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Current Osteoporosis Reports

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01-06-2017 | Kidney and Bone (S Moe and I Salusky, Section Editors)

Treatment of Pediatric Chronic Kidney Disease-Mineral and Bone Disorder

Authors: Mark R. Hanudel, Isidro B. Salusky

Published in: Current Osteoporosis Reports | Issue 3/2017

Abstract

Purpose of Review

In this paper, we review the pathogenesis and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD), especially as it relates to pediatric CKD patients.

Recent Findings

Disordered regulation of bone and mineral metabolism in CKD may result in fractures, skeletal deformities, and poor growth, which is especially relevant for pediatric CKD patients. Moreover, CKD-MBD may result in extra-skeletal calcification and cardiovascular morbidity. Early increases in fibroblast growth factor 23 (FGF23) levels play a key, primary role in CKD-MBD pathogenesis. Therapeutic approaches in pediatric CKD-MBD aim to minimize complications to the growing skeleton and prevent extra-skeletal calcifications, mainly by addressing hyperphosphatemia and secondary hyperparathyroidism. Ongoing clinical trials are focused on assessing the benefit of FGF23 reduction in CKD.

Summary

CKD-MBD is a systemic disorder that has significant clinical implications. Treatment of CKD-MBD in children requires special consideration in order to maximize growth, optimize skeletal health, and prevent cardiovascular disease.

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Title: Treatment of Pediatric Chronic Kidney Disease-Mineral and Bone Disorder
Authors: Mark R. Hanudel
Isidro B. Salusky
Publication date: 01-06-2017
Publisher: Springer US
Published in: Current Osteoporosis Reports / Issue 3/2017
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-017-0365-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Treatment of Pediatric Chronic Kidney Disease-Mineral and Bone Disorder

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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