Skip to main content
Top
Published in: Current Pain and Headache Reports 6/2016

01-06-2016 | Secondary Headache (M Robbins, Section Editor)

Post-Traumatic Headache Therapy in the Athlete

Author: Tad Seifert

Published in: Current Pain and Headache Reports | Issue 6/2016

Login to get access

Abstract

Post-traumatic headache can occur after any traumatic brain injury, regardless of severity. Headache is consistently the most common symptom following concussion and occurs in over 90 % of athletes with sports-related concussion. Despite this prevalence, the complaint of headache after a possible concussive injury is often dismissed. Even when sports-related concussion is accurately diagnosed, many athletes fall victim to mismanagement of this associated symptom by clinicians who are not well-versed in headache treatment. Furthermore, benign headaches may also occur incidentally in the context of head trauma. This complex, and often non-specific, nature of headaches provides a significant challenge in return to play decision-making. Post-traumatic headaches are generally categorized according to primary headache disorders in an attempt to guide treatment; however, there is minimal medical literature on headache management in the concussed athlete. There is clearly a continued need for prospective studies of existing treatments and new approaches.
Literature
1.
go back to reference Meehan WP, d’Hemecourt P, Comstock RD. High school concussion in the 2008–2009 academic year: mechanism, symptoms, and management. Am J Sports Med. 2010;38(12):2405–9.CrossRefPubMedPubMedCentral Meehan WP, d’Hemecourt P, Comstock RD. High school concussion in the 2008–2009 academic year: mechanism, symptoms, and management. Am J Sports Med. 2010;38(12):2405–9.CrossRefPubMedPubMedCentral
2.
go back to reference Headache Classification Committee of the International Headache Society (IHS). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808. Headache Classification Committee of the International Headache Society (IHS). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.
3.
go back to reference Register-Mihalik MA, Guskiewicz KM, Douglas Mann J, et al. The effects of headache on clinical measures of neurocognitive function. Clin J Sport Med. 2007;17(4):282–8.CrossRefPubMed Register-Mihalik MA, Guskiewicz KM, Douglas Mann J, et al. The effects of headache on clinical measures of neurocognitive function. Clin J Sport Med. 2007;17(4):282–8.CrossRefPubMed
5.
go back to reference Weiss HD, Stern BJ, Goldberg J. Posttraumatic migraine: chronic migraine precipitated by minor head or neck trauma. Headache. 1991;31(7):451–6.CrossRefPubMed Weiss HD, Stern BJ, Goldberg J. Posttraumatic migraine: chronic migraine precipitated by minor head or neck trauma. Headache. 1991;31(7):451–6.CrossRefPubMed
6.
go back to reference Gilkey SJ, Ramadan NM, Aurora TK, et al. Cerebral blood flow in chronic posttraumatic headache. Headache. 1997;37:583–7.CrossRefPubMed Gilkey SJ, Ramadan NM, Aurora TK, et al. Cerebral blood flow in chronic posttraumatic headache. Headache. 1997;37:583–7.CrossRefPubMed
7.
go back to reference Lauritzen M. Pathophysiology of the migraine aura: the spreading depression theory. Brain. 1994;117:119–210.CrossRef Lauritzen M. Pathophysiology of the migraine aura: the spreading depression theory. Brain. 1994;117:119–210.CrossRef
8.
go back to reference Lucas S. Headache management in concussion and mild traumatic brain injury. PM R. 2011;2(1 suppl 2):S406–12.CrossRef Lucas S. Headache management in concussion and mild traumatic brain injury. PM R. 2011;2(1 suppl 2):S406–12.CrossRef
9.
go back to reference Leao AA. Further observations on the spreading depression of activity in the cerebral cortex. J Neurophysiol. 1947;10(6):409–14.PubMed Leao AA. Further observations on the spreading depression of activity in the cerebral cortex. J Neurophysiol. 1947;10(6):409–14.PubMed
10.
go back to reference Church AJ, Andrew RD. Spreading depression expands traumatic injury in neocortical brain slices. J Neurotrauma. 2005;22(2):277–90.CrossRefPubMed Church AJ, Andrew RD. Spreading depression expands traumatic injury in neocortical brain slices. J Neurotrauma. 2005;22(2):277–90.CrossRefPubMed
11.
