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Current Infectious Disease Reports
Published in: Current Infectious Disease Reports 2/2010

01-03-2010

Epidemic of Sexually Transmitted Hepatitis C Virus Infection Among HIV-Infected Men

Author: Daniel Seth Fierer

Published in: Current Infectious Disease Reports | Issue 2/2010

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Abstract

Sexual contact is thought to be an inefficient mode of hepatitis C virus (HCV) transmission. However, reports of sexually transmitted HCV infection among HIV-infected men who have sex with men (MSM) began to appear in 2004. The patients were of early middle age with well-controlled HIV infection, participated in unprotected receptive sex, and frequently used noninjection recreational drugs. Molecular studies showed evidence of clusters of transmission between patients in different countries in Europe. Spontaneous clearance was relatively rare, but treatment with pegylated interferon and ribavirin resulted in cure in about two thirds of patients. Of concern was the finding of moderately advanced fibrosis during the early stages of HCV infection. HIV-infected MSM are a new risk group for HCV infection and so should be screened regularly for HCV infection.
Literature
1.
Vandelli C, Renzo F, Romano L, et al.: Lack of evidence of sexual transmission of hepatitis C among monogamous couples: results of a 10-year prospective follow-up study. Am J Gastroenterol 2004, 99:855–859.CrossRefPubMed
2.
Marincovich B, Castilla J, del Romero J, et al.: Absence of hepatitis C virus transmission in a prospective cohort of heterosexual serodiscordant couples. Sex Transm Infect 2003, 79:160–162.CrossRefPubMed
3.
Tahan V, Karaca C, Yildirim B, et al.: Sexual transmission of HCV between spouses. Am J Gastroenterol 2005, 100:821–824.CrossRefPubMed
4.
Buffington J, Murray PJ, Schlanger K, et al.: Low prevalence of hepatitis C virus antibody in men who have sex with men who do not inject drugs. Public Health Rep 2007, 122 Suppl 2:63–67.PubMed
5.
Matthews-Greer JM, Caldito GC, Adley SD, et al.: Comparison of hepatitis C viral loads in patients with or without human immunodeficiency virus. Clin Diagn Lab Immunol 2001, 8:690–694.PubMed
6.
Briat A, Dulioust E, Galimand J, et al.: Hepatitis C virus in the semen of men coinfected with HIV-1: prevalence and origin. AIDS 2005, 19:1827–1835.CrossRefPubMed
7.
Ghosn J, Pierre-Francois S, Thibault V, et al.: Acute hepatitis C in HIV-infected men who have sex with men. HIV Med 2004, 5:303–306.CrossRefPubMed
8.
Gambotti L, Batisse D, Colin-de-Verdiere N, et al.: Acute hepatitis C infection in HIV positive men who have sex with men in Paris, France, 2001–2004. Euro Surveill 2005, 10:115–117.PubMed
9.
Browne R, Asboe D, Gilleece Y, et al.: Increased numbers of acute hepatitis C infections in HIV positive homosexual men; is sexual transmission feeding the increase? Sex Transm Infect 2004, 80:326–327.CrossRefPubMed
10.
• Gilleece YC, Browne RE, Asboe D, et al.: Transmission of hepatitis C virus among HIV-positive homosexual men and response to a 24-week course of pegylated interferon and ribavirin. J Acquir Immune Defic Syndr 2005, 40:41–46.CrossRefPubMed
11.
Götz HM, van Doornum G, Niesters HG, et al.: A cluster of acute hepatitis C virus infection among men who have sex with men–results from contact tracing and public health implications. AIDS 2005, 19:969–974.CrossRefPubMed
12.
Vogel M, Bieniek B, Jessen H, et al.: Treatment of acute hepatitis C infection in HIV-infected patients: a retrospective analysis of eleven cases. J Viral Hepat 2005, 12:207–211.CrossRefPubMed
13.
Dominguez S, Ghosn J, Valantin MA, et al.: Efficacy of early treatment of acute hepatitis C infection with pegylated interferon and ribavirin in HIV-infected patients. AIDS 2006, 20:1157–1161.CrossRefPubMed
14.
Serpaggi J, Chaix ML, Batisse D, et al.: Sexually transmitted acute infection with a clustered genotype 4 hepatitis C virus in HIV-1–infected men and inefficacy of early antiviral therapy. AIDS 2006, 20:233–240.CrossRefPubMed
15.
Vogel M, Nattermann J, Baumgarten A, et al.: Pegylated interferon-alfa for the treatment of sexually transmitted acute hepatitis C in HIV-infected individuals. Antivir Ther 2006, 11:1097–1101.PubMed
