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Current Hematologic Malignancy Reports
Published in: Current Hematologic Malignancy Reports 1/2014

01-03-2014 | Chronic Leukemias (J Goldman, Section Editor)

Immunology and Immunotherapy of Chronic Myeloid Leukemia

Authors: Mette Ilander, Can Hekim, Satu Mustjoki

Published in: Current Hematologic Malignancy Reports | Issue 1/2014

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Abstract

Chronic myeloid leukemia (CML) is a clonal bone marrow stem cell neoplasia known to be responsive to immunotherapy. Despite the success of tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 oncokinase, patients are not considered to be cured with the current therapy modalities. However, there have been recent advancements in understanding the immunobiology of the disease (such as tumor specific antigens and immunostimulatory agents), and this may lead to the development of novel, curative treatment strategies. Already there are promising results showing that a small proportion of CML patients are able to discontinue the therapy although they have a minimal amount of residual leukemia cells left. This implies that the immune system is able to restrain the tumor cell expansion. In this review, we aim to give a brief update of the novel aspects of the immune system in CML patients and of the developing strategies for controlling CML by the means of immunotherapy.
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Metadata
Title
Immunology and Immunotherapy of Chronic Myeloid Leukemia
Authors
Mette Ilander
Can Hekim
Satu Mustjoki
Publication date
01-03-2014
Publisher
Springer US
Published in
Current Hematologic Malignancy Reports / Issue 1/2014
Print ISSN: 1558-8211
Electronic ISSN: 1558-822X
DOI
https://doi.org/10.1007/s11899-013-0190-1

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

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