Skip to main content
Top
Published in: Current Neurology and Neuroscience Reports 5/2018

01-05-2018 | Movement Disorders (S Fox, Section Editor)

Managing Gait, Balance, and Posture in Parkinson’s Disease

Authors: Bettina Debû, Clecio De Oliveira Godeiro, Jarbas Correa Lino, Elena Moro

Published in: Current Neurology and Neuroscience Reports | Issue 5/2018

Login to get access

Abstract

Purpose of Review

Postural instability and gait difficulties inexorably worsen with Parkinson’s disease (PD) progression and become treatment resistant, with a severe impact on autonomy and quality of life. We review the main characteristics of balance instability, gait disabilities, and static postural alterations in advanced PD, and the available treatment strategies.

Recent Findings

It remains very difficult to satisfactorily alleviate gait and postural disturbances in advanced PD. Medical and surgical interventions often fail to provide satisfactory or durable alleviation of these axial symptoms, that may actually call for differential treatments. Exercise and adapted physical activity programs can contribute to improving the patients’ condition.

Summary

Gait, balance, and postural disabilities are often lumped together under the Postural Instability and Gait Difficulties umbrella term. This may lead to sub-optimal patients’ management as data suggest that postural, balance, and gait problems might depend on distinct underlying mechanisms. We advocate for a multidisciplinary approach from the day of diagnosis.
Literature
1.
go back to reference Kudlicka A, Clare L, Hindle JV. Executive functions in Parkinson’s disease: systematic review and meta-analysis. Mov Disord. 2011;26:2305–15.PubMedCrossRef Kudlicka A, Clare L, Hindle JV. Executive functions in Parkinson’s disease: systematic review and meta-analysis. Mov Disord. 2011;26:2305–15.PubMedCrossRef
2.
go back to reference Isella V, Melzi P, Grimaldi M, Iurlaro S, Piolti R, Ferrarese C, et al. Clinical, neuropsychological, and morphometric correlates of apathy in Parkinson’s disease. Mov Disord. 2002;17:366–71.PubMedCrossRef Isella V, Melzi P, Grimaldi M, Iurlaro S, Piolti R, Ferrarese C, et al. Clinical, neuropsychological, and morphometric correlates of apathy in Parkinson’s disease. Mov Disord. 2002;17:366–71.PubMedCrossRef
3.
go back to reference Morris R, Lord S, Lawson RA, Coleman S, Galna B, Duncan GW, et al. Gait rather than cognition predicts decline in specific cognitive domains in early Parkinson’s disease. J Gerontol Ser A. 2017;72:1656–62.CrossRef Morris R, Lord S, Lawson RA, Coleman S, Galna B, Duncan GW, et al. Gait rather than cognition predicts decline in specific cognitive domains in early Parkinson’s disease. J Gerontol Ser A. 2017;72:1656–62.CrossRef
4.
go back to reference Marras C, McDermott MP, Rochon PA, Tanner CM, Naglie G, Lang AE, et al. Predictors of deterioration in health-related quality of life in Parkinson’s disease: results from the DATATOP trial. Mov Disord. 2008;23:653–9. quiz 776PubMedCrossRef Marras C, McDermott MP, Rochon PA, Tanner CM, Naglie G, Lang AE, et al. Predictors of deterioration in health-related quality of life in Parkinson’s disease: results from the DATATOP trial. Mov Disord. 2008;23:653–9. quiz 776PubMedCrossRef
5.
go back to reference Vitale C, Falco F, Trojano L, Erro R, Moccia M, Allocca R, et al. Neuropsychological correlates of Pisa syndrome in patients with Parkinson’s disease. Acta Neurol Scand. 2016;134:101–7.PubMedCrossRef Vitale C, Falco F, Trojano L, Erro R, Moccia M, Allocca R, et al. Neuropsychological correlates of Pisa syndrome in patients with Parkinson’s disease. Acta Neurol Scand. 2016;134:101–7.PubMedCrossRef
6.
go back to reference Lord S, Rochester L, Hetherington V, Allcock LM, Burn D. Executive dysfunction and attention contribute to gait interference in “off” state Parkinson’s disease. Gait Posture. 2010;31:169–74.PubMedCrossRef Lord S, Rochester L, Hetherington V, Allcock LM, Burn D. Executive dysfunction and attention contribute to gait interference in “off” state Parkinson’s disease. Gait Posture. 2010;31:169–74.PubMedCrossRef
7.
go back to reference Smulders K, van Nimwegen M, Munneke M, Bloem BR, Kessels RPC, Esselink RAJ. Involvement of specific executive functions in mobility in Parkinson’s disease. Parkinsonism Relat Disord. 2013;19:126–8.PubMedCrossRef Smulders K, van Nimwegen M, Munneke M, Bloem BR, Kessels RPC, Esselink RAJ. Involvement of specific executive functions in mobility in Parkinson’s disease. Parkinsonism Relat Disord. 2013;19:126–8.PubMedCrossRef
8.
go back to reference Latt MD, Menz HB, Fung VS, Lord SR. Acceleration patterns of the head and pelvis during gait in older people with Parkinson’s disease: a comparison of fallers and nonfallers. J Gerontol A Biol Sci Med Sci. 2009;64:700–6.PubMedCrossRef Latt MD, Menz HB, Fung VS, Lord SR. Acceleration patterns of the head and pelvis during gait in older people with Parkinson’s disease: a comparison of fallers and nonfallers. J Gerontol A Biol Sci Med Sci. 2009;64:700–6.PubMedCrossRef
9.
go back to reference Horak FB, Mancini M, Carlson-Kuhta P, Nutt JG, Salarian A. Balance and gait represent independent domains of mobility in Parkinson disease. Phys Ther. 2016;96:1364–71.PubMedPubMedCentralCrossRef Horak FB, Mancini M, Carlson-Kuhta P, Nutt JG, Salarian A. Balance and gait represent independent domains of mobility in Parkinson disease. Phys Ther. 2016;96:1364–71.PubMedPubMedCentralCrossRef
11.
go back to reference Foreman KB, Wisted C, Addison O, Marcus RL, Lastayo PC, Dibble LE. Improved dynamic postural task performance without improvements in postural responses: the blessing and the curse of dopamine replacement. Parkinson Dis. 2012;2012:692150. Foreman KB, Wisted C, Addison O, Marcus RL, Lastayo PC, Dibble LE. Improved dynamic postural task performance without improvements in postural responses: the blessing and the curse of dopamine replacement. Parkinson Dis. 2012;2012:692150.
12.
go back to reference Curtze C, Nutt JG, Carlson-Kuhta P, Mancini M, Horak FB. Levodopa is a double-edged sword for balance and gait in people with Parkinson’s disease. Mov Disord. 2015;30:1361–70.PubMedPubMedCentralCrossRef Curtze C, Nutt JG, Carlson-Kuhta P, Mancini M, Horak FB. Levodopa is a double-edged sword for balance and gait in people with Parkinson’s disease. Mov Disord. 2015;30:1361–70.PubMedPubMedCentralCrossRef
13.
go back to reference Devos D, Defebvre L, Bordet R. Dopaminergic and non-dopaminergic pharmacological hypotheses for gait disorders in Parkinson’s disease: pharmacology of parkinsonian gait disorders. Fundam Clin Pharmacol. 2010;24:407–21.PubMedCrossRef Devos D, Defebvre L, Bordet R. Dopaminergic and non-dopaminergic pharmacological hypotheses for gait disorders in Parkinson’s disease: pharmacology of parkinsonian gait disorders. Fundam Clin Pharmacol. 2010;24:407–21.PubMedCrossRef
14.
go back to reference Boonstra TA, van der Kooij H, Munneke M, Bloem BR. Gait disorders and balance disturbances in Parkinson’s disease: clinical update and pathophysiology. Curr Opin Neurol. 2008;21:461–71.PubMedCrossRef Boonstra TA, van der Kooij H, Munneke M, Bloem BR. Gait disorders and balance disturbances in Parkinson’s disease: clinical update and pathophysiology. Curr Opin Neurol. 2008;21:461–71.PubMedCrossRef
15.
go back to reference Perez-Lloret S, Peralta MC, Barrantes FJ. Pharmacotherapies for Parkinson’s disease symptoms related to cholinergic degeneration. Expert Opin Pharmacother. 2016;17:2405–15.PubMedCrossRef Perez-Lloret S, Peralta MC, Barrantes FJ. Pharmacotherapies for Parkinson’s disease symptoms related to cholinergic degeneration. Expert Opin Pharmacother. 2016;17:2405–15.PubMedCrossRef
16.
go back to reference Nonnekes J, Timmer MHM, de Vries NM, Rascol O, Helmich RC, Bloem BR. Unmasking levodopa resistance in Parkinson’s disease: unmasking levodopa resistance IN PD. Mov Disord. 2016;31:1602–9.PubMedCrossRef Nonnekes J, Timmer MHM, de Vries NM, Rascol O, Helmich RC, Bloem BR. Unmasking levodopa resistance in Parkinson’s disease: unmasking levodopa resistance IN PD. Mov Disord. 2016;31:1602–9.PubMedCrossRef
17.
go back to reference Devos D, Moreau C, Dujardin K, Cabantchik I, Defebvre L, Bordet R. New pharmacological options for treating advanced Parkinson’s disease. Clin Ther. 2013;35:1640–52.PubMedCrossRef Devos D, Moreau C, Dujardin K, Cabantchik I, Defebvre L, Bordet R. New pharmacological options for treating advanced Parkinson’s disease. Clin Ther. 2013;35:1640–52.PubMedCrossRef
18.
go back to reference Moreau C, Devos D, Defebvre L. Acetylcholinesterase inhibitors and gait: a steadying hand? Lancet Neurol. 2016;15:232–3.PubMedCrossRef Moreau C, Devos D, Defebvre L. Acetylcholinesterase inhibitors and gait: a steadying hand? Lancet Neurol. 2016;15:232–3.PubMedCrossRef
19.
go back to reference Ebersbach G. Exercise matters in patients with PD—another piece of evidence: Parkinson disease. Nat Rev Neurol. 2015;11:9–10.PubMedCrossRef Ebersbach G. Exercise matters in patients with PD—another piece of evidence: Parkinson disease. Nat Rev Neurol. 2015;11:9–10.PubMedCrossRef
20.
go back to reference Oguh O, Eisenstein A, Kwasny M, Simuni T. Back to the basics: regular exercise matters in Parkinson’s disease: results from the National Parkinson Foundation QII Registry study. Parkinsonism Relat Disord. 2014;20:1221–5.PubMedCrossRef Oguh O, Eisenstein A, Kwasny M, Simuni T. Back to the basics: regular exercise matters in Parkinson’s disease: results from the National Parkinson Foundation QII Registry study. Parkinsonism Relat Disord. 2014;20:1221–5.PubMedCrossRef
