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Published in: Current Diabetes Reports 9/2014

01-09-2014 | Microvascular Complications—Retinopathy (JK Sun, Section Editor)

Multifocal Electroretinography in Diabetic Retinopathy and Diabetic Macular Edema

Authors: Marcus A. Bearse Jr., Glen Y. Ozawa

Published in: Current Diabetes Reports | Issue 9/2014

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Abstract

In this review article, we first present a brief overview of the vascular and neural components of diabetic retinopathy. Next, the multifocal electroretinogram (mfERG) technique, which can map neuroretinal function noninvasively, is described. Findings in diabetic retinal disease using the mfERG are reviewed. We then describe the progress that has been made to predict the onset and progression of diabetic retinopathy and edema in specific retinal locations, using quantitative models based on the mfERG. Finally, we consider the implications for the future of these predictive models.
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go back to reference Harrison WW, Bearse Jr MA, Ng JS, Jewell NP, Barez S, Burger D, et al. Multifocal electroretinograms predict onset of diabetic retinopathy in adult patients with diabetes. Invest Ophthalmol Vis Sci. 2011;52:772–7. This paper describes the first model based on the mfERG to predict the initial onset of diabetic retinopathy in adults. The model was cross-validated and demonstrates impressive accuracy.PubMedCentralPubMedCrossRef Harrison WW, Bearse Jr MA, Ng JS, Jewell NP, Barez S, Burger D, et al. Multifocal electroretinograms predict onset of diabetic retinopathy in adult patients with diabetes. Invest Ophthalmol Vis Sci. 2011;52:772–7. This paper describes the first model based on the mfERG to predict the initial onset of diabetic retinopathy in adults. The model was cross-validated and demonstrates impressive accuracy.PubMedCentralPubMedCrossRef
68.••
go back to reference Harrison WW, Bearse Jr MA, Schneck ME, Wolff BE, Jewell NP, Barez S, et al. Prediction, by retinal location, of the onset of diabetic edema in patients with nonproliferative diabetic retinopathy. Invest Ophthalmol Vis Sci. 2011;52:6825–31. This report describes the formulation of the first mfERG-based model to predict the onset of diabetic retinal edema in adults. The cross-validated model demonstrates impressive accuracy.PubMedCentralPubMedCrossRef Harrison WW, Bearse Jr MA, Schneck ME, Wolff BE, Jewell NP, Barez S, et al. Prediction, by retinal location, of the onset of diabetic edema in patients with nonproliferative diabetic retinopathy. Invest Ophthalmol Vis Sci. 2011;52:6825–31. This report describes the formulation of the first mfERG-based model to predict the onset of diabetic retinal edema in adults. The cross-validated model demonstrates impressive accuracy.PubMedCentralPubMedCrossRef
Metadata
Title
Multifocal Electroretinography in Diabetic Retinopathy and Diabetic Macular Edema
Authors
Marcus A. Bearse Jr.
Glen Y. Ozawa
Publication date
01-09-2014
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 9/2014
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-014-0526-9

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