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Current Pain and Headache Reports
Published in: Current Pain and Headache Reports 2/2012

01-04-2012 | Trigeminal Autonomic Cephalalgias (M Matharu, Section Editor)

Interictal Pain in Primary Headache Syndromes

Authors: Michael J. Marmura, William B. Young

Published in: Current Pain and Headache Reports | Issue 2/2012

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Abstract

Primary headache disorders are generally characterized by the pain, time course, and associated symptoms of their attacks, but often are accompanied by milder interictal pain. Patients with chronic migraine, chronic tension-type headache, hemicrania continua, and new daily-persistent headache have constant pain more often than not. Patients with trigeminal autonomic cephalalgias such as cluster headache commonly have interictal pain as well, usually much milder and unilateral to the side of attacks. Even those with rare headache types, including hypnic headache and trigeminal neuralgia, commonly have interictal pain. This review describes the incidence of interictal pain in primary headache disorders and suggests the significance and biological meanings of this pain.
Literature
1.
Hershey AD, Winner P, Kabbouche M, et al. Use of the ICHD-II criteria in the diagnosis of pediatric migraine. Headache. 2005;45:1288–97.PubMedCrossRef
2.
Lipton RB, Stewart WF, Diamond S, et al. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache. 2001;41:646–57.PubMedCrossRef
3.
Stewart WF, Lipton RB, Celentano DD, et al. Prevalence of migraine headache in the United States. Relation to age, income, race and other sociodemographic factors. JAMA. 1992;267:64–9.PubMedCrossRef
4.
Castillo J, Munoz P, Guitera V, et al. Epidemiology of chronic daily headache in the general population. Headache. 1998;38:378.
5.
Lu SR, Fuh JL, Chen WT, et al. Chronic daily headache in Taipei, Taiwan: prevalence, follow-up and outcome predictors. Cephalalgia. 2001;21:980–6.PubMedCrossRef
6.
Scher AI, Stewart WF, Buse D, et al. Major life changes before and after the onset of chronic daily headache: a population-based study. Cephalalgia. 2008;28:868–76.PubMedCrossRef
7.
Scher AI, Stewart WFRAJ, Lipton RB. Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain. 2003;106:81–9.PubMedCrossRef
8.
Ailani J, Silberstein SD. Chronic daily headache. Cephalalgia. 2009;29:81.
9.
Dodick D, Silberstein S. Central sensitization theory of migraine: clinical implications. Headache. 2006;46 Suppl 4:S182–91.PubMedCrossRef
10.
Lovati C, D’Amico D, Rosa S, et al. Allodynia in different forms of migraine. Neurol Sci. 2007;28 Suppl 2:S220–1.PubMedCrossRef
11.
Piao ZG, Cho IH, Park CK, et al. Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury. Pain. 2006;121:219–31.PubMedCrossRef
12.
•• Bigal ME, Lipton RB. Overuse of acute migraine medications and migraine chronification. Curr Pain Headache Rep 2009;13:301–7. Landmark research examining the clinical consequences of medication overuse in migraine. PubMedCrossRef
13.
Zhang Y, Li H, Li Y, et al. Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice. Neurosci Lett. 2011;489:43–7.PubMedCrossRef
14.
Headache Classification Committee. The International Classification of Headache Disorders, 2nd Edition. Cephalalgia. 2004;24:1–160.
15.
Lavados PM, Tenham E. Epidemiology of tension-type headache in Santiago, Chile: a prevalence study. Cephalalgia. 1998;18:552–8.PubMedCrossRef
16.
Donnet A, Lanteri-Minet M, Guegan-Massardier E, et al. Chronic cluster headache: a French clinical descriptive study. J Neurol Neurosurg Psychiatry. 2007;78:1354–8.PubMedCrossRef
17.
•• Marmura MJ, Pello SJ, Young WB. Interictal pain in cluster headache. Cephalalgia 2010;30:1531–4. A detailed clinical description of the pain between attacks.PubMedCrossRef
18.
