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Current Hematologic Malignancy Reports

Published in:

01-04-2019 | Acute Lymphoblastic Leukemia

Recent Advances in Adult Acute Lymphoblastic Leukemia

Authors: Guillaume Richard-Carpentier, Hagop Kantarjian, Elias Jabbour

Published in: Current Hematologic Malignancy Reports | Issue 2/2019

Abstract

Purpose of Review

This article reviews the recent advances in the pathophysiology and management of acute lymphoblastic leukemia (ALL) in adults.

Recent Findings

Addition of rituximab to standard chemotherapy improves survival in the frontline treatment of B cell ALL, and measurable residual disease (MRD) is the most important prognostic factor. Tyrosine kinase inhibitors (TKI), particularly ponatinib, in combination with Hyper-CVAD significantly improve outcomes in Ph + ALL challenging the benefit of allogeneic stem cell transplant in first line for these patients. Blinatumomab, inotuzumab ozogamicin, and chimeric antigen receptor (CAR) T cells are better options than chemotherapy alone for the treatment of relapsed or refractory ALL. Combination of these agents with chemotherapy and their incorporation in the frontline setting show promises to improve cure rates of ALL.

Summary

Development of monoclonal antibodies, CAR T, and potent TKI has improved the outcome of ALL. Advances in our understanding of ALL biology are expected to bring new therapeutic strategies in the upcoming years.

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Title: Recent Advances in Adult Acute Lymphoblastic Leukemia
Authors: Guillaume Richard-Carpentier
Hagop Kantarjian
Elias Jabbour
Publication date: 01-04-2019
Publisher: Springer US
Keywords: Acute Lymphoblastic Leukemia
Rituximab
Tyrosine Kinase Inhibitors
Tyrosine Kinase Inhibitors
Ponatinib
Blinatumomab
Rituximab
Cytostatic Therapy
Published in: Current Hematologic Malignancy Reports / Issue 2/2019
Print ISSN: 1558-8211
Electronic ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-019-00503-1

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