Published in:
01-03-2012 | Future Therapeutics (P Miller, Section Editor)
Inhibition of Cathepsin K for Treatment of Osteoporosis
Authors:
Steven Boonen, Elizabeth Rosenberg, Frank Claessens, Dirk Vanderschueren, Socrates Papapoulos
Published in:
Current Osteoporosis Reports
|
Issue 1/2012
Login to get access
Abstract
Cathepsin K is the protease that is primarily responsible for the degradation of bone matrix by osteoclasts. Inhibitors of cathepsin K are in development for treatment of osteoporosis. Currently available antiresorptive drugs interfere with osteoclast function. They inhibit both bone resorption and formation, due to the coupling between these processes. Cathepsin K inhibitors, conversely, target the resorption process itself and may not interfere with osteoclast stimulation of bone formation. In fact, when cathepsin K is absent or inhibited in mice, rabbits, or monkeys, bone formation is maintained or increased. In humans, inhibition of cathepsin K is associated with sustained reductions in bone resorption markers but with smaller and transient reductions in bone formation markers. The usefulness of cathepsin K inhibitors in osteoporosis is now being examined in phase 2 and phase 3 clinical trials of postmenopausal osteoporotic women.