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Current Infectious Disease Reports
Published in: Current Infectious Disease Reports 2/2010

Open Access 01-03-2010

Update on HHV-8-Associated Malignancies

Authors: Meena Sunil, Erin Reid, Mary Jo Lechowicz

Published in: Current Infectious Disease Reports | Issue 2/2010

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Abstract

The human herpesvirus 8 (HHV-8) is the oncogenic virus associated with Kaposi’s sarcoma (KS) and lymphoproliferative disorders, namely, primary effusion lymphoma and multicentric Castleman’s disease. KS is among the most common malignancies seen in HIV-infected patients despite the decreased incidence of KS in the era of highly active antiretroviral therapy. Advances in molecular pathology reveal HHV-8 tumorigenesis is mediated through molecular mimicry wherein viral-encoded proteins can activate several cellular signaling cascades while evading immune surveillance. This knowledge has led to the evolution of multiple therapeutic strategies against specific molecular targets. Many such therapeutic modalities have shown activity, but none have proven to be curative. Identifying possible prognostic factors is another active area of research. This review summarizes the recent developments in the fields of virus transmission, molecular biology, and treatment of HHV-8-related neoplasms.
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Metadata
Title
Update on HHV-8-Associated Malignancies
Authors
Meena Sunil
Erin Reid
Mary Jo Lechowicz
Publication date
01-03-2010
Publisher
Current Science Inc.
Published in
Current Infectious Disease Reports / Issue 2/2010
Print ISSN: 1523-3847
Electronic ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-010-0092-5

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