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Molecular Pain
Published in: Molecular Pain 1/2010

Open Access 01-12-2010 | Review

A key role of the basal ganglia in pain and analgesia - insights gained through human functional imaging

Authors: David Borsook, Jaymin Upadhyay, Eric H Chudler, Lino Becerra

Published in: Molecular Pain | Issue 1/2010

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Abstract

The basal ganglia (BG) are composed of several nuclei involved in neural processing related to the execution of motor, cognitive and emotional activities. Preclinical and clinical data have implicated a role for these structures in pain processing. Recently neuroimaging has added important information on BG activation in conditions of acute pain, chronic pain and as a result of drug effects. Our current understanding of alterations in cortical and sub-cortical regions in pain suggests that the BG are uniquely involved in thalamo-cortico-BG loops to integrate many aspects of pain. These include the integration of motor, emotional, autonomic and cognitive responses to pain.
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Metadata
Title
A key role of the basal ganglia in pain and analgesia - insights gained through human functional imaging
Authors
David Borsook
Jaymin Upadhyay
Eric H Chudler
Lino Becerra
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Molecular Pain / Issue 1/2010
Electronic ISSN: 1744-8069
DOI
https://doi.org/10.1186/1744-8069-6-27

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