21.
go back to reference Speelman AD, van de Warrenburg BP, van Nimwegen M, Petzinger GM, Munneke M, Bloem BR. How might physical activity benefit patients with Parkinson disease? Nat Rev Neurol. 2011;7:528–34.PubMedCrossRef Speelman AD, van de Warrenburg BP, van Nimwegen M, Petzinger GM, Munneke M, Bloem BR. How might physical activity benefit patients with Parkinson disease? Nat Rev Neurol. 2011;7:528–34.PubMedCrossRef
22.
go back to reference Mulligan HF, Hale LA, Whitehead L, Baxter GD. Barriers to physical activity for people with long-term neurological conditions: a review study. Adapt Phys Act Q. 2012;29:243–65.CrossRef Mulligan HF, Hale LA, Whitehead L, Baxter GD. Barriers to physical activity for people with long-term neurological conditions: a review study. Adapt Phys Act Q. 2012;29:243–65.CrossRef
23.
go back to reference Woollacott MH, Shumway-Cook A, Nashner LM. Aging and posture control: changes in sensory organization and muscular coordination. Int J Aging Hum Dev. 1986;23:97–114.PubMedCrossRef Woollacott MH, Shumway-Cook A, Nashner LM. Aging and posture control: changes in sensory organization and muscular coordination. Int J Aging Hum Dev. 1986;23:97–114.PubMedCrossRef
24.
go back to reference Woollacott MH, Shumway-Cook A. Changes in posture control across the life span—a systems approach. Phys Ther. 1990;70:799–807.PubMedCrossRef Woollacott MH, Shumway-Cook A. Changes in posture control across the life span—a systems approach. Phys Ther. 1990;70:799–807.PubMedCrossRef
25.
go back to reference Bronte-Stewart HM, Minn AY, Rodrigues K, Buckley EL, Nashner LM. Postural instability in idiopathic Parkinson’s disease: the role of medication and unilateral pallidotomy. Brain J Neurol. 2002;125:2100–14.CrossRef Bronte-Stewart HM, Minn AY, Rodrigues K, Buckley EL, Nashner LM. Postural instability in idiopathic Parkinson’s disease: the role of medication and unilateral pallidotomy. Brain J Neurol. 2002;125:2100–14.CrossRef
26.
go back to reference Shivitz N, Koop MM, Fahimi J, Heit G, Bronte-Stewart HM. Bilateral subthalamic nucleus deep brain stimulation improves certain aspects of postural control in Parkinson’s disease, whereas medication does not. Mov Disord. 2006;21:1088–97.PubMedCrossRef Shivitz N, Koop MM, Fahimi J, Heit G, Bronte-Stewart HM. Bilateral subthalamic nucleus deep brain stimulation improves certain aspects of postural control in Parkinson’s disease, whereas medication does not. Mov Disord. 2006;21:1088–97.PubMedCrossRef
27.
go back to reference Visser M, Marinus J, Bloem BR, Kisjes H, van den Berg BM, van Hilten JJ. Clinical tests for the evaluation of postural instability in patients with Parkinson’s disease. Arch Phys Med Rehabil. 2003;84:1669–74.PubMedCrossRef Visser M, Marinus J, Bloem BR, Kisjes H, van den Berg BM, van Hilten JJ. Clinical tests for the evaluation of postural instability in patients with Parkinson’s disease. Arch Phys Med Rehabil. 2003;84:1669–74.PubMedCrossRef
29.
go back to reference Jacobs JV, Horak FB, Tran VK, Nutt JG. Multiple balance tests improve the assessment of postural stability in subjects with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2006;77:322–6.PubMedPubMedCentralCrossRef Jacobs JV, Horak FB, Tran VK, Nutt JG. Multiple balance tests improve the assessment of postural stability in subjects with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2006;77:322–6.PubMedPubMedCentralCrossRef
30.
go back to reference Bloem BR, Beckley DJ, van Hilten BJ, Roos RA. Clinimetrics of postural instability in Parkinson’s disease. J Neurol. 1998;245:669–73.PubMedCrossRef Bloem BR, Beckley DJ, van Hilten BJ, Roos RA. Clinimetrics of postural instability in Parkinson’s disease. J Neurol. 1998;245:669–73.PubMedCrossRef
31.
go back to reference Munhoz RP, Li J-Y, Kurtinecz M, Piboolnurak P, Constantino A, Fahn S, et al. Evaluation of the pull test technique in assessing postural instability in Parkinson’s disease. Neurology. 2004;62:125–7.PubMedCrossRef Munhoz RP, Li J-Y, Kurtinecz M, Piboolnurak P, Constantino A, Fahn S, et al. Evaluation of the pull test technique in assessing postural instability in Parkinson’s disease. Neurology. 2004;62:125–7.PubMedCrossRef
32.
go back to reference Jacobs JV, Horak FB, Van Tran K, Nutt JG. An alternative clinical postural stability test for patients with Parkinson’s disease. J Neurol. 2006;253:1404–13.PubMedCrossRef Jacobs JV, Horak FB, Van Tran K, Nutt JG. An alternative clinical postural stability test for patients with Parkinson’s disease. J Neurol. 2006;253:1404–13.PubMedCrossRef
33.
go back to reference Nonnekes J, Goselink R, Weerdesteyn V, Bloem BR. The retropulsion test: a good evaluation of postural instability in Parkinson’s disease? J Parkinson Dis. 2015;5:43–7. Nonnekes J, Goselink R, Weerdesteyn V, Bloem BR. The retropulsion test: a good evaluation of postural instability in Parkinson’s disease? J Parkinson Dis. 2015;5:43–7.
34.
go back to reference Ebersbach G, Gunkel M. Posturography reflects clinical imbalance in Parkinson’s disease. Mov Disord. 2011;26:241–6.PubMedCrossRef Ebersbach G, Gunkel M. Posturography reflects clinical imbalance in Parkinson’s disease. Mov Disord. 2011;26:241–6.PubMedCrossRef
35.
go back to reference Ganesan M, Pal PK, Gupta A, Sathyaprabha TN. Dynamic posturography in evaluation of balance in patients of Parkinson’s disease with normal pull test: concept of a diagonal pull test. Parkinsonism Relat Disord. 2010;16:595–9.PubMedCrossRef Ganesan M, Pal PK, Gupta A, Sathyaprabha TN. Dynamic posturography in evaluation of balance in patients of Parkinson’s disease with normal pull test: concept of a diagonal pull test. Parkinsonism Relat Disord. 2010;16:595–9.PubMedCrossRef
36.
go back to reference Frenklach A, Louie S, Koop MM, Bronte-Stewart H. Excessive postural sway and the risk of falls at different stages of Parkinson’s disease. Mov Disord. 2009;24:377–85.PubMedCrossRef Frenklach A, Louie S, Koop MM, Bronte-Stewart H. Excessive postural sway and the risk of falls at different stages of Parkinson’s disease. Mov Disord. 2009;24:377–85.PubMedCrossRef
37.
go back to reference Rocchi L, Chiari L, Horak FB. Effects of deep brain stimulation and levodopa on postural sway in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2002;73:267–74.PubMedPubMedCentralCrossRef Rocchi L, Chiari L, Horak FB. Effects of deep brain stimulation and levodopa on postural sway in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2002;73:267–74.PubMedPubMedCentralCrossRef
38.
go back to reference Nantel J, McDonald JC, Bronte-Stewart H. Effect of medication and STN-DBS on postural control in subjects with Parkinson’s disease. Parkinsonism Relat Disord. 2012;18:285–9.PubMedCrossRef Nantel J, McDonald JC, Bronte-Stewart H. Effect of medication and STN-DBS on postural control in subjects with Parkinson’s disease. Parkinsonism Relat Disord. 2012;18:285–9.PubMedCrossRef
39.
go back to reference Maurer C, Mergner T, Xie J, Faist M, Pollak P, Lücking CH. Effect of chronic bilateral subthalamic nucleus (STN) stimulation on postural control in Parkinson’s disease. Brain J Neurol. 2003;126:1146–63.CrossRef Maurer C, Mergner T, Xie J, Faist M, Pollak P, Lücking CH. Effect of chronic bilateral subthalamic nucleus (STN) stimulation on postural control in Parkinson’s disease. Brain J Neurol. 2003;126:1146–63.CrossRef
40.
41.
go back to reference Beuter A, Hernández R, Rigal R, Modolo J, Blanchet PJ. Postural sway and effect of levodopa in early Parkinson’s disease. Can J Neurol Sci. 2008;35:65–8.PubMedCrossRef Beuter A, Hernández R, Rigal R, Modolo J, Blanchet PJ. Postural sway and effect of levodopa in early Parkinson’s disease. Can J Neurol Sci. 2008;35:65–8.PubMedCrossRef
42.
go back to reference Revilla FJ, Larsh TR, Mani A, Duker AP, Cox C, Succop P, et al. Effect of dopaminergic medication on postural sway in advanced Parkinson’s disease. Front Neurol. 2013;4:202.PubMedPubMedCentralCrossRef Revilla FJ, Larsh TR, Mani A, Duker AP, Cox C, Succop P, et al. Effect of dopaminergic medication on postural sway in advanced Parkinson’s disease. Front Neurol. 2013;4:202.PubMedPubMedCentralCrossRef
43.
go back to reference Johnson L, Rodrigues J, Teo W-P, Walters S, Stell R, Thickbroom G, et al. Interactive effects of GPI stimulation and levodopa on postural control in Parkinson’s disease. Gait Posture. 2015;41:929–34.PubMedCrossRef Johnson L, Rodrigues J, Teo W-P, Walters S, Stell R, Thickbroom G, et al. Interactive effects of GPI stimulation and levodopa on postural control in Parkinson’s disease. Gait Posture. 2015;41:929–34.PubMedCrossRef
44.
go back to reference St George RJ, Carlson-Kuhta P, Nutt JG, Hogarth P, Burchiel KJ, Horak FB. The effect of deep brain stimulation randomized by site on balance in Parkinson’s disease. Mov Disord. 2014;29:949–53.PubMedPubMedCentralCrossRef St George RJ, Carlson-Kuhta P, Nutt JG, Hogarth P, Burchiel KJ, Horak FB. The effect of deep brain stimulation randomized by site on balance in Parkinson’s disease. Mov Disord. 2014;29:949–53.PubMedPubMedCentralCrossRef
45.
go back to reference Guehl D, Cuny E, Benazzouz A, Rougier A, Tison F, Machado S, et al. Side-effects of subthalamic stimulation in Parkinson’s disease: clinical evolution and predictive factors. Eur J Neurol. 2006;13:963–71.PubMedCrossRef Guehl D, Cuny E, Benazzouz A, Rougier A, Tison F, Machado S, et al. Side-effects of subthalamic stimulation in Parkinson’s disease: clinical evolution and predictive factors. Eur J Neurol. 2006;13:963–71.PubMedCrossRef
