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Current Oncology Reports
Published in: Current Oncology Reports 3/2020

01-03-2020 | Nephrectomy | Genitourinary Cancers (DP Petrylak and JW Kim, Section Editors)

Current State of Systemic Therapies for Advanced Renal Cell Carcinoma

Authors: Shuchi Gulati, Ulka Vaishampayan

Published in: Current Oncology Reports | Issue 3/2020

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Abstract

Purpose of Review

Due to the rapidly changing field of kidney cancer therapeutics, addressing the state of the art systemic therapy regimens, and sequencing with cytoreductive nephrectomy are the primary focus of this review. We will also discuss the role of biomarkers and novel therapeutic targets in the management of renal cell carcinoma.

Recent Findings

The management of metastatic renal cell cancer has undergone a paradigm shift with immune checkpoint inhibitors being used in the frontline setting. Over the last 4 years, programmed cell death-1 (PD-1) inhibitors as well as programmed cell death ligand-1 inhibitors have become available in various combinations with cytotoxic T lymphocyte-associated protein-4 (CTLA-4) inhibitors and tyrosine kinase inhibitors (TKIs). These drugs have improved outcomes in patients with renal cell cancer and more work is being done to refine these targets as well as discover newer ones.

Summary

Despite the availability of several new treatment options, some questions that still need to be addressed in the management of kidney cancer include the sequencing of treatment options, treatment of patients who progress on immune checkpoint inhibitors, and role of biomarkers to ascertain the best treatment options to minimize costs and improve outcomes.
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Metadata
Title
Current State of Systemic Therapies for Advanced Renal Cell Carcinoma
Authors
Shuchi Gulati
Ulka Vaishampayan
Publication date
01-03-2020
Publisher
Springer US
Published in
Current Oncology Reports / Issue 3/2020
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-020-0892-1

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