16.
•• Danta M, Brown D, Bhagani S, et al.: Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. AIDS 2007, 21:983–991. This article describes the largest case-control study identifying risk factors for new HCV infection in HIV-infected MSM as well as molecular epidemiology showing clustered transmission among MSM.CrossRefPubMed
17.
•• van de Laar TJ, van der Bij AK, Prins M, et al.: Increase in HCV incidence among men who have sex with men in Amsterdam most likely caused by sexual transmission. J Infect Dis 2007, 196:230–238. This article describes a large molecular epidemiology study showing clustered transmission among MSM and with clear data showing lack of transmission in HIV-uninfected MSM.CrossRefPubMed
18.
Turner JM, Rider AT, Imrie J, et al.: Behavioural predictors of subsequent hepatitis C diagnosis in a UK clinic sample of HIV positive men who have sex with men. Sex Transm Infect 2006, 82:298–300.CrossRefPubMed
19.
•• Matthews GV, Hellard M, Haber P, et al.: Characteristics and treatment outcomes among HIV-infected individuals in the Australian Trial in Acute Hepatitis C. Clin Infect Dis 2009, 48:650–658. This article describes the first study in Australia showing sexual transmission of HCV among HIV-infected MSM; the investigators also showed treatment within 24 weeks of infection is not necessary for excellent treatment outcomes.CrossRefPubMed
20.
Luetkemeyer A, Hare CB, Stansell J, et al.: Clinical presentation and course of acute hepatitis C infection in HIV-infected patients. J Acquir Immune Defic Syndr 2006, 41:31–36.CrossRefPubMed
21.
Ristig MB, Tebas P, Gandy I, et al.: Cure of acute hepatitis C in HIV co-infection? J Clin Gastroenterol 2004, 38:303.CrossRefPubMed
22.
•• Fierer DS, Uriel AJ, Carriero DC, et al.: Liver fibrosis during an outbreak of acute hepatitis C virus infection in HIV-infected men: a prospective cohort study. J Infect Dis 2008, 198:683–686. The authors present the first demonstration of accelerated fibrosis progression during new HCV infection in HIV-infected men and the first prospective study of HIV-infected MSM in the United States.CrossRefPubMed
23.
Rauch A, Rickenbach M, Weber R, et al.: Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study. Clin Infect Dis 2005, 41:395–402.CrossRefPubMed
24.
Ghosn J, Deveau C, Goujard C, et al.: Increase in hepatitis C virus incidence in HIV-1–infected patients followed up since primary infection. Sex Transm Infect 2006, 82:458–460.CrossRefPubMed
25.
• Richardson D, Fisher M, Sabin CA. Sexual transmission of hepatitis C in MSM may not be confined to those with HIV infection. J Infect Dis 2008, 197:1213–1214; author reply 1214–1215. The authors showed an increasing incidence of sexually transmitted HCV infection in HIV-infected MSM between 2000 and 2006 but a low incidence in HIV-uninfected MSM in Brighton, UK.
26.
• Giraudon I, Ruf M, Maguire H, et al.: Increase in diagnosed newly acquired hepatitis C in HIV-positive men who have sex with men across London and Brighton, 2002–2006: is this an outbreak? Sex Transm Infect 2008, 84:111–115. This article showed an increasing incidence of sexually transmitted HCV infection in HIV-infected MSM since 2002 in the southern region of the United Kingdom.CrossRefPubMed
27.
• Fox J, Nastouli E, Thomson E, et al.: Increasing incidence of acute hepatitis C in individuals diagnosed with primary HIV in the United Kingdom. AIDS 2008, 22:666–668. The authors demonstrated the increasing incidence of sexually transmitted HCV infection in MSM with new HIV infection since 2004 in London, suggesting that risky sexual behavior was not inhibited by becoming newly HIV infected.CrossRefPubMed
28.
Alary M, Joly JR, Vincelette J, et al.: Lack of evidence of sexual transmission of hepatitis C virus in a prospective cohort study of men who have sex with men. Am J Public Health 2005, 95:502–505.CrossRefPubMed
29.
Bodsworth NJ, Cunningham P, Kaldor J, Donovan B. Hepatitis C virus infection in a large cohort of homosexually active men: independent associations with HIV-1 infection and injecting drug use but not sexual behaviour. Genitourin Med 1996, 72:118–122.PubMed