46.
go back to reference Colnat-Coulbois S, Gauchard GC, Maillard L, Barroche G, Vespignani H, Auque J, et al. Bilateral subthalamic nucleus stimulation improves balance control in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2005;76:780–7.PubMedPubMedCentralCrossRef Colnat-Coulbois S, Gauchard GC, Maillard L, Barroche G, Vespignani H, Auque J, et al. Bilateral subthalamic nucleus stimulation improves balance control in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2005;76:780–7.PubMedPubMedCentralCrossRef
47.
go back to reference St George RJ, Nutt JG, Burchiel KJ, Horak FB. A meta-regression of the long-term effects of deep brain stimulation on balance and gait in PD. Neurology. 2010;75:1292–9.PubMedPubMedCentralCrossRef St George RJ, Nutt JG, Burchiel KJ, Horak FB. A meta-regression of the long-term effects of deep brain stimulation on balance and gait in PD. Neurology. 2010;75:1292–9.PubMedPubMedCentralCrossRef
48.
go back to reference Allen NE, Sherrington C, Paul SS, Canning CG. Balance and falls in Parkinson’s disease: a meta-analysis of the effect of exercise and motor training. Mov Disord. 2011;26:1605–15.PubMedCrossRef Allen NE, Sherrington C, Paul SS, Canning CG. Balance and falls in Parkinson’s disease: a meta-analysis of the effect of exercise and motor training. Mov Disord. 2011;26:1605–15.PubMedCrossRef
49.
go back to reference Yang Y, Qiu WQ, Hao YL, Lv ZY, Jiao SJ, Teng JF. The efficacy of traditional Chinese Medical Exercise for Parkinson’s disease: a systematic review and meta-analysis. PLoS One. 2015;10:e0122469.PubMedPubMedCentralCrossRef Yang Y, Qiu WQ, Hao YL, Lv ZY, Jiao SJ, Teng JF. The efficacy of traditional Chinese Medical Exercise for Parkinson’s disease: a systematic review and meta-analysis. PLoS One. 2015;10:e0122469.PubMedPubMedCentralCrossRef
50.
go back to reference Cascaes da Silva F, Iop Rda R, Domingos Dos Santos P, Aguiar Bezerra de Melo LM, Barbosa Gutierres Filho PJ, da Silva R. Effects of physical-exercise-based rehabilitation programs on the quality of life of patients with Parkinson’s disease: a systematic review of randomized controlled trials. J Aging Phys Act. 2016;24:484–96.PubMedCrossRef Cascaes da Silva F, Iop Rda R, Domingos Dos Santos P, Aguiar Bezerra de Melo LM, Barbosa Gutierres Filho PJ, da Silva R. Effects of physical-exercise-based rehabilitation programs on the quality of life of patients with Parkinson’s disease: a systematic review of randomized controlled trials. J Aging Phys Act. 2016;24:484–96.PubMedCrossRef
51.
go back to reference Li F, Harmer P, Fitzgerald K, Eckstrom E, Stock R, Galver J, et al. Tai chi and postural stability in patients with Parkinson’s disease. N Engl J Med. 2012;366:511–9.PubMedPubMedCentralCrossRef Li F, Harmer P, Fitzgerald K, Eckstrom E, Stock R, Galver J, et al. Tai chi and postural stability in patients with Parkinson’s disease. N Engl J Med. 2012;366:511–9.PubMedPubMedCentralCrossRef
52.
go back to reference Bloem BR, Grimbergen YA, Cramer M, Willemsen M, Zwinderman AH. Prospective assessment of falls in Parkinson’s disease. J Neurol. 2001;248:950–8.PubMedCrossRef Bloem BR, Grimbergen YA, Cramer M, Willemsen M, Zwinderman AH. Prospective assessment of falls in Parkinson’s disease. J Neurol. 2001;248:950–8.PubMedCrossRef
53.
go back to reference Pickering RM, Grimbergen YAM, Rigney U, Ashburn A, Mazibrada G, Wood B, et al. A meta-analysis of six prospective studies of falling in Parkinson’s disease. Mov Disord. 2007;22:1892–900.PubMedCrossRef Pickering RM, Grimbergen YAM, Rigney U, Ashburn A, Mazibrada G, Wood B, et al. A meta-analysis of six prospective studies of falling in Parkinson’s disease. Mov Disord. 2007;22:1892–900.PubMedCrossRef
54.
go back to reference Wood BH, Bilclough JA, Bowron A, Walker RW. Incidence and prediction of falls in Parkinson’s disease: a prospective multidisciplinary study. J Neurol Neurosurg Psychiatry. 2002;72:721–5.PubMedPubMedCentralCrossRef Wood BH, Bilclough JA, Bowron A, Walker RW. Incidence and prediction of falls in Parkinson’s disease: a prospective multidisciplinary study. J Neurol Neurosurg Psychiatry. 2002;72:721–5.PubMedPubMedCentralCrossRef
55.
go back to reference Allen NE, Schwarzel AK, Canning CG. Recurrent falls in Parkinson’s disease: a systematic review. Parkinsons Dis. 2013;2013:906274.PubMedPubMedCentral Allen NE, Schwarzel AK, Canning CG. Recurrent falls in Parkinson’s disease: a systematic review. Parkinsons Dis. 2013;2013:906274.PubMedPubMedCentral
56.
go back to reference Almeida LRS, Sherrington C, Allen NE, Paul SS, Valenca GT, Oliveira-Filho J, et al. Disability is an independent predictor of falls and recurrent falls in people with Parkinson’s disease without a history of falls: a one-year prospective study. J Parkinsons Dis. 2015;5:855–64.PubMedCrossRef Almeida LRS, Sherrington C, Allen NE, Paul SS, Valenca GT, Oliveira-Filho J, et al. Disability is an independent predictor of falls and recurrent falls in people with Parkinson’s disease without a history of falls: a one-year prospective study. J Parkinsons Dis. 2015;5:855–64.PubMedCrossRef
57.
go back to reference Lindholm B, Nilsson MH, Hansson O, Hagell P. External validation of a 3-step falls prediction model in mild Parkinson’s disease. J Neurol. 2016;263:2462–9.PubMedPubMedCentralCrossRef Lindholm B, Nilsson MH, Hansson O, Hagell P. External validation of a 3-step falls prediction model in mild Parkinson’s disease. J Neurol. 2016;263:2462–9.PubMedPubMedCentralCrossRef
58.
go back to reference Paul SS, Canning CG, Sherrington C, Lord SR, Close JCT, Fung VSC. Three simple clinical tests to accurately predict falls in people with Parkinson’s disease. Mov Disord. 2013;28:655–62.PubMedCrossRef Paul SS, Canning CG, Sherrington C, Lord SR, Close JCT, Fung VSC. Three simple clinical tests to accurately predict falls in people with Parkinson’s disease. Mov Disord. 2013;28:655–62.PubMedCrossRef
59.
go back to reference Duncan RP, Cavanaugh JT, Earhart GM, Ellis TD, Ford MP, Foreman KB, et al. External validation of a simple clinical tool used to predict falls in people with Parkinson disease. Parkinsonism Relat Disord. 2015;21:960–3.PubMedPubMedCentralCrossRef Duncan RP, Cavanaugh JT, Earhart GM, Ellis TD, Ford MP, Foreman KB, et al. External validation of a simple clinical tool used to predict falls in people with Parkinson disease. Parkinsonism Relat Disord. 2015;21:960–3.PubMedPubMedCentralCrossRef
62.
go back to reference Patel P, Lamar M, Bhatt T. Effect of type of cognitive task and walking speed on cognitive-motor interference during dual-task walking. Neuroscience. 2014;260:140–8.PubMedCrossRef Patel P, Lamar M, Bhatt T. Effect of type of cognitive task and walking speed on cognitive-motor interference during dual-task walking. Neuroscience. 2014;260:140–8.PubMedCrossRef
63.
go back to reference Schubert T. The central attentional limitation and executive control. Front Biosci. 2008;13:3569–80.PubMedCrossRef Schubert T. The central attentional limitation and executive control. Front Biosci. 2008;13:3569–80.PubMedCrossRef
64.
go back to reference Nieuwboer A, Giladi N. Characterizing freezing of gait in Parkinson’s disease: models of an episodic phenomenon. Mov Disord. 2013;28:1509–19.PubMedCrossRef Nieuwboer A, Giladi N. Characterizing freezing of gait in Parkinson’s disease: models of an episodic phenomenon. Mov Disord. 2013;28:1509–19.PubMedCrossRef
65.
go back to reference Galna B, Lord S, Burn DJ, Rochester L. Progression of gait dysfunction in incident Parkinson’s disease: impact of medication and phenotype. Mov Disord. 2015;30:359–67.PubMedCrossRef Galna B, Lord S, Burn DJ, Rochester L. Progression of gait dysfunction in incident Parkinson’s disease: impact of medication and phenotype. Mov Disord. 2015;30:359–67.PubMedCrossRef
66.
go back to reference Giladi N, Nieuwboer A. Understanding and treating freezing of gait in parkinsonism, proposed working definition, and setting the stage. Mov Disord. 2008;23(Suppl 2):S423–5.PubMedCrossRef Giladi N, Nieuwboer A. Understanding and treating freezing of gait in parkinsonism, proposed working definition, and setting the stage. Mov Disord. 2008;23(Suppl 2):S423–5.PubMedCrossRef
67.
go back to reference Hely MA, Reid WGJ, Adena MA, Halliday GM, Morris JGL. The Sydney multicenter study of Parkinson’s disease: the inevitability of dementia at 20 years. Mov Disord. 2008;23:837–44.PubMedCrossRef Hely MA, Reid WGJ, Adena MA, Halliday GM, Morris JGL. The Sydney multicenter study of Parkinson’s disease: the inevitability of dementia at 20 years. Mov Disord. 2008;23:837–44.PubMedCrossRef
68.
go back to reference Baker K, Rochester L, Nieuwboer A. The effect of cues on gait variability—reducing the attentional cost of walking in people with Parkinson’s disease. Parkinsonism Relat Disord. 2008;14:314–20.PubMedCrossRef Baker K, Rochester L, Nieuwboer A. The effect of cues on gait variability—reducing the attentional cost of walking in people with Parkinson’s disease. Parkinsonism Relat Disord. 2008;14:314–20.PubMedCrossRef
69.
go back to reference Ginis P, Heremans E, Ferrari A, Bekkers EMJ, Canning CG, Nieuwboer A. External input for gait in people with Parkinson’s disease with and without freezing of gait: one size does not fit all. J Neurol. 2017;264:1488–96.PubMedCrossRef Ginis P, Heremans E, Ferrari A, Bekkers EMJ, Canning CG, Nieuwboer A. External input for gait in people with Parkinson’s disease with and without freezing of gait: one size does not fit all. J Neurol. 2017;264:1488–96.PubMedCrossRef
