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01-06-2011 | Research Article

Uptake Decrease of Proliferative PET Tracer ¹⁸FLT in Bone Marrow after Carbon Ion Therapy in Lung Cancer

Authors: Mitsuru Koizumi, Tsuneo Saga, Masayuki Inubushi, Toshimitsu Fukumura, Kyosan Yoshikawa, Naoyoshi Yamamoto, Mio Nakajima, Toshio Sugane, Masayuki Baba

Published in: Molecular Imaging and Biology | Issue 3/2011

Abstract

Purpose

The aim of this study was to investigate the change of 3′-[¹⁸F]fluoro-3′-deoxy-l-thymidine (¹⁸FLT) uptake in normal bone marrow (BM) after inevitable radiation.

Procedures

Twenty-one non-small cell lung cancer patients who received carbon ion radiotherapy (CIRT) were studied with ¹⁸FLT-positron emission tomography/computed tomography (PET/CT) at pre- and post-CIRT. Radiation dose was calculated by radiation planning. Irradiated BM was divided into three groups (<10% of maximum dose, 10–30%, and >30%).

Results

¹⁸FLT uptake clearly decreased at >10% irradiated areas and mildly decreased at <10% areas. ¹⁸FLT uptake was lowest just after CIRT, somewhat increased at 3 months, and remained unchanged for more than 1 year. There was no significant difference between 10–30% and >30% areas.

Conclusion

¹⁸FLT revealed that BM function decreased by small dose such as <4.2–4.4 GyE/1 fraction of CIRT and is eradicated by >4.2–4.4 GyE/1 fraction.

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Title: Uptake Decrease of Proliferative PET Tracer 18FLT in Bone Marrow after Carbon Ion Therapy in Lung Cancer
Authors: Mitsuru Koizumi
Tsuneo Saga
Masayuki Inubushi
Toshimitsu Fukumura
Kyosan Yoshikawa
Naoyoshi Yamamoto
Mio Nakajima
Toshio Sugane
Masayuki Baba
Publication date: 01-06-2011
Publisher: Springer-Verlag
Published in: Molecular Imaging and Biology / Issue 3/2011
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-010-0363-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Uptake Decrease of Proliferative PET Tracer ¹⁸FLT in Bone Marrow after Carbon Ion Therapy in Lung Cancer

Abstract

Purpose

Procedures

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Procedures

Results

Conclusion

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