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01-02-2013 | Hypertension and the Kidney (RM Carey and A Mimran, Section Editors)

The “His and Hers” of the Renin-Angiotensin System

Authors: Lucinda M. Hilliard, Amanda K. Sampson, Russell D. Brown, Kate M. Denton

Published in: Current Hypertension Reports | Issue 1/2013

Abstract

Sex differences exist in the regulation of arterial pressure and renal function by the renin-angiotensin system (RAS). This may in part stem from a differential balance in the pressor and depressor arms of the RAS. In males, the ACE/AngII/AT₁R pathways are enhanced, whereas, in females, the balance is shifted towards the ACE2/Ang(1-7)/MasR and AT₂R pathways. Evidence clearly demonstrates that premenopausal women, as compared to aged-matched men, are protected from renal and cardiovascular disease, and this differential balance of the RAS between the sexes likely contributes. With aging, this cardiovascular protection in women is lost and this may be related to loss of estrogen postmenopause but the possible contribution of other sex hormones needs to be further examined. Restoration of these RAS depressor pathways in older women, or up-regulation of these in males, represents a therapeutic target that is worth pursuing.

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Title: The “His and Hers” of the Renin-Angiotensin System
Authors: Lucinda M. Hilliard
Amanda K. Sampson
Russell D. Brown
Kate M. Denton
Publication date: 01-02-2013
Publisher: Current Science Inc.
Published in: Current Hypertension Reports / Issue 1/2013
Print ISSN: 1522-6417
Electronic ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-012-0319-y

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