72.
go back to reference Giladi N, McDermott MP, Fahn S, Przedborski S, Jankovic J, Stern M, et al. Freezing of gait in PD: prospective assessment in the DATATOP cohort. Neurology. 2001;56:1712–21.PubMedCrossRef Giladi N, McDermott MP, Fahn S, Przedborski S, Jankovic J, Stern M, et al. Freezing of gait in PD: prospective assessment in the DATATOP cohort. Neurology. 2001;56:1712–21.PubMedCrossRef
73.
go back to reference Forsaa EB, Larsen JP, Wentzel-Larsen T, Alves G. A 12-year population-based study of freezing of gait in Parkinson’s disease. Parkinsonism Relat Disord. 2015;21:254–8.PubMedCrossRef Forsaa EB, Larsen JP, Wentzel-Larsen T, Alves G. A 12-year population-based study of freezing of gait in Parkinson’s disease. Parkinsonism Relat Disord. 2015;21:254–8.PubMedCrossRef
74.
go back to reference Macht M, Kaussner Y, Möller JC, Stiasny-Kolster K, Eggert KM, Krüger H-P, et al. Predictors of freezing in Parkinson’s disease: a survey of 6,620 patients. Mov Disord. 2007;22:953–6.PubMedCrossRef Macht M, Kaussner Y, Möller JC, Stiasny-Kolster K, Eggert KM, Krüger H-P, et al. Predictors of freezing in Parkinson’s disease: a survey of 6,620 patients. Mov Disord. 2007;22:953–6.PubMedCrossRef
75.
go back to reference Vercruysse S, Devos H, Munks L, Spildooren J, Vandenbossche J, Vandenberghe W, et al. Explaining freezing of gait in Parkinson’s disease: motor and cognitive determinants. Mov Disord. 2012;27:1644–51.PubMedCrossRef Vercruysse S, Devos H, Munks L, Spildooren J, Vandenbossche J, Vandenberghe W, et al. Explaining freezing of gait in Parkinson’s disease: motor and cognitive determinants. Mov Disord. 2012;27:1644–51.PubMedCrossRef
76.
go back to reference Factor SA, Scullin MK, Sollinger AB, Land JO, Wood-Siverio C, Zanders L, et al. Freezing of gait subtypes have different cognitive correlates in Parkinson’s disease. Parkinsonism Relat Disord. 2014;20:1359–64.PubMedCrossRef Factor SA, Scullin MK, Sollinger AB, Land JO, Wood-Siverio C, Zanders L, et al. Freezing of gait subtypes have different cognitive correlates in Parkinson’s disease. Parkinsonism Relat Disord. 2014;20:1359–64.PubMedCrossRef
77.
go back to reference Walton CC, Shine JM, Hall JM, O’Callaghan C, Mowszowski L, Gilat M, et al. The major impact of freezing of gait on quality of life in Parkinson’s disease. J Neurol. 2015;262:108–15.PubMedCrossRef Walton CC, Shine JM, Hall JM, O’Callaghan C, Mowszowski L, Gilat M, et al. The major impact of freezing of gait on quality of life in Parkinson’s disease. J Neurol. 2015;262:108–15.PubMedCrossRef
78.
go back to reference Henderson EJ, Lord SR, Brodie MA, Gaunt DM, Lawrence AD, Close JC, et al. Rivastigmine for gait stability in patients with Parkinson’s disease (ReSPonD): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Neurol. 2016;15:249–58.PubMedCrossRef Henderson EJ, Lord SR, Brodie MA, Gaunt DM, Lawrence AD, Close JC, et al. Rivastigmine for gait stability in patients with Parkinson’s disease (ReSPonD): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Neurol. 2016;15:249–58.PubMedCrossRef
79.
go back to reference Ferraye MU, Debû B, Pollak P. Deep brain stimulation effect on freezing of gait. Mov Disord. 2008;23:S489–94.PubMedCrossRef Ferraye MU, Debû B, Pollak P. Deep brain stimulation effect on freezing of gait. Mov Disord. 2008;23:S489–94.PubMedCrossRef
80.
go back to reference Ferraye MU, Ardouin C, Lhommée E, Fraix V, Krack P, Chabardès S, et al. Levodopa-resistant freezing of gait and executive dysfunction in Parkinson’s disease. Eur Neurol. 2013;69:281–8.PubMedCrossRef Ferraye MU, Ardouin C, Lhommée E, Fraix V, Krack P, Chabardès S, et al. Levodopa-resistant freezing of gait and executive dysfunction in Parkinson’s disease. Eur Neurol. 2013;69:281–8.PubMedCrossRef
81.
go back to reference Espay AJ, Fasano A, van Nuenen BFL, Payne MM, Snijders AH, Bloem BR. “On” state freezing of gait in Parkinson disease: a paradoxical levodopa-induced complication. Neurology. 2012;78:454–7.PubMedPubMedCentralCrossRef Espay AJ, Fasano A, van Nuenen BFL, Payne MM, Snijders AH, Bloem BR. “On” state freezing of gait in Parkinson disease: a paradoxical levodopa-induced complication. Neurology. 2012;78:454–7.PubMedPubMedCentralCrossRef
82.
go back to reference Smulders K, Dale ML, Carlson-Kuhta P, Nutt JG, Horak FB. Pharmacological treatment in Parkinson's disease: Effects on gait. Parkinsonism Relat Disord. 2016;31:3–13. Smulders K, Dale ML, Carlson-Kuhta P, Nutt JG, Horak FB. Pharmacological treatment in Parkinson's disease: Effects on gait. Parkinsonism Relat Disord. 2016;31:3–13.
83.
go back to reference Rascol O. The pharmacological therapeutic management of levodopa-induced dyskinesias in patients with Parkinson’s disease. J Neurol. 2000;247(Suppl 2):II51–7.PubMed Rascol O. The pharmacological therapeutic management of levodopa-induced dyskinesias in patients with Parkinson’s disease. J Neurol. 2000;247(Suppl 2):II51–7.PubMed
84.
go back to reference Ikeda K, Hirayama T, Takazawa T, Kawabe K, Iwasaki Y. Transdermal patch of rotigotine attenuates freezing of gait in patients with Parkinson’s disease: an open-label comparative study of three non-ergot dopamine receptor agonists. Intern Med (Tokyo). 2016;55:2765–9.CrossRef Ikeda K, Hirayama T, Takazawa T, Kawabe K, Iwasaki Y. Transdermal patch of rotigotine attenuates freezing of gait in patients with Parkinson’s disease: an open-label comparative study of three non-ergot dopamine receptor agonists. Intern Med (Tokyo). 2016;55:2765–9.CrossRef
85.
go back to reference Chung KA, Lobb BM, Nutt JG, et al. Effects of a central cholinesterase inhibitor on reducing falls in Parkinson disease. Neurology. 2010;75:1263–9. Chung KA, Lobb BM, Nutt JG, et al. Effects of a central cholinesterase inhibitor on reducing falls in Parkinson disease. Neurology. 2010;75:1263–9.
86.
go back to reference Rascol O, Brooks DJ, Melamed E, Oertel W, Poewe W, Stocchi F, Tolosa E; LARGO study group. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial. Lancet. 2005;365(9463):947–54. Rascol O, Brooks DJ, Melamed E, Oertel W, Poewe W, Stocchi F, Tolosa E; LARGO study group. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial. Lancet. 2005;365(9463):947–54.
87.
go back to reference Espay AJ, Dwivedi AK, Payne M, Gaines L, Vaughan JE, Maddux BN, et al. Methylphenidate for gait impairment in Parkinson disease: a randomized clinical trial. Neurology. 2011;76:1256–62.PubMedPubMedCentralCrossRef Espay AJ, Dwivedi AK, Payne M, Gaines L, Vaughan JE, Maddux BN, et al. Methylphenidate for gait impairment in Parkinson disease: a randomized clinical trial. Neurology. 2011;76:1256–62.PubMedPubMedCentralCrossRef
88.
go back to reference Moreau C, Delval A, Defebvre L, Dujardin K, Duhamel A, Petyt G, et al. Methylphenidate for gait hypokinesia and freezing in patients with Parkinson’s disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial. Lancet Neurol. 2012;11:589–96.PubMedCrossRef Moreau C, Delval A, Defebvre L, Dujardin K, Duhamel A, Petyt G, et al. Methylphenidate for gait hypokinesia and freezing in patients with Parkinson’s disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial. Lancet Neurol. 2012;11:589–96.PubMedCrossRef
89.
go back to reference Malkani R, Zadikoff C, Melen O, Videnovic A, Borushko E, Simuni T. Amantadine for freezing of gait in patients with Parkinson disease. Clin Neuropharmacol. 2012;35:266–8.PubMedPubMedCentralCrossRef Malkani R, Zadikoff C, Melen O, Videnovic A, Borushko E, Simuni T. Amantadine for freezing of gait in patients with Parkinson disease. Clin Neuropharmacol. 2012;35:266–8.PubMedPubMedCentralCrossRef
90.
go back to reference Lee JY, Oh S, Kim JM, Kim JS, Oh E, Kim H-T, et al. Intravenous amantadine on freezing of gait in Parkinson’s disease: a randomized controlled trial. J Neurol. 2013;260:3030–8.PubMedCrossRef Lee JY, Oh S, Kim JM, Kim JS, Oh E, Kim H-T, et al. Intravenous amantadine on freezing of gait in Parkinson’s disease: a randomized controlled trial. J Neurol. 2013;260:3030–8.PubMedCrossRef
91.
go back to reference Chan HF, Kukkle PL, Merello M, Lim SY, Poon YY, Moro E. Amantadine improves gait in PD patients with STN stimulation. Parkinsonism Relat Disord. 2013;19(3):316–9. Chan HF, Kukkle PL, Merello M, Lim SY, Poon YY, Moro E. Amantadine improves gait in PD patients with STN stimulation. Parkinsonism Relat Disord. 2013;19(3):316–9.
92.
go back to reference Vaamonde Gamo J, Cabello JP, Gallardo Alcañiz MJ, Flores Barragan JM, Carrasco García de León S, Ibañez Alonso RE. Freezing of gait unresponsive to dopaminergic stimulation in patients with severe parkinsonism. Neurologia. 2010;25:27–31.PubMedCrossRef Vaamonde Gamo J, Cabello JP, Gallardo Alcañiz MJ, Flores Barragan JM, Carrasco García de León S, Ibañez Alonso RE. Freezing of gait unresponsive to dopaminergic stimulation in patients with severe parkinsonism. Neurologia. 2010;25:27–31.PubMedCrossRef
93.
go back to reference Devos D; French DUODOPA Study Group. Patient profile, indications, efficacy and safety of duodenal levodopa infusion in advanced Parkinson’s disease. Mov Disord. 2009 May 15;24(7):993–1000. Devos D; French DUODOPA Study Group. Patient profile, indications, efficacy and safety of duodenal levodopa infusion in advanced Parkinson’s disease. Mov Disord. 2009 May 15;24(7):993–1000.
94.
