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Current Infectious Disease Reports
Published in: Current Infectious Disease Reports 4/2011

01-08-2011

Prosthetic Vascular Graft Infections: A Contemporary Approach to Diagnosis and Management

Authors: Avish Nagpal, Muhammad R. Sohail

Published in: Current Infectious Disease Reports | Issue 4/2011

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Abstract

Improvements in manufacturing and implantation techniques, coupled with an increasing prevalence of atherosclerosis in an aging population, have led to increased utilization of prosthetic vascular grafts. The infection rates of vascular grafts are low. However, when they do occur, high rates of morbidity and mortality can be expected. The purpose of this article is to review the published literature regarding epidemiology, risk factors, pathogenesis, and clinical manifestations of prosthetic vascular graft infections. Moreover, we provide a practical approach to the diagnosis and management of these complicated infections based on empirically grounded evidence.
Literature
1.
Darouiche RO. Treatment of infections associated with surgical implants. N Engl J Med. 2004;350:1422–9.PubMedCrossRef
2.
3.
Seeger JM, Pretus HA, Welborn MB, et al. Long-term outcome after treatment of aortic graft infection with staged extra-anatomic bypass grafting and aortic graft removal. J Vasc Surg. 2000;32:451–9. discussion 460–451.PubMedCrossRef
4.
Mussa FF, Hedayati N, Zhou W, et al. Prevention and treatment of aortic graft infection. Expert Rev Anti Infect Ther. 2007;5:305–15.PubMedCrossRef
5.
Quinones-Baldrich WJ, Hernandez JJ, Moore WS. Long-term results following surgical management of aortic graft infection. Arch Surg. 1991;126:507–11.PubMed
6.
Seeger JM. Management of patients with prosthetic vascular graft infection. Am Surg. 2000;66:166–77.PubMed
7.
Chaudhary R, Simmons RL. Pathogenesis of vascular graft infections. J Vasc Surg. 1991;13:755–6.PubMed
8.
Antonios VS, Noel AA, Steckelberg JM, et al. Prosthetic vascular graft infection: a risk factor analysis using a case-control study. J Infect. 2006;53:49–55.PubMedCrossRef
9.
Baddour LM, Bettmann MA, Bolger AF, et al. Nonvalvular cardiovascular device-related infections. Clin Infect Dis. 2004;38:1128–30.PubMedCrossRef
10.
Cramton SE, Gerke C, Schnell NF, et al. The intercellular adhesion (ica) locus is present in Staphylococcus aureus and is required for biofilm formation. Infect Immun. 1999;67:5427–33.PubMed
11.
Heilmann C, Schweitzer O, Gerke C, et al. Molecular basis of intercellular adhesion in the biofilm-forming Staphylococcus epidermidis. Mol Microbiol. 1996;20:1083–91.PubMedCrossRef
12.
Wann ER, Gurusiddappa S, Höök M. The Fibronectin-binding MSCRAMM FnbpA of Staphylococcus aureus Is a Bifunctional Protein That Also Binds to Fibrinogen. J Biol Chem. 2000;275:13863–71.PubMedCrossRef
13.
Hayes PD, Nasim A, London NJ, et al. In situ replacement of infected aortic grafts with rifampicin-bonded prostheses: the Leicester experience (1992 to 1998). J Vasc Surg. 1999;30:92–8.PubMedCrossRef
14.
Wilson SE. New alternatives in management of the infected vascular prosthesis. Surg Infect (Larchmt). 2001;2:171–5. discussion 175–177.CrossRef
15.
Pitsch R, Lawrence P: Natural history of graft infections. B. TJ. Armonk, NY: Futura; 1994.
16.
Bandyk DF, Berni GA, Thiele BL, Towne JB. Aortofemoral graft infection due to Staphylococcus epidermidis. Arch Surg. 1984;119:102–8.PubMed
17.
Orton DF, LeVeen RF, Saigh JA, et al. Aortic prosthetic graft infections: radiologic manifestations and implications for management. Radiographics. 2000;20:977–93.PubMed
18.
Low RN, Wall SD, Jeffrey RB, et al. Aortoenteric fistula and perigraft infection: evaluation with CT. Radiology. 1990;175:157–62.PubMed
19.
Agarwal R, Brunelli SM, Williams K, et al. Gadolinium-based contrast agents and nephrogenic systemic fibrosis: a systematic review and meta-analysis. Nephrol Dial Transplant. 2009;24:856–63.PubMedCrossRef
20.
