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Current Allergy and Asthma Reports
Published in: Current Allergy and Asthma Reports 4/2017

01-04-2017 | Allergens (RK Bush and JA Woodfolk, Section Editors)

New Insights into Cockroach Allergens

Authors: Anna Pomés, Geoffrey A. Mueller, Thomas A. Randall, Martin D. Chapman, L. Karla Arruda

Published in: Current Allergy and Asthma Reports | Issue 4/2017

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Abstract

Purpose of Review

This review addresses the most recent developments on cockroach allergen research in relation to allergic diseases, especially asthma.

Recent Findings

The number of allergens relevant to cockroach allergy has recently expanded considerably up to 12 groups. New X-ray crystal structures of allergens from groups 1, 2, and 5 revealed interesting features with implications for allergen standardization, sensitization, diagnosis, and therapy.

Summary

Cockroach allergy is strongly associated with asthma particularly among children and young adults living in inner-city environments, posing challenges for disease control. Environmental interventions targeted at reducing cockroach allergen exposure have provided conflicting results. Immunotherapy may be a way to modify the natural history of cockroach allergy and decrease symptoms and asthma severity among sensitized and exposed individuals. The new information on cockroach allergens is important for the assessment of allergen markers of exposure and disease, and for the design of immunotherapy trials.
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Metadata
Title
New Insights into Cockroach Allergens
Authors
Anna Pomés
Geoffrey A. Mueller
Thomas A. Randall
Martin D. Chapman
L. Karla Arruda
Publication date
01-04-2017
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 4/2017
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-017-0694-1

Other articles of this Issue 4/2017

Current Allergy and Asthma Reports 4/2017 Go to the issue

Immunotherapy and Immunomodulators (B Vickery, Section Editor)

Human Immune Monitoring Techniques during Food Allergen Immunotherapy

Allergic Skin Diseases (L Fonacier, Section Editor)

Non-immediate Cutaneous Reactions to Beta-Lactams: Approach to Diagnosis

Rhinosinusitis (J Mullol, Section Editor)

Economics of Chronic Rhinosinusitis

Rhinosinusitis (J Mullol, Section Editor)

Impact of Respiratory Virus Infections in Exacerbation of Acute and Chronic Rhinosinusitis

Food Allergy (T Green, Section Editor)

Primary Prevention of Food Allergy

Pediatric Allergy and Immunology (W Dolen, Section Editor)

Severe Asthma in Children