Antonaci F, Pareja JA, Caminero AB, et al. Chronic paroxysmal hemicrania and hemicrania continua. Parenteral indomethacin: the ‘indotest’. Headache. 1998;38:122–8.PubMedCrossRef
19.
Cittadini E, Matharu MS, Goadsby PJ. Paroxysmal hemicrania: a prospective clinical study of 31 cases. Brain. 2008;131:1142–55.PubMedCrossRef
20.
Cohen AS, Matharu MS, Goadsby PJ. Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA)—a prospective clinical study of SUNCT and SUNA. Brain. 2006;129:2746–60.PubMedCrossRef
21.
Schwaag S, Frese A, Husstedt IW, et al. SUNCT syndrome: the first German case series. Cephalalgia. 2003;23:398–400.PubMedCrossRef
22.
Cittadini E, Goadsby PJ. Hemicrania continua: a clinical study of 39 patients with diagnostic implications. Brain. 2010;133:1973–86.PubMedCrossRef
23.
Leone M, Cecchini AP, Mea E, et al. Epidemiology of fixed unilateral headaches. Cephalalgia. 2008;28:8–11.PubMedCrossRef
24.
Yablon LA, Newman LC. Hemicrania continua: a second case in which the remitting form evolved from the chronic form. Headache. 2010;50:1381–3.PubMedCrossRef
25.
Muller KI, Bekkelund SI. Hemicrania continua changed to chronic paroxysmal hemicrania after treatment with cyclooxygenase-2 inhibitor. Headache. 2011;51:300–5.PubMedCrossRef
26.
Prakash S, Shah ND. Delayed response of indomethacin in patients with hemicrania continua: real or phantom headache? Cephalalgia. 2010;30:375–9.PubMed
27.
Marmura MJ, Silberstein SD, Gupta M. Hemicrania continua: who responds to indomethacin? Cephalalgia. 2009;29:300–7.PubMedCrossRef
28.
Donnet A, Lanteri-Minet M. A consecutive series of 22 cases of hypnic headache in France. Cephalalgia. 2009;29:928–34.PubMedCrossRef
29.
Evers S, Goadsby PJ. Hypnic headache. Clinical features, pathophysiology, and treatment. Neurology. 2003;60:305–9.
30.
Dodick DW, Jones JM, Capobianco DJ. Hypnic headache: another indomethacin-responsive headache syndrome? Headache. 2000;40:830–5.PubMedCrossRef
31.
32.
Sindou M, Leston J, Decullier E, et al. Microvascular decompression for primary trigeminal neuralgia: long-term effectiveness and prognostic factors in a series of 362 consecutive patients with clear-cut neurovascular conflicts who underwent pure decompression. J Neurosurg. 2007;107:1144–53.PubMedCrossRef
33.
34.
• Borsook D, Upadhyay J, Chudler EH, et al. A key role of the basal ganglia in pain and analgesia—insights gained through human functional imaging. Mol Pain 2010;6:27. This is an important study of functional neuroimaging in chronic pain disorders, with relevance to chronic headache disorders. PubMedCrossRef
35.
36.
Ferrari A, Leone S, Tacchi R, et al. The link between pain patient and analgesic medication is greater in migraine than in rheumatic disease patients. Cephalalgia. 2009;29:31–7.PubMedCrossRef
37.
Paemeleire K, Evers S, Goadsby PJ. Medication-overuse headache in patients with cluster headache. Curr Pain Headache Rep. 2008;12:122–7.PubMedCrossRef
38.
Flor H, Nikolajsen L, Staehelin JT. Phantom limb pain: a case of maladaptive CNS plasticity? Nat Rev Neurosci. 2006;7:873–81.PubMedCrossRef
39.
Morgane PJ, Galler JR, Mokler DJ. A review of systems and networks of the limbic forebrain/limbic midbrain. Prog Neurobiol. 2005;75:143–60.PubMedCrossRef
40.
Jongsma ML, Postma SA, Souren P, et al. Neurodegenerative properties of chronic pain: cognitive decline in patients with chronic pancreatitis. PLoS One. 2011;6:e23363.PubMedCrossRef
41.
Ji RR, Kohno T, Moore KA, et al. Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci. 2003;26:696–705.PubMedCrossRef
Metadata
Title
Interictal Pain in Primary Headache Syndromes
Authors
Michael J. Marmura
William B. Young
Publication date
01-04-2012
Publisher
Current Science Inc.
Published in
Current Pain and Headache Reports / Issue 2/2012
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-012-0243-5

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