adults. Curr Opin Psychiatry. 2013;26:60–5.PubMedCrossRef Deuschle M. Effects of antidepressants on glucose metabolism and diabetes mellitus type 2 in adults. Curr Opin Psychiatry. 2013;26:60–5.PubMedCrossRef
50.
go back to reference Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem. 1994;40(2):288–95.PubMed Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem. 1994;40(2):288–95.PubMed
51.
go back to reference Manjarrez G, Herrera R, Leon M, Hernandez-R J. A Low Brain Serotonergic Neurotransmission in Children With Type 1 Diabetes Detected Through the Intensity Dependence of Auditory-Evoked Potentials. Diabetes Care. 2006;29(1):73–7.PubMedCrossRef Manjarrez G, Herrera R, Leon M, Hernandez-R J. A Low Brain Serotonergic Neurotransmission in Children With Type 1 Diabetes Detected Through the Intensity Dependence of Auditory-Evoked Potentials. Diabetes Care. 2006;29(1):73–7.PubMedCrossRef
52.
go back to reference Kloiber S, Kohli MA, Brueckl T, et al. Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. Mol Psychiatry. 2010;15(7):736–47.PubMedCrossRef Kloiber S, Kohli MA, Brueckl T, et al. Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. Mol Psychiatry. 2010;15(7):736–47.PubMedCrossRef
53.
go back to reference Lara C. Early-Life Psychosocial Factors and Adult-Onset Diabetes. In: von Korff M, Scott KM, Gureje O, editors. Global Perspectives on Mental-Physical Comorbidity. Cambridge: Cambridge University Press; 2009. p. 136–53. Lara C. Early-Life Psychosocial Factors and Adult-Onset Diabetes. In: von Korff M, Scott KM, Gureje O, editors. Global Perspectives on Mental-Physical Comorbidity. Cambridge: Cambridge University Press; 2009. p. 136–53.
54.
go back to reference Scott KM, Von Korff M, Angermeyer MC, et al. Association of childhood adversities and early-onset mental disorders with adult-onset chronic physical conditions. Arch Gen Psychiatry. 2011;68(8):838–44.PubMedCrossRef Scott KM, Von Korff M, Angermeyer MC, et al. Association of childhood adversities and early-onset mental disorders with adult-onset chronic physical conditions. Arch Gen Psychiatry. 2011;68(8):838–44.PubMedCrossRef
55.
go back to reference Renzaho AMN, Houng B, Oldroyd J et al. Stressful life events and the onset of chronic diseases among Australian adults: findings from a longitudinal survey. Eur J Public Health. 2013 Feb 8. [Epub ahead of print]. Renzaho AMN, Houng B, Oldroyd J et al. Stressful life events and the onset of chronic diseases among Australian adults: findings from a longitudinal survey. Eur J Public Health. 2013 Feb 8. [Epub ahead of print].
56.
go back to reference Knol MJ, Heerdink ER, Egberts ACG, et al. Depressive Symptoms in Subjects With Diagnosed and Undiagnosed Type 2 Diabetes. Psychosomatic Med. 2007;69(4):300–5.CrossRef Knol MJ, Heerdink ER, Egberts ACG, et al. Depressive Symptoms in Subjects With Diagnosed and Undiagnosed Type 2 Diabetes. Psychosomatic Med. 2007;69(4):300–5.CrossRef
57.
go back to reference Nouwen A, Nefs G, Caramlau I, et al. Prevalence of Depression in Individuals With Impaired Glucose Metabolism or Undiagnosed Diabetes. Diabetes Care. 2011;34:752–62.PubMedCrossRef Nouwen A, Nefs G, Caramlau I, et al. Prevalence of Depression in Individuals With Impaired Glucose Metabolism or Undiagnosed Diabetes. Diabetes Care. 2011;34:752–62.PubMedCrossRef
58.
go back to reference Katon WJ, Russo JE, Heckbert SR, et al. The relationship between changes in depression symptoms and changes in health risk behaviors in patients with diabetes. Int J Geriatric Psychiatry. 2010;25(5):466–75.CrossRef Katon WJ, Russo JE, Heckbert SR, et al. The relationship between changes in depression symptoms and changes in health risk behaviors in patients with diabetes. Int J Geriatric Psychiatry. 2010;25(5):466–75.CrossRef
59.
go back to reference Gale CR, Kivimaki M, Lawlor DA, et al. Fasting Glucose, Diagnosis of Type 2 Diabetes, and Depression: The Vietnam Experience Study. Biol Psychiatry. 2010;67(2):189–92.PubMedCrossRef Gale CR, Kivimaki M, Lawlor DA, et al. Fasting Glucose, Diagnosis of Type 2 Diabetes, and Depression: The Vietnam Experience Study. Biol Psychiatry. 2010;67(2):189–92.PubMedCrossRef
60.