go back to reference Fukada K, Endo T, Yokoe M, Hamasaki T, Hazama T, Sakoda S. L-threo-3,4-dihydroxyphenylserine (L-DOPS) co-administered with entacapone improves freezing of gait in Parkinson’s disease. Med Hypotheses. 2013;80(2):209–12. Fukada K, Endo T, Yokoe M, Hamasaki T, Hazama T, Sakoda S. L-threo-3,4-dihydroxyphenylserine (L-DOPS) co-administered with entacapone improves freezing of gait in Parkinson’s disease. Med Hypotheses. 2013;80(2):209–12.
95.
go back to reference Chang FCF, Tsui DS, Mahant N, Wolfe N, Kim SD, Ha AD, et al. 24 h levodopa-carbidopa intestinal gel may reduce falls and “unresponsive” freezing of gait in Parkinson’s disease. Parkinsonism Relat Disord. 2015;21:317–20.PubMedCrossRef Chang FCF, Tsui DS, Mahant N, Wolfe N, Kim SD, Ha AD, et al. 24 h levodopa-carbidopa intestinal gel may reduce falls and “unresponsive” freezing of gait in Parkinson’s disease. Parkinsonism Relat Disord. 2015;21:317–20.PubMedCrossRef
96.
go back to reference Ferraye MU, Debu B, Fraix V, Xie-Brustolin J, Chabardes S, Krack P, et al. Effects of subthalamic nucleus stimulation and levodopa on freezing of gait in Parkinson disease. Neurology. 2008;70:1431–7.PubMedCrossRef Ferraye MU, Debu B, Fraix V, Xie-Brustolin J, Chabardes S, Krack P, et al. Effects of subthalamic nucleus stimulation and levodopa on freezing of gait in Parkinson disease. Neurology. 2008;70:1431–7.PubMedCrossRef
97.
98.
go back to reference Sensi M, Preda F, Trevisani L, Contini E, Gragnaniello D, Capone JG, et al. Emerging issues on selection criteria of levodopa carbidopa infusion therapy: considerations on outcome of 28 consecutive patients. J Neural Transm (Vienna). 2014;121:633–42.CrossRef Sensi M, Preda F, Trevisani L, Contini E, Gragnaniello D, Capone JG, et al. Emerging issues on selection criteria of levodopa carbidopa infusion therapy: considerations on outcome of 28 consecutive patients. J Neural Transm (Vienna). 2014;121:633–42.CrossRef
99.
go back to reference Cossu G, Ricchi V, Pilleri M, Mancini F, Murgia D, Ricchieri G, et al. Levodopa-carbidopa intrajejunal gel in advanced Parkinson disease with “on” freezing of gait. Neurol Sci. 2015;36:1683–6.PubMedCrossRef Cossu G, Ricchi V, Pilleri M, Mancini F, Murgia D, Ricchieri G, et al. Levodopa-carbidopa intrajejunal gel in advanced Parkinson disease with “on” freezing of gait. Neurol Sci. 2015;36:1683–6.PubMedCrossRef
100.
go back to reference Rascol O, Perez-Lloret S, Ferreira JJ. New treatments for levodopa-induced motor complications. Mov Disord. 2015;30:1451–60.PubMedCrossRef Rascol O, Perez-Lloret S, Ferreira JJ. New treatments for levodopa-induced motor complications. Mov Disord. 2015;30:1451–60.PubMedCrossRef
101.
go back to reference Stolze H, Klebe S, Poepping M, Lorenz D, Herzog J, Hamel W, et al. Effects of bilateral subthalamic nucleus stimulation on parkinsonian gait. Neurology. 2001;57:144–6.PubMedCrossRef Stolze H, Klebe S, Poepping M, Lorenz D, Herzog J, Hamel W, et al. Effects of bilateral subthalamic nucleus stimulation on parkinsonian gait. Neurology. 2001;57:144–6.PubMedCrossRef
102.
go back to reference Bakker M, Esselink RAJ, Munneke M, Limousin-Dowsey P, Speelman HD, Bloem BR. Effects of stereotactic neurosurgery on postural instability and gait in Parkinson’s disease. Mov Disord. 2004;19:1092–9.PubMedCrossRef Bakker M, Esselink RAJ, Munneke M, Limousin-Dowsey P, Speelman HD, Bloem BR. Effects of stereotactic neurosurgery on postural instability and gait in Parkinson’s disease. Mov Disord. 2004;19:1092–9.PubMedCrossRef
103.
go back to reference Schlenstedt C, Shalash A, Muthuraman M, Falk D, Witt K, Deuschl G. Effect of high-frequency subthalamic neurostimulation on gait and freezing of gait in Parkinson’s disease: a systematic review and meta-analysis. Eur J Neurol. 2017;24:18–26.PubMedCrossRef Schlenstedt C, Shalash A, Muthuraman M, Falk D, Witt K, Deuschl G. Effect of high-frequency subthalamic neurostimulation on gait and freezing of gait in Parkinson’s disease: a systematic review and meta-analysis. Eur J Neurol. 2017;24:18–26.PubMedCrossRef
104.
go back to reference Weaver FM, Follett K, Stern M, Hur K, Harris C, Marks WJ, et al. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA. 2009;301:63–73.PubMedPubMedCentralCrossRef Weaver FM, Follett K, Stern M, Hur K, Harris C, Marks WJ, et al. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA. 2009;301:63–73.PubMedPubMedCentralCrossRef
105.
go back to reference Moreau C, Defebvre L, Destee A, Bleuse S, Clement F, Blatt JL, et al. STN-DBS frequency effects on freezing of gait in advanced Parkinson disease. Neurology. 2008;71:80–4.PubMedCrossRef Moreau C, Defebvre L, Destee A, Bleuse S, Clement F, Blatt JL, et al. STN-DBS frequency effects on freezing of gait in advanced Parkinson disease. Neurology. 2008;71:80–4.PubMedCrossRef
106.
go back to reference Brozova H, Barnaure I, Alterman RL, Tagliati M. STN-DBS frequency effects on freezing of gait in advanced Parkinson disease. Neurology. 2009;72:770. author reply 770-771PubMedCrossRef Brozova H, Barnaure I, Alterman RL, Tagliati M. STN-DBS frequency effects on freezing of gait in advanced Parkinson disease. Neurology. 2009;72:770. author reply 770-771PubMedCrossRef
107.
go back to reference Ricchi V, Zibetti M, Angrisano S, Merola A, Arduino N, Artusi CA, et al. Transient effects of 80 Hz stimulation on gait in STN DBS treated PD patients: a 15 months follow-up study. Brain Stimul. 2012;5:388–92.PubMedCrossRef Ricchi V, Zibetti M, Angrisano S, Merola A, Arduino N, Artusi CA, et al. Transient effects of 80 Hz stimulation on gait in STN DBS treated PD patients: a 15 months follow-up study. Brain Stimul. 2012;5:388–92.PubMedCrossRef
108.
go back to reference Xie T, Vigil J, MacCracken E, Gasparaitis A, Young J, Kang W, et al. Low-frequency stimulation of STN-DBS reduces aspiration and freezing of gait in patients with PD. Neurology. 2015;84:415–20.PubMedPubMedCentralCrossRef Xie T, Vigil J, MacCracken E, Gasparaitis A, Young J, Kang W, et al. Low-frequency stimulation of STN-DBS reduces aspiration and freezing of gait in patients with PD. Neurology. 2015;84:415–20.PubMedPubMedCentralCrossRef
109.
go back to reference Sidiropoulos C, Walsh R, Meaney C, Poon YY, Fallis M, Moro E. Low-frequency subthalamic nucleus deep brain stimulation for axial symptoms in advanced Parkinson’s disease. J Neurol. 2013;260:2306–11.PubMedCrossRef Sidiropoulos C, Walsh R, Meaney C, Poon YY, Fallis M, Moro E. Low-frequency subthalamic nucleus deep brain stimulation for axial symptoms in advanced Parkinson’s disease. J Neurol. 2013;260:2306–11.PubMedCrossRef
110.
go back to reference Khoo HM, Kishima H, Hosomi K, Maruo T, Tani N, Oshino S, et al. Low-frequency subthalamic nucleus stimulation in Parkinson’s disease: a randomized clinical trial: 60-HZ STN-DBS in Parkinson’s disease. Mov Disord. 2014;29:270–4.PubMedCrossRef Khoo HM, Kishima H, Hosomi K, Maruo T, Tani N, Oshino S, et al. Low-frequency subthalamic nucleus stimulation in Parkinson’s disease: a randomized clinical trial: 60-HZ STN-DBS in Parkinson’s disease. Mov Disord. 2014;29:270–4.PubMedCrossRef
111.
go back to reference Khoo HM, Kishima H, Oshino S, Yoshimine T. Reply to: Low-frequency subthalamic nucleus stimulation in Parkinson’s disease: a randomized clinical trial. Mov Disord. 2014;29:1569–70.PubMedCrossRef Khoo HM, Kishima H, Oshino S, Yoshimine T. Reply to: Low-frequency subthalamic nucleus stimulation in Parkinson’s disease: a randomized clinical trial. Mov Disord. 2014;29:1569–70.PubMedCrossRef
112.
go back to reference Phibbs FT, Arbogast PG, Davis TL. 60-Hz frequency effect on gait in Parkinson’s disease with subthalamic nucleus deep brain stimulation: 60 Hz STN DBS effect on gait in Parkinson’s disease. Neuromodulation. 2014;17:717–20.PubMedCrossRef Phibbs FT, Arbogast PG, Davis TL. 60-Hz frequency effect on gait in Parkinson’s disease with subthalamic nucleus deep brain stimulation: 60 Hz STN DBS effect on gait in Parkinson’s disease. Neuromodulation. 2014;17:717–20.PubMedCrossRef
113.
go back to reference Vallabhajosula S, Haq IU, Hwynn N, Oyama G, Okun M, Tillman MD, et al. Low-frequency versus high-frequency subthalamic nucleus deep brain stimulation on postural control and gait in Parkinson’s disease: a quantitative study. Brain Stimul. 2015;8:64–75.PubMedCrossRef Vallabhajosula S, Haq IU, Hwynn N, Oyama G, Okun M, Tillman MD, et al. Low-frequency versus high-frequency subthalamic nucleus deep brain stimulation on postural control and gait in Parkinson’s disease: a quantitative study. Brain Stimul. 2015;8:64–75.PubMedCrossRef
114.
go back to reference Baizabal-Carvallo JF, Alonso-Juarez M. Low-frequency deep brain stimulation for movement disorders. Parkinsonism Relat Disord. 2016;31:14–22.PubMedCrossRef Baizabal-Carvallo JF, Alonso-Juarez M. Low-frequency deep brain stimulation for movement disorders. Parkinsonism Relat Disord. 2016;31:14–22.PubMedCrossRef
115.
go back to reference di Biase L, Fasano A. Low-frequency deep brain stimulation for Parkinson’s disease: great expectation or false hope? Mov Disord. 2016;31:962–7.PubMedCrossRef di Biase L, Fasano A. Low-frequency deep brain stimulation for Parkinson’s disease: great expectation or false hope? Mov Disord. 2016;31:962–7.PubMedCrossRef
116.
go back to reference Chastan N, Westby GWM, Yelnik J, Bardinet E, Do MC, Agid Y, et al. Effects of nigral stimulation on locomotion and postural stability in patients with Parkinson’s disease. Brain. 2008;132:172–84.PubMedCrossRef Chastan N, Westby GWM, Yelnik J, Bardinet E, Do MC, Agid Y, et al. Effects of nigral stimulation on locomotion and postural stability in patients with Parkinson’s disease. Brain. 2008;132:172–84.PubMedCrossRef
