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Current Cardiology Reports
Published in: Current Cardiology Reports 12/2016

Open Access 01-12-2016 | Stroke (JF Meschia, Section Editor)

Genetic Risk Factors for Ischemic and Hemorrhagic Stroke

Authors: Ganesh Chauhan, Stéphanie Debette

Published in: Current Cardiology Reports | Issue 12/2016

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Abstract

Understanding the genetic risk factors for stroke is an essential step to decipher the underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize the design of prevention strategies. A very small proportion of strokes are attributable to monogenic conditions, the vast majority being multifactorial, with multiple genetic and environmental risk factors of small effect size. Genome-wide association studies and large international consortia have been instrumental in finding genetic risk factors for stroke. While initial studies identified risk loci for specific stroke subtypes, more recent studies also revealed loci associated with all stroke and all ischemic stroke. Risk loci for ischemic stroke and its subtypes have been implicated in atrial fibrillation (PITX2 and ZFHX3), coronary artery disease (ABO, chr9p21, HDAC9, and ALDH2), blood pressure (ALDH2 and HDAC9), pericyte and smooth muscle cell development (FOXF2), coagulation (HABP2), carotid plaque formation (MMP12), and neuro-inflammation (TSPAN2). For hemorrhagic stroke, two loci (APOE and PMF1) have been identified.
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Metadata
Title
Genetic Risk Factors for Ischemic and Hemorrhagic Stroke
Authors
Ganesh Chauhan
Stéphanie Debette
Publication date
01-12-2016
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 12/2016
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-016-0804-z

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