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01-06-2012 | Original Article

Resection Margin with Anatomic or Nonanatomic Hepatectomy for Liver Metastasis from Colorectal Cancer

Authors: Yoshihiro Inoue, Michihiro Hayashi, Koji Komeda, Shinsuke Masubuchi, Masashi Yamamoto, Hidenori Yamana, Hajime Kayano, Tetsunosuke Shimizu, Mitsuhiro Asakuma, Fumitoshi Hirokawa, Yoshiharu Miyamoto, Atsushi Takeshita, Yuro Shibayama, Kazuhisa Uchiyama

Published in: Journal of Gastrointestinal Surgery | Issue 6/2012

Abstract

Background

When hepatectomy is used as a primary treatment for liver metastasis from colorectal cancer (CRCLM), the balance between surgical curability and functional preservation of the remnant liver is of great importance.

Methods

A total of 108 patients who underwent initial hepatectomy for CRCLM were retrospectively analyzed with respect to tumor extent, operative method, and prognosis, including recurrence.

Results

The 1-, 2-, 3-, and 5-year overall survival rates (OS) for all patients were 90.5%, 77.8%, 63.2%, and 51.6%, respectively. Multivariate analysis indicated serum carbohydrate antigen 19-9 (CA 19-9) level after hepatectomy (<36 or ≥36 mAU/mL) and presence of recurrence as independent prognostic factors of OS (P = 0.0458 and 0.0249, respectively), and tumor depth of colorectal cancer (<se (a2) vs. ≥se (a2)) and serum CA 19-9 level after hepatectomy as the significant factors affecting disease-free survival (DFS) (P = 0.0025 and 0.00138, respectively). Neither resection margin nor type of hepatectomy (anatomic or nonanatomic) for CRCLM was a significant prognostic factor for OS or DFS or CRCLM recurrence, including intrahepatic recurrence.

Conclusions

In CRCLM, we believe that nonanatomic hepatectomy with narrow margin is indicated, and optimal treatment would include functional preservation of as much of the remnant liver as possible.

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Title: Resection Margin with Anatomic or Nonanatomic Hepatectomy for Liver Metastasis from Colorectal Cancer
Authors: Yoshihiro Inoue
Michihiro Hayashi
Koji Komeda
Shinsuke Masubuchi
Masashi Yamamoto
Hidenori Yamana
Hajime Kayano
Tetsunosuke Shimizu
Mitsuhiro Asakuma
Fumitoshi Hirokawa
Yoshiharu Miyamoto
Atsushi Takeshita
Yuro Shibayama
Kazuhisa Uchiyama
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 6/2012
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-012-1840-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Resection Margin with Anatomic or Nonanatomic Hepatectomy for Liver Metastasis from Colorectal Cancer

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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