117.
go back to reference Weiss D, Walach M, Meisner C, Fritz M, Scholten M, Breit S, et al. Nigral stimulation for resistant axial motor impairment in Parkinson’s disease? A randomized controlled trial. Brain J Neurol. 2013;136:2098–108.CrossRef Weiss D, Walach M, Meisner C, Fritz M, Scholten M, Breit S, et al. Nigral stimulation for resistant axial motor impairment in Parkinson’s disease? A randomized controlled trial. Brain J Neurol. 2013;136:2098–108.CrossRef
118.
go back to reference Fasano A, Herzog J, Seifert E, Stolze H, Falk D, Reese R, et al. Modulation of gait coordination by subthalamic stimulation improves freezing of gait. Mov Disord. 2011;26:844–51.PubMedCrossRef Fasano A, Herzog J, Seifert E, Stolze H, Falk D, Reese R, et al. Modulation of gait coordination by subthalamic stimulation improves freezing of gait. Mov Disord. 2011;26:844–51.PubMedCrossRef
119.
go back to reference Mazzone P, Lozano A, Stanzione P, Galati S, Scarnati E, Peppe A, et al. Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson’s disease. Neuroreport. 2005;16:1877–81.PubMedCrossRef Mazzone P, Lozano A, Stanzione P, Galati S, Scarnati E, Peppe A, et al. Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson’s disease. Neuroreport. 2005;16:1877–81.PubMedCrossRef
120.
go back to reference Plaha P, Gill SS. Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson’s disease. Neuroreport. 2005;16:1883–7.PubMedCrossRef Plaha P, Gill SS. Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson’s disease. Neuroreport. 2005;16:1883–7.PubMedCrossRef
121.
go back to reference Stefani A, Lozano AM, Peppe A, Stanzione P, Galati S, Tropepi D, et al. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson’s disease. Brain. 2007;130:1596–607.PubMedCrossRef Stefani A, Lozano AM, Peppe A, Stanzione P, Galati S, Tropepi D, et al. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson’s disease. Brain. 2007;130:1596–607.PubMedCrossRef
122.
go back to reference Ferraye MU, Debu B, Fraix V, Goetz L, Ardouin C, Yelnik J, et al. Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson’s disease. Brain. 2010;133:205–14.PubMedCrossRef Ferraye MU, Debu B, Fraix V, Goetz L, Ardouin C, Yelnik J, et al. Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson’s disease. Brain. 2010;133:205–14.PubMedCrossRef
123.
go back to reference Moro E, Hamani C, Poon Y-Y, Al-Khairallah T, Dostrovsky JO, Hutchison WD, et al. Unilateral pedunculopontine stimulation improves falls in Parkinson’s disease. Brain. 2010;133:215–24.PubMedCrossRef Moro E, Hamani C, Poon Y-Y, Al-Khairallah T, Dostrovsky JO, Hutchison WD, et al. Unilateral pedunculopontine stimulation improves falls in Parkinson’s disease. Brain. 2010;133:215–24.PubMedCrossRef
124.
go back to reference •• Thevathasan W, Debu B, Aziz T, Bloem BR, Blahak C, Butson C, et al. Pedunculopontine nucleus deep brain stimulation in Parkinson’s disease: a clinical review. Mov Disord. 2018;33:10–20. Conclusions of the Movement Disorders Society working group on PPN stimulation. Although the outcome is very variable between patients, published data suggest that freezing of gait and falls refractory to medication can be improved by low frequency stimulation of the PPN. PubMedCrossRef •• Thevathasan W, Debu B, Aziz T, Bloem BR, Blahak C, Butson C, et al. Pedunculopontine nucleus deep brain stimulation in Parkinson’s disease: a clinical review. Mov Disord. 2018;33:10–20. Conclusions of the Movement Disorders Society working group on PPN stimulation. Although the outcome is very variable between patients, published data suggest that freezing of gait and falls refractory to medication can be improved by low frequency stimulation of the PPN. PubMedCrossRef
125.
go back to reference Welter M-L, Demain A, Ewenczyk C, Czernecki V, Lau B, El Helou A, et al. PPNa-DBS for gait and balance disorders in Parkinson’s disease: a double-blind, randomised study. J Neurol. 2015;262:1515–25.PubMedCrossRef Welter M-L, Demain A, Ewenczyk C, Czernecki V, Lau B, El Helou A, et al. PPNa-DBS for gait and balance disorders in Parkinson’s disease: a double-blind, randomised study. J Neurol. 2015;262:1515–25.PubMedCrossRef
126.
go back to reference • de Andrade EM, Ghilardi MG, Cury RG, Barbosa ER, Fuentes R, Teixeira MJ, et al. Spinal cord stimulation for Parkinson’s disease: a systematic review. Neurosurg Rev. 2016;39:27–35. This is a meta-analysis based on the few (8) available studies of spinal cord stimulation for PD. PubMedCrossRef • de Andrade EM, Ghilardi MG, Cury RG, Barbosa ER, Fuentes R, Teixeira MJ, et al. Spinal cord stimulation for Parkinson’s disease: a systematic review. Neurosurg Rev. 2016;39:27–35. This is a meta-analysis based on the few (8) available studies of spinal cord stimulation for PD. PubMedCrossRef
127.
go back to reference Hassan S, Amer S, Alwaki A, Elborno A. A patient with Parkinson’s disease benefits from spinal cord stimulation. J Clin Neurosci. 2013;20:1155–6.PubMedCrossRef Hassan S, Amer S, Alwaki A, Elborno A. A patient with Parkinson’s disease benefits from spinal cord stimulation. J Clin Neurosci. 2013;20:1155–6.PubMedCrossRef
128.
go back to reference Pinto de Souza C, Hamani C, Oliveira Souza C, Lopez Contreras WO, dos Santos Ghilardi MG, Cury RG, et al. Spinal cord stimulation improves gait in patients with Parkinson’s disease previously treated with deep brain stimulation: spinal cord stimulation in PD. Mov Disord. 2017;32:278–82.PubMedCrossRef Pinto de Souza C, Hamani C, Oliveira Souza C, Lopez Contreras WO, dos Santos Ghilardi MG, Cury RG, et al. Spinal cord stimulation improves gait in patients with Parkinson’s disease previously treated with deep brain stimulation: spinal cord stimulation in PD. Mov Disord. 2017;32:278–82.PubMedCrossRef
129.
go back to reference Fénelon G, Goujon C, Gurruchaga J-M, Cesaro P, Jarraya B, Palfi S, et al. Spinal cord stimulation for chronic pain improved motor function in a patient with Parkinson’s disease. Parkinsonism Relat Disord. 2012;18:213–4.PubMedCrossRef Fénelon G, Goujon C, Gurruchaga J-M, Cesaro P, Jarraya B, Palfi S, et al. Spinal cord stimulation for chronic pain improved motor function in a patient with Parkinson’s disease. Parkinsonism Relat Disord. 2012;18:213–4.PubMedCrossRef
130.
go back to reference Landi A, Trezza A, Pirillo D, Vimercati A, Antonini A, Sganzerla EP. Spinal cord stimulation for the treatment of sensory symptoms in advanced Parkinson’s disease: SCS in advanced Parkinson’s diseases. Neuromodulation. 2013;16:276–9.PubMedCrossRef Landi A, Trezza A, Pirillo D, Vimercati A, Antonini A, Sganzerla EP. Spinal cord stimulation for the treatment of sensory symptoms in advanced Parkinson’s disease: SCS in advanced Parkinson’s diseases. Neuromodulation. 2013;16:276–9.PubMedCrossRef
131.
go back to reference Nishioka K, Nakajima M. Beneficial therapeutic effects of spinal cord stimulation in advanced cases of Parkinson’s disease with intractable chronic pain: a case series. Neuromodulation. 2015;18:751–3.PubMedCrossRef Nishioka K, Nakajima M. Beneficial therapeutic effects of spinal cord stimulation in advanced cases of Parkinson’s disease with intractable chronic pain: a case series. Neuromodulation. 2015;18:751–3.PubMedCrossRef
133.
go back to reference Agari T, Date I. Spinal cord stimulation for the treatment of abnormal posture and gait disorder in patients with Parkinson’s disease. Neurol Med Chir (Tokyo). 2012;52:470–4.CrossRef Agari T, Date I. Spinal cord stimulation for the treatment of abnormal posture and gait disorder in patients with Parkinson’s disease. Neurol Med Chir (Tokyo). 2012;52:470–4.CrossRef
134.
go back to reference Thevathasan W, Mazzone P, Jha A, Djamshidian A, Dileone M, Di Lazzaro V, et al. Spinal cord stimulation failed to relieve akinesia or restore locomotion in Parkinson disease. Neurology. 2010;74:1325–7.PubMedPubMedCentralCrossRef Thevathasan W, Mazzone P, Jha A, Djamshidian A, Dileone M, Di Lazzaro V, et al. Spinal cord stimulation failed to relieve akinesia or restore locomotion in Parkinson disease. Neurology. 2010;74:1325–7.PubMedPubMedCentralCrossRef
135.
go back to reference • Tomlinson CL, Patel S, Meek C, Herd CP, Clarke CE, Stowe R, et al. Physiotherapy versus placebo or no intervention in Parkinson’s disease. Cochrane Database Syst Rev. 2013;CD002817. A comprehensive review of randomized controlled trials of physiotherapy intervention in PD. The effectiveness of intervention was assessed for gait and balance issues. • Tomlinson CL, Patel S, Meek C, Herd CP, Clarke CE, Stowe R, et al. Physiotherapy versus placebo or no intervention in Parkinson’s disease. Cochrane Database Syst Rev. 2013;CD002817. A comprehensive review of randomized controlled trials of physiotherapy intervention in PD. The effectiveness of intervention was assessed for gait and balance issues.
136.
go back to reference •• Mak MK, Wong-Yu IS, Shen X, Chung CL. Long-term effects of exercise and physical therapy in people with Parkinson disease. Nat Rev Neurol. 2017;13:689–703. This paper discusses long term benefits of exercise programs on gait and balance issues in PD. The authors make recommendation of clinical practice. PubMedCrossRef •• Mak MK, Wong-Yu IS, Shen X, Chung CL. Long-term effects of exercise and physical therapy in people with Parkinson disease. Nat Rev Neurol. 2017;13:689–703. This paper discusses long term benefits of exercise programs on gait and balance issues in PD. The authors make recommendation of clinical practice. PubMedCrossRef
