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01-04-2018 | Nephrology - Review

Novel acute kidney injury biomarkers: their characteristics, utility and concerns

Authors: Braian M. Beker, Mateo G. Corleto, Cecilia Fieiras, Carlos G. Musso

Published in: International Urology and Nephrology | Issue 4/2018

Abstract

Acute kidney injury (AKI) consists of a rapid renal function decline which usually increases serum urea and creatinine levels. Since kidney injury begins by inducing biological and molecular changes which evolve to cellular damage, biomarkers could be used as tools for monitoring early AKI appearance, and predicting its recovery. Among the main AKI biomarkers the neutrophil gelatinase-associated lipocalin, cystatin C, kidney injury molecule-1, monocyte chemotactic peptide-1, N-acetyl-β-D-glucosaminidase, interleukin-18, liver-type fatty acid-binding protein, netrin-1, cycle arrest markers, endogenous ouabain, selenium-binding protein 1, and BPIFA2 marker, have been described. Even though novel biomarkers seem to be more helpful to early detect AKI and/or predict the need for renal replacement, and mortality compared to serum creatinine, more comprehensive studies are still required to determine their clinical utility.

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Title: Novel acute kidney injury biomarkers: their characteristics, utility and concerns
Authors: Braian M. Beker
Mateo G. Corleto
Cecilia Fieiras
Carlos G. Musso
Publication date: 01-04-2018
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue 4/2018
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-017-1781-x

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