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Current Neurology and Neuroscience Reports
Published in: Current Neurology and Neuroscience Reports 2/2024

03-01-2024 | Glioma

Updated Response Assessment in Neuro-Oncology (RANO) for Gliomas

Authors: Gilbert Youssef, Patrick Y. Wen

Published in: Current Neurology and Neuroscience Reports | Issue 2/2024

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Abstract

Purpose of Review

The response assessment in Neuro-Oncology (RANO) criteria and its versions were developed by expert opinion consensus to standardize response evaluation in glioma clinical trials. New patient-based data informed the development of updated response assessment criteria, RANO 2.0.

Recent Findings

In a recent study of patients with glioblastoma, the post-radiation brain MRI was a superior baseline MRI compared to the pretreatment MRI, and confirmation scans were only beneficial within the first 12 weeks of completion of radiation in newly diagnosed disease. Nonenhancing disease evaluation did not improve the correlation between progression-free survival and overall survival in newly diagnosed and recurrent settings.

Summary

RANO 2.0 recommends a single common response criteria for high- and low-grade gliomas, regardless of the treatment modality being evaluated. It also provides guidance on the evaluation of nonenhancing tumors and tumors with both enhancing and nonenhancing components.
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Metadata
Title
Updated Response Assessment in Neuro-Oncology (RANO) for Gliomas
Authors
Gilbert Youssef
Patrick Y. Wen
Publication date
03-01-2024
Publisher
Springer US
Published in
Current Neurology and Neuroscience Reports / Issue 2/2024
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-023-01329-4