Shahidi S, Eskil A, Lundof E, et al. Detection of abdominal Aortic graft infection: comparison of magnetic resonance imaging and indium-labeled white blood cell scanning. Ann Vasc Surg. 2007;21:586–92.PubMedCrossRef
21.
Lauwers P, Van den Broeck S, Carp L, et al. The use of positron emission tomography with (18)F-fluorodeoxyglucose for the diagnosis of vascular graft infection. Angiology. 2008;58:717–24.CrossRef
22.
Keidar Z, Engel A, Hoffman A, et al. Prosthetic vascular graft infection: the role of 18F-FDG PET/CT. J Nucl Med. 2007;48:1230–6.PubMedCrossRef
23.
•• Bruggink JLM, Glaudemans AWJM, Saleem BR, et al. Accuracy of FDG-PET-CT in the diagnostic work-up of vascular prosthetic graft infection. Eur J Vasc Endovasc Surg. 2010;40:348–54. Authors compared results of FDG-PET to CT and combined FDG-PET/CT in 15 patients. FDG-PET was found to have excellent interobserver consistency and provided a better diagnostic accuracy than CT for the diagnosis of PVGIs.PubMedCrossRef
24.
•• Saleem BR, Meerwaldt R, Tielliu IFJ, et al. Conservative treatment of vascular prosthetic graft infection is associated with high mortality. Am J Surg. 2010;200:47–52. Authors report outcomes on 44 patients with PVGIs. Conservative treatment with antibiotics alone was found to be the only variable associated with poor outcome.PubMedCrossRef
25.
Roy D, Grove DI. Efficacy of long-term antibiotic suppressive therapy in proven or suspected infected abdominal aortic grafts. J Infect. 2000;40:184–7.PubMed
26.
Baddour LM, The Infectious Diseases Society of America’s Emerging Infections Network. Long-term suppressive antimicrobial therapy for intravascular device-related infections. Am J Med Sci. 2001;322:209–12.PubMedCrossRef
27.
Younis G, Reul GJ, Krajcer Z. Combined endovascular and surgical treatment of infected carotid-carotid bypass graft. J Endovasc Ther. 2006;13:687–92.PubMedCrossRef
28.
Javerliat I, Goëau-Brissonnière O, Bruneval P, Coggia M. Experimental study of a new vascular graft prebonded with antibiotic: healing, toxicity, and antibiotic retention. Ann Vasc Surg. 2007;21:603–10.PubMedCrossRef
29.
Giacometti A, Cirioni O, Ghiselli R, et al. Polycationic peptides as prophylactic agents against methicillin-susceptible or methicillin-resistant Staphylococcus epidermidis vascular graft infection. Antimicrob Agents Chemother. 2000;44:3306–9.PubMedCrossRef
30.
Huh J, Chen JC, Furman GM, et al. Local treatment of prosthetic vascular graft infection with multivesicular liposome-encapsulated amikacin. J Surg Res. 1998;74:54–8.PubMedCrossRef
31.
Yasim A, Gul M, Atahan E, et al. Efficacy of vancomycin, teicoplanin and fusidic acid as prophylactic agents in prevention of vascular graft infection: an experimental study in rat. Eur J Vasc Endovasc Surg. 2006;31:274–9.PubMedCrossRef
32.
O’Connor S, Andrew P, Batt M, Becquemin JP. A systematic review and meta-analysis of treatments for aortic graft infection. J Vasc Surg. 2006;44:38–45.e38.PubMedCrossRef
33.
Chiesa R, Astore D, Frigerio S, et al. Vascular prosthetic graft infection: epidemiology, bacteriology, pathogenesis and treatment. Acta Chir Belg. 2002;102:238–47.PubMed
34.
• Sato S, Nitta Y, Saiki Y, et al. Enhanced perigraft angiogenesis prevents prosthetic graft infection. Ann Thorac Surg. 2008;86:1278–84. In vitro experiments in this study demonstrated that incorporation of basic fibroblast growth factor into graft material was associated with decreased number of bacterial colonies and enhanced angiogenesis.PubMedCrossRef
35.
•• Sohail MR, Wilson WR, Baddour LM. Infections of nonvalvular cardiovascular devices. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. Philadelphia: Churchill Livingstone/Elsevier; 2010. p. 1127–42. Comprehensive review of various aspects related to PVGIs.
Metadata
Title
Prosthetic Vascular Graft Infections: A Contemporary Approach to Diagnosis and Management
Authors
Avish Nagpal
Muhammad R. Sohail
Publication date
01-08-2011
Publisher
Current Science Inc.
Published in
Current Infectious Disease Reports / Issue 4/2011
Print ISSN: 1523-3847
Electronic ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-011-0191-y

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