30.
• Taylor LE, Mayer KH. Acute hepatitis C virus infection in an HIV clinic and in community settings. Gastroenterology 2009, 136:2411–2412. Risk factors for sexual transmission of HCV were present in cohort of HIV-infected MSM in a US city where HCV prevalence was not yet high, showing the potential for spread of HCV if introduced into that local population.CrossRefPubMed
31.
Cox AL, Page K, Bruneau J, et al.: Rare birds in North America: acute hepatitis C cohorts. Gastroenterology 2009, 136:26–31.CrossRefPubMed
32.
•• van de Laar T, Pybus O, Bruisten S, et al.: Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men. Gastroenterology 2009, 136:1609–1617. The article describes an international collaboration (except North America) demonstrating that most new HCV infections occurred since 2000 and were highly related to each other, linking the epidemic across country boundaries although not continents.CrossRefPubMed
33.
Ruiz-Sancho A, Barreiro P, Castellares C, et al.: Outbreak of syphilis, but not of acute hepatitis C, among HIV-infected homosexual men in Madrid. HIV Clin Trials 2007, 8:98–101.CrossRefPubMed
34.
Palacios R, Mata R, Aguilar I, et al.: High seroprevalence but low incidence of HCV infection in a cohort of patients with sexually transmitted HIV in Andalusia, Spain. J Int Assoc Physicians AIDS Care (Chic Ill) 2009, 8:100–105.CrossRef
35.
•• Urbanus AT, van de Laar TJ, Stolte IG, et al.: Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. AIDS 2009, 23:F1–F7.CrossRefPubMed
36.
Osinusi A, Kleiner D, Wood B, et al.: Rapid development of advanced liver fibrosis after acquisition of hepatitis C infection during primary HIV infection. AIDS Patient Care STDS 2009, 23:403–406.CrossRefPubMed
37.
Thomson EC, Nastouli E, Main J, et al.: Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCV. AIDS 2009, 23:89–93.CrossRefPubMed
38.
Glynn SA, Wright DJ, Kleinman SH, et al.: Dynamics of viremia in early hepatitis C virus infection. Transfusion 2005, 45:994–1002.CrossRefPubMed
39.
• Vogel M, Deterding K, Wiegand J, et al.: Initial presentation of acute hepatitis C virus (HCV) infection among HIV-negative and HIV-positive individuals-experience from 2 large German networks on the study of acute HCV infection. Clin Infect Dis 2009, 49:317–319; author reply 319. The authors observed that the initial presentation of HCV in HIV-infected patients could be more subtle than in HIV-uninfected patients.
40.
41.
McGovern BH, Birch CE, Bowen MJ, et al.: Improving the diagnosis of acute hepatitis C virus infection with expanded viral load criteria. Clin Infect Dis 2009, 49:1051–1060.CrossRefPubMed
42.
Nastouli E, Thomson EC, Karayiannis P, et al.: Diagnosing acute hepatitis C in HIV-infected patients: nucleic acid testing compared with antibody and antigen-antibody detecting methods. J Clin Virol 2009, 44:78–80.CrossRefPubMed
43.
Page K, Hahn JA, Evans J, et al.: Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfection. J Infect Dis 2009, 200:1216–1226.CrossRefPubMed
44.
Benhamou Y, Bochet M, Di Martino V, et al.: Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. Hepatology 1999, 30:1054–1058.CrossRefPubMed
45.
Kamal SM, Turner B, He Q, et al.: Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis. Hepatology 2006, 43:771–779.CrossRefPubMed
46.
Berenguer M, Ferrell L, Watson J, et al.: HCV-related fibrosis progression following liver transplantation: increase in recent years. J Hepatol 2000, 32:673–684.CrossRefPubMed
47.
Delladetsima I, Psichogiou M, Sypsa V, et al.: The course of hepatitis C virus infection in pretransplantation anti-hepatitis C virus-negative renal transplant recipients: a retrospective follow-up study. Am J Kidney Dis 2006, 47:309–316.CrossRefPubMed
Metadata
Title
Epidemic of Sexually Transmitted Hepatitis C Virus Infection Among HIV-Infected Men
Author
Daniel Seth Fierer
Publication date
01-03-2010
Publisher
Current Science Inc.
Published in
Current Infectious Disease Reports / Issue 2/2010
Print ISSN: 1523-3847
Electronic ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-010-0088-1

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