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Current Hypertension Reports
Published in: Current Hypertension Reports 2/2016

01-02-2016 | Therapeutic Trials (M Weir, Section Editor)

GLP-1 Agonists and Blood Pressure: A Review of the Evidence

Authors: Aditya Goud, Jixin Zhong, Matthew Peters, Robert D. Brook, Sanjay Rajagopalan

Published in: Current Hypertension Reports | Issue 2/2016

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Abstract

Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease. The presence of concomitant hypertension in diabetics is a major driver of excess cardiovascular risk. Glucagon-like peptide-1 receptor agonists (GLP-1a) act on numerous pathways that intersect glycemic, weight, and blood pressure (BP) control. BP-lowering effects have been observed in mouse models of hypertension with a variety of GLP-1a. Acute administration of GLP-1a in humans has been shown to no effects and sometimes increased BP in humans. Chronic administration of GLP-1a, however, reduces clinic systolic BP (≈2 mmHg) at least when evaluated as a secondary end point in glycemia-lowering studies while simultaneously increasing heart rate. BP lowering has not been consistently observed in two recent double-blind controlled clinical trials evaluating ambulatory BP as the primary end point. While a number of mechanisms including vascular, myocardial, renal, and central nervous system pathways have been suggested in animal studies, these mechanistic pathways have not been sufficiently detailed in humans and it is unclear if the same pathways are operational. Further studies need to be conducted to unravel the full spectrum of effects of this drug class. An understanding of their effects on BP may help provide an explanation for the ability of GLP-1a to influence cardiovascular (CV) events in ongoing event-driven CV trials.
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Metadata
Title
GLP-1 Agonists and Blood Pressure: A Review of the Evidence
Authors
Aditya Goud
Jixin Zhong
Matthew Peters
Robert D. Brook
Sanjay Rajagopalan
Publication date
01-02-2016
Publisher
Springer US
Published in
Current Hypertension Reports / Issue 2/2016
Print ISSN: 1522-6417
Electronic ISSN: 1534-3111
DOI
https://doi.org/10.1007/s11906-015-0621-6

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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