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Current Allergy and Asthma Reports
Published in: Current Allergy and Asthma Reports 4/2017

01-04-2017 | Immunotherapy and Immunomodulators (B Vickery, Section Editor)

Human Immune Monitoring Techniques during Food Allergen Immunotherapy

Authors: Blake Rust, Erik Wambre

Published in: Current Allergy and Asthma Reports | Issue 4/2017

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Abstract

Purpose of Review

Encouraging results from recent food allergen immunotherapy clinical trials indicate that the immune system plays an essential role in peripheral tolerance to food allergen. Thus, the monitoring of changes in immune responses and their possible correlation with clinical outcome in allergic patients receiving immunotherapies could theoretically serve as surrogate markers and be harnessed as rationale for food allergen immunotherapy development.

Recent Findings

A shift towards antigen specificity in recent assays has provided a solid foundation for the elucidation of cellular mechanisms involved in food allergen immunotherapy as well as the tracking of allergen-specific immune cells.

Summary

In this review, we overview the current challenges and technologies used in immune monitoring during immunotherapy in allergic patients with a focus on cell-mediated immunity. We also discuss critical steps involved in some of the cellular immune assays utilized in clinical trials.
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Metadata
Title
Human Immune Monitoring Techniques during Food Allergen Immunotherapy
Authors
Blake Rust
Erik Wambre
Publication date
01-04-2017
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 4/2017
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-017-0689-y

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