Published in:
Open Access
01-06-2018 | Research Article
PET Imaging with S-[11C]Methyl-L-Cysteine and L-[Methyl-11C]Methionine in Rat Models of Glioma, Glioma Radiotherapy, and Neuroinflammation
Authors:
Andrea Parente, Aren van Waarde, Alexandre Shoji, Daniele de Paula Faria, Bram Maas, Rolf Zijlma, Rudi A. J. O. Dierckx, Johannes A. Langendijk, Erik F.J. de Vries, Janine Doorduin
Published in:
Molecular Imaging and Biology
|
Issue 3/2018
Login to get access
Abstract
Purpose
S-[11C]-methyl-L-cysteine ([11C]MCYS) has been claimed to offer higher tumor selectivity than L-[methyl-
11C]methionine ([11C]MET). We examined this claim in animal models.
Procedures
Rats with implanted untreated (n = 10) or irradiated (n = 7, 1 × 25 Gy, on day 8) orthotopic gliomas were scanned after 6, 9, and 12 days, using positron emission tomography. Rats with striatal injections of saline (n = 9) or bacterial lipopolysaccharide (n = 9) were scanned after 3 days.
Results
Uptake of the two tracers in untreated gliomas was similar. [11C]MCYS was not accumulated in salivary glands, nasal epithelium, and healing wounds, in contrast to [11C]MET, but showed 40 % higher accumulation in the healthy brain. Both tracers showed a reduced tumor uptake 4 days after irradiation and minor accumulation in inflamed striatum. [11C]MCYS indicated higher lesion volumes than [11C]MET (untreated tumor + 47 %; irradiated tumor up to + 500 %; LPS-inflamed striatum + 240 %).
Conclusions
[11C]MCYS was less accumulated in some non-tumor tissues than [11C]MET, but showed lower tumor-to-brain contrast.