137.
go back to reference de Dreu MJ, van der Wilk ASD, Poppe E, Kwakkel G, van Wegen EEH. Rehabilitation, exercise therapy and music in patients with Parkinson’s disease: a meta-analysis of the effects of music-based movement therapy on walking ability, balance and quality of life. Parkinsonism Relat Disord. 2012;18(Suppl 1):S114–9.PubMedCrossRef de Dreu MJ, van der Wilk ASD, Poppe E, Kwakkel G, van Wegen EEH. Rehabilitation, exercise therapy and music in patients with Parkinson’s disease: a meta-analysis of the effects of music-based movement therapy on walking ability, balance and quality of life. Parkinsonism Relat Disord. 2012;18(Suppl 1):S114–9.PubMedCrossRef
138.
go back to reference Alves Da Rocha P, McClelland J, Morris ME. Complementary physical therapies for movement disorders in Parkinson’s disease: a systematic review. Eur J Phys Rehabil Med. 2015;51:693–704.PubMed Alves Da Rocha P, McClelland J, Morris ME. Complementary physical therapies for movement disorders in Parkinson’s disease: a systematic review. Eur J Phys Rehabil Med. 2015;51:693–704.PubMed
139.
go back to reference dos Santos Delabary M, Komeroski IG, Monteiro EP, Costa RR, Haas AN. Effects of dance practice on functional mobility, motor symptoms and quality of life in people with Parkinson’s disease: a systematic review with meta-analysis. Aging Clin Exp Res [Internet]. 2017 [cited 2017 Dec 19]; Available from: http://link.springer.com/10.1007/s40520-017-0836-2. dos Santos Delabary M, Komeroski IG, Monteiro EP, Costa RR, Haas AN. Effects of dance practice on functional mobility, motor symptoms and quality of life in people with Parkinson’s disease: a systematic review with meta-analysis. Aging Clin Exp Res [Internet]. 2017 [cited 2017 Dec 19]; Available from: http://​link.​springer.​com/​10.​1007/​s40520-017-0836-2.
140.
go back to reference Janssen S, Soneji M, Nonnekes J, Bloem BR. A painted staircase illusion to alleviate freezing of gait in Parkinson’s disease. J Neurol. 2016;263:1661–2.PubMedCrossRef Janssen S, Soneji M, Nonnekes J, Bloem BR. A painted staircase illusion to alleviate freezing of gait in Parkinson’s disease. J Neurol. 2016;263:1661–2.PubMedCrossRef
141.
go back to reference Janssen S, Bolte B, Nonnekes J, Bittner M, Bloem BR, Heida T, et al. Usability of three-dimensional augmented visual cues delivered by smart glasses on (freezing of) gait in Parkinson’s disease. Front Neurol. 2017;8:279.PubMedPubMedCentralCrossRef Janssen S, Bolte B, Nonnekes J, Bittner M, Bloem BR, Heida T, et al. Usability of three-dimensional augmented visual cues delivered by smart glasses on (freezing of) gait in Parkinson’s disease. Front Neurol. 2017;8:279.PubMedPubMedCentralCrossRef
142.
go back to reference Ginis P, Heremans E, Ferrari A, Dockx K, Canning CG, Nieuwboer A. Prolonged walking with a wearable system providing intelligent auditory input in people with Parkinson’s disease. Front Neurol. 2017;8:128.PubMedPubMedCentralCrossRef Ginis P, Heremans E, Ferrari A, Dockx K, Canning CG, Nieuwboer A. Prolonged walking with a wearable system providing intelligent auditory input in people with Parkinson’s disease. Front Neurol. 2017;8:128.PubMedPubMedCentralCrossRef
143.
go back to reference Barthel C, Nonnekes J, van Helvert M, Haan R, Janssen A, Delval A, et al. The laser shoes: a new ambulatory device to alleviate freezing of gait in Parkinson disease. Neurology. 2017; Barthel C, Nonnekes J, van Helvert M, Haan R, Janssen A, Delval A, et al. The laser shoes: a new ambulatory device to alleviate freezing of gait in Parkinson disease. Neurology. 2017;
144.
go back to reference Ferraye MU, Fraix V, Pollak P, Bloem BR, Debû B. The laser-shoe: a new form of continuous ambulatory cueing for patients with Parkinson’s disease. Parkinsonism Relat Disord. 2016;29:127–8.PubMedCrossRef Ferraye MU, Fraix V, Pollak P, Bloem BR, Debû B. The laser-shoe: a new form of continuous ambulatory cueing for patients with Parkinson’s disease. Parkinsonism Relat Disord. 2016;29:127–8.PubMedCrossRef
145.
go back to reference Castrioto A, Piscicelli C, Pérennou D, Krack P, Debû B. The pathogenesis of Pisa syndrome in Parkinson’s disease: Pisa syndrome in Parkinson’s disease. Mov Disord. 2014;29:1100–7.PubMedCrossRef Castrioto A, Piscicelli C, Pérennou D, Krack P, Debû B. The pathogenesis of Pisa syndrome in Parkinson’s disease: Pisa syndrome in Parkinson’s disease. Mov Disord. 2014;29:1100–7.PubMedCrossRef
146.
go back to reference • Barone P, Santangelo G, Amboni M, Pellecchia MT, Vitale C. Pisa syndrome in Parkinson’s disease and parkinsonism: clinical features, pathophysiology, and treatment. Lancet Neurol. 2016;15:1063–74. This paper discusses the different pathophysiological hypotheses of Pisa The authors examined the effects of STN DBS on camptocormia. Multifactorial analysis revealed the link between duration of camptocormia and DBS benefit. PubMedCrossRef • Barone P, Santangelo G, Amboni M, Pellecchia MT, Vitale C. Pisa syndrome in Parkinson’s disease and parkinsonism: clinical features, pathophysiology, and treatment. Lancet Neurol. 2016;15:1063–74. This paper discusses the different pathophysiological hypotheses of Pisa The authors examined the effects of STN DBS on camptocormia. Multifactorial analysis revealed the link between duration of camptocormia and DBS benefit. PubMedCrossRef
147.
go back to reference Fasano A, Di Matteo A, Vitale C, Squintani G, Ferigo L, Bombieri F, et al. Reversible Pisa syndrome in patients with Parkinson’s disease on rasagiline therapy. Mov Disord. 2011;26:2578–80.PubMedCrossRef Fasano A, Di Matteo A, Vitale C, Squintani G, Ferigo L, Bombieri F, et al. Reversible Pisa syndrome in patients with Parkinson’s disease on rasagiline therapy. Mov Disord. 2011;26:2578–80.PubMedCrossRef
148.
go back to reference Doherty KM, van de Warrenburg BP, Peralta MC, Silveira-Moriyama L, Azulay J-P, Gershanik OS, et al. Postural deformities in Parkinson’s disease. Lancet Neurol. 2011;10:538–49.PubMedCrossRef Doherty KM, van de Warrenburg BP, Peralta MC, Silveira-Moriyama L, Azulay J-P, Gershanik OS, et al. Postural deformities in Parkinson’s disease. Lancet Neurol. 2011;10:538–49.PubMedCrossRef
149.
go back to reference Bonanni L, Thomas A, Varanese S, Scorrano V, Onofrj M. Botulinum toxin treatment of lateral axial dystonia in parkinsonism. Mov Disord. 2007;22:2097–103.PubMedCrossRef Bonanni L, Thomas A, Varanese S, Scorrano V, Onofrj M. Botulinum toxin treatment of lateral axial dystonia in parkinsonism. Mov Disord. 2007;22:2097–103.PubMedCrossRef
150.
go back to reference Bloch F, Houeto JL, du Montcel ST, Bonneville F, Etchepare F, Welter ML, et al. Parkinson’s disease with camptocormia. J Neurol Neurosurg Psychiatry. 2006;77:1223–8.PubMedPubMedCentralCrossRef Bloch F, Houeto JL, du Montcel ST, Bonneville F, Etchepare F, Welter ML, et al. Parkinson’s disease with camptocormia. J Neurol Neurosurg Psychiatry. 2006;77:1223–8.PubMedPubMedCentralCrossRef
151.
go back to reference Margraf NG, Wrede A, Rohr A, Schulz-Schaeffer WJ, Raethjen J, Eymess A, et al. Camptocormia in idiopathic Parkinson’s disease: a focal myopathy of the paravertebral muscles. Mov Disord. 2010;25:542–51.PubMedCrossRef Margraf NG, Wrede A, Rohr A, Schulz-Schaeffer WJ, Raethjen J, Eymess A, et al. Camptocormia in idiopathic Parkinson’s disease: a focal myopathy of the paravertebral muscles. Mov Disord. 2010;25:542–51.PubMedCrossRef
152.
go back to reference Wrede A, Margraf NG, Goebel HH, Deuschl G, Schulz-Schaeffer WJ. Myofibrillar disorganization characterizes myopathy of camptocormia in Parkinson’s disease. Acta Neuropathol (Berl). 2012;123:419–32.CrossRef Wrede A, Margraf NG, Goebel HH, Deuschl G, Schulz-Schaeffer WJ. Myofibrillar disorganization characterizes myopathy of camptocormia in Parkinson’s disease. Acta Neuropathol (Berl). 2012;123:419–32.CrossRef
153.
go back to reference • Srivanitchapoom P, Hallett M. Camptocormia in Parkinson’s disease: definition, epidemiology, pathogenesis and treatment modalities. J Neurol Neurosurg Psychiatry. 2016;87:75–85. A review of the clinical manifestations, pathophysiological hypotheses, and pharmacological and non-pharmacological approaches to camptocormia management. PubMed • Srivanitchapoom P, Hallett M. Camptocormia in Parkinson’s disease: definition, epidemiology, pathogenesis and treatment modalities. J Neurol Neurosurg Psychiatry. 2016;87:75–85. A review of the clinical manifestations, pathophysiological hypotheses, and pharmacological and non-pharmacological approaches to camptocormia management. PubMed
154.
go back to reference Vorovenci RJ, Biundo R, Antonini A. Therapy-resistant symptoms in Parkinson’s disease. J Neural Transm. 2016;123:19–30.PubMedCrossRef Vorovenci RJ, Biundo R, Antonini A. Therapy-resistant symptoms in Parkinson’s disease. J Neural Transm. 2016;123:19–30.PubMedCrossRef
155.
go back to reference Ye X, Lou D, Ding X, Xie C, Gao J, Lou Y, et al. A clinical study of the coronal plane deformity in Parkinson disease. Eur Spine J. 2017;26:1862–70.PubMedCrossRef Ye X, Lou D, Ding X, Xie C, Gao J, Lou Y, et al. A clinical study of the coronal plane deformity in Parkinson disease. Eur Spine J. 2017;26:1862–70.PubMedCrossRef
157.
go back to reference Tiple D, Fabbrini G, Colosimo C, Ottaviani D, Camerota F, Defazio G, et al. Camptocormia in Parkinson disease: an epidemiological and clinical study. J Neurol Neurosurg Psychiatry. 2009;80:145–8.PubMedCrossRef Tiple D, Fabbrini G, Colosimo C, Ottaviani D, Camerota F, Defazio G, et al. Camptocormia in Parkinson disease: an epidemiological and clinical study. J Neurol Neurosurg Psychiatry. 2009;80:145–8.PubMedCrossRef
