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Archives of Osteoporosis
Published in: Archives of Osteoporosis 1/2018

Open Access 01-12-2018 | Original Article

RETRACTED ARTICLE: Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010

Authors: Shahab Abtahi, Johanna H.M. Driessen, Peter Vestergaard, Joop van den Bergh, Annelies Boonen, Frank de Vries, Andrea M. Burden

Published in: Archives of Osteoporosis | Issue 1/2018

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Abstract

Summary

We investigated the incidence trend in all major osteoporotic fractures for the whole country of Denmark between 1995 and 2010. Hip and other osteoporotic fractures declined for the general population and especially among women. But, we observed some increasing trend among men which needs more attention.

Purpose

The trend in osteoporotic fractures is varied across the globe, and there is no updated information in the case of Denmark for all major osteoporotic fractures (MOF). Thus, we investigated the incidence rates (IRs) of MOF among 50+ adults in Denmark over the period 1995–2010.

Methods

A series of cross-sectional analyses was done using the Danish National Health Service Register. Participants were 50+ adults in the full country Denmark with a MOF between 1995 and 2010. Gender- specific IRs of MOF per 10,000 person years (PYs) were estimated, in addition to IRs of individual fracture sites (hip, vertebrae, humerus, and radius/ulna), and women-to-men IR ratios for MOF.

Results

A general decline was observed in IRs of MOF for the whole population (from 169.8 per 10,000 PYs in 1995, to 148.0 in 2010), which was more pronounced among women. Thirty-one and nineteen percent of decline was observed in hip fracture rates among women and men, respectively. The trend in clinical vertebral fracture was slightly decreasing for women and increasing for men. The women-to-men rate ratio of MOF decreased noticeably from 2.93 to 2.72 during study period.

