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01-09-2019 | Insulins | Economics and Policy in Diabetes (AA Baig and N Laiteerapong, Section Editors)

Economics of Beta-Cell Replacement Therapy

Authors: Cátia Bandeiras, Albert J. Hwa, Joaquim M. S. Cabral, Frederico Castelo Ferreira, Stan N. Finkelstein, Robert A. Gabbay

Published in: Current Diabetes Reports | Issue 9/2019

Abstract

Purpose of Review

Type 1 diabetes impacts 1.3 million people in the USA with a total direct lifetime medical cost of $133.7 billion. Management requires a mix of daily exogenous insulin administration and frequent glucose monitoring. Decision-making by the individual can be burdensome.

Recent Findings

Beta-cell replacement, which involves devices protecting cells from autoimmunity and allo-rejection, aims at restoring physiological glucose regulation and improving clinical outcomes in patients. Given the significant burden of T1D in the healthcare systems, cost-effectiveness analyses can drive innovation and policymaking in the area.

Summary

This review presents the health economics analyses performed for donor-derived islet transplantation and the possible outcomes of stem cell-derived beta cells. Long-term cost-effectiveness of islet transplantation depends on the engraftment of these transplants, and the expenses and thresholds assumed by healthcare systems in different countries. Early health technology assessment analyses for stem cell-derived beta-cell replacement suggest manufacturing optimization is necessary to reduce upfront costs.

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Title: Economics of Beta-Cell Replacement Therapy
Authors: Cátia Bandeiras
Albert J. Hwa
Joaquim M. S. Cabral
Frederico Castelo Ferreira
Stan N. Finkelstein
Robert A. Gabbay
Publication date: 01-09-2019
Publisher: Springer US
Keywords: Insulins
Insulins
Type 1 Diabetes
Published in: Current Diabetes Reports / Issue 9/2019
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-019-1203-9

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