go back to reference Champaneri S, Wand GS, Malhotra SS, Casagrande SS, Golden SH. Biological Basis of Depression in Adults with Diabetes. Curr Diab Rep. 2010;10(6):396–405.PubMedCrossRef Champaneri S, Wand GS, Malhotra SS, Casagrande SS, Golden SH. Biological Basis of Depression in Adults with Diabetes. Curr Diab Rep. 2010;10(6):396–405.PubMedCrossRef
61.
go back to reference Schmidt HD, Shelton RC, Duman RS. Functional Biomarkers of Depression: Diagnosis, Treatment, and Pathophysiology. Neuropsychopharmacology. 2011;36(12):2375–94.PubMedCrossRef Schmidt HD, Shelton RC, Duman RS. Functional Biomarkers of Depression: Diagnosis, Treatment, and Pathophysiology. Neuropsychopharmacology. 2011;36(12):2375–94.PubMedCrossRef
62.
go back to reference Gragnoli C. Depression and type 2 diabetes: Cortisol pathway implication and investigational needs. J Cell Physiol. 2012;227(6):2318–22.PubMedCrossRef Gragnoli C. Depression and type 2 diabetes: Cortisol pathway implication and investigational needs. J Cell Physiol. 2012;227(6):2318–22.PubMedCrossRef
63.
go back to reference Pan A, Keum N, Okereke OI, et al. Bidirectional Association Between Depression and Metabolic Syndrome: A systematic review and meta-analysis of epidemiological studies. Diabetes Care. 2012;35(5):1171–80.PubMedCrossRef Pan A, Keum N, Okereke OI, et al. Bidirectional Association Between Depression and Metabolic Syndrome: A systematic review and meta-analysis of epidemiological studies. Diabetes Care. 2012;35(5):1171–80.PubMedCrossRef
64.
go back to reference Stuart MJ, Baune BT. Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity. NeurosciBiobehav Rev. 2012;36(1):658–76. Stuart MJ, Baune BT. Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity. NeurosciBiobehav Rev. 2012;36(1):658–76.
65.
go back to reference Maes M. Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(3):664–75.PubMedCrossRef Maes M. Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(3):664–75.PubMedCrossRef
66.
go back to reference Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011;11(2):98–107.PubMedCrossRef Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011;11(2):98–107.PubMedCrossRef
67.
go back to reference Hood KK, Lawrence JM, Anderson A, et al. Metabolic and Inflammatory Links to Depression in Youth With Diabetes. Diabetes Care. 2012;35(12):2443–6.PubMedCrossRef Hood KK, Lawrence JM, Anderson A, et al. Metabolic and Inflammatory Links to Depression in Youth With Diabetes. Diabetes Care. 2012;35(12):2443–6.PubMedCrossRef
68.
go back to reference Richardson LK, Egede LE, Mueller M, Echols CL, Gebregziabher M. Longitudinal effects of depression on glycemic control in veterans with type 2 diabetes. Gen Hosp Psychiatry. 2008;30(6):509–14.PubMedCrossRef Richardson LK, Egede LE, Mueller M, Echols CL, Gebregziabher M. Longitudinal effects of depression on glycemic control in veterans with type 2 diabetes. Gen Hosp Psychiatry. 2008;30(6):509–14.PubMedCrossRef
69.
go back to reference Aikens JE, Perkins DW, Lipton B, Piette JD. Longitudinal Analysis of Depressive Symptoms and Glycemic Control in Type 2 Diabetes. Diabetes Care. 2009;32(7):1177–81.PubMedCrossRef Aikens JE, Perkins DW, Lipton B, Piette JD. Longitudinal Analysis of Depressive Symptoms and Glycemic Control in Type 2 Diabetes. Diabetes Care. 2009;32(7):1177–81.PubMedCrossRef
70.
go back to reference de Groot M, Jacobson AM, Samson JA, Welch G. Glycemic control and major depression in patients with type 1 and type 2 diabetes mellitus. J Psychosomatic Res. 1999;46(5):425–35.CrossRef de Groot M, Jacobson AM, Samson JA, Welch G. Glycemic control and major depression in patients with type 1 and type 2 diabetes mellitus. J Psychosomatic Res. 1999;46(5):425–35.CrossRef
71.