Conclusions

We observed declining trends in MOF and hip fracture for both sexes. However, a lower rate of decrease of hip fracture and an increasing trend in vertebral fracture was noticed among men. Considering our observations and the major economic burden which accompanies this devastating disease, more attention should be paid to MOF, especially in men.
Literature
1.
Lad SP, Patil CG, Lad EM, Boakye M (2007) Trends in pathological vertebral fractures in the United States: 1993 to 2004. J Neurosurg Spine 7(3):305–310CrossRefPubMed
2.
Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17(12):1726–1733CrossRefPubMed
3.
Briggs AM, Sun W, Miller LJ, Geelhoed E, Huska A, Inderjeeth CA (2015) Hospitalisations, admission costs and re-fracture risk related to osteoporosis in Western Australia are substantial: a 10-year review. Aust N Z J Public Health 39(6):557–562CrossRefPubMed
4.
Singer A, Exuzides A, Spangler L, O'Malley C, Colby C, Johnston K, Agodoa I, Baker J, Kagan R (2015) Burden of illness for osteoporotic fractures compared with other serious diseases among postmenopausal women in the United States. Mayo Clin Proc 90(1):53–62CrossRefPubMed
5.
Christensen L, Iqbal S, Macarios D, Badamgarav E, Harley C (2010) Cost of fractures commonly associated with osteoporosis in a managed-care population. J Med Econ 13(2):302–313CrossRefPubMed
6.
Pike C, Birnbaum HG, Schiller M, Sharma H, Burge R, Edgell ET (2010) Direct and indirect costs of non-vertebral fracture patients with osteoporosis in the US. PharmacoEconomics 28(5):395–409CrossRefPubMed
7.
Sasser AC, Rousculp MD, Birnbaum HG, Oster EF, Lufkin E, Mallet D (2005 May-Jun) Economic burden of osteoporosis, breast cancer, and cardiovascular disease among postmenopausal women in an employed population. Womens Health Issues 15(3):97–108CrossRefPubMed
8.
Orsini LS, Rousculp MD, Long SR, Wang S (2005) Health care utilization and expenditures in the United States: a study of osteoporosis-related fractures. Osteoporos Int 16(4):359–371CrossRefPubMed
9.
Hansen L, Mathiesen AS, Vestergaard P, Ehlers LH, Petersen KD (2013) A health economic analysis of osteoporotic fractures: who carries the burden? Arch Osteoporos 8:126CrossRefPubMedPubMedCentral
10.
11.
Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res 22(3):465–475CrossRefPubMed
12.
Si L, Winzenberg TM, Jiang Q, Chen M, Palmer AJ (2015) Projection of osteoporosis-related fractures and costs in China: 2010-2050. Osteoporos Int 26(7):1929–1937CrossRefPubMed
13.
Cooper C, Campion G, Melton LJ (1992) Hip fractures in the elderly: a world-wide projection. Osteoporos Int 2(6):285–289CrossRefPubMed
14.
van der Velde RY, Wyers CE, Curtis EM, Geusens PPMM, van den Bergh JPW, de Vries F, Cooper C, van Staa TP, Harvey NC (2016) Secular trends in fracture incidence in the United Kingdom between 1990 and 2012. Osteoporos Int 27(11):3197–3206CrossRefPubMedPubMedCentral
15.
Leslie WD, O'Donnell S, Jean S, Lagacé C, Walsh P, Bancej C, Morin S, Hanley DA, Papaioannou A, Osteoporosis Surveillance Expert Working Group (2009) Trends in hip fracture rates in Canada. JAMA 302(8):883–889CrossRefPubMed
16.
17.
Dimai HP, Svedbom A, Fahrleitner-Pammer A, Pieber T, Resch H, Zwettler E, Chandran M, Borgstrom F (2011) Epidemiology of hip fractures in Austria: evidence for a change in the secular trend. Osteoporos Int 22(2):685–692CrossRefPubMed
18.
Maravic M, Taupin P, Landais P, Roux C (2011) Change in hip fracture incidence over the last 6 years in France. Osteoporos Int 22(3):797–801CrossRefPubMed
19.
Crisp A, Dixon T, Jones G, Cumming RG, Laslett LL, Bhatia K, Webster A, Ebeling PR (2012) Declining incidence of osteoporotic hip fracture in Australia. Arch Osteoporos 7:179–185CrossRefPubMed
20.
Chen FP, Shyu YC, Fu TS, Sun CC, Chao AS, Tsai TL, Huang TS (2017) Secular trends in incidence and recurrence rates of hip fracture: a nationwide population-based study. Osteoporos Int 28(3):811–818CrossRefPubMed
21.
Cooper C, Cole ZA, Holroyd CR, Earl SC, Harvey NC, Dennison EM, Melton LJ, Cummings SR, Kanis JA, IOF CSA Working Group on Fracture Epidemiology (2011) Secular trends in the incidence of hip and other osteoporotic fractures. Osteoporos Int 22(5):1277–1288CrossRefPubMedPubMedCentral
22.
Vestergaard P, Rejnmark L, Mosekilde L (2008) Strongly increasing incidence of hip fractures in Denmark from 1977 to 1999. Ugeskr Laeger 170(8):621–623 [Danish]PubMed
23.
Abrahamsen B, Vestergaard P (2010) Declining incidence of hip fractures and the extent of use of anti-osteoporotic therapy in Denmark 1997-2006. Osteoporos Int 21(3):373–380CrossRefPubMed
24.