go back to reference Taylor AR, Bell TK. Slowing of cerebral circulation after concussional head injury: a controlled trial. Lancet. 1966;2:178–80.CrossRefPubMed Taylor AR, Bell TK. Slowing of cerebral circulation after concussional head injury: a controlled trial. Lancet. 1966;2:178–80.CrossRefPubMed
12.
go back to reference Piovesan EJ, Kowacs PA, Oshinsky ML. Convergence of cervical and trigeminal sensory afferents. Curr Pain Headache Rep. 2003;7(5):377–83.CrossRefPubMed Piovesan EJ, Kowacs PA, Oshinsky ML. Convergence of cervical and trigeminal sensory afferents. Curr Pain Headache Rep. 2003;7(5):377–83.CrossRefPubMed
13.
go back to reference Kors EE, Terwindt GM, Vermeulen FL, et al. Delayed cerebral edema and fatal coma after minor head trauma: role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine. Ann Neurol. 2001;49(6):753–60.CrossRefPubMed Kors EE, Terwindt GM, Vermeulen FL, et al. Delayed cerebral edema and fatal coma after minor head trauma: role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine. Ann Neurol. 2001;49(6):753–60.CrossRefPubMed
14.••
go back to reference Giza CC, Hovda DA. The new neurometabolic cascade of concussion. Neurosurgery. 2014;75:524–33. An exceptional article summarizing the latest updates in existing knowledge regarding post-concussion neurometabolic changes including how these changes are related to clinical symptoms and possibly long-term impairment.CrossRef Giza CC, Hovda DA. The new neurometabolic cascade of concussion. Neurosurgery. 2014;75:524–33. An exceptional article summarizing the latest updates in existing knowledge regarding post-concussion neurometabolic changes including how these changes are related to clinical symptoms and possibly long-term impairment.CrossRef
15.
go back to reference Becker WJ, Findlay T, Moga C, et al. Guideline for primary care management of headache in adults. Can Fam Physician. 2015;61(8):670–9.PubMedPubMedCentral Becker WJ, Findlay T, Moga C, et al. Guideline for primary care management of headache in adults. Can Fam Physician. 2015;61(8):670–9.PubMedPubMedCentral
16.
go back to reference Chan S, Burowski B, Byczkowski T, et al. Intravenous migraine therapy in children with posttraumatic headache in the ED. Am J Emerg Med. 2015;33:635–9.CrossRefPubMedPubMedCentral Chan S, Burowski B, Byczkowski T, et al. Intravenous migraine therapy in children with posttraumatic headache in the ED. Am J Emerg Med. 2015;33:635–9.CrossRefPubMedPubMedCentral
17.
go back to reference McBeath JG, Nanda A. Use of dihydroergotamine in patients with postconcussion syndrome. Headache. 1994;34(3):148–51.CrossRefPubMed McBeath JG, Nanda A. Use of dihydroergotamine in patients with postconcussion syndrome. Headache. 1994;34(3):148–51.CrossRefPubMed
18.
go back to reference Loder E, Biondi D. Use of botulinum toxins for chronic headaches: a focused review. Clin J Pain. 2002;18:169–76.CrossRef Loder E, Biondi D. Use of botulinum toxins for chronic headaches: a focused review. Clin J Pain. 2002;18:169–76.CrossRef
19.
go back to reference Yerry JA, Kuehn D, Finkel AG. Onobotulinum toxin a for the treatment of headache in service members with a history of mild traumatic brain injury: a cohort study. Headache. 2015;55(3):395–406.CrossRefPubMed Yerry JA, Kuehn D, Finkel AG. Onobotulinum toxin a for the treatment of headache in service members with a history of mild traumatic brain injury: a cohort study. Headache. 2015;55(3):395–406.CrossRefPubMed
20.
go back to reference Hecht JS. Occipital nerve blocks in postconcussive headaches: a retrospective review and report of ten patients. J Head Trauma Rehabil. 2004;19(1):58–71.CrossRefPubMed Hecht JS. Occipital nerve blocks in postconcussive headaches: a retrospective review and report of ten patients. J Head Trauma Rehabil. 2004;19(1):58–71.CrossRefPubMed
21.
go back to reference Zaremski JL, Hurley RW, Herman D, et al. Occipital neuralgia blockade as a treatment after concussions: a case series. PM R. 2014;6(9S):S249.CrossRef Zaremski JL, Hurley RW, Herman D, et al. Occipital neuralgia blockade as a treatment after concussions: a case series. PM R. 2014;6(9S):S249.CrossRef
22.
