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Current Diabetes Reports
Published in: Current Diabetes Reports 12/2018

01-12-2018 | Pathogenesis of Type 1 Diabetes (A Pugliese and SJ Richardson, Section Editors)

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update

Authors: Marian Rewers, Heikki Hyöty, Åke Lernmark, William Hagopian, Jin-Xiong She, Desmond Schatz, Anette-G Ziegler, Jorma Toppari, Beena Akolkar, Jeffrey Krischer, the TEDDY Study Group

Published in: Current Diabetes Reports | Issue 12/2018

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Abstract

Purpose of Review

The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D.

Recent Findings

As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome.

Summary

TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D.
Appendix
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Metadata
Title
The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update
Authors
Marian Rewers
Heikki Hyöty
Åke Lernmark
William Hagopian
Jin-Xiong She
Desmond Schatz
Anette-G Ziegler
Jorma Toppari
Beena Akolkar
Jeffrey Krischer
the TEDDY Study Group
Publication date
01-12-2018
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 12/2018
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-018-1113-2

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