158.
go back to reference Tinazzi M, Geroin C, Gandolfi M, Smania N, Tamburin S, Morgante F, et al. Pisa syndrome in Parkinson’s disease: an integrated approach from pathophysiology to management: Pisa syndrome in Parkinson’s disease. Mov Disord. 2016;31:1785–95.PubMedCrossRef Tinazzi M, Geroin C, Gandolfi M, Smania N, Tamburin S, Morgante F, et al. Pisa syndrome in Parkinson’s disease: an integrated approach from pathophysiology to management: Pisa syndrome in Parkinson’s disease. Mov Disord. 2016;31:1785–95.PubMedCrossRef
159.
go back to reference Doherty KM, Davagnanam I, Molloy S, Silveira-Moriyama L, Lees AJ. Pisa syndrome in Parkinson’s disease: a mobile or fixed deformity? J Neurol Neurosurg Psychiatry. 2013;84:1400–3.PubMedPubMedCentralCrossRef Doherty KM, Davagnanam I, Molloy S, Silveira-Moriyama L, Lees AJ. Pisa syndrome in Parkinson’s disease: a mobile or fixed deformity? J Neurol Neurosurg Psychiatry. 2013;84:1400–3.PubMedPubMedCentralCrossRef
160.
go back to reference Su PC, Tseng H-M, Liou H-H. Postural asymmetries following unilateral subthalomotomy for advanced Parkinson’s disease. Mov Disord. 2002;17:191–4.PubMedCrossRef Su PC, Tseng H-M, Liou H-H. Postural asymmetries following unilateral subthalomotomy for advanced Parkinson’s disease. Mov Disord. 2002;17:191–4.PubMedCrossRef
161.
go back to reference van de Warrenburg BPC, Bhatia KP, Quinn NP. Pisa syndrome after unilateral pallidotomy in Parkinson’s disease: an unrecognised, delayed adverse event? J Neurol Neurosurg Psychiatry. 2007;78:329–30.PubMedPubMedCentralCrossRef van de Warrenburg BPC, Bhatia KP, Quinn NP. Pisa syndrome after unilateral pallidotomy in Parkinson’s disease: an unrecognised, delayed adverse event? J Neurol Neurosurg Psychiatry. 2007;78:329–30.PubMedPubMedCentralCrossRef
162.
go back to reference Finsterer J, Strobl W. Presentation, etiology, diagnosis, and management of camptocormia. Eur Neurol. 2010;64:1–8.PubMedCrossRef Finsterer J, Strobl W. Presentation, etiology, diagnosis, and management of camptocormia. Eur Neurol. 2010;64:1–8.PubMedCrossRef
163.
go back to reference Pezzoli G, Zini M. Levodopa in Parkinson’s disease: from the past to the future. Expert Opin Pharmacother. 2010;11:627–35.PubMedCrossRef Pezzoli G, Zini M. Levodopa in Parkinson’s disease: from the past to the future. Expert Opin Pharmacother. 2010;11:627–35.PubMedCrossRef
164.
go back to reference Mensikova K, Kaiserova M, Vastik M, Kurcova S, Kanovsky P. Treatment of camptocormia with continuous subcutaneous infusions of apomorphine: 1-year prospective pilot study. J Neural Transm (Vienna). 2015;122:835–9.CrossRef Mensikova K, Kaiserova M, Vastik M, Kurcova S, Kanovsky P. Treatment of camptocormia with continuous subcutaneous infusions of apomorphine: 1-year prospective pilot study. J Neural Transm (Vienna). 2015;122:835–9.CrossRef
165.
go back to reference Azher SN, Jankovic J. Camptocormia pathogenesis, classification, and response to therapy. Neurology. 2005;65:355–9.PubMedCrossRef Azher SN, Jankovic J. Camptocormia pathogenesis, classification, and response to therapy. Neurology. 2005;65:355–9.PubMedCrossRef
166.
go back to reference von Coelln R, Raible A, Gasser T, Asmus F. Ultrasound-guided injection of the iliopsoas muscle with botulinum toxin in camptocormia: botulinum toxin in camptocormia. Mov Disord. 2008;23:889–92.CrossRef von Coelln R, Raible A, Gasser T, Asmus F. Ultrasound-guided injection of the iliopsoas muscle with botulinum toxin in camptocormia: botulinum toxin in camptocormia. Mov Disord. 2008;23:889–92.CrossRef
167.
go back to reference Wijemanne S, Jimenez-Shahed J. Improvement in dystonic camptocormia following botulinum toxin injection to the external oblique muscle. Parkinsonism Relat Disord. 2014;20:1106–7.PubMedCrossRef Wijemanne S, Jimenez-Shahed J. Improvement in dystonic camptocormia following botulinum toxin injection to the external oblique muscle. Parkinsonism Relat Disord. 2014;20:1106–7.PubMedCrossRef
168.
go back to reference Furusawa Y, Mukai Y, Kawazoe T, Sano T, Nakamura H, Sakamoto C, et al. Long-term effect of repeated lidocaine injections into the external oblique for upper camptocormia in Parkinson’s disease. Parkinsonism Relat Disord. 2013;19:350–4.PubMedCrossRef Furusawa Y, Mukai Y, Kawazoe T, Sano T, Nakamura H, Sakamoto C, et al. Long-term effect of repeated lidocaine injections into the external oblique for upper camptocormia in Parkinson’s disease. Parkinsonism Relat Disord. 2013;19:350–4.PubMedCrossRef
169.
go back to reference •• Schulz-Schaeffer WJ, Margraf NG, Munser S, Wrede A, Buhmann C, Deuschl G, et al. Effect of neurostimulation on camptocormia in Parkinson’s disease depends on symptom duration. Mov Disord. 2015;30:368–72. The authors examined the effects of STN DBS on camptocormia. Multifactorial analysis revealed the link between duration of camptocormia and DBS benefit. PubMedPubMedCentralCrossRef •• Schulz-Schaeffer WJ, Margraf NG, Munser S, Wrede A, Buhmann C, Deuschl G, et al. Effect of neurostimulation on camptocormia in Parkinson’s disease depends on symptom duration. Mov Disord. 2015;30:368–72. The authors examined the effects of STN DBS on camptocormia. Multifactorial analysis revealed the link between duration of camptocormia and DBS benefit. PubMedPubMedCentralCrossRef
170.
go back to reference Capecci M, Serpicelli C, Fiorentini L, Censi G, Ferretti M, Orni C, et al. Postural rehabilitation and Kinesio taping for axial postural disorders in Parkinson’s disease. Arch Phys Med Rehabil. 2014;95:1067–75.PubMedCrossRef Capecci M, Serpicelli C, Fiorentini L, Censi G, Ferretti M, Orni C, et al. Postural rehabilitation and Kinesio taping for axial postural disorders in Parkinson’s disease. Arch Phys Med Rehabil. 2014;95:1067–75.PubMedCrossRef
171.
go back to reference Cannas A, Solla P, Floris G, Tacconi P, Serra A, Piga M, et al. Reversible Pisa syndrome in patients with Parkinson’s disease on dopaminergic therapy. J Neurol. 2009;256:390–5.PubMedCrossRef Cannas A, Solla P, Floris G, Tacconi P, Serra A, Piga M, et al. Reversible Pisa syndrome in patients with Parkinson’s disease on dopaminergic therapy. J Neurol. 2009;256:390–5.PubMedCrossRef
172.
go back to reference Umemura A, Oka Y, Ohkita K, Yamawaki T, Yamada K. Effect of subthalamic deep brain stimulation on postural abnormality in Parkinson disease. J Neurosurg. 2010;112:1283–8.PubMedCrossRef Umemura A, Oka Y, Ohkita K, Yamawaki T, Yamada K. Effect of subthalamic deep brain stimulation on postural abnormality in Parkinson disease. J Neurosurg. 2010;112:1283–8.PubMedCrossRef
173.
go back to reference Shih LC, Vanderhorst VG, Lozano AM, Hamani C, Moro E. Improvement of Pisa syndrome with contralateral pedunculopontine stimulation. Mov Disord. 2013;28:555–6.PubMedPubMedCentralCrossRef Shih LC, Vanderhorst VG, Lozano AM, Hamani C, Moro E. Improvement of Pisa syndrome with contralateral pedunculopontine stimulation. Mov Disord. 2013;28:555–6.PubMedPubMedCentralCrossRef
174.
go back to reference Bartolo M, Serrao M, Tassorelli C, Don R, Ranavolo A, Draicchio F, et al. Four-week trunk-specific rehabilitation treatment improves lateral trunk flexion in Parkinson’s disease: trunk-specific rehabilitation treatment in PD. Mov Disord. 2010;25:325–31.PubMedCrossRef Bartolo M, Serrao M, Tassorelli C, Don R, Ranavolo A, Draicchio F, et al. Four-week trunk-specific rehabilitation treatment improves lateral trunk flexion in Parkinson’s disease: trunk-specific rehabilitation treatment in PD. Mov Disord. 2010;25:325–31.PubMedCrossRef
175.
go back to reference Sørensen J, Sørensen JB, Skovgaard T, Bredahl T, Puggaard L. Exercise on prescription: changes in physical activity and health-related quality of life in five Danish programmes. Eur J Pub Health. 2011;21:56–62.CrossRef Sørensen J, Sørensen JB, Skovgaard T, Bredahl T, Puggaard L. Exercise on prescription: changes in physical activity and health-related quality of life in five Danish programmes. Eur J Pub Health. 2011;21:56–62.CrossRef
176.
go back to reference Chakravarthy MV, Joyner MJ, Booth FW. An obligation for primary care physicians to prescribe physical activity to sedentary patients to reduce the risk of chronic health conditions. Mayo Clin Proc. 2002;77:165–73.PubMedCrossRef Chakravarthy MV, Joyner MJ, Booth FW. An obligation for primary care physicians to prescribe physical activity to sedentary patients to reduce the risk of chronic health conditions. Mayo Clin Proc. 2002;77:165–73.PubMedCrossRef
177.
go back to reference Francardo V, Schmitz Y, Sulzer D, Cenci MA. Neuroprotection and neurorestoration as experimental therapeutics for Parkinson’s disease. Exp Neurol. 2017;298:137–47.PubMedCrossRef Francardo V, Schmitz Y, Sulzer D, Cenci MA. Neuroprotection and neurorestoration as experimental therapeutics for Parkinson’s disease. Exp Neurol. 2017;298:137–47.PubMedCrossRef
Metadata
Title
Managing Gait, Balance, and Posture in Parkinson’s Disease
Authors
Bettina Debû
Clecio De Oliveira Godeiro
Jarbas Correa Lino
Elena Moro
Publication date
01-05-2018
Publisher
Springer US
Published in
Current Neurology and Neuroscience Reports / Issue 5/2018
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-018-0828-4

Other articles of this Issue 5/2018

Current Neurology and Neuroscience Reports 5/2018 Go to the issue

Epilepsy (CW Bazil, Section Editor)

Infantile Spasms—Have We Made Progress?