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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 5/2008

Open Access 01-09-2008 | Research Article

2-Deoxy-2[F-18]FDG-PET for Detection of Recurrent Laryngeal Carcinoma after Radiotherapy: Interobserver Variability in Reporting

Authors: L. van der Putten, O. S. Hoekstra, R. de Bree, D. J. Kuik, E. F. I. Comans, J. A. Langendijk, C. R. Leemans

Published in: Molecular Imaging and Biology | Issue 5/2008

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Abstract

Purpose

To evaluate accuracy and interobserver variability in the assessment of 2-deoxy-2[F-18]fluoro-d-glucose-positron emission tomography (FDG-PET) for detection of recurrent laryngeal carcinoma after radiotherapy.

Procedures

Eleven experienced nuclear physicians from eight centres assessed 30 FDG-PET scans on the appearance of local recurrence (negative/equivocal/positive). Conservative (equivocal analysed as negative) and sensitive (equivocal analysed as positive) assessment strategies were compared to the reference standard (recurrence within 6months after PET).

Results

Seven patients had proven recurrences. For the conservative and sensitive strategy, the mean sensitivity was 87% and 97%, specificity 81% and 63%, positive predictive values 61% and 46% and negative predictive values 96% and 99%, respectively. Interobserver variability showed a reasonable relation in comparison to the reference standard (kappa = 0.55).

Conclusions

FDG-PET has acceptable interobserver agreement and yields good negative predictive value for detection of recurrent laryngeal carcinoma. It could therefore be used as first diagnostic step and may reduce futile invasive diagnostics.
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Metadata
Title
2-Deoxy-2[F-18]FDG-PET for Detection of Recurrent Laryngeal Carcinoma after Radiotherapy: Interobserver Variability in Reporting
Authors
L. van der Putten
O. S. Hoekstra
R. de Bree
D. J. Kuik
E. F. I. Comans
J. A. Langendijk
C. R. Leemans
Publication date
01-09-2008
Publisher
Springer-Verlag
Published in
Molecular Imaging and Biology / Issue 5/2008
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-008-0154-3

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