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01-07-2014 | Vascular Biology (RS Rosenson, Section Editor)

CD39: Interface Between Vascular Thrombosis and Inflammation

Authors: Yogendra M. Kanthi, Nadia R. Sutton, David J. Pinsky

Published in: Current Atherosclerosis Reports | Issue 7/2014

Abstract

Extracellular nucleotides play a critical role in vascular thrombosis and inflammation. Alterations in purinergic extracellular nucleotide concentrations activate pathways that result in platelet degranulation and aggregation, and endothelial and leukocyte activation and recruitment. CD39, the dominant vascular nucleotidase, hydrolyzes ATP and ADP to provide the substrate for generation of the anti-inflammatory and antithrombotic mediator adenosine. The purinergic signaling system, with CD39 at its center, plays an important role in modulating vascular homeostasis and the response to vascular injury, as seen in clinically relevant diseases such as stroke, ischemia–reperfusion injury, and pulmonary hypertension. A growing body of knowledge of the purinergic signaling pathway implicates CD39 as a critical modulator of vascular thrombosis and inflammation. Therapeutic strategies targeting CD39 offer promising opportunities in the management of vascular thromboinflammatory diseases.

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Title: CD39: Interface Between Vascular Thrombosis and Inflammation
Authors: Yogendra M. Kanthi
Nadia R. Sutton
David J. Pinsky
Publication date: 01-07-2014
Publisher: Springer US
Published in: Current Atherosclerosis Reports / Issue 7/2014
Print ISSN: 1523-3804
Electronic ISSN: 1534-6242
DOI: https://doi.org/10.1007/s11883-014-0425-1

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