go back to reference Seeger TA, Orr S, Bodell L, et al. Occipital nerve blocks for pediatric posttraumatic headache: a case series. J Child Neurol. 2015;30(9):1142–6.CrossRefPubMed Seeger TA, Orr S, Bodell L, et al. Occipital nerve blocks for pediatric posttraumatic headache: a case series. J Child Neurol. 2015;30(9):1142–6.CrossRefPubMed
23.
go back to reference Walker J, Howell S. Ultrasound guided greater occipital nerve blocks for post-traumatic occipital neuralgia. W V Med J. 2014;110(2):12–3.PubMed Walker J, Howell S. Ultrasound guided greater occipital nerve blocks for post-traumatic occipital neuralgia. W V Med J. 2014;110(2):12–3.PubMed
24.
go back to reference Panero A, Delgado A, Hotz G, et al. Efficacy and safety of frontal & occipital nerve blocks in post-traumatic headache: a retrospective study. PM R. 2012;4(10S):S193.CrossRef Panero A, Delgado A, Hotz G, et al. Efficacy and safety of frontal & occipital nerve blocks in post-traumatic headache: a retrospective study. PM R. 2012;4(10S):S193.CrossRef
25.
go back to reference Cady R, Saper J, Dexter K, et al. Long-term efficacy of a double-blind, placebo-controlled, randomized study for repetitive sphenopalatine blockade with bupivacaine vs. saline with the Tx360® device for treatment of chronic migraine. Headache. 2015;55(4):529–42.CrossRefPubMed Cady R, Saper J, Dexter K, et al. Long-term efficacy of a double-blind, placebo-controlled, randomized study for repetitive sphenopalatine blockade with bupivacaine vs. saline with the Tx360® device for treatment of chronic migraine. Headache. 2015;55(4):529–42.CrossRefPubMed
26.
go back to reference Sussman W, Mason RA, Mautner K. Sphenopalatine ganglion (SPG) block for management of chronic post-traumatic headaches after a sport-related concussion: case report. PM R. 2015;7:S197.CrossRef Sussman W, Mason RA, Mautner K. Sphenopalatine ganglion (SPG) block for management of chronic post-traumatic headaches after a sport-related concussion: case report. PM R. 2015;7:S197.CrossRef
27.
go back to reference Elahi F, Reddy C. Neuromodulation of the great auricular nerve for persistent post-traumatic headache. Pain Physician. 2014;17(4):E531–6.PubMed Elahi F, Reddy C. Neuromodulation of the great auricular nerve for persistent post-traumatic headache. Pain Physician. 2014;17(4):E531–6.PubMed
28.
go back to reference Moeller DR, Duffy JM, Goolsby AM, et al. Use of a removable mandibular neuroprosthesis for the reduction of posttraumatic stress disorder (PTSD) and mild traumatic brain injury/PTSD/associated nightmares, headaches, and sleep disturbances. J Spec Oper Med. 2014;14(3):64–73.PubMed Moeller DR, Duffy JM, Goolsby AM, et al. Use of a removable mandibular neuroprosthesis for the reduction of posttraumatic stress disorder (PTSD) and mild traumatic brain injury/PTSD/associated nightmares, headaches, and sleep disturbances. J Spec Oper Med. 2014;14(3):64–73.PubMed
29.
go back to reference Leung A, Shukla S, Fallah A, et al. Repetitive transcranial magnetic stimulation in managing mild traumatic brain injury-related headaches. Neuromodulation. 2015; E-pub ahead of print. doi:10.1111/ner.12364. Leung A, Shukla S, Fallah A, et al. Repetitive transcranial magnetic stimulation in managing mild traumatic brain injury-related headaches. Neuromodulation. 2015; E-pub ahead of print. doi:10.​1111/​ner.​12364.
30.
go back to reference Koski L, Kolivakis T, Yu C, et al. Noninvasive brain stimulation for persistent postconcussion symptoms in mild traumatic brain injury. J Neurotrauma. 2015;32(1):38–44.CrossRefPubMed Koski L, Kolivakis T, Yu C, et al. Noninvasive brain stimulation for persistent postconcussion symptoms in mild traumatic brain injury. J Neurotrauma. 2015;32(1):38–44.CrossRefPubMed
31.
go back to reference Lipton RB, Pearlman SH. Transcranial magnetic stimulation in the treatment of migraine. Neurother. 2010;7:204–12.CrossRef Lipton RB, Pearlman SH. Transcranial magnetic stimulation in the treatment of migraine. Neurother. 2010;7:204–12.CrossRef
32.•
go back to reference Lucas S, Hoffman JM, Bell KR, et al. A prospective study of prevalence and characterization of headache following mild traumatic brain injury. Cephalalgia. 2014;34(2):93–102. This well-designed prospective study was one of the first to propose assertive, early treatment of PTH to avoid associated chronicity and disability.CrossRefPubMed Lucas S, Hoffman JM, Bell KR, et al. A prospective study of prevalence and characterization of headache following mild traumatic brain injury. Cephalalgia. 2014;34(2):93–102. This well-designed prospective study was one of the first to propose assertive, early treatment of PTH to avoid associated chronicity and disability.CrossRefPubMed