go back to reference Sacco WP, Bykowski CA. Depression and haemoglobin A1c in type 1 and type 2 diabetes: the role of self-efficacy. Diabetes Res Clin Pract. 2010;90:141–6.PubMedCrossRef Sacco WP, Bykowski CA. Depression and haemoglobin A1c in type 1 and type 2 diabetes: the role of self-efficacy. Diabetes Res Clin Pract. 2010;90:141–6.PubMedCrossRef
72.
go back to reference Melin EO, Thunander M. Depression, obesity and smoking were independently associated with inadequate glycaemic control in patients with type I diabetes. Eur J Endrocrinol. 2013;168(6):861–9.CrossRef Melin EO, Thunander M. Depression, obesity and smoking were independently associated with inadequate glycaemic control in patients with type I diabetes. Eur J Endrocrinol. 2013;168(6):861–9.CrossRef
73.
go back to reference van Bastelaar KM, Pouwer F, Geelhoed-Duijvestijn PH, et al. Diabetes-specific emotional distress mediates the association betweeen depressive symptoms and glycaemic control in type 1 and type 2 diabetes. Diabet Med. 2010;27:798–803.PubMedCrossRef van Bastelaar KM, Pouwer F, Geelhoed-Duijvestijn PH, et al. Diabetes-specific emotional distress mediates the association betweeen depressive symptoms and glycaemic control in type 1 and type 2 diabetes. Diabet Med. 2010;27:798–803.PubMedCrossRef
74.
go back to reference van Steenbergen-Weijenburg KM, van Puffelen AL, Horn EK, et al. More co-morbid depression in patients with Type 2 diabetes with multiple complications. An observational study at a specialized outpatient clinic. Diabetic Med. 2011;28(1):86–9.PubMedCrossRef van Steenbergen-Weijenburg KM, van Puffelen AL, Horn EK, et al. More co-morbid depression in patients with Type 2 diabetes with multiple complications. An observational study at a specialized outpatient clinic. Diabetic Med. 2011;28(1):86–9.PubMedCrossRef
75.
go back to reference van Dooren FEP, Nefs G, Schram MT, et al. Depression and Risk of Mortality in People with Diabetes Mellitus: A Systematic Review and Meta-Analysis. PLoS ONE. 2013;8(3):e57058.PubMedCrossRef van Dooren FEP, Nefs G, Schram MT, et al. Depression and Risk of Mortality in People with Diabetes Mellitus: A Systematic Review and Meta-Analysis. PLoS ONE. 2013;8(3):e57058.PubMedCrossRef
76.
go back to reference Coleman SM, Katon W, Lin E, Von Korff M. Depression and Death in Diabetes; 10-Year Follow-Up of All-Cause and Cause-Specific Mortality in a Diabetic Cohort. Psychosomatics. 2013. doi: 10.1016/j.psym.2013.02.015. Coleman SM, Katon W, Lin E, Von Korff M. Depression and Death in Diabetes; 10-Year Follow-Up of All-Cause and Cause-Specific Mortality in a Diabetic Cohort. Psychosomatics. 2013. doi: 10.​1016/​j.​psym.​2013.​02.​015.
77.
go back to reference Sullivan MD, O’Connor P, Feeney P, et al. Depression Predicts All-Cause Mortality: Epidemiological evaluation from the ACCORD HRQL substudy. Diabetes Care. 2012;35(8):1708–15.PubMedCrossRef Sullivan MD, O’Connor P, Feeney P, et al. Depression Predicts All-Cause Mortality: Epidemiological evaluation from the ACCORD HRQL substudy. Diabetes Care. 2012;35(8):1708–15.PubMedCrossRef
78.
go back to reference Ahola AJ, Harjutsalo V, Saraheimo M, Forsblom C, Groop PH. Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men. Diabetologia. 2012;55(1):73–9.PubMedCrossRef Ahola AJ, Harjutsalo V, Saraheimo M, Forsblom C, Groop PH. Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men. Diabetologia. 2012;55(1):73–9.PubMedCrossRef
79.
go back to reference Chereches RM, Litan CM, Zlati AM, Bloom JR. Does co-morbid depression impact diabetes related costs? Evidence from a cross-sectional survey in a low-income country. J Ment Health Policy Econ. 2012;15(3):127–38.PubMed Chereches RM, Litan CM, Zlati AM, Bloom JR. Does co-morbid depression impact diabetes related costs? Evidence from a cross-sectional survey in a low-income country. J Ment Health Policy Econ. 2012;15(3):127–38.PubMed
80.