Rosengren BE, Björk J, Cooper C, Abrahamsen B (2017) Recent hip fracture trends in Sweden and Denmark with age-period-cohort effects. Osteoporos Int 28(1):139–149CrossRefPubMed
25.
Neuburger J, Wakeman R (2016) Is the incidence of hip fracture increasing among older men in England? J Epidemiol Community Health 70(10):1049–1050CrossRefPubMed
26.
Abrahamsen B, Jørgensen NR, Schwarz P (2015) Epidemiology of forearm fractures in adults in Denmark: national age- and gender-specific incidence rates, ratio of forearm to hip fractures, and extent of surgical fracture repair in inpatients and outpatients. Osteoporos Int 26(1):67–76CrossRefPubMed
27.
Driessen JH, Hansen L, Eriksen SA, van Onzenoort HA, Henry RM, van den Bergh J, Abrahamsen B, Vestergaard P, de Vries F (2016) The epidemiology of fractures in Denmark in 2011. Osteoporos Int 27(6):2017–2025CrossRefPubMedPubMedCentral
28.
29.
Andersen TF, Madsen M, Jørgensen J, Mellemkjoer L, Olsen JH (1999) The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 46(3):263–268PubMed
30.
Hundrup YA, Høidrup S, Obel EB, Rasmussen NK (2004) The validity of self-reported fractures among Danish female nurses: comparison with fractures registered in the Danish National Hospital Register. Scand J Public Health 32(2):136–143CrossRefPubMed
31.
WHO Scientific Group on the Assessment of Osteoporosis at Primary Health Care Level. Summary meeting report. 5–7 May 2004. Brussels, Belgium: World Health Organization; 2004:9
32.
33.
Amin S, Achenbach SJ, Atkinson EJ, Khosla S, Melton LJ 3rd. (2014) Trends in fracture incidence: a population-based study over 20 years. J Bone Miner Res 29(3):581–589CrossRefPubMed
34.
Leslie WD, Sadatsafavi M, Lix LM, Azimaee M, Morin S, Metge CJ, Caetano P (2011) Secular decreases in fracture rates 1986-2006 for Manitoba, Canada: a population-based analysis. Osteoporos Int 22(7):2137–2143CrossRefPubMed
35.
Tsukutani Y, Hagino H, Ito Y, Nagashima H (2015) Epidemiology of fragility fractures in Sakaiminato, Japan: incidence, secular trends, and prognosis. Osteoporos Int 26(9):2249–2255CrossRefPubMed
36.
Hagino H, Furukawa K, Fujiwara S, Okano T, Katagiri H, Yamamoto K, Teshima R (2009) Recent trends in the incidence and lifetime risk of hip fracture in Tottori, Japan. Osteoporos Int 20(4):543–548CrossRefPubMed
37.
Koh LK, Saw SM, Lee JJ, Leong KH, Lee J, National Working Committee on Osteoporosis (2001) Hip fracture incidence rates in Singapore 1991-1998. Osteoporos Int 12(4):311–318CrossRefPubMed
38.
Ballane G, Cauley JA, Luckey MM, Gel-H F (2014) Secular trends in hip fractures worldwide: opposing trends East versus West. J Bone Miner Res 29(8):1745–1755CrossRefPubMed
39.
Curtis EM, Moon RJ, Harvey NC, Cooper C (2017) Reprint of: the impact of fragility fracture and approaches to osteoporosis risk assessment worldwide. Int J Orthop Trauma Nurs 26:7–17CrossRefPubMedPubMedCentral
40.
Kanis JA, Delmas P, Burckhardt P, Cooper C, Torgerson D (1997) Guidelines for diagnosis and management of osteoporosis. The European Foundation for Osteoporosis and Bone Disease. Osteoporos Int 7(4):390–406CrossRefPubMed
41.
Compston J, Cooper A, Cooper C, Francis R, Kanis JA, Marsh D, McCloskey EV, Reid DM, Selby P, Wilkins M, National Osteoporosis Guideline Group (NOGG) (2009 Feb) Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas 62(2):105–108CrossRefPubMed
42.
43.
44.
Sanderson J, Martyn-St James M, Stevens J, Goka E, Wong R, Campbell F, Selby P, Gittoes N, Davis S (2016) Clinical effectiveness of bisphosphonates for the prevention of fragility fractures: a systematic review and network meta-analysis. Bone 89:52–58CrossRefPubMed
45.
Nguyen ND, Eisman JA, Nguyen TV (2006) Anti-hip fracture efficacy of bisphosphonates: a Bayesian analysis of clinical trials. J Bone Miner Res 21(2):340–349CrossRefPubMed
46.
Vestergaard P, Mosekilde L, Langdahl B (2011) Fracture prevention in postmenopausal women. BMJ Clin Evid 3:2011
47.
Johnell O, Kanis J (2005) Epidemiology of osteoporotic fractures. Osteoporos Int 16(Suppl 2):S3–S7CrossRefPubMed
48.
Cattiaux J, Vautard R, Cassou C, Yiou P, Masson-Delmotte V, Codron F (2010) Winter 2010 in Europe: a cold extreme in a warming climate. Geophys Res Lett 37:L20704CrossRef
Metadata
Title
RETRACTED ARTICLE: Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010
Authors
Shahab Abtahi
Johanna H.M. Driessen
Peter Vestergaard
Joop van den Bergh
Annelies Boonen
Frank de Vries
Andrea M. Burden
Publication date
01-12-2018
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2018
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-018-0503-z

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