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Current Pain and Headache Reports
Published in: Current Pain and Headache Reports 6/2016

01-06-2016 | Concussion and Head Injury (T Seifert, Section Editor)

The Pathophysiology of Concussion

Author: Meeryo C. Choe

Published in: Current Pain and Headache Reports | Issue 6/2016

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Abstract

Concussion is a significant issue in medicine and the media today. With growing interest on the long-term effects of sports participation, it is important to understand what occurs in the brain after an impact of any degree. While some of the basic pathophysiology has been elucidated, much is still unknown about what happens in the brain after traumatic brain injury, particularly with milder injuries where no damage can be seen at the structural level on standard neuroimaging. Understanding the chain of events from a cellular level using studies investigating more severe injuries can help to drive research efforts in understanding the symptomatology that is seen in the acute phase after concussion, as well as point to mechanisms that may underlie persistent post-concussive symptoms. This review discusses the basic neuropathology that occurs after traumatic brain injury at the cellular level. We also present the pathology of chronic traumatic encephalopathy and its similarities to other neurodegenerative diseases. We conclude with recent imaging and biomarker findings looking at changes that may occur after repeated subconcussive blows, which may help to guide efforts in understanding if cumulative subconcussive mechanical forces upon the brain are detrimental in the long term or if concussive symptoms mark the threshold for brain injury.
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Metadata
Title
The Pathophysiology of Concussion
Author
Meeryo C. Choe
Publication date
01-06-2016
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 6/2016
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-016-0573-9

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Post-Traumatic Headache Therapy in the Athlete

Concussion and Head Injury (T Seifert, Section Editor)

Interventional Treatment for Post-traumatic Headache

Concussion and Head Injury (T Seifert, Section Editor)

Neuropsychological Assessment Following Concussion: an Evidence‐Based Review of the Role of Neuropsychological Assessment Pre- and Post-Concussion

Other Pain (N Vadivelu and A Kaye, Section Editors)

Drug Formulation Advances in Extended-Release Medications for Pain Control

Concussion and Head Injury (T Seifert, Section Editor)

Concussion in the Military: an Evidence-Base Review of mTBI in US Military Personnel Focused on Posttraumatic Headache