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Journal of Gastrointestinal Surgery

Published in:

01-12-2009 | Original Article

Sleeve Gastrectomy Provides a Better Control of Diabetes by Decreasing Ghrelin in the Diabetic Goto–Kakizaki Rats

Authors: Feng Li, Guangyong Zhang, Jianwei Liang, Xiangjiu Ding, Zhiqiang Cheng, Sanyuan Hu

Published in: Journal of Gastrointestinal Surgery | Issue 12/2009

Abstract

Aim

Sleeve gastrectomy (SG) and modified duodenal jejunal bypass (MDJB) were compared as procedures for glucose control. We aim to form the initial conclusions with respect to the possibility of (1) whether gastric fundus exclusion is essential for the control of diabetes and (2) application as a low morbidity procedure.

Materials and Methods

SG and MDJB were performed on 10- to 12-week-old Goto–Kakizaki rats that spontaneously develop type 2 diabetes. Rats were observed for 36 weeks after surgery, and glucose, insulin, glucagons-like peptide-1 (GLP-1), glucose tolerate, insulin sensitivity, cholesterol, triglycerides, and free fatty acid levels were measured.

Results

Apart from distinct weight loss of SG and MDJB after 1 month compared with sham-operated rats (P < 0.001), SG showed strikingly improved blood glucose levels and significantly decreased Ghrelin secretion (P < 0.001). Furthermore, SG resulted in a shorter operative time (P < 0.01) and postoperative recovery time (P < 0.01) than MDJB group.

Conclusions

SG shows better control in terms of glucose tolerance and other measurements. This study provides direct evidence that SG possesses better improvement of diabetes by reduction of Ghrelin.

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Title: Sleeve Gastrectomy Provides a Better Control of Diabetes by Decreasing Ghrelin in the Diabetic Goto–Kakizaki Rats
Authors: Feng Li
Guangyong Zhang
Jianwei Liang
Xiangjiu Ding
Zhiqiang Cheng
Sanyuan Hu
Publication date: 01-12-2009
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 12/2009
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-009-0997-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sleeve Gastrectomy Provides a Better Control of Diabetes by Decreasing Ghrelin in the Diabetic Goto–Kakizaki Rats

Abstract

Aim

Materials and Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Aim

Materials and Methods

Results

Conclusions

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