33.
go back to reference Heyer GL, Idris SA. Does analgesic overuse contribute to chronic post-traumatic headaches in adolescent concussion patients? Ped Neuro. 2014;50:464–8.CrossRef Heyer GL, Idris SA. Does analgesic overuse contribute to chronic post-traumatic headaches in adolescent concussion patients? Ped Neuro. 2014;50:464–8.CrossRef
35.
go back to reference Conidi FX. Sports-related concussion: the role of the headache specialist. Headache. 2012;52(S1):15–21.CrossRefPubMed Conidi FX. Sports-related concussion: the role of the headache specialist. Headache. 2012;52(S1):15–21.CrossRefPubMed
36.
go back to reference Griesbach GS. Exercise after traumatic brain injury: is it a double-edged sword. PM R. 2011;3(6 suppl 1):S64–72.CrossRefPubMed Griesbach GS. Exercise after traumatic brain injury: is it a double-edged sword. PM R. 2011;3(6 suppl 1):S64–72.CrossRefPubMed
37.
go back to reference Archer T, Svensson K, Alricsson M. Physical exercise ameliorates deficits induced by traumatic brain injury. Acta Neurol Scand. 2012;125(5):293–302.CrossRefPubMed Archer T, Svensson K, Alricsson M. Physical exercise ameliorates deficits induced by traumatic brain injury. Acta Neurol Scand. 2012;125(5):293–302.CrossRefPubMed
38.
go back to reference Varkey E, Cider A, Carlsson J, Linde M. Exercise as migraine prophylaxis: a randomized study using relaxation and topiramate as controls. Cephalalgia. 2011;31(14):1428–38.CrossRefPubMedPubMedCentral Varkey E, Cider A, Carlsson J, Linde M. Exercise as migraine prophylaxis: a randomized study using relaxation and topiramate as controls. Cephalalgia. 2011;31(14):1428–38.CrossRefPubMedPubMedCentral
39.
go back to reference Darabaneanu S, Overath CH, Rubin D, et al. Aerobic exercise as a therapy option for migraine: a pilot study. Int J Sports Med. 2011;32(6):455–60.CrossRefPubMed Darabaneanu S, Overath CH, Rubin D, et al. Aerobic exercise as a therapy option for migraine: a pilot study. Int J Sports Med. 2011;32(6):455–60.CrossRefPubMed
40.
go back to reference Koseoglu E, Akboyraz A, Soyuer A, et al. Aerobic exercise and plasma beta endorphin levels in patients with migrainous headache without aura. Cephalalgia. 2003;23:972–6.CrossRefPubMed Koseoglu E, Akboyraz A, Soyuer A, et al. Aerobic exercise and plasma beta endorphin levels in patients with migrainous headache without aura. Cephalalgia. 2003;23:972–6.CrossRefPubMed
41.
go back to reference Seifert TD. Sport concussion and associated post-traumatic headache. Headache. 2013;53(3):726–36.CrossRefPubMed Seifert TD. Sport concussion and associated post-traumatic headache. Headache. 2013;53(3):726–36.CrossRefPubMed
42.
go back to reference Manuel JC, Shilt JS, Curl WW, et al. Coping with sports injuries: an examination of the adolescent athlete. J Adolesc Health. 2002;31(5):391–3.CrossRefPubMed Manuel JC, Shilt JS, Curl WW, et al. Coping with sports injuries: an examination of the adolescent athlete. J Adolesc Health. 2002;31(5):391–3.CrossRefPubMed
43.
go back to reference Milde-Busch A, Blaschek A, Borggrafe I, et al. Associations of diet and lifestyle with headache in high-school students: results from a cross-sectional study. Headache. 2010;50(7):1104–14.CrossRefPubMed Milde-Busch A, Blaschek A, Borggrafe I, et al. Associations of diet and lifestyle with headache in high-school students: results from a cross-sectional study. Headache. 2010;50(7):1104–14.CrossRefPubMed
44.
go back to reference Leddy JJ, Kozlowski K, Donnelly J, et al. A preliminary study of subsymptom threshold exercise training for refractory post-concussion syndrome. Clin J Sports Med. 2010;20:21–7.CrossRef Leddy JJ, Kozlowski K, Donnelly J, et al. A preliminary study of subsymptom threshold exercise training for refractory post-concussion syndrome. Clin J Sports Med. 2010;20:21–7.CrossRef
45.
