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01-03-2012 | Future Therapeutics (P Miller, Section Editor)

Sclerostin: Therapeutic Horizons Based Upon Its Actions

Authors: Aline G. Costa, John P. Bilezikian

Published in: Current Osteoporosis Reports | Issue 1/2012

Abstract

Inactivating mutations of the SOST gene cause a reduction in sclerostin levels and are associated with high bone mass. The clinical phenotypes, sclerosteosis and van Buchem’s disease, were described in 1950s. Much later, it was learned that both diseases are due to loss-of-function mutations in the SOST gene. As a regulator of an important osteoanabolic pathway, Wnt, inactivation of SOST leads to a stimulation of the pathway it regulates. The high bone mass in patients with either sclerosteosis or van Buchem’s disease is associated with unusual skeletal strength; they do not fracture. Knowledge of this molecule and its actions led rather quickly to the development of anti-sclerostin antibodies that lead to marked increases in bone mass in both animals and human subjects. Blocking sclerostin action with anti-sclerostin antibodies is a promising new therapeutic approach to osteoanabolic therapy of osteoporosis.

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Title: Sclerostin: Therapeutic Horizons Based Upon Its Actions
Authors: Aline G. Costa
John P. Bilezikian
Publication date: 01-03-2012
Publisher: Current Science Inc.
Published in: Current Osteoporosis Reports / Issue 1/2012
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-011-0089-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sclerostin: Therapeutic Horizons Based Upon Its Actions

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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