go back to reference Le TK, Curtis B, Kahle-Wrobleski K, et al. Treatment patterns and resource use among patients with comorbid diabetes mellitus and major depressive disorder. J Med Econ. 2011;14(4):440–7.PubMed Le TK, Curtis B, Kahle-Wrobleski K, et al. Treatment patterns and resource use among patients with comorbid diabetes mellitus and major depressive disorder. J Med Econ. 2011;14(4):440–7.PubMed
81.
go back to reference Das-Munshi J, Stewart R, Ismail K, et al. Diabetes, Common Mental Disorders, and Disability: Findings From the UK National Psychiatric Morbidity Survey. Psychosomatic Med. 2007;69(6):543–50.CrossRef Das-Munshi J, Stewart R, Ismail K, et al. Diabetes, Common Mental Disorders, and Disability: Findings From the UK National Psychiatric Morbidity Survey. Psychosomatic Med. 2007;69(6):543–50.CrossRef
82.
go back to reference Dismuke CE, Egede LE. Association between major depression, depressive symptoms and personal income in US adults with diabetes. Gen Hosp Psychiatry. 2010;32(5):484–91.PubMedCrossRef Dismuke CE, Egede LE. Association between major depression, depressive symptoms and personal income in US adults with diabetes. Gen Hosp Psychiatry. 2010;32(5):484–91.PubMedCrossRef
83.
go back to reference •• Baumeister H, Hutter N, Bengel J. Psychological and pharmacological intervention for depression in patients with diabetes mellitus and depression. Cochrane Database Syst Rev. 2012;12. Psychological and pharmacological interventions are effective in treating depression symptoms in patients with diabetes. While pharmacological interventions improve glycaemic control, the effects of psychological interventiions on glycaemic control is inconclusive. •• Baumeister H, Hutter N, Bengel J. Psychological and pharmacological intervention for depression in patients with diabetes mellitus and depression. Cochrane Database Syst Rev. 2012;12. Psychological and pharmacological interventions are effective in treating depression symptoms in patients with diabetes. While pharmacological interventions improve glycaemic control, the effects of psychological interventiions on glycaemic control is inconclusive.
84.
go back to reference Markowitz SM, Gonzalez JS, Wilkinson JL, Safren SA. A Review of Treating Depression in Diabetes: Emerging Findings. Psychosomatics. 2011;52(1):1–18.PubMedCrossRef Markowitz SM, Gonzalez JS, Wilkinson JL, Safren SA. A Review of Treating Depression in Diabetes: Emerging Findings. Psychosomatics. 2011;52(1):1–18.PubMedCrossRef
85.
go back to reference Lustman PJ, Clouse RE, Nix BD, et al. Sertraline for prevention of depression recurrence in diabetes mellitus: A randomized, double-blind, placebo-controlled trial. Arch Gen Psychiatry. 2006;63(5):521–9.PubMedCrossRef Lustman PJ, Clouse RE, Nix BD, et al. Sertraline for prevention of depression recurrence in diabetes mellitus: A randomized, double-blind, placebo-controlled trial. Arch Gen Psychiatry. 2006;63(5):521–9.PubMedCrossRef
86.
go back to reference Lustman PJ, Williams MM, Sayuk GS, Nix BD, Clouse RE. Factors influencing glycemic control in type 2 diabetes during acute- and maintenance-phase treatment of major depressive disorder with bupropion. Diabetes Care. 2007;30(3):459–66.PubMedCrossRef Lustman PJ, Williams MM, Sayuk GS, Nix BD, Clouse RE. Factors influencing glycemic control in type 2 diabetes during acute- and maintenance-phase treatment of major depressive disorder with bupropion. Diabetes Care. 2007;30(3):459–66.PubMedCrossRef
87.
go back to reference Katon WJ, Lin EHB, Von Korff M, et al. Collaborative Care for Patients with Depression and Chronic Illnesses. New Engl J Med. 2010;363(27):2611–20.PubMedCrossRef Katon WJ, Lin EHB, Von Korff M, et al. Collaborative Care for Patients with Depression and Chronic Illnesses. New Engl J Med. 2010;363(27):2611–20.PubMedCrossRef
88.
go back to reference Coleman SM, Katon W. Treatment implication for comorbid diabetes mellitus and depression. IPsychiatry Times. 2013;30:1–5. Coleman SM, Katon W. Treatment implication for comorbid diabetes mellitus and depression. IPsychiatry Times. 2013;30:1–5.
Metadata
Title
The Comorbidity between Depression and Diabetes
Authors
Bibilola D. Oladeji
Oye Gureje
Publication date
01-09-2013
Publisher
Springer US
Published in
Current Psychiatry Reports / Issue 9/2013
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-013-0390-3

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