go back to reference Vancampfort D, Probst M, Adriaens A, et al. Changes in physical activity, physical fitness, self-perception and quality of life following a 6-month physical activity counseling and cognitive behavioral therapy program in outpatients with binge eating disorder. Psychiatry Res. 2014;219(2):361–6.CrossRefPubMed Vancampfort D, Probst M, Adriaens A, et al. Changes in physical activity, physical fitness, self-perception and quality of life following a 6-month physical activity counseling and cognitive behavioral therapy program in outpatients with binge eating disorder. Psychiatry Res. 2014;219(2):361–6.CrossRefPubMed
46.
47.
go back to reference Evans RW. The postconcussion syndrome. In: Aminoff M, editor. Neurology and General Medicine. 4th ed. Philadelphia: Elsevier; 2007. p. 593–603. Evans RW. The postconcussion syndrome. In: Aminoff M, editor. Neurology and General Medicine. 4th ed. Philadelphia: Elsevier; 2007. p. 593–603.
48.
go back to reference Giza CC, Kutcher JS, Ashwal S, et al. Summary of evidence-based guideline update: evaluation and management of concussion in sports: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2013;80(24):2250–7.CrossRefPubMedPubMedCentral Giza CC, Kutcher JS, Ashwal S, et al. Summary of evidence-based guideline update: evaluation and management of concussion in sports: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2013;80(24):2250–7.CrossRefPubMedPubMedCentral
49.
go back to reference Eisenberg MA, Andrea J, Meehan W, et al. Time interval between concussions and symptom duration. Pediatrics. 2013;132(1):8–17.CrossRefPubMed Eisenberg MA, Andrea J, Meehan W, et al. Time interval between concussions and symptom duration. Pediatrics. 2013;132(1):8–17.CrossRefPubMed
50.
go back to reference Mihalik JP, Stump JE, Collins MW, et al. Posttraumatic migraine characteristics in athletes following sports-related concussion. J Neurosurgery. 2005;102(5):850–5.CrossRef Mihalik JP, Stump JE, Collins MW, et al. Posttraumatic migraine characteristics in athletes following sports-related concussion. J Neurosurgery. 2005;102(5):850–5.CrossRef
51.
go back to reference Register-Mihalik MA, Guskiewicz KM, Mann JD, et al. The effects of headache on clinical measures of neurocognitive function. Clin J Sport Med. 2007;17(4):282–8.CrossRefPubMed Register-Mihalik MA, Guskiewicz KM, Mann JD, et al. The effects of headache on clinical measures of neurocognitive function. Clin J Sport Med. 2007;17(4):282–8.CrossRefPubMed
52.••
go back to reference Kontos AP, Elbin RJ, Lau B, et al. Posttraumatic migraine as a predictor of recovery and cognitive impairment after sport-related concussion. Am J Sports Med. 2013;41(7):1497–504. This cohort study investigates the predictive value of posttraumatic migraine in the recovery after sports-related concussion. Their findings provide further evidence suggesting that PTM is associated with cognitive impairments and protracted recovery from this injury.CrossRefPubMed Kontos AP, Elbin RJ, Lau B, et al. Posttraumatic migraine as a predictor of recovery and cognitive impairment after sport-related concussion. Am J Sports Med. 2013;41(7):1497–504. This cohort study investigates the predictive value of posttraumatic migraine in the recovery after sports-related concussion. Their findings provide further evidence suggesting that PTM is associated with cognitive impairments and protracted recovery from this injury.CrossRefPubMed
53.
go back to reference Grady MF. Concussion in the adolescent athlete. Curr Probl Adolesc Health Care. 2010;40:154–69.CrossRef Grady MF. Concussion in the adolescent athlete. Curr Probl Adolesc Health Care. 2010;40:154–69.CrossRef
55.
go back to reference Schneider KJ, Meeuwisse WH, Kang J, et al. Preseason reports of neck pain, dizziness, and headache as risk factors for concussion in male youth ice hockey players. Clin J Sports Med. 2013;23(4):267–72.CrossRef Schneider KJ, Meeuwisse WH, Kang J, et al. Preseason reports of neck pain, dizziness, and headache as risk factors for concussion in male youth ice hockey players. Clin J Sports Med. 2013;23(4):267–72.CrossRef
56.
go back to reference Kucziynski A, Crawford S, Bodell L, et al. Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort. Dev Med Child Neurol. 2013;55(7):636–41.CrossRef Kucziynski A, Crawford S, Bodell L, et al. Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort. Dev Med Child Neurol. 2013;55(7):636–41.CrossRef
