Published in:
01-11-2010
Molecular- and Flow Cytometry-based Diagnosis of Primary Immunodeficiency Disorders
Authors:
Joao B. Oliveira, Thomas A. Fleisher
Published in:
Current Allergy and Asthma Reports
|
Issue 6/2010
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Abstract
Primary immunodeficiencies are an expanding group of genetic disorders resulting in recurrent and/or severe infections, autoimmunity, or autoinflammation. The laboratory plays a critical role in the diagnosis of these conditions given their frequently overlapping signs and symptoms. We discuss here advances in flow cytometry and molecular techniques applied to the study of primary immunodeficiencies.