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Journal of Gastrointestinal Surgery

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01-12-2013 | Original Article

Enucleation of Pancreatic Lesions: Indications, Outcomes, and Risk Factors for Clinical Pancreatic Fistula

Authors: Taiping Zhang, Jianwei Xu, Tianxiao Wang, Quan Liao, Menghua Dai, Yupei Zhao

Published in: Journal of Gastrointestinal Surgery | Issue 12/2013

Abstract

Background

There are few large samples and single-center series that focus on the outcomes of pancreatic enucleation and risk factors for clinical pancreatic fistula (PF). This study aimed to evaluate the indications, short- and long-term results, and risk factors for clinical PF after pancreatic enucleation.

Methods

Patients who underwent pancreatic enucleation from January 2005 to April 2011 at the Peking Union Medical College Hospital in China were included. Clinical data were collected and analyzed.

Results

A total of 119 patients underwent enucleation. PF was the most common complication; the incidence of clinical PF (grades B and C) was 27.7 %. The most common indications were endocrine neoplasms (76.5 %). During a median follow-up of 41 months, no patient developed exocrine insufficiency. Three elderly patients developed non-insulin-dependent diabetes mellitus. One patient with VIPoma developed recurrence and liver metastasis. New York Heart Association (NYHA) class II or III (P = 0.009; hazard ratio (HR) 3.191; 95 % confidence interval (CI) 1.334–7.632), operative time ≥180 min (P = 0.025; HR 2.664; 95 % CI 1.112–6.386) were the independent risk factors for clinical PF.

Conclusion

Enucleation is a safe and effective treatment for benign and low malignant lesions of the pancreas. NYHA class II or III and operation time of ≥180 min are independent risk factors for clinical PF.

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Title: Enucleation of Pancreatic Lesions: Indications, Outcomes, and Risk Factors for Clinical Pancreatic Fistula
Authors: Taiping Zhang
Jianwei Xu
Tianxiao Wang
Quan Liao
Menghua Dai
Yupei Zhao
Publication date: 01-12-2013
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 12/2013
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-013-2355-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Enucleation of Pancreatic Lesions: Indications, Outcomes, and Risk Factors for Clinical Pancreatic Fistula

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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