57.
go back to reference Kutcher JS, Eckner JT. At-risk populations in sports-related concussion. Curr Sports Med Rep. 2010;9(1):16–20.CrossRefPubMed Kutcher JS, Eckner JT. At-risk populations in sports-related concussion. Curr Sports Med Rep. 2010;9(1):16–20.CrossRefPubMed
58.
go back to reference Brown AW, Watanbe TK, Hoffman JM, et al. Headache after traumatic brain injury: a national survey of clinical practices and treatment approaches. PM R. 2015;7:3–8.CrossRefPubMed Brown AW, Watanbe TK, Hoffman JM, et al. Headache after traumatic brain injury: a national survey of clinical practices and treatment approaches. PM R. 2015;7:3–8.CrossRefPubMed
59.
60.
go back to reference University of Washington. Amitriptyline to prevent headache after traumatic brain injury. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://clinicaltrials.gov/show/NCT01856270. Accessed 1 Mar 2016. University of Washington. Amitriptyline to prevent headache after traumatic brain injury. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://​clinicaltrials.​gov/​show/​NCT01856270. Accessed 1 Mar 2016.
61.
62.
63.
go back to reference VA Office of Research and Development. Chronic postconcussive headache: a placebo-controlled trial of prazosin. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://clinicaltrials.gov/show/NCT02266329. Accessed 1 Mar 2016. VA Office of Research and Development. Chronic postconcussive headache: a placebo-controlled trial of prazosin. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://​clinicaltrials.​gov/​show/​NCT02266329. Accessed 1 Mar 2016.
64.
go back to reference Akershus University College. Is chiropractic spinal manipulative therapy an efficient treatment option in cervicogenic headache. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://clinicaltrials.gov/show/NCT01687881. Accessed 1 Mar 2016. Akershus University College. Is chiropractic spinal manipulative therapy an efficient treatment option in cervicogenic headache. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://​clinicaltrials.​gov/​show/​NCT01687881. Accessed 1 Mar 2016.
65.
go back to reference Alabama Physical Therapy & Acupuncture. Manual therapy and exercise in patients with cervicogenic headache. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://clinicaltrials.gov/show/NCT01580280. Accessed 1 Mar 2016. Alabama Physical Therapy & Acupuncture. Manual therapy and exercise in patients with cervicogenic headache. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://​clinicaltrials.​gov/​show/​NCT01580280. Accessed 1 Mar 2016.
66.
go back to reference Alabama Physical Therapy & Acupuncture. Spinal manipulation and dry needling versus conventional physical therapy in patients with cervicogenic headache. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://clinicaltrials.gov/show/NCT02373605. Accessed 1 Mar 2016. Alabama Physical Therapy & Acupuncture. Spinal manipulation and dry needling versus conventional physical therapy in patients with cervicogenic headache. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://​clinicaltrials.​gov/​show/​NCT02373605. Accessed 1 Mar 2016.
67.
go back to reference McMaster Children’s Hospital. Use of ibuprofen and acetaminophen for treatment of acute headache post concussion in children. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://clinicaltrials.gov/show/NCT02268058. Accessed 1 Mar 2016. McMaster Children’s Hospital. Use of ibuprofen and acetaminophen for treatment of acute headache post concussion in children. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://​clinicaltrials.​gov/​show/​NCT02268058. Accessed 1 Mar 2016.
68.
go back to reference University of Washington. Treatment of chronic post-traumatic headache with onabotulinumtoxinA. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://clinicaltrials.gov/show/NCT02160535. Accessed 1 Mar 2016. University of Washington. Treatment of chronic post-traumatic headache with onabotulinumtoxinA. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://​clinicaltrials.​gov/​show/​NCT02160535. Accessed 1 Mar 2016.
69.
go back to reference University of Monstir. Titrated versus high and low dose nebulized morphine to reduce pain in emergency settings (TIMORNEB). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://clinicaltrials.gov/show/NCT02200185. Accessed 1 Mar 2016. University of Monstir. Titrated versus high and low dose nebulized morphine to reduce pain in emergency settings (TIMORNEB). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://​clinicaltrials.​gov/​show/​NCT02200185. Accessed 1 Mar 2016.
70.
go back to reference University of California, Los Angeles. Yoga training for returning veterans with headache. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://clinicaltrials.gov/show/NCT01993069. Accessed 1 Mar 2016. University of California, Los Angeles. Yoga training for returning veterans with headache. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2015 Nov 09]. Available from: https://​clinicaltrials.​gov/​show/​NCT01993069. Accessed 1 Mar 2016.
71.
go back to reference Packard RC. The relationship of neck injury and post-traumatic headache. Curr Pain Headache Rep. 2002;6:301–7.CrossRefPubMed Packard RC. The relationship of neck injury and post-traumatic headache. Curr Pain Headache Rep. 2002;6:301–7.CrossRefPubMed
72.
go back to reference Elliott MB, Oshinsky ML, Amenta PS, et al. Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. Headache. 2010;52:966–84.CrossRef Elliott MB, Oshinsky ML, Amenta PS, et al. Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. Headache. 2010;52:966–84.CrossRef
73.
go back to reference Dodick DW, Goadsby PJ, Silberstein SD, et al. Safety and effi cacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial. Lancet Neurol. 2014;13:1100–7.CrossRefPubMed Dodick DW, Goadsby PJ, Silberstein SD, et al. Safety and effi cacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial. Lancet Neurol. 2014;13:1100–7.CrossRefPubMed
74.•
go back to reference Bigal ME, Edvinsson L, Rapoport AM, et al. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol 2015; published online Sept 30. http://dx.doi.org/10.1016/S1474-4422(15)00245-8. This study reports definite short-term efficacy and excellent tolerability of this compound in patients with the most difficult types of migraine, confirming the promise of CGRP antibodies for migraine prevention. Bigal ME, Edvinsson L, Rapoport AM, et al. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Lancet Neurol 2015; published online Sept 30. http://​dx.​doi.​org/​10.​1016/​S1474-4422(15)00245-8. This study reports definite short-term efficacy and excellent tolerability of this compound in patients with the most difficult types of migraine, confirming the promise of CGRP antibodies for migraine prevention.
75.
go back to reference Zhao J, Levy D. The sensory innervation of the calvarial periosteum is nociceptive and contributes to headache-like behavior. Pain. 2014;155(7):1392–400.CrossRefPubMedPubMedCentral Zhao J, Levy D. The sensory innervation of the calvarial periosteum is nociceptive and contributes to headache-like behavior. Pain. 2014;155(7):1392–400.CrossRefPubMedPubMedCentral
76.
go back to reference Benromano T, Defrin R, Ahn AH, et al. Mild closed head injury promotes a selective trigeminal hypernociception: implications for the acute emergence of post-traumatic headache. Eur J Pain. 2015;19(5):621–8.CrossRefPubMedPubMedCentral Benromano T, Defrin R, Ahn AH, et al. Mild closed head injury promotes a selective trigeminal hypernociception: implications for the acute emergence of post-traumatic headache. Eur J Pain. 2015;19(5):621–8.CrossRefPubMedPubMedCentral
Metadata
Title
Post-Traumatic Headache Therapy in the Athlete
Author
Tad Seifert
Publication date
01-06-2016
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 6/2016
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-016-0568-6

Other articles of this Issue 6/2016

Current Pain and Headache Reports 6/2016 Go to the issue

Concussion and Head Injury (T Seifert, Section Editor)

Interventional Treatment for Post-traumatic Headache

Concussion and Head Injury (T Seifert, Section Editor)

The Pathophysiology of Concussion

Psychological and Behavioral Aspects of Headache and Pain (D Buse, Section Editor)

The Role of Resilience in the Clinical Management of Chronic Pain

Other Pain (N Vadivelu and A Kaye, Section Editors)

Drug Formulation Advances in